教育及工作经历
2024–现在 四川大学化学学院，特聘研究员，博士生导师
2023–2023 多特蒙德工业大学，Walter Benjamin博士后研究员，合作导师：Guido Clever教授
2019–2023 剑桥大学，Walter Benjamin博士后研究员，合作导师：Jonathan Nitschke教授
2015–2019 柏林工业大学，博士，导师：Martin Oestreich教授
2012–1015 上海大学，硕士，导师：龚和贵 教授
2008–2012 河南大学，学士，导师：史峰 教授
主要研究方向
1.配位超分子化学：聚焦手性金属有机笼的精准设计与可控构筑，系统研究其在分子识别、不对称催化及功能材料等领域中的应用潜力。
2.手性超分子化学：开展多层次手性超分子结构的理性设计与构筑，重点探索其新型手性光学与自旋相关性能，包括圆偏振发光和手性诱导自旋选择性效应。
3.金属有机化学：围绕丰产金属催化偶联反应的新方法开发，结合理论计算与实验研究，深入阐明反应机理，为绿色合成及复杂分子构建提供创新策略。
围绕上述研究方向，已累计发表学术论文50余篇，其中以第一作者或通讯作者（含共同）身份发表论文20余篇，包括J. Am. Chem. Soc.（4篇）、Angew. Chem. Int. Ed.（5篇）、Nat. Commun. （1篇）Chem. Soc. Rev.（1篇）、ACS Cent. Sci.（1篇）以及JACS Au（1篇）等。
我们的课题组依托于四川大学化学学院有机金属络合物催化研究所，成立于2024年1月。我们诚挚邀请博士后、博士研究生、硕士研究生、研究助理以及联合培养学生的加入。同时，我们也鼓励本科生参与科研项目和毕业设计研究。如有意向，您可直接前往化学学院有机金属络合物催化研究所办公室咨询，或通过电子邮件与我们联系。
主要奖励及荣誉
2025国家海外高层次人才引进计划
2025四川省天府峨眉青年人才计划
2024 四川大学双百B人才计划，四川大学
2019 Walter Benjamin博士后项目，德国科学基金会（DFG）
2019 最优等博士学位Summa Cum Laude，柏林工业大学
2015 研究生国家奖学金，上海大学
2015 光华奖学金，上海大学
承担项目
国家自然科学基金优秀青年科学基金项目（海外）2026-2028 主持 在研
四川省科技厅面上项目 2026-2027 主持 在研
四川大学青年教师科技创新能力提升项目2025-2026 主持 在研
四川大学人才科研启动基金 2024-2027 主持 在研
代表性论文和著作
SCU
2026年
1.D. Yang‡, S. Zhao‡ (本科生), Z. Liu, X. Zheng, R. Li, H. Chen, H. Fu*, J. R. Nitschke, W. Xue*. Steric Bulk Controls Δ/Λ Handedness Enabling Stereodivergent Self-Sssembly of FeII₂L₃ Cages, Inorg. Chem. 2026, 65, 1038–1044.
2.Y. Yang, S. Tao, L. Chen, Y. Tan, J. Xu, H. Fu, R. Li, H. Chen, W. Xue*, X. Zheng*. Electrochemical Cross-Electrophile Coupling of Unactivated Tertiary Alkyl Bromides with Benzyl Chloride to Access Quaternary Stereocenters, Org. Biomol. Chem. 2026, 24, 800–804.
2025年
3.S. Yang, J. Zhao, X. Nie, X. Zheng, X. Xie, X. Zheng, H. Fu, H. Chen, R. Li, W. Xue*, J. Xu*. A Tandem Electrocatalysis and Hydroformylation Approach to Synthesize High-Carbon Aldehydes from CO₂, Chem. Commun. 2025, 61, 17165–17168.
4.J. Zhao, Y. Shi, D. Yang, J. Xu, M. Yang, C. Zhang, X. Zheng, R. Li, H. Fu*, W. Xue*, H. Chen*. Pd-Catalyzed Four-Component Cascade Cyclization of Alkynols, Aryl Iodides, CO, and Amines, Org. Lett. 2025, 27, 10745–10753.
5.S. Li‡, Y. Shi‡, J. Tang, M. Yan, S. Huang, T. Dou, S. Wang, X. Jin, Z. Su, W. Jiang, J. Xu, X. Zheng, R. Li, H. Chen, W. Xue*, H. Fu*. Skeletal Editing of 4-Arylpyrimidines into Diverse Nitrogen Heteroaromatics via Four-Atom Synthons, Nat. Commun. 2025, 16, 7112.
6.S. Tao, Y. Yang, L. Chen, J. Xu, H. Fu, H. Chen, W. Jiang, R. Li, W. Xue*, X. Zheng*. Electrochemical Synergistic Ni/Co-Catalyzed Carbonylative Cross-Electrophile Coupling of Aryl and Alkyl Halides with CO. JACS Au. 2025, 5,1413–1420.
2024年
7.W. Xue*, E. Benchimol, A. Walther, N. Ouyang, J. J. Holstein, T. K. Ronson, J. Openy, Y. Zhou, K. Wu, R. Chowdhury, G. H. Clever*, J. R. Nitschke*. Interplay of Stereochemistry and Charge Governs Guest Binding in Flexible ZnII4L4 Cages. J. Am. Chem. Soc. 2024, 146, 32730–32737.
8.S. Li, J. Tang, Y. Shi, M. Yan, Y. Fu, Z. Su, J. Xu, W. Xue, X. Zheng, Y. Ge, R. Li, H. Chen, H. Fu. C3 Selective Chalcogenation and Fluorination of Pyridine Using Classic Zincke Imine Intermediates. Nat. Commun. 2024, 15. 7420.
9.M. Li, H. Zhu, S. Adorinni, W. Xue, A. Heard, A. M. Garcia, S. Kralj, J. R. Nitschke, S. Marchesan. Metal Ions Trigger the Gelation of Cysteine-Containing Peptide-Appended Coordination Cages. Angew. Chem. Int. Ed. 2024, 63, e202406909.
10.H. Zhu, L. Pesce, R. Chowdhury, W. Xue, K. Wu, T. K. Ronson, R. H. Friend, G. M. Pavan, J. R. Nitschke. Stereocontrolled Self-Assembly of a Helicate-Bridged CuI12L4 Cage That Emits Circularly Polarized Light. J. Am. Chem. Soc. 2024, 146, 2379–2386.
11.X. Peng, S. Tao, W. Xue, H. Fu, J. Xu, R. Li, H. Chen, X. Zheng. Organoboron-Promoted Electrochemical Chlorosulfonylation of Alkenes with Sulfonyl Chlorides. Org. Lett. 2024, 26, 4018–4023.
12.J. Tang, S. Li, Y. Fu, Z. Su, J. Xu, W. Xue, X. Zheng, R. Li, H. Chen, H. Fu. Radical meta-C–H Halogenation of Azines via N-Benzyl Activation Strategy. Org. Lett. 2024, 26, 5899–5904.
Before SCU
13.W. Xue, L. Pesce, B. Adinarayana, T. K. Ronson, K. Wu, D. Zhang, N. Vanthuyne, T. Brotin, A. Martinez, G. M. Pavan, J. R. Nitschke. Subtle Stereochemical Effects Influence Binding and Purification Abilities of an FeII4L4 Cage. J. Am. Chem. Soc. 2023, 145, 5570–5575.
14.W. Xue, K. Wu, N. Ouyang, T. Brotin, J. R. Nitschke. Allosterically Regulated Guest Binding Determines Framework Symmetry for an FeII4L4 Cage. Angew. Chem. Int. Ed. 2023, 62, e202301319.
15.W. Xue, T. K. Ronson, Z. Lu, J. R. Nitschke. Solvent Drives Switching between Λ and Δ Metal Center Stereochemistry of M8L6 Cubic Cages. J. Am. Chem. Soc. 2022, 144, 6136–6142.
16.W. Xue,* X. Jia, X. Wang, X. Tao, Z. Yin, H. Gong*. Nickel-Catalyzed Formation of Quaternary Carbon Centers Using Tertiary Alkyl Electrophiles. Chem. Soc. Rev. 2021, 50, 4162–4184.
17.W. Xue, M. Oestreich. Beyond Carbon: Enantioselective and Enantiospecific Reactions with Catalytically Generated Boryl- and Silylcopper Intermediates. ACS Cent. Sci. 2020, 6, 1070–1081.
18.W. Xue,‡ W. Mao,‡ L, Zhang, M. Oestreich. Mechanistic Dichotomy of Magnesium- and Zinc-Based Germanium Nucleophiles in the C(sp3)–Ge Cross-Coupling with Alkyl Electrophiles. Angew. Chem. Int. Ed. 2019, 58, 6440–6443.
19.W. Mao,‡ W. Xue,‡ E. Irran, M. Oestreich. Copper-Catalyzed Regio- and Enantioselective Addition of Silicon Grignard Reagents to Alkenes Activated by Azaaryl Groups. Angew. Chem. Int. Ed. 2019, 58, 10723–10726. (Highlighted as Hot Paper; Synfacts 2019, 15, 1024).
20.W. Xue, R. Shishido, M. Oestreich. Bench-Stable Stock Solutions of Silicon Grignard Reagents: Application to Iron- and Cobalt-Catalyzed Radical C(sp3)–Si Cross-Coupling Reactions. Angew. Chem. Int. Ed. 2018, 57, 12141–12145. (Highlighted as VIP Paper; Synfacts 2018, 14, 1174; Org. Process Res. Dev. 2018, 22 ,1687)
21.W. Xue, M. Oestreich. Copper-Catalyzed Decarboxylative Radical Silylation of Redox-Active Aliphatic Carboxylic Acid Derivatives. Angew. Chem. Int. Ed. 2017, 56, 11649–11652.
22.W. Xue, Z.-W. Qu. S. Grimme, M. Oestreich. Copper-Catalyzed Cross-Coupling of Silicon Pronucleophiles with Unactivated Alkyl Electrophiles Coupled with Radical Cyclization. J. Am. Chem. Soc. 2016, 138, 14222–14225.
23.W. Xue, M. Oestreich. Silicon Grignard Reagents as Nucleophiles in Transition-Metal-Catalyzed Allylic Substitution. Synthesis 2019, 51, 233–239.
24.W. Xue,‡ H. Xu,‡ Z. Liang, H. Gong. Nickel-Catalyzed Reductive Cyclization of Alkyl Dihalides.Org. Lett. 2014, 16, 4984–4987. (Highlighted by Synfacts, 2015, 11, 0076)
25.Z. Liang,‡ W. Xue,‡ K. Lin, H. Gong. Nickel-Catalyzed Reductive Reductive Methylation of Alkyl Halides and Acid Chlorides with Methyl p-Tosylate. Org. Lett. 2014, 16, 5620–5623.
26.Z. Zhao, Y. Gong, W. Tong, W. Xue*, H. Gong.* Ni-Catalyzed Cross-Electrophile Coupling of Aryl Triflates withThiocarbonates via C–O/C–O Bond Cleavage. Org. Lett. 2021, 23,2158–2163.
27.X. Tao, K. Yao,* W. Xue.* Ni-Catalyzed Cross-Electrophile Coupling of α-Hydroxy Carbonyl Compound-Derived Oxalates with Vinyl Triflates. Tetrahedron Lett. 2021, 73, 153129.
28.K. Wu, T. K. Ronson, L. Goh, W. Xue, A. W. Heard, P. Su, X. Li, M. Vinković, J. R. Nitschke. A Diverse Array of Large Capsules Transform in Response to Stimuli. J. Am. Chem. Soc. 2023, 145, 11356–11363
29.S. Bähr, W. Xue, M. Oestreich. C(sp3)–Si Cross-Coupling. ACS Catal. 2019, 9, 16–24.
30.M. Zheng, W. Xue, T. Xue, H. Gong. Ester Formation via Nickel-Catalyzed Reductive Coupling of Alkyl Halides with Chloroformates. Org. Lett. 2016, 18, 6152–6155.
31.X. Wang, S. Wang, W. Xue, H. Gong. Nickel-Catalyzed Reductive Coupling of Aryl Bromides withTertiary Alkyl Halides. J. Am. Chem. Soc. 2015, 137, 11562–11565.
32.J. Gu, X. Wang, W. Xue, H. Gong. Nickel-Catalyzed Reductive Coupling of Alkyl Halides with Other Electrophiles: Concept and Mechanistic Considerations. Org. Chem. Front. 2015, 2, 1411–1421. (ESI Highly Cited Paper)
33.P. Li, C. Wu, J. Zhao, Y. Li, W. Xue, F. Shi. One-Pot Synthesis of Dihydrobenzisoxazoles from Hydroxylamines, Acetylenedicarboxylates, and Arynes via in situ Generation of Nitrones. Can. J. Chem. 2013, 91, 43–50.
34.C. Wu, P. Li, Y, Fang, J, Zhao, W. Xue, Y. Li, R. C. Larock, F. Shi. Pd-Catalyzed Oxidative Coupling of Monosubstituted Sydnones and Terminal Alkynes. Tetrahedron Lett. 2011, 52, 3797–3801.
