主要研究方向

化学与生物信息学

具体研究兴趣包括：蛋白质序列、结构与功能的关系研究；蛋白质与其它分子（蛋白质、DNA、RNA）的相互作用建模；计算机辅助药物靶标的设计与预测；蛋白质、micro rRNA等与疾病的关联模型分析。

主要工作业绩

已取得的成果包括：1）全面进行蛋白质一级序列特征筛选与优化，提出了一系列氨基酸替代模型的构建新方法。2）在蛋白质三维结构层面上，对蛋白质-蛋白质的相互作用面在物化性质、构象、能量等方面进行解析，提出了一系列新的表征蛋白质相互作用面的特征参数。3）对蛋白质功能位点的环境进行数学表征与模拟，实现对其功能位点如甲基化、磷酸化修饰位点等的识别。发表第一作者SCI论文4篇，包括Nucleic Acids Res 1篇（他引148次）、Amino acids 1篇（他引78次）；通讯作者SCI论文20篇。获2015年教育部自然科学二等奖1 项（排名第2）。个人H因子为15。

代表性成果 (获奖成果、专著、论文、专利)

第一或通讯作者论文

1.Yu Wang, Yun Lin, Yanzhi Guo*, Xuemei Pu,   Menglong Li*, Scientific Reports, 2017,7, 3159

2.Yu Wang, Yanzhi Guo*, Xuemei Pu,   Menglong Li*, RSC Advances, 2017, 31, 2046-2069.

3.Zhongyu Liu, Yanzhi Guo*, Xuemei Pu, Menglong   Li*. Scientific Reports, 2016, 6, 34172.

4.JiesiLuo, Wenling Li, Zhongyu Liu, Yanzhi Guo*,   XuemeiPu, Menglong Li*, Analyst, 2015, 2015,140, 3048-3056.

5.Yayun Hu, Yanzhi Guo*, Yinan Shi, Menglong Li   and XuemeiPu*, RSC Advances, 2015, 5, 42009-42019.

6.Yinanshi, Yanzhi Guo*, Yayun Hu, Menglong Li*, Scientific   Reports, 2015, 2015,5,12403.

7.Xu Dai, Runyu Jing, Yanzhi Guo*, Yongcheng Dong,   Yuelong Wang, Yuan Liu, XuemeiPu, Menglong Li*, Current Pharmaceutical   Design, 2015, 21, 3051-3061.

8.Jiesi Luo, Zhongyu Liu, Yanzhi Guo*, Menglong Li*, Scientific   Reports, 2015,5,14214

9.Yu Wang, Yanzhi Guo*, QifanKuang, XuemeiPu,   YueJi, Zhihang Zhang, Menglong Li*, Journal of Computer Aided Molecule   Design, 2015, 29, 349-360.

10.Yuanyuan Fu, Yanzhi Guo*, Yuelong Wang,   JiesiLuo, XuemeiPu, Menglong Li* Zhihang Zhang, Computational Biology and   Chemistry, 2015, 56, 41-48.

11.JiesiLuo, Yanzhi Guo*, Yuanyuan Fu, Yu Wang,   Wenling Li, Menglong Li*, Proteins: structure, function, and   bioinformatics, 2014, 82, 3090–3100.

12.JiesiLuo, Yanzhi Guo*, Yun Zhong, Duo Ma,   Wenling Li, Menglong Li*. Journal of Computer Aided Molecule Design,   2014, 28, 619-629.

13.Duo Ma, Yanzhi Guo*, JiesiLuo, XuemeiPu, Menglong   Li*, Chemometrics and Intelligent Laboratory Systems, 2014,138, 7-13.

14.YunZhong, Yanzhi Guo*, Jiesi Luo, Xuemei Pu,   Menglong Li*, Chemometrics and Intelligent Laboratory Systems,   2014,136, 97-103.

15.Xiaojiao Yang, Yanzhi Guo*, Jiesi Luo, Xuemei Pu,   Menglong Li*, Plos ONE, 2013, 8, e84439.

16.Wen Liu, Yanzhi Guo*, Jiesi Luo, Yun Zhong,   Xiaojiao Yang, Xuemei Pu, Menglong Li*, Chemometrics and Intelligent   Laboratory Systems, 2013, 126, 117-122.

17.Lezheng Yu, Jiesi Luo, Yanzhi Guo*, Yizhou Li, Xuemei   Pu, Menglong Li*, Computational Biology and Medicine, 2013, 43,   1177-1181.

18.Jiesi Luo, Lezheng Yu, Yanzhi Guo*, Menglong   Li*, ChemometrIntellt Lab, 2012,110, 163-167.

19.Wenli Qin, Yizhou Li, Juan Li, Lezheng Yu, Di Wu, Runyu Jing,   Xuemei Pu, Yanzhi Guo*, Menglong Li*, Computational Biology   and Chemistry, 2012, 36, 31-35.

20.Xia Wang, Gang Mi, Cuicui Wang, Yongqing Zhang, Juan Li, Yanzhi   Guo*, Xuemei Pu, Menglong Li*, Computational Biology and Medicine,   2012, 42, 1053-1059.

21.Juan Li, Yongqing Zhang, Wenli Qin, Yanzhi Guo*,   Lezheng Yu, Xuemei Pu, Menglong Li, Jing Sun. Natural Science, 2012,   4, 304-312.

22.Yanzhi Guo, Menglong Li*, Xuemei Pu, Gongbin   Li, Juan Li. BMC Research Notes，2010,   3, 145.

23.Yanzhi Guo, Lezheng Yu, Zhining Wen, Menglong   Li. Nucleic Acids Research, 2008, 36, 3025-3030.

24.Yanzhi Guo, Menglong Li, Minchun Lu, Zhining   Wen, Kelong Wang, Gongbin Li, Jiang Wu, Amino Acids, 2006, 30,   397-402.

25.YanzhiGuo, Menglong Li, Minchun Lu, Zhining   Wen, Zhongtian Huang. Proteins: structure, function, and bioinformatics,   2006, 65, 55-60.

26.Yanzhi Guo, Menglong Li, Kelong Wang, Zhining   Wen, Minchun Lu, Lixia Liu, Lin Jiang. ActaBiochimica et BiophysicaSinica,   2005, 37, 759–766.