四川大学化学学院
师资力量

赵小虎     副教授

研究方向:化学生物学(生物正交化学反应方向);有机合成化学。

联系方式:19150201459          Email:xhzhao@scu.edu.cn

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简历

教育及工作经历

2019.9 - 至今 四川大学化学学院 特聘副研究员

2017.8 - 2019.8 新加坡南洋理工大学,博士后(合作导师:Steve Zhou教授)

2016.7 - 2016.11 陕西科技大学,讲师

2011.9 - 2016.6 四川大学化学学院有机化学专业,博士(导师:冯小明教授)

2007.9 - 2011.6 四川大学化学学院化学专业,学士(导师:冯小明教授)

主要研究方向

新型生物正交反应的设计、合成以及其在活体标记中的应用;利用生物正交反应作为生物分子的小分子探针对活体动物中的靶标分子进行实时跟踪和可视化研究。

主要工作业绩

主要获奖和荣誉

2015年四川大学国家奖学金

2015年四川大学博士一等奖学金

2015年四川大学“Moresco”奖学奖

2013-2014学年四川大学优秀博士

2009-2010学年国家励志奖学金

2009-2010学年四川大学单项二等奖学奖

2008-2009学年四川大学单项二等奖学奖

2007-2008学年四川大学单项二等奖学奖

科研项目

1.四川大学引进人才科研启动经费项目 (2019-2022)

代表性成果 (获奖成果、专著、论文、专利)


1. Xiaohu Zhao,   Haiyan Xu, Xiaolei Huang and Jianrong Steve Zhou*, "Asymmetric Stepwise   Reductive Amination of Sulfonamides, Sulfamates and a Phosphinamide via   Nickel Catalysis" Angew. Chem.   Int. Ed, 2019, 58, 292-296. Highlight by Synfacts   2019, 15(03), 0258.

2Xiaohu Zhao, Hongjiang Mei, Qian   Xiong, Kai Fu, Lili Lin, Xiaohua Liu and Xiaoming Feng*, "Highly   enantioselective construction of carbazole derivatives via [4+2]   cycloaddition of silyloxyvinylindoles and β,γ-unsaturated α-ketoesters" Chem. Commun., 2016, 52, 10692–10695.

3. Xiaohu Zhao,   Xiaohua Liu, Hongjiang Mei, Jing Guo, Lili Lin. Xiaoming   Feng*,"Asymmetric Dearomatization of Indoles through   Michael/Friedel–Crafts-Type Cascade to Construct Polycyclic   Spiroindolines", Angew. Chem. Int.   Ed, 2015, 54, 4032–4035.

4. Xiaohu Zhao,   Xiaohua Liu, Qian Xiong, Hongjiang Mei, Baiwei Ma, Lili Lin and Xiaoming   Feng*, "The asymmetric synthesis of polycyclic 3-spirooxindolealkaloids   via the cascade reaction of 2-isocyanoethylindoles" Chem. Commun., 2015, 51, 16076–16079.

5. Xiaohu Zhao,   Mingsheng Xie, Xiaohua Liu, Yulong Zhang, Xiao Xiao, Lili Lin, and Xiaoming   Feng*, "Chiral N,N′-Dioxide–Yttrium Triflate Complexes-Catalyzed   Asymmetric Aldol Cyclization of α-Keto Esters with α- Isothiocyanato   Imide", Adv. Synth. Catal, 2013, 355, 3253–3262.

6. Xiaoxia Wu, Mingsheng Xie, Xiaohu Zhao, Xiaohua Liu, Lili Lin, Xiaoming Feng*,   Enantioselective fluorescent sensor for amino acid derivatives basedon BINOL   bearing hexahydropyrrolo[1,2-c]imidazol-1-one units. Tetrahedron. Lett., 2014,   55, 3446–3449 .

7. Hongjiang   Mei, Xiao Xiao, Xiaohu Zhao, Bing   Fang, Xiaohua Liu, Lili Lin and Xiaoming Feng*, "Catalytic Asymmetric   Henry Reaction of Nitroalkanes and Aldehydes Catalyzed by a Chiral   N,N′-Dioxide/Cu(I) Complex. J. Org.   Chem. 2015, 80, 2272-2280.

8. Qian Xiong,   Lili Lin, Xiaohu Zhao, Jiawen   Lang, Xiaohua Liu, and Xiaoming Feng*, "Zinc(II)-Catalyzed Asymmetric   Diels–Alder Reaction of (E)-1-Phenyl Dienes with β,γ-Unsaturated   α-Ketoesters. J. Org. Chem. 2018, 83, 12527-12534.

9. Yulong   Zhang, Xiaohua Liu, Xiaohu Zhao,   Jianlin Zhang, Lin Zhou, Lili Lin and Xiaoming Feng*, "Enantioselective   Friedel–Crafts alkylation for synthesis of 2-substituted indole   derivatives" Chem. Commun. 2013, 49, 11311-11313.

10. Yan Lu, Min   Wang, Xiaohu Zhao, Xiaohua Liu,   Lili Lin, Xiaoming Feng*, "Cooperative Chiral Guanidine/AgPF6Catalyzed   Asymmetric Isocyanoacetate Aldol Reaction with Isatins" Synlett., 2015, 26, 1545-1548.

11. Xiao Xiao, Hongjiang Mei, Quangang Chen, Xiaohu Zhao, Lili Lin, Xiaohua Liu   and Xiaoming Feng* Direct asymmetric vinylogous Michael addition of 3-alkylidene   oxindoles to chalcones catalyzed by a chiral N,N0-dioxide ytterbium(III)   complex. Chem. Commun., 2015, 51, 580—583.

12. Yin Zhu, Mingsheng Xie, Shunxi Dong, Xiaohu Zhao, Lili Lin, Xiaohua Liu   and Xiaoming Feng*, "Asymmetric Cycloaddition of β,γ-Unsaturated   α-Ketoesters with Electron-Rich Alkenes Catalyzed by a Chiral Er(OTf)3/N,N′-Dioxide   Complex: Highly Enantioselective Synthesis of 3,4-Dihydro-2H-pyrans" Chem. Eur. J. 2011, 17, 8202–8208.

13. Mingsheng Xie, Xiaohua Liu, Yin Zhu, Xiaohu Zhao, Yong Xia, Lili Lin and   Xiaoming Feng*, "Asymmetric Synthesis of Tetrahydroquinolines with   Quaternary Stereocenters through the Povarov Reaction" Chem. Eur. J. 2011, 17, 13800-13805.

14. Zuliang Zhang, Xiaohua Liu, Zhen Wang, Xiaohu Zhao, Lili Lin, Xiaoming   Feng*, "Chiral Co(II) complex catalyzed asymmetric Michael   reactions of ß-ketoamides to   nitroolefins and alkynones" Tetrahedron.   Lett., 2014, 55, 3797-3801.

15. Xiaoyu Hao, Xiaohua Liu, Wei Li, Fei Tan, Yangyang   Chu, Xiaohu Zhao, Lili Lin and   Xiaoming Feng*, "Chiral Lewis Acid Catalyzed Asymmetric Cycloadditions   of Disubstituted Ketenes for Synthesis of ß-Lactones and δ-Lactones" Org. Lett. 2014, 16, 134−137


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