主要研究方向

Research at Analytical DNA Nanotechnology Laboratory (ADNL) is at the interface of bioanalytical chemistry and DNA nanotechnology. We consider DNA both as important biomarkers for diverse biological processes and clinical diagnostics and also as a class of highly programmable engineering material. As such, we are interested in developing advanced tools for nucleic acid testing and protein detection at decentralized conditions, such as for point-of-care diagnosis and field-deployable tests. We are also interested in the fundamentals and applications of DNA nanotechnology, where we program DNA into diverse   nanodevices and nanomachines with predictable behaviors and function.

主要工作业绩

2021 CSC Fred Beamish Award, 加拿大化学协会

2019 Young Investigators in Analytical and Bioanalytical Science，Analytical   and Bioanalytical Chemistry（Springer旗下期刊）

2019 山西省百人计划短期项目，山西省委组织部

2018 入选Ontario-China Young Scientist Exchange   Program，中国科技部与加拿大安大略政府共同资助

2018 Ontario Early Researcher Award，加拿大安大略省政府

2016 Emerging Investigator in Analytical Science，Analyst（英国皇家化学会旗下期刊）

2014 JDRF Postdoctoral Fellowship（declined），美国糖尿病协会

2013 Doctoral Dissertation Award（推荐人：Analytical   Chemistry主编Jonathan Sweedler教授），University of Alberta

2013 国家优秀自费留学生奖，中国教育部

2013 Bill Davidson Graduate Student Travel Award, 7th   International Symposium on Enabling Technologies

2012 Young Scientist Travel Award, 28th International Symposium   on Microscale Separations and Bioanalysis

2012 J. Gordin Kaplan Graduate Student Award, University of   Alberta

2012纳米技术创业大赛二等奖，University of Alberta

代表性成果 (获奖成果、专著、论文、专利)

代表性论文（*代表通讯作者，完整文章列表见小组主页）

1. Li, Y.; Mansour, H.; Watson, C.; Tang, Y.;* MacNeil, D. A.; Li, F.* Amplified detection of nucleic acids and proteins using an isothermal proximity CRISPR Cas12a assay. Chemical Science, 2021, 12, 2133-2137.

2. Wang, G.A.; Xie, X.; Mansour, H.; Chen, F.; Matamoros, G.; Sanchez, A. L.; Fan, C.; Li, F.* Expanding detection windows for discriminating single nucleotide variants using rationally designed DNA equalizer probes. Nature Communications, 2020, 11, 5473-5483.

3. Traynor, S. M.; Wang, G. A.; Pandey, R.; Li, F.*; Soleymani, L.* Dynamic Bio‐Barcode Assay Enables Electrochemical Detection of a Cancer Biomarker in Undiluted Human Plasma: A Sample‐In‐Answer‐Out Approach. Angewandte Chemie International Edition, 2020, 59, 2-8.

4. Lin, X.;Yang, S.;Huang, D.;Guo, C.;Chen, D.;Yang, Q.*; Li, F.* A supramolecular aggregation-based constitutional dynamic network for information processing. Chemical Science, 2020, 11, 9617-9622.

5. Dong, T.; Mansour, H.; Hu, H.; Wang, G. A.; Watson, C. J. F.; Yousef, M.; Matamoros, G.; Sanchez, A. L.; MacNeil, A. J.; Wu, P.;* Li, F.* Colorimetric polymerase chain reaction enabled by a fast light-activated substrate chromogenic (FLASH) detection platform. Analytical Chemistry, 2020, 92, 6456-6461.

6. Mason, S. D.; Wang, G. A.; Yang, P.; Li, Y.; Li, F.* Probing and controlling dynamic interactions at biomolecule-nanoparticle interfaces using stochastic DNA walkers. ACS Nano, 2019, 13, 8106-8113.

7. Li, Y.; Wang, G, A.; Mason, S. D.; Yang, X.; Yu, Z.; Tang, Y.; Li, F.* Simulation-guided engineering of an enzyme-powered three dimensional DNA nanomachine for discriminating single nucleotide variants. Chemical Science, 2018, 9, 6434-6439.

8. Yang, X.; Tang, Y.; Traynor, S. M.; Li, F.* Regulation of DNA strand displacement using allosteric DNA toehold. Journal of the American Chemical Society, 2016, 138, 14076-14082.

9. Yang, X.; Tang, Y.; Mason, S. D.; Chen, J.; Li, F.* Enzyme-powered three dimensional DNA nanomachine for DNA walking, payload release, and biosensing. ACS Nano, 2016, 10, 2324-2330.

10. Yang, X.Tang, Y.; Wang, Z.; Yang, X.; Chen, J.; Liu, L.; Zhao, W.; Le, X. C.; Li, F.* Constructing real-time, wash-free, and reiterative sensors for cell surface proteins using binding-induced dynamic DNA assembly. Chemical Science, 2015, 6, 5729-5733.