主要研究方向

主要研究方向

有机催化方法学

绿色有机合成化学

有机反应机理研究

生物活性化合物合成新方法研究

诚招副研究员、博后、研究助理、硕博生以及交流生！

欢迎本科生加入本课题组开展“大创”项目和本科毕业设计！

主要工作业绩

承担科研项目及基金

国家自然科学基金委青年基金项目（2017获批）

国家自然科学基金委面上基金项目（2019获批）

科技部“合成生物学”重大专项（青年）项目（2019获批）

基金委创新群体项目子课题（2019获批）

主要工作业绩

不对称催化合成是化学学科、乃至药物和材料领域的前沿和研究热点，手性化合物尤其是具有潜在生理活性的手性分子的精准构筑是当前合成化学们关注的重点。王天利博士先后在金属不对称催化（主要是过渡金属催化芳香杂环不对称氢化）和有机小分子不对称催化（主要是有机膦（Ⅲ）催化不对称合成）这两个大的不对称催化领域开展了系统深入的研究，取得了系列开拓性的重要创新成果。

回国入职四川大学开始独立工作以来，主要围绕“五价鏻/膦催化的不对称合成化学”开展研究，基于廉价易得的天然氨基酸手性骨架，发展了结构新颖和多样的手性双功能季鏻盐催化剂，率先建立了手性催化剂库，重点开展基于季鏻催化的不对称合成化学前沿研究。设计发展的多功能手性季鏻盐催化剂在多种不对称催化反应中表现出了优秀的催化效果，成功实现了许多传统催化剂（如季铵盐、三级胺及手性磷酸等）不能实现的有机转化反应，解决了不对称催化和手性合成领域的研究难题。课题组重点发展潜在生理活性分子的精准高效构筑新方法，已经实现了多种手性杂环（比如三、四、五、六元环状分子，七元杂环分子等）、手性螺环、手性桥环、以及多类手性共存的复杂有机分子的精准不对称合成。最近，基于C-X键的不对称构建策略，精准合成了一系列杂原子取代的手性季碳分子，为手性季碳类化合物尤其是相关的手性药物及先导化合物的开发提供了新的创制途径。

目前已在Acc. Chem. Res., J. Am. Chem. Soc., Angew.   Chem. Int. Ed. 以及 ACS   Catal. 等国际顶级及权威刊物上发表SCI论文30余篇。部分研究成果（如J. Am. Chem. Soc. 2011）已被多篇综述和多本专著收录，并被选作相关领域的重要进展被重点评述（Chem. Soc. Rev. 2014, 43, 1660; Chem.   Rev. 2012, 112, 2557; “Organic Reaction Mechanisms” (Wiley,   2011)、“Progress   in Heterocyclic Chemistry” (Elsevier, 2012)、“Comprehensive Organic Synthesis II” (Elsevier, 2014)）；部分论文（如Angew. Chem. Int. Ed. 2019; Angew. Chem. Int. Ed. 2013;   J. Am. Chem. Soc. 2016）被 Synfacts , X-mol以及Chin. J. Org. Chem. 等专业评述杂志或网站作亮点推荐。

主要奖励和荣誉

2019年，ACP Lectureship Award   (to Japan)

2019年，拔尖创新人才培养优秀指导教师（四川大学）

2019年，大学生创新创业教育优秀指导教师（四川大学）

2019年，四川大学优秀本科毕业设计一等奖指导教师

2019年，四川大学巾帼建功立业奖

2019年，成都市特聘专家

2018年，四川省特聘专家

2018年，四川大学优秀本科毕业设计指导教师

2017年，科学中国人2017年度人物奖（青年）

2017年，四川大学青年科技人才奖

2017年，四川大学好未来优秀学者奖

2016年，Gold Award of   Outstanding Mentor for “Singapore Science and Engineering Fair (SSEF) 2016”（金奖，新加坡教育部）

2011年，中国科学院化学研究所“研究生系列报告奖”

2010年，中国科学院化学研究所“青年科学特别奖”

2010年，第三届 “CCME-IOC &   ICCAS-LMRSS” Alfa Aesa 研究生学术研讨会优秀报告奖

2009年，中国科学院化学研究所“青年科学优秀奖”

2009年，The Third ChemComm   International Symposium “The Three Best Poster Prize”（英国皇家化学会）

2009年，中国科学院研究生院“三好学生”

2008年，中国科学院化学研究所“青年科学优秀奖”

2007年，中国科学院研究生院“三好学生”

2007年，中国科学院研究生院“优秀学生干部”

2002-2006，国家一等奖学金（2003），四川大学优秀毕业论文一等奖（2006），并多次获得四川大学“一等奖学金、优秀学生干部、三好学生、优秀学生”等荣誉。

代表性成果 (获奖成果、专著、论文、专利)

 代表性成果 

1.Hongkui Zhang, Chunhui Jiang, Jian-Ping Tan, Hui-Lin Hu, Yayun Chen, Xiaoyu Ren, Hong-Su Zhang, Tianli Wang* “Highly Enantioselective Construction of Fully-substituted Stereocenters Enabled by In-situ Phosphonium-containing Organocatalysis”, ACS   Catal. 2020, in press.

2.Juan Du, Jia-Hong Wu, Lixiang Zhu, Xiaoyu Ren,   Chunhui Jiang, Tianli Wang* “Bifunctional Phosphonium   Salt-Catalyzed Enantioselective [4 + 2] Annulation of Isoindigos with   Allenes: Access to Complex Heterocycles with Centerpiece of 4H-Pyrans”, Adv. Synth. Catal. 2020, in press.

3. Dongming Lu, Xin Liu, Jia-Hong Wu, Song Zhang, Jian-Ping Tan, Xiaojun Yu, Tianli Wang* “Asymmetric Construction of Bispiro‐Cyclopropane‐Pyrazolones via a [2 + 1] Cyclization Reaction by Dipeptide‐Based Phosphonium Salt Catalysis”, Adv.   Synth. Catal. 2020, in press.

4. Jia-Hong Wu, Jianke Pan, Juan Du, Xiaoxia Wang, Xuemei Wang, Chunhui Jiang, Tianli Wang,*   “Enantioselective Synthesis of Multifunctionalized 4H-Pyrans via Formal [4 + 2] Annulation Process by Bifunctional Phosphonium Salt Catalysis”, Org. Lett. 2020, 22, 395-399.

5. Xiaojun Yu, Song Zhang, Zhiyu Jiang, Hong-Su Zhang, Tianli Wang,* “Highly efficient and convenient access to   phosphinates via CHCl3-assisted direct phosphorylation between R2P(O)H and ROH by phosphonium salt catalysis”, Eur. J. Org. Chem. 2020, in   press.

6.  Jian-Ping Tan, Hongkui Zhang, Zhiyu Jiang, Yuan Chen, Xiaoyu Ren, Chunhui Jiang, Tianli Wang,*   “Enantioselective Construction of Spiro[chroman-thiazolones]: Bifunctional Phosphonium Salt-Catalyzed [2+4] Annulation between 5-Alkenyl Thiazolones and   ortho-Hydroxyphenyl- Substituted para-Quinone Methides”, Adv. Synth.   Catal. 2020, 362, 1058-1063.

7.   Xin Liu, Dongming Lu, Jia-Hong Wu,  Jian-Ping Tan, Chunhui Jiang, Guowei Gao,* Tianli Wang,* “Stereoselective Synthesis of CF3-Containing   Spirooxindoles via 1,3-Dipolar Cycloaddition by Dipeptide-Based Phosphonium   Salt Catalysis”, Adv. Synth. Catal. 2020, 362, 1490-1495.

8.  Jianke Pan; Jia-Hong Wu; Hongkui Zhang; Xiaoyu   Ren; Jian-Ping Tan; Lixiang Zhu; Hong-Su Zhang; Chunhui Jiang; Tianli   Wang,* “Highly Enantioselective Synthesis of Fused Tri- and   Tetrasubstituted Aziridines: aza-Darzens Reaction of Cyclic Imines with α-Halogenated   Ketones Catalyzed by Bifunctional Phosphonium Salt”, Angew.  Chem. Int. Ed. 2019,  58, 7425 –7430. ( Highlighted by Synfacts 2019, and X-mol)

9.   Jian-Ping Tan, Peiyuan Yu, Jia-Hong Wu, Yuan   Chen, Jianke Pan, Chunhui Jiang, Xiaoyu Ren, Hong-Su Zhang, Tianli   Wang,* “Bifunctional Phosphonium Salt Directed Enantioselective   Formal [4 + 1] Annulation of Hydroxyl-Substituted para-Quinone   Methides with α-Halogenated Ketones”, Org. Lett. 2019, DOI: 10.1021/acs.orglett.9b02560.

10.   Chunhui Jiang, Yayun Chen, Hongkui Zhang, Jian-Ping Tan, Tianli Wang,* “Catalyst-Free Synthesis of α-Functionalized 2H-Chromenes   in Water: A Tandem Self-Promoted pseudo-Substitution and Decarboxylation   Process”, Chem. Asian J. 2019, 14, 2938−2944.

11.   Guofei Huang, Xiaoyu Ren, Chunhui Jiang, Jia-Hong Wu, Guowei Gao, Tianli Wang,* “Efficient synthesis of   (E)-2-nitromethylcinnamates via phosphine-catalyzed tandem α-addition and 1,3-rearrangement”, Org. Chem. Front., 2019, 6, 2872–2876.

12.   Jia-Hong Wu, Jianke Pan, Tianli Wang,*   “Dipeptide-Based Phosphonium Salt Catalysis: Application to Enantioselective Synthesis of Fused Tri- and Tetrasubstituted Aziridines”, Synlett., 2019,   DOI: 10.1055/s-0039-1690192.

13.   Tianli Wang, Xiaoyu Han, Fangrui Zhong, Weijun Yao, and Yixin Lu,* “Amino   Acid-derived Bifunctional Phosphines for Enantioselective Transformations”, Acc. Chem. Res., 2016, 49, 1369−1378.

14.   Tianli Wang, Zhaoyuan Yu, Ding Long Hoon, Claire Yan Phee, Yu Lan,   and Yixin Lu,* “Regiodivergent   Enantioselective γ-Additions of Oxazolones to 2,3-Butadienoates Catalyzed by   Phosphines: Synthesis of α,α-Disubstituted α-Amino Acids and N,O-Acetal   Derivatives”, J. Am. Chem. Soc. 2016, 138, 265−271. ( Highlighted by Synfacts 2016, 12,   309)

15.   Tianli Wang, Ya Chen, Guanghui Ouyang, Yan-Mei He,* Zhiyan Li and   Qing-Hua Fan* “Solvent Regulated Asymmetric Hydrogenation of   Quinoline Derivatives in Oligo(ethylene glycol)s via Host-Guest Interactions”,   Chem. Asian   J. 2016, 11, 2773−2777.

16.   Tianli Wang, Zhaoyuan Yu,   Ding Long Hoon, Kuo-Wei Huang, Yu Lan,* Yixin Lu,* “Highly Enantioselective Construction of Tertiary   Thioethers and Alcohols via Phosphine-Catalyzed Asymmetric g-Addition reactions of 5H-Thiazol-4-ones and 5H-Oxazol-4-ones:   Scope and Mechanistic Understandings”, Chem. Sci. 2015, 6, 4912−4922.

17.   Tianli Wang, Ding Long   Hoon, and Yixin Lu,* “Enantioselective   Synthesis of 3-Fluoro-3-allyl-oxindoles via Phos-phine-Catalyzed Asymmetric g-addition of 3-Fluoro-Oxindoles to 2,3-Butadienoates”, Chem. Commun. 2015, 51,   10186−10189.

18.   Tianli Wang, Weijun Yao, Fangrui Zhong, Guo Hao Pang, Yixin Lu,*   “Phosphine-Catalyzed Enantioselective g-Addition of 3-Substituted Oxindoles to 2,3-Butadienoates   and 2-Butynoates: Use of Prochiral Nucleophiles”, Angew. Chem. Int. Ed.   2014, 53, 2964−2968.

19.   Tianli Wang, Fei Chen, Jie Qin, Yan-Mei He, Qing-Hua Fan,*   “Asymmetric Ruthenium-Catalyzed Hydrogenation of 2- and 2,9-Substituted   1,10-Phenanthrolines”, Angew. Chem. Int. Ed. 2013, 52,   7172−7176. (Highlighted by Chin. J. Org. Chem. 2013, 33,   2028)

20.   Tianli Wang, Lian-Gang Zhuo,   Zhi Wei Li, Fei Chen, Zi Yuan Ding, Yanmei He, Qing-Hua Fan,* Jun   Feng Xiang, Zhi-Xiang Yu,* Albert   S. C. Chan, “Highly Enantioselective Hydrogenation of   Quinolines Using Phosphine-Free Chiral Cationic Ruthenium Catalysts: Scope,   Mechanism and Origin of Enantioselectivity”, J. Am. Chem. Soc. 2011,   133, 9878−9891.

21.   Tianli Wang, Guanghui Ouyang, Yan-Mei He   and Qing-Hua Fan,* “Asymmetric Tandem Reduction   of 2-(Aroylmethyl)quinolines with Phosphine-Free Ru-TsDPEN Catalyst”, Synlett.   2011, 7,   939−942.

22.   Zhen Wang, Tianli Wang,Weijun   Yao, Yixin Lu,* “Phosphine-Catalyzed Enantioselective [4 + 2] Annulation of   o-Quinone Methides with Allene Ketones”, Org. Lett. 2017, 19,   4126-4129.

23.   Xiaoyu Han, Weijun Yao, Tianli Wang,   Yong Ren Tan, Ziyu Yan, Jacek. Kwiatkowski, Yixin. Lu,* “Asymmetric Synthesis   of Spiropyrazolones through Phosphine-Catalyzed [4+1] Annulation”, Angew.   Chem. Int. Ed. 2014, 53, 5643−5647.

24.   Zi-Yuan Ding, Tianli Wang,   Yan-Mei He, Fei Chen, Hai-Feng Zhou, Qing-Hua Fan,* Qingxiang Guo,* and   Albert S. C. Chan, “Highly Enantioselective Synthesis of Chiral   Tetrahydroquinolines and Tetrahydroisoquinolines by Ruthenium-Catalyzed Asymmetric   Hydrogenation in Ionic Liquid”, Adv. Synth. Catal. 2013, 355,   3727−3735.

25.   Fei Chen, Tianli Wang,   Yanmei He, Ziyuan Ding, Zhiwei Li, Lijin Xu and Qing-Hua Fan,* "Asymmetric   Hydrogenation of N-Alkyl Ketimines with   Phosphine-Free, Chiral, Cationic Ru-MsDPEN Catalysts", Chem. –Eur.   J. 2011, 17, 1109−1113.

26.   Zhi-Wei Li, Tianli Wang,   Yan-Mei He, Zhi-Jian Wang, Qing-Hua   Fan,* Jie Pan and Li-Jin Xu,* "Air-Stable and   Phosphine-Free Iridium Catalysts for Highly Enantioselective Hydrogenation of   Quinoline Derivatives", Org. Lett. 2008, 10,   5265−5268.

27.   Haifeng Zhou, Zhiwei Li,   Zhijian Wang, Tianli Wang, Lijin Xu, Yanmei He, Qing-Hua Fan,* Jie Pan,   Lianquan Gu and Albert S. C. Chan,* "Hydrogenation of Quinolines Using a   Recyclable Phosphine-Free Chiral Cationic Ruthenium Catalyst: Enhancement of   Catalyst Stability and Selectivity in an Ionic Liquid", Angew. Chem. Int. Ed. 2008, 47,   8464−8467.

28.   Zhi-Jian Wang, Hai-Feng Zhou,   Tianli Wang, Yan-Mei He, Qing-Hua   Fan,* "Highly Enantioselective Hydrogenation of Quinolines   under Solvent-Free or Highly Concentrated Conditions", Green Chem. 2009, 11, 767−769.

29.   Fei Chen, Ziyuan Ding, Jie   Qin, Tianli Wang, Yanmei He and Qing-Hua Fan,* "Highly   Effective Asymmetric Hydrogenation of Cyclic N-Alkyl   Imines with Chiral Cationic Ru-MsDPEN Catalysts", Org. Lett, 2011, 13, 4348−4351.

30.   Weijun Tang, Yawei Sun, Lijin   Xu,* Tianli Wang, Qing-Hua   Fan, Kim-Hung Lam and Albert S. C. Chan, "Highly Efficient   and Enantioselective Hydrogenation of Quinolines and Pyridines with   Ir-Difluorphos Catalyst", Org. Biomol. Chem. 2010, 8,   3464−3471.

31.   Fei Chen, Ziyuan Ding, Yanmei   He, Jie Qin, Tianli Wang and Qing-Hua   Fan,* "Asymmetric Hydrogenation of N-Alkyl   and N-Aryl Ketimines using Chiral   CationicRu(Diamine) Complexes as Catalysts: The Counteranion and Solvent   Effects, and Substrate Scope", Tetrahedron 2012, 68,   5248−5257.