四川大学化学学院
师资力量

张 骥     教 授,化学生物学教研室主任

研究方向:化学生物学,有机化学

联系方式:028-85418580          Email:jzhang@scu.edu.cn

个人主页:点击进入

个人简介

四川大学化学学院教授,博士生导师。2002年获理学博士学位,2003-2005年香港大学化学系Research Assistant2011年入选教育部“新世纪优秀人才支持计划”,第十三批四川省学术和技术带头人后备人选。从事有机化学、化学生物学教学科研工作,四川省线下一流本科课程《有机化学(I)》负责人。科研方向为生物纳米材料,或多项国家自然科学基金、重点研发项目课题、省应用基础项目等资助,发表SCI论文130余篇,主编本科教材及英文专著各1部。

教学科研概况

讲授本科课程:

《有机化学(I)》(203112030 & 203113030, 四川省线下一流本科课程)

《生物化学》(203080030, 双语课程)

《化学生物学实验》(203197020

《有机化学实验》

《应用化学设计实验》(203130020

讲授研究生课程:

《生物材料化学》(M0703Z202

科研方向:

纳米生物材料:新型核酸和药物递送系统的设计和构建,基因/药物载体的构效关系,以及相关基因治疗和免疫治疗研究。

主要工作业绩

教育部“新世纪优秀人才支持计划”(2011);

四川省学术和技术带头人后备人选(第十三批,2021);

教育部高等学校科学研究优秀成果奖(科学技术)自然科学奖一等奖(2010,排名第三);

四川大学第七届“姜维平优秀教学奖”(2021);

四川大学第四届“探究式-小班化”教学竞赛一等奖、四川大学“探究式-小班化”教学示范教师/课程(有机化学I)(2021);

四川大学首届“五粮春青年教师优秀教学奖”(2015);

四川大学先进个人(优秀教师)(2015~16);

四川大学十佳青年教师教学奖(2012~13);

及其它各类学校教学奖励20余项。

代表性成果 (获奖成果、专著、论文、专利)

获奖成果:

简单金属盐催化的C-C键和C-N键形成反应,教育部高等学校科学研究优秀成果奖(科学技术)自然科学奖一等奖,2010,第三完成人。

主编著作:

        1.  《有机化学基础》(第三版),2020,科学出版社。ISBN: 978-7-03-064996-6.

        2.   <Macrocyclic Polyamines: Synthesis and Applications>, 2018, Wiley-VCH, ISBN: 978-3-527-34187-0.

近年部分代表性论文:

1.  Yang, H.-Z.; Zhang, J.*; Guo, Y.; Pu, L.; Yu, X.-Q.* “A fluorescent self-reporting vector with GSH reduction responsiveness for nucleic acid delivery” ACS Appl. Bio Mater. 2021, 4(7), 5717-5726.

2.  Chen, P.; Zhang, J.*; He, X.; Liu, Y.-H.; Yu, X.-Q.* “Hydrophobically Modified Carbon Dots as Multifunctional Platform for Serum-Resistant Gene Delivery and Cell Imaging” Biomater. Sci. 2020, 8(13), 3730-3740.

3.  Xiao, Y.-P.; Zhang, J.*; Liu, Y.-H.; Huang, Z.; Guo, Y.; Yu, X.-Q.* “Bioinspired pyrimidine-contained cationic polymers as effective nano-carriers for DNA and protein delivery” J. Mater. Chem. B 2020, 8(11), 2275-2285.

4.  He, X.; Luo, Q.; Zhang, J.*; Chen, P.; Wang, H.-J.; Luo, K.; Yu, X.-Q.* “Gadolinium-doped Carbon Dots as Nano-theranostic Agent for MR/FL Imaging and Gene Delivery” Nanoscale 2019, 11(27), 12973-12982.

5.  He, X.; Chen, P.; Zhang, J.*; Luo, T.-Y.; Wang, H.-J.; Liu, Y.-H.; Yu, X.-Q.* “Cationic Polymer-Derived Carbon Dots for Enhanced Gene Delivery and Cell Imaging” Biomater. Sci. 2019, 7(5), 1940-1948.

6.  Yu, Q.-Y.; Guo, Y.; Zhang, J.*; Huang, Z.; Yu, X.-Q.* “Zn(II) coordination to cyclen-based polycations for enhanced gene delivery” J. Mater. Chem. B 2019, 7(3), 451-459.

7.  Zhang, Y.-M; Huang, Z.; Wu, X.-R.; Zhang, J.*; Liu, Y.-H.; Yu, X.-Q.* “A small combinatorial library of lipidoids as gene delivery vectors” ACS Appl. Nano Mater. 2018, 1(8), 3925-3934.

8.  Wang, B.; Zhang, J.*; Liu, Y.-H.; Zhang, W.; Xiao, Y.-P.; Zhao, R.-M.; Yu, X.-Q.* “A reduction-responsive liposomal nanocarrier with self-reporting ability for efficient gene delivery” J. Mater. Chem. B 2018, 6(18), 2860-2868.

9.  Xiao, Y.-P., Zhang, J.*; Liu, Y.-H.; Chen, X.-C.; Yu, Q.-Y.; Luan, C.-R.; Zhang, J.-H.; Wei, X.; Yu, X.-Q.* “Ring-opening polymerization of diepoxides as an alternative method to overcome PEG dilemma in gene delivery” Polymer 2018, 134, 53-62.

10. Wang, B.; Chen, P.; Zhang, J.*; Liu, Y.-H.; Huang, Z.; Yu, Q.-Y.; Zhang, J.-H.; Zhang, W.; Yu, X.-Q.* “Self-assembled core-shell-corona multifunctional AIE non-viral vector for efficient hepatocytes targeting gene delivery” Polymer Chem. 2017, 8(48), 7486-7498.

11.  Xiao, Y.-P.; Zhang, J.*; Liu, Y.-H.; Huang, Z.; Wang, B.; Zhang, Y.-M.; Yu, X.-Q.* “Cross-linked polymers with fluorinated bridge for efficient gene delivery” J. Mater. Chem. B 2017, 5(43), 8542-8553.

12.  Wang, H.-J.; He, X.; Luo, T.-Y.; Zhang, J.*; Liu, Y.-H.; Yu, X.-Q.* “Amphiphilic carbon dots as versatile vector for nucleic acid and drug delivery” Nanoscale. 2017, 9(18), 5935-5947.

13.  Zhang, Y.-M; Huang, Z.; Zhang, J.*; Wu, W.-X.; Liu, Y.-H.; Yu, X.-Q.* “Amphiphilic polymers from ring-opening polymerization: a strategy for the enhancement of gene delivery” Biomater. Sci. 2017, 5(4), 718-729.

14. Huang, Z.; Zhang, Y.-M.; Cheng, Q.; Zhang, J.*; Liu, Y.-H.; Wang, B.; Yu, X.-Q.* “Structure-activity relationship studies of symmetrical cationic bolasomes as non-viral gene vectors” J. Mater. Chem. B 2016, 4(33), 5575-5584.

15.  Luan, C.-R.; Liu, Y.-H.; Zhang, J.*; Yu, Q.-Y.; Huang, Z.; Wang, B.; Yu, X.-Q.* “Low molecular weight oligomers with aromatic backbone as efficient non-viral gene vectors” ACS Appl. Mater. Interf. 2016, 8(17), 10743-10751.

16.  Xun, M.-M.; Xiao, Y.-P.; Zhang, J.*; Liu, Y.-H.; Peng, Q.; Guo, Q.; Wu, W.-X.; Xu, Y.; Yu, X.-Q.* “Low molecular weight PEI-based polycationic gene vectors via Michael addition polymerization with improved serum-tolerance” Polymer 2015, 65, 45-54.

17.  Guo, Q.; Liu, Y.-H.; Xun, M.-M.; Zhang, J.*; Huang, Z.; Zhou, X.-D.; Yu, X.-Q.* “Diol glycidyl ether-bridged low molecular weight PEI as potential gene delivery vehicles” J. Mater. Chem. B 2015, 3(13), 2660-2670.

18. Zhang, Q.-F.; Yu, Q.-Y.; Geng, Y.; Zhang, J.*; Wu, W.-X.; Wang, G.; Gu, Z.; Yu, X.-Q.* “Ring-opening polymerization for hyperbranched polycationic gene delivery vectors with excellent serum tolerance” ACS Appl. Mater. Interfaces 2014, 6(18), 15733-15742.

19.  Yi, W.-J.; Yu, X.-C.; Wang, B.; Zhang, J.*; Yu, Q.-Y.; Zhou, X.-D.; Yu, X.-Q.* “TACN-based oilgomers with aromatic backbones for efficient nucleic acid delivery” Chem. Commun. 2014, 50(49), 6454-6457.

20.  Yi, W.-J.; Zhang, Q.-F.; Zhang, J.*; Liu, Q.; Ren, L.; Chen, Q.-M.; Guo, L.; Yu, X.-Q.* “Cyclen-based lipidic oligomers as potential gene delivery vehicles” Acta Biomater. 2014, 10(3), 1412-1422.

21.  Wang, H.-J.; Liu, Y.-H.; Zhang, J.*; Zhang, Y.; Xia, Y.; Yu, X.-Q.* “Cyclen-based cationic lipids with double hydrophobic tails for efficient gene delivery” Biomaterials Sci. 2014, 2(10), 1460-1470.

22.  Zhang, Q.-F.; Yi, W.-J.; Wang, B.; Zhang, J.*; Ren, L.; Chen, Q.-M.; Guo, L.; Yu, X.-Q.* “Linear polycations by ring-opening polymerization as non-viral gene delivery vectors: structure-activity relationship studies” Biomaterials 2013, 34(21), 5391-5401.

 

关闭