四川大学化学学院
师资力量

曹伟地     教授

研究方向:不对称合成,光催化,有机硅化学,手性药物和生物活性化合物合成

联系方式:86-28-85418249          Email:wdcao@scu.edu.cn

个人主页:点击进入

简历:

2006.9 - 2010.6    四川大学化学学院化学专业,学士

2010.9 - 2015.6    四川大学化学学院有机化学专业,博士(导师:冯小明教授)

2015.9 - 2018.2    新加坡南洋理工大学,博士后(导师: Choon-Hong Tan教授)

2018.4 - 2021.12  四川大学化学学院  特聘副研究员

2022.1 - 至今       四川大学化学学院  研究员

主要研究方向

不对称催化、光催化、有机硅化学、手性药物和生物活性化合物的合成

主要工作业绩

2021 入选四川省海内外高层次人才引进计划(青年人才项目)

2021 获四川大学青年科技学术带头人培育项目资助

2019 获教育部高等学校科学研究优秀成果奖自然科学一等奖(第五完成人)

2016 获第14届国际华人有机化学会议和11届国际华人无机化学会议优秀墙报奖

代表性成果 (获奖成果、专著、论文、专利)

1.  Fengcai Zhang, Xinpeng Sang, Yuqiao Zhou, Weidi Cao,* Xiaoming Feng,* Enantioselective Synthesis of Azetidines through [3 + 1]-Cycloaddition of Donor−Acceptor Aziridines with Isocyanides, Org. Lett. 2022, 24, ASAP, DOI: 10.1021/acs.orglett.2c00190.

2.  Changqiang He, Zhikun Wu, Yuqiao Zhou, Weidi Cao,* Xiaoming Feng,* Asymmetric Catalytic Nitrooxylation and Azidation of β-Keto Amides/esters with Hypervalent Iodine Reagents, Org. Chem. Front. 2022, 9, 703−708.

3.  Li Dai, Wen Liu, Yuqiao Zhou, Zi Zeng, Xinyue Hu, Weidi Cao,* Xiaoming Feng,* Catalytic Asymmetric Halogenation/Semipinacol Rearrangement of 3-Hydroxyl-3-vinyl Oxindoles: A Stereodivergent Kinetic Resolution Process, Angew. Chem. Int. Ed. 2021, 60, 2659926603

4.  Guihua Pan, Changli He, Min Chen, Qian Xiong, Weidi Cao,* Xiaoming Feng,* Synthesis of Dihydroisoquinoline and Dihydropyridine Derivatives via Asymmetric Dearomative Three-component Reaction, CCS Chem. 2021, 3, 2012-2020.

5.  Mingming Guan, Shiyu Wang, Yao Luo, Weidi Cao,* Xiaohua Liu, Xiaoming Feng,* Catalytic Asymmetric Addition of Thiols to Silyl Glyoxylates for Synthesis of Multi-hetero-atom Substituted Carbon Stereocenter, Chem. Sci. 2021, 12, 7498–7503.

6.  Mingyi Jiang, Kaiqi Hu, Yuqiao Zhou, Qian Xiong, Weidi Cao,* Xiaoming Feng,* Enantioselective Isocyanide-based Multicomponent Reaction with Alkylidene Malonates and Phenols, Org. Lett. 2021, 23, 5261-5265.

7.  Weidi Cao, Xiaohua Liu,* Asymmetric Formal Hetero-Ene Reaction of Allylgold Intermediates, Chin. J. Org. Chem. 2021, 41, 857−858

8.  Ziwei Zhong, Zhijie Xiao, Xiaohua Liu, Weidi Cao,* Xiaoming Feng,*Catalytic Asymmetric Synthesis of 3,2'-Pyrrolinyl Spirooxindoles via Conjugate Addition/Schmidt-type Rearrangement of Vinyl Azides and (E)-Alkenyloxindoles, Chem. Sci. 2020, 11, 11492−11497.

9.  Liuzhen Hou, Tengfei Kang, Liangkun Yang, Weidi Cao,* Xiaoming Feng,* Enantioselective Imino-Ene Reaction of N-Sulfonyl Ketimines with Silyl Enol Ethers: Access to Chiral Benzosultams, Org. Lett. 2020, 22, 1390−1395.

10.  Yu Zhang, Hao Pan, Wen Liu, Weidi Cao,* Xiaoming Feng,*Asymmetric Catalytic Synthesis of Epoxides via Three-Component Reaction of Diazoacetates, 2‑Oxo-3-ynoates, and Nitrosoarenes, Org. Lett. 2020, 22, 6744−6749.

11.  Xiangqiang Li, Mingyi Jiang, Tangyu Zhan, Weidi Cao,* Xiaoming Feng,* Catalytic Asymmetric Three-component Hydroacyloxylation/1,4-Conjugate Addition of Ynamides, Chem Asian J. 2020, 15, 1953−1956.

12.  Weidi Cao, Xiaohua Liu, Xiaoming Feng,* Chiral N,Nʹ-dioxide and Their Metal Complexes in Asymmetric Catalysis (in Chinese), Chin. Sci. Bull. 2020, 65, 2941−2951.

13. Bin Shen, Wen Liu, Weidi Cao,* Xiaohua Liu, Xiaoming Feng,* Asymmetric Synthesis of α,β-Epoxy-γ-lactams through Tandem Darzens/Hemiaminalization Reaction, Org. Lett. 2019, 21, 47134716.

14.  Yan Wang, Kaixuan Wang, Weidi Cao,* Xiaohua Liu, Xiaoming Feng,* Diastereo- and Enantioselective 1,6-Conjugate Addition of 2‑Azaarylacetamides to para-Quinone Methides, Org. Lett. 2019, 21, 6063−6067.

15.  Weidi Cao, Xiaoming Feng, Xiaohua Liu,* Reversal of Enantioselectivity in Chiral Metal Complex-catalyzed Asymmetric Reactions, Org. Biomol. Chem. 2019, 17, 6538−6550.

16. Wen Liu, Weidi Cao,* Haipeng Hu, Lili Lin, Xiaoming Feng,* Dynamic Kinetic Asymmetric Transformations of β-Halo-α-Keto Esters by N,N′-Dioxide/Ni(II)-Catalyzed Carbonyl-Ene Reaction, Chem. Commun. 2018, 54, 89018904.

17. Hang Zhang, Qian Yao, Weidi Cao,* Shulin Ge, Jinxiu Xu, Xiaohua Liu and Xiaoming Feng,* Catalytic Enantioselective Ene-type Reactions of Vinylogous Hydrazone: Construction of α-Methylene-g-butyrolactone Derivatives, Chem. Commun. 2018, 54, 12511–12514.

18.  Lifeng Wang, Weidi Cao,* Hongjiang Mei, Linfeng Hu, Xiaoming Feng,*Catalytic Asymmetric Synthesis of Chiral Spiro-Cyclopropyl Oxindoles from 3-Alkenyl-Oxindoles and Sulfoxonium Ylides, Adv. Synth. Catal. 2018, 360, 4089-4093. (VIP)

19. Changqiang He, Weidi Cao,* Jianlin Zhang, Shulin Ge, Xiaoming Feng,*Chirall N,N'-Dioxide/Scandium(III)-Catalyzed Asymmetric Alkylation of N-Unprotected 3-Substituted Oxindoles, Adv. Synth. Catal. 2018, 360, 4301-4305.

20. Weidi Cao, Xiaohua Liu,* Xiaoming Feng, Chiral Organobases: Properties and Applications in Asymmetric Catalysis, Chin. Chem. Lett. 2018, 29, 1201−1208.

21. Weidi Cao, Davin Tan, Richmond Lee,* Choon-Hong Tan,*Enantioselective 1,2-Anionotropic Rearrangement of Acylsilane through a Bisguanidinium Silicate Ion Pair, J. Am. Chem. Soc. 2018, 140, 1952−1955.

22. Weidi Cao, Xiaohua Liu, Jing Guo, Lili Lin, Xiaoming Feng,* Asymmetric Tandem 1,5-Hydride Shift/Ring Closure for the Synthesis of Chiral Spirooxindole Tetrahydroquinolines, Chem. Eur. J. 2015, 21, 16321636.

23.  Weidi Cao, Xiaohua Liu, Ruixue Peng, Peng He, Lili Lin, Xiaoming Feng,* Catalytic Asymmetric Cross-Dehydrogenative Coupling: Activation of C–H Bonds by a Cooperative Bimetallic Catalyst System, Chem. Commun. 2013, 49, 34703472.

24.  Weidi Cao, Xiaohua Liu, Wentao Wang, Lili Lin, Xiaoming Feng,*Highly Enantioselective Synthesis of Tetrahydroquinolines via Cobalt(II)-Catalyzed Tandem 1,5-Hydride Transfer/Cyclization, Org. Lett. 2011, 13, 600603.

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