简历：

学习经历

2016.09-2021.06：Brock University, Canada，获理学博士学位

2013.09-2016.06：Illinois Institute of Technology, U.S.A.，获工学硕士学位

2009.09-2013.06：华东理工大学，获理学学士学位

工作经历

2024.9-至今：四川大学化学学院，副研究员

2021.12-2024.9：四川大学化学学院，专职博士后

主要研究方向

DNA纳米技术在生物分析中的应用

主要工作业绩

1、国家自然科学基金项目(青年)，22204112，2022.1-2025.12，主持；

2、中国博士后科学基金（面上），2023M732423，2023.7-2024.8，主持；

3、四川省博士后科研项目特别资助，TB2023003，2024.1-2025.12，主持；

主要奖励和荣誉  

1、2024年     中国分析测试协会分析测试科学奖，省部级，一等奖

2、2018年     Jack M. Miller Excellence in Research Award, Brock University

代表性成果 （获奖成果、专著、论文、专利）

1. Xu, J.;^† Deng, H.;^† Wu, L.; Song, J.; Feng, X.; Liu, Y.; Wang, G, A.*; Li, F.* Binder-Responsive DNA Strand Displacement Enables High-Throughput and High-Fidelity Discovering of Small Molecular DNA Binders. Anal. Chem., 2024, 96, 30, 12213–12216.

2. Wu, Y.;^† Wang, G, A.;^† Yang, Q.; Li, F.* Native Characterization of Noncanonical Nucleic Acid Thermodynamics via Programmable Dynamic DNA Chemistry. J. Am. Chem. Soc., 2024, 146(26), 18041–18049.

3. Wu, L.;^† Wang, G, A.;^† Li, F.* A plug-and-play module for reversible and continuous control of DNA strand displacement kinetics. J. Am. Chem. Soc., 2024, 146(10), 6516–6521.

4. Wang, G. A^†; Wu, X. ^†; Chen, F.; Shen, C.; Yang, Q.; Li, F.* Toehold-exchange-based activation of aptamer switches enables high thermal robustness and programmability. J. Am. Chem. Soc., 2023, 145(5), 2750–2753.

5. Wang, G. A.; Kong, C.; Li, F.* Design and Bioanalytical Applications of Stochastic DNA Walkers. Chem. Commun., 2023, 59, 5492-5501.

6. Wang, G. A.; Xu, J.; Traynor, S. M.; Wu, X.; Yan, H.; Li, F.* DNA balance for native characterization of chemically modified DNA. J. Am. Chem. Soc., 2021, 143(34), 13655-13663.

7. Wang, G. A.; Xie, X.; Mansour, H.; Chen, F.; Matamoros, G.; Sanchez, A. L.; Fan, C.; Li, F.* Expanding detection windows for discriminating single nucleotide variants using rationally designed DNA equalizer probes. Nat. Commun. 2020, 11, 5473-5483.

8. Li, Y.;^† Wang, G, A.;^† Mason, S. D.; Yang, X.; Yu, Z.; Tang, Y.; Li, F.* Simulation-guided engineering of an enzyme-powered three-dimensional DNA nanomachine for discriminating single nucleotide variants. Chem. Sci. 2018, 9, 6434-6439. (^†Equal Contribution)

9. Wang, G. A.;^† Dong, T.;^† Mansour H.; Matamoros, G.; Sanchez, A. L.; Li, F.* Paper-based DNA reader for visualized quantification of soil-transmitted helminth infections. ACS Sens. 2018, 3, 205-210. (^†Equal Contribution)

10. Guo, C. ^†; Deng, H. ^†; Yang, Q. ^†; Huang, D.; Shen, C.; Wang, G.A.; Li, F.* Coding intrinsic disorder into DNA hybridization probes enables discrimination of single nucleotide variants over wide and tunable temperature ranges. Angew. Chem. Int. Ed., 2023, e202314386.

11. Huang, D.; ^† Deng, H.; ^† Zhou, J.; ^† Wang, G. A.; Lei, Q.; Guo, C.; Peng, W.; Liang, P.; Shen, C.; Ying, B.;* Li, W.;* Li, F.* Mismatch-Guided Deoxyribonucleic Acid Assembly Enables Ultrasensitive and Multiplex Detection of Low-Allele-Fraction Variants in Clinical Samples. J. Am. Chem. Soc., 2023, 145, 37, 20412–20421.

12. Xu, J.; Wang, G. A.; Gao, L.; Wu, L.; Lei, Q.; Deng, H.; Li, F. Enabling Programmable Dynamic DNA Chemistry Using Small-Molecule DNA Binders. Nat. Commun., 2023, 14 (1), 4248.

13. Traynor, S. M.; Wang, G. A.; Pandey, R.; Li, F.;* Soleymani, L.* Dynamic bio-barcode assay enables electrochemical detection of a cancer biomarker in undiluted human plasma: A sample-in-answer-out approach. Angew. Chem. Int. Ed. 2020, 132, 22806–22811.

14. Mason, S. D.; Wang, G. A.; Yang, P.; Li, Y.; Li, F.* Probing and controlling dynamic interactions at biomolecule-nanoparticle interfaces using stochastic DNA walkers. ACS Nano 2019, 13, 8106-8113.

15. Dong, T.; Mansour, H.; Hu, H.; Wang, G. A.; Watson, C. J. F.; Yousef, M.; Matamoros, G.; Sanchez, A. L.; MacNeil, A. J.; Wu, P.;* Li, F.* Colorimetric polymerase chain reaction enabled by a fast light-activated substrate chromogenic (FLASH) detection platform. Anal. Chem. 2020, 92, 6456-6461.

16. Tang, W.;^† Zhong, W.;^† Tan, Y.;^† Wang, G. A.;^† Li, F.;* Liu, Y.* DNA Strand displacement reaction: a powerful tool for discriminating single nucleotide variants. Topics in Current Chemistry 2020, 378, 10.

17. Dong, T.; Wang, G. A.; Li, F.* Shaping up field-deployable nucleic acid testing using microfluidic paper-based analytical devices. Anal. Bioanal. Chem., 2019, 411, 4401-4414.

18. Dong, T.; Wang, G. A.; Li, M. W.; Li, F.* Systematic investigation of a quantitative paper-based DNA reader (QPDR) for distance-based quantification of nucleic acids and mercury ions. Anal. Methods 2019, 11, 5376–5380.