四川大学化学学院
师资力量

林丽丽     教 授

研究方向:有机化学

联系方式:          Email:lililin@scu.edu.cn

个人主页:点击进入

简历

1999–2003,四川大学,化学学院应用化学专业,本科

2003–2008,四川大学,化学学院有机化学专业,博士

2008–2011,四川大学,化学学院有机化学专业,讲师

2011–2016,四川大学,化学学院有机化学专业,副教授,硕导

2016–至今 四川大学,化学学院有机化学专业,教授

2018-至今 四川大学,化学学院有机化学专业,博导

主要研究方向

新型手性催化剂的发展、不对称催化反应及其在天然产物、药物合成中的应用。

主要工作业绩

发展特色双哌啶骨架手性催化剂,已证明其可作为优秀的有机小分子催化剂,并有作为配体与金属形成配合物催化不对称反应的潜力。已经在Nature communication, Angew. Chem. Int. Ed.等刊物上发表论文四十多篇;承担国家自然科学基金项目4项;作为第三完成人获2009和2019年教育部自然科学奖一等奖和2012年国家自然科学奖二等奖。

代表性成果 (获奖成果、专著、论文、专利)


  1. Gonglin Li, Mohuizi Liu, Sijia Zou, Xiaoming Feng, Lili Lin,* A Bispidine-Based Chiral Amine Catalyst for Asymmetric Mannich Reaction of Ketones with Isatin Ketimines, Org. Lett. 2020, 22, 8708–8713.

  2. Fenzhen Chang, Bin Shen, Sijing Wang, Lili Lin,* Xiaoming Feng,* Lewis Acid Catalysed Asymmetric Cascade Reaction of Cyclopropyl Ketones: Concise Synthesis of Pyrrolobenzothiazoles, Chem. Commun. 2020, 56, 13429−13432.

  3. Weiwei Li, Pengfei Zhou, Gonglin Li, Lili Lin,* Xiaoming Feng,* Catalytic Asymmetric Halohydroxylation of α,β-Unsaturated Ketones with Water as the Nucleophile, Adv. Synth. Catal. 2020, 362, 1982−1987.

  4. Chaoran Xu, Kaixuan Wang, Dawei Li, Lili Lin,* and Xiaoming Feng,* Asymmetric Synthesis of Oxa-Bridged Oxazocines by Rh(II)/Zn(II) Relay Catalytic [4+3] Cycloaddition Reaction, Angew. Chem. Int. Ed. 2019, 58, 18438-18442.

  5. Fengcai Zhang, Yu Zhang, Qingfa Tan, Lili Lin,* Xiaohua Liu, Xiaoming Feng,* Kinetic Resolution of Aziridines via Catalytic Asymmetric Ring Opening Reaction with Mercaptobenzothiazoles, Org. Lett. 2019, 21, 5928−5932.

  6. Sijia Zou, Weiwei Li, Kai Fu, Weidi Cao, Lili Lin,* Xiaoming Feng,* Chiral N,N’-Dioxide/Tm(OTf)3 Complex-Catalyzed Asymmetric Bisvinylogous Mannich Reaction of Silyl Ketene Acetal with Aldimines, Adv. Synth. Catal. 2019, 361, 2295−2300.

  7. Qian Xiong, Lili Lin,* Xiaohu Zhao, Jiawen Lang, Xiaohua Liu, Xiaoming Feng,* Zinc(II)-Catalyzed Asymmetric DielsAlder Reaction of (E)1-Phenyl Dienes with β,γ-Unsaturated αKetoesters, J. Org. Chem. 2018, 83, 12527–12534.

  8. Xinyue Hu, Yuhang zhou, Yan Lu, Sijia Zou, Lili Lin,* Xiaohua Liu, Xiaoming Feng,* Catalytic Asymmetric Inverse-Electron-Demand Hetero-Diels−Alder Reaction of Dioxopyrrolidines with Hetero-Substituted Alkenes, J. Org. Chem. 2018, 83, 8679–8687.

  9. Hongjiang Mei, Lili Lin,* Bin Shen, Xiaohua Liu, Xiaoming Feng,* Highly Enantioselective Desymmetrization of Prochiral Cyclic α,α-Dicyanoalkenes via the Direct Vinylogous Michael/Cyclization Domino Reaction, Org. Chem. Front. 2018, 5, 2505–2509.

  10. Fenzhen Chang, Lili Lin,* Yong Xia, Hang Zhang, Shunxi Dong, Xiaohua Liu, Xiaoming Feng*, Chiral N,N′-Dioxide/ScIII-Complex-Catalyzed Asymmetric Ring-Opening Reaction of Cyclopropyl Ketones with Indoles, Adv. Synth. Catal. 2018, 360, 2608–2612.

  11. Haipeng Hu, Jinxiu Xu, Wen Liu, Shunxi Dong, Lili Lin,* and Xiaoming Feng,* Copper-Catalyzed Asymmetric Addition of Tertiary Carbon Nucleophiles to 2HAzirines: Access to Chiral Aziridines with Vicinal Tetrasubstituted Stereocenters, Org. Lett. 2018, 20, 5601–5605.

  12. Jingchuan Zhang, Kai Fu, Lili Lin,* Yan Lu, Xiaohua Liu, Xiaoming Feng,* Efficient Catalytic Enantioselective Hydroxyamination of ɑ-Aryl-ɑ-Cyanoacetates with 2-Nitrosopyridines, Chem. Eur. J. 2018, 24, 4289–4293.

  13. Yan Lu, Yuhang Zhou, Jingchuan Zhang, Lili Lin,* Xiaohua Liu, Xiaoming Feng*, Highly Regio- and Enantioselective Nitroso Diels-Alder Reaction of 1,3-Diene-1-carbamates Catalyzed by Chiral N,N’-Dioxide/Copper(II) Complex. Adv. Synth. Catal. 2018, 360, 186–191.

  14. Jianlin Zhang, Lili Lin,* Changqiang He, Qian Xiong, Xiaohua Liu, Xiaoming Feng,* A Chiral Scandium-Complex-Catalyzed Asymmetric Inverse-Electron-Demand oxa-Diels–Alder Reaction of o-Quinone Methides with Fulvenes. Chem. Commun. 2018, 54, 74–77.

  15. Qiong Tang, Lili Lin,* Jie Ji, Haipeng Hu, Xiaohua Liu, Xiaoming Feng*, Catalytic Asymmetric Direct Vinylogous Aldol Reaction of Isatins with β,γ-Unsaturated Butenolides, Chem. Eur. J. 2017, 23, 16447–16451.

  16. Yuhang Zhou, Yan Lu, Xinyue Hu, Hongjiang Mei, Lili Lin,* Xiaohua Liu, Xiaoming Feng*, Highly diastereo- and enantioselective synthesis of spirooxindole-cyclohexaneamides through N,N’-dioxide/Ni(II)-catalyzed Diels–Alder reactions, Chem. Commun., 2017, 53, 2060–2063.

  17. Hongjiang Mei, Lili Lin, * Lifeng Wang, Li Dai, Xiaohua Liu, Xiaoming Feng*, Highly regio-, diastereo- and enantioselective deracemization of axially chiral 3-alkylideneoxindoles, Chem. Commun., 2017, 53, 8763–8766.

  18. Zhengmeng Wang, Lili Lin,* Pengfei Zhou, Xiaohua Liu, Xiaoming Feng*, Chiral N,N’-dioxide-Sc(NTf2)3 complex-catalyzed asymmetric bromoamination of chalones with N-bromosuccinimide as both bromine and amide source, Chem. Commun., 2017, 53, 3462–3465.

  19. Dong Zhang, Chengkai Yin, Yuhang Zhou, Yali Xu, Lili Lin,* Xiaohua Liu, Xiaoming Feng*, Chiral N,N’-dioxide/Co(II)-promoted asymmetric 1,3-dipolar cycloaddition of nitrones with methyleneindolinones, Chem. Commun., 2017, 53, 7925–7928.

  20. Shulin Ge, Tengfei Kang, Lili Lin,* Xiying Zhang, Peng Zhao, Xiaohua Liu, Xiaoming Feng*, Chiral N,N’-dioxide/Sc(OTf)3 complex-catalyzed asymmetric dearomatization of β-naphthols, Chem. Commun., 2017, 53, 11759–11762.

  21. Hang Zhang, Qian Yao, Lili Lin,* Chaoran Xu, Xiaohua Liu, Xiaoming Feng*, Catalytic Asymmetric Epoxidation of Electron-Deficient Enynes Promoted by Chiral N,N’-Dioxide-Scandium(III) Complex, Adv. Synth. Catal. 2017, 359, 3454–3459.

  22. Xiangqiang Li, Jing Guo, Lili Lin,* Haipeng Hu, Fenzhen Chang, Xiaohua Liu, Xiaoming Feng*, Chiral Magnesium(II) Complex-Catalyzed Enantioselective Desymmetrization of meso-Aziridines with Pyrazoles, Adv. Synth. Catal. 2017, 359, 3532–3537.

  23. Yuheng Zhang, Lili Lin,* Yushuang Chen, Xiaohua Liu, Xiaoming Feng*, N,N’-Dioxide–Lanthanum(III)-Catalyzed Asymmetric Cyclopropanation of 2-Cyano-3-arylacrylates with 2-Bromomalonates, Adv. Synth. Catal. 2017, 359, 1831–1836.

  24. Xiaoyu Hao, Lili Lin,* Fei Tan, Shulin Ge, Xiaohua Liu, Xiaoming Feng*, Asymmetric synthesis of chromans via the Friedel–Crafts alkylation–hemiketalization catalysed by an N,N’-dioxide scandium(III) complex, Org. Chem. Front. 2017, 4, 1647–1650.

  25. Qian Yao, Lili Lin,* Hang Zhang, Han Yu, Qian Xiong, Xiaohua Liu, Xiaoming Feng*, The asymmetric synthesis of multisubstituted diquinanes via the domino reaction of electrondeficient enynes, Org. Chem. Front. 2017, 4, 2012–2015.

  26. Lili Lin, Xiaoming Feng*, Catalytic Strategies for Diastereodivergent Synthesis, Chem. Eur. J. 2017, 23, 6464–6482.

  27. Wangbin Wu, Sijia Zou, Lili Lin,* Jie Ji, Yuheng Zhang, Baiwei Ma, Xiaohua Liu, Xiaoming Feng*, Catalytic asymmetric Meerwein–Ponndorf–Verley reduction of glyoxylates induced by a chiral N,N’-dioxide/Y(OTf)3 complex, Chem. Commun., 2017, 53, 3232-3235.

  28. Kai Fu, Jingchuan Zhang, Lili Lin,* Jun Li, Xiaohua Liu, and Xiaoming Feng*, Chiral N,N’-Dioxide/Lanthanide(III) Complex Catalyzed Asymmetric Bisvinylogous Mukaiyama Aldol Reactions, Org. Lett. 2017, 19, 332-335.

  29. Juhua Feng, Xiao Yuan, Weiwei Luo, Lili Lin,* Xiaohua Liu, Xiaoming Feng*, Chiral N,N’-Dioxide-Organocatalyzed Regio-, Diastereo- and Enantioselective Michael Addition–Alkylation Reaction, Chem. Eur. J. 2016, 22, 15650–15653.

  30. Jianfeng Zheng, Lili Lin,* Li Dai, Xiao Yuan, Xiaohua Liu, Xiaoming Feng*, Chiral N,N′-Dioxide–Scandium(III) Complex-Catalyzed Asymmetric Friedel-Crafts Alkylation Reaction of ortho-Hydroxybenzyl Alcohols with C3-Substitued N-Protected Indoles, Chem. Eur. J. 2016, 22, 18254-18258

  31. Xiaohu Zhao, Hongjiang Mei, Qian Xiong, Kai Fu, Lili Lin,* Xiaohua Liu, Xiaoming Feng*, Highly enantioselective construction of carbazole derivatives via [4+2] cycloaddition of silyloxyvinylindoles and ß,γ-unsaturated a-ketoesters, Chem. Commun., 2016, 52,10692–10695

  32. Yan Lu, Yuhang Zhou, Lili Lin,* Haifeng Zheng, Kai Fu, Xiaohua Liu, Xiaoming Feng*, N,N’-Dioxide/nickel(II)-catalyzed asymmetric Diels–Alder reaction of cyclopentadiene with 2,3-dioxopyrrolidines and 2-alkenoyl pyridines, Chem. Commun., 2016, 52, 8255—8258.

  33. Kai Fu, Jianfeng Zheng, Lili Lin,* Xiaohua Liu and Xiaoming Feng*, Chiral N,N’-dioxide–In(OTf)3-catalyzed asymmetric vinylogous Mukaiyama aldol reactions, Chem. Commun., 2015, 51, 3106—3108.

  34. Xiying Zhang, Jianlin Zhang, Lili Lin,* Haifeng Zheng, Wangbin Wu, Xiaohua Liu, Xiaoming Feng*, Chiral N,N’-Dioxide-Zinc(II) Complex-Catalyzed Asymmetric Aza-Friedel–Crafts Reaction of Isatin-Derived Ketimines with Indoles, Adv. Synth. Catal. 2016, 358, 3021-3026.

  35. Xiao Xiao, Lili Lin,* Xiangjin Lian, Xiaohua Liu, Xiaoming Feng*, Catalytic asymmetric α-amination of β-ketoesters and β-keto amides with a chiral N,N’-dioxide–copper(I) complex, Org. Chem. Front., 2016, 3, 809–812.

  36. Xiao Yuan, Lili Lin,* Weiliang Chen, Wangbin Wu, Xiaohua Liu, Xiaoming Feng*, Synthesis of Chiral Tetrahydrofurans via Catalytic Asymmetric [3+2] Cycloaddition of Heterosubstituted Alkenes with Oxiranes, J. Org. Chem. 2016, 81, 1237-1243.

  37. Ruixue Peng, Lili Lin,* Yuheng Zhang, Wangbin Wu, Yan Lu, Xiaohua Liu, Xiaoming Feng*, The assignment of the configuration for α-hydroxy acid esters using a CEC strategy, Org. Biomol. Chem., 2016, 14, 5258–5262.

  38. Xuan Fu, Lili Lin,* Yong Xia, Pengfei Zhou, Xiaohua Liu, Xiaoming Feng*, Catalytic asymmetric [3+3] annulation of cyclopropanes with mercaptoacet aldehyde, Org. Biomol. Chem., 2016, 14, 5914–5917.

  39. Jianfeng Zheng, Lili Lin*, Kai Fu, Haifeng Zheng, Xiaohua Liu, Xiaoming Feng*, Synthesis of Optically Pure Spiro[cyclohexane-oxindoline] Derivatives via Catalytic Asymmetric Diels-Alder Reaction of Brassard-Type Diene with Methyleneindolines, J. Org. Chem. 2015, 80, 8836?8842

  40. Ruixue Peng, Lili Lin*, Weidi Cao, Jing Guo, Xiaohua Liu, Xiaoming Feng*, A racemic N,N’-dioxide-iron(III) complex chemosensor for determination of enantiomeric excess, concentration and identity of hydroxy carboxylic acids with circular dichroism and fuorescence responses, Tetrahedron Letters 2015, 56, 3882–3885.

  41. Hongjiang Mei, Xiao Xiao, Xiaohu Zhao, Bing Fang, Xiaohua Liu, Lili Lin,* Xiaoming Feng*, Catalytic Asymmetric Henry Reaction of Nitroalkanes and Aldehydes Catalyzed by a Chiral N,N’-Dioxide/Cu(I) Complex, J. Org. Chem. 2015, 80, 2272-2280.

  42. Zhenhua Dong, Juhua Feng, Weidi Cao, Xiaohua Liu, Lili Lin*, Xiaoming Feng*, N,N’-Dioxide–nickel(II) complex catalyzed asymmetric Michael addition of cyclic 1,3-dicarbonyl compounds to β,γ-unsaturated α-ketoesters, Tetrahedron Lett, 2011, 52, 3433-3436.

  43. Lili Lin, Yulong Kuang, Xiaohua Liu, Xiaoming Feng*, Indium(III)-Catalyzed Asymmetric Hetero-Diels–Alder Reaction of Brassard-Type Diene with Aliphatic Aldehydes, Org. Lett, 2011, 13, 3868-3871.

  44. Lili Lin, Zhenling Chen, Xu Yang, Xiaohua Liu, and Xiaoming Feng*, An Efficient Enantioselective Hetero-Diels-Alder Reaction of Brassard’s Dienes with Aliphatic Aldehydes: A One-Step Synthesis of (R)-(+)-Kavain and (S)-(+)-Dihydrokavain, Org. Lett. 2008, 10, 1311-1314.

  45. Lili Lin, Xiaohua Liu, Xiaoming Feng, Asymmetric Hetero-Diels–Alder Reactions of Danishefsky’s and Brassard’s Dienes with Aldehydes, Synlett 2007, 14, 2147-2157.

  46. Lili Lin, Qian Fan, Bo Qin, and Xiaoming Feng*, Highly Enantio- and Diasteroselective Brassard Type Hetero-Diels-Alder Approach to 5-Methyl-Containing α,β-Unsaturated δ-Lactones, J. Org. Chem. 2006, 71, 4141-4146.


 

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