四川大学化学学院
师资力量

曾小明     教授,博士生导师

研究方向:金属有机化学 (单胺基卡宾配体和铬催化研究)

联系方式:          Email:zengxiaoming@scu.edu.cn

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简历

2017.05—至今           四川大学化学学院从事教学与科研工作,教授、博士生导师

2012.012017.04      西安交通大学前沿科学技术研究院从事科研工作,教授、博士生导师

2010.042011.12      东京大学化学系,JSPS博士后,合作导师:Eiichi Nakamura 教授

2007.092009.09      加州大学河滨分校化学系,联合培养博士,导师:Guy Bertrand 教授

2004.092009.12      四川大学化学学院有机化学专业攻读博士学位,导师:罗美明教授

2002.092004.07      广东省新兴县华侨中学从事高中化学教学工作

1998.092002.07      四川师范大学化学学院应用化学专业本科学习

学术任职:任Current Chinese Chemistry Journal杂志编委(2019–目前)Elsevier数据库旗下期刊Heliyon的国际编委(2015–2019)

主要研究方向

1)单胺基卡宾配体促进的铑和铬催化研究

与常用的双胺基氮杂环卡宾比较,单胺基卡宾拥有较高能级的HOMO和较低能级的LUMO分子轨道,表现出强的亲核和亲电性,具有作为优秀配体的潜质。研究方向之一是利用这类卡宾的富电特性促进金属催化、解决合成中突出的化学与立体选择性难题。

2)低价铬在惰性化学键活化与氢功能化中的催化基础研究

金属铬全球储量超过120亿吨,是地壳中含量最丰富的五种过渡金属之一。相较于第一过渡系其它金属如铁、钴、镍、锰及铜的二氯化物,二氯化铬的毒性更低(Organometallics 2017,   36, 4071)。研究方向之一是探索金属铬独特的催化活性与发展铬催化合成策略,揭示铬催化的特点和规律,解决惰性化学键活化及不饱和化合物氢功能化中存在的挑战。

主要工作业绩

1)单胺基卡宾配体在芳烃去芳香性及炔烃选择性催化氢化中的应用基础研究:

构建单胺基卡宾促进的芳烃去芳香性氢化的催化体系,为环已酮有机化工原料及顺式的多取代环烷烃基础化学品的快速、选择性地制备提供合成策略。

2)铬在惰性化学键活化及氢功能化中的催化基础研究:

构建铬催化惰性化学键偶联体系,揭示低价铬螯合切断惰性碳-氧、碳-氮键的特征,发现两种惰性化学键还原偶联模式。

     作为主要贡献人分别在Chem. Rev., J. Am. Chem.   Soc., Angew. Chem. Int. Ed., Nat. Commun., ACS Catal.,   Chem. Common., Org. Lett., Organometallics等刊物上发表论文五十余篇,其中单篇最高他引270余次,7篇论文他引超过一百次,被同行正面评价和推介近二十次。


主要奖励和荣誉

2020年获得“Thieme Chemistry Journal Award

2019年获得“ACP Lectureship Awards (Japan)

2019年获得“ACP Lectureship Awards (Singapore)

2018年入选第十二批四川省学术和技术带头人后备人选

2017年入选四川省千人计划“青年人才项目”

2016年入选西安交通大学青年拔尖人才计划A

2015年获得美国化学会三年会员奖励

2010年获得日本学术振兴会外国人特别研究员奖学金

2007年获得中国留学基金委公派留学奖学金

代表性成果 (获奖成果、专著、论文、专利)

一.发表主要论文

1. Jinghua Tang,   Fei Fan, Xuefeng Cong, Lixing Zhao, Meiming Luo, and Xiaoming   Zeng*

Reductive   Cross-Coupling between Unactivated C(aryl)–N and C(aryl)–O Bonds by Chromium   Catalysis Using a Bipyridyl Ligand

J. Am. Chem. Soc. 2020,   DOI: 10.1021/jacs.0c05730. (These authors contributed equally)

2. Jinghua Tang,   Liu Leo Liu, Shangru Yang, Xuefeng Cong, Meiming Luo,   and Xiaoming Zeng*

Chemoselective   Cross-Coupling between Two Different and Unactivated C(aryl)–O Bonds Enabled   by Chromium Catalysis

J. Am. Chem. Soc. 2020,   142 (17), 7715–7720. (These authors contributed equally)

3. Xiaoming Zeng*

Recent Advances in   Chromium-Catalyzed Organic Transformations

Synlett 2020,   31 (3), 205–210.

4. Xue Zhang, Liang   Ling, Meiming Luo, and Xiaoming Zeng*

Accessing   Equatorially Difluoromethylated and Trifluoromethylated cis-Cycloalkanes   and Saturated Heterocycles by Preferential Hydrogen-Addition to the   Substitution Sites for Dearomatization

Angew.   Chem. Int. Ed. 2019, 58 (47), 16785–16789.

5. Zhi Rong, Meiming   Luo,* and Xiaoming Zeng*

Modular Arene   Difunctionalization by Sequential Cleavage of Unactivated C–O and C–H Bonds   in One Pot with Chromium Catalysis

Org. Lett. 2019, 21(17),   6869–6873.

6. Hong Meng, Sen   Gao, Meiming Luo,* and Xiaoming Zeng*

Iron and Phenol Co‐Catalysis   for Rapid Synthesis of Nitriles under Mild Conditions

Eur. J. Org. Chem. 2019, 2019   (28) 46174623.


7. Bo Han, Pengchen   Ma, Xuefeng Cong, Hui Chen,* and Xiaoming Zeng*

Chromium- and   Cobalt-Catalyzed, Regiocontrolled Hydrogenation of Polycyclic Aromatic   Hydrocarbons: A Combined Experimental and Theoretical Study

J. Am. Chem. Soc. 2019,   141 (22), 90189026.

8. Liang Ling, Yuan   He, Xue Zhang, Meiming Luo, and Xiaoming Zeng*

Hydrogenation of   (Hetero)aryl Boronate Esters with a Cyclic (Alkyl)(amino)carbene-Rhodium   Complex: Direct Access to cis-Substituted Borylated Cycloalkanes and   Saturated Heterocycles

Angew. Chem. Int. Ed. 2019,   58 (20), 6554–6558.

9. Liang Ling, Changpeng   Chen, Meiming Luo,* and Xiaoming Zeng*

Chromium-Catalyzed   Activation of Acyl C–O Bonds with Magnesium for Amidation of Esters with   Nitroarenes

Org. Lett. 2019,   21 (6), 1912–1916.

10. Jinghua Tang,   Xuejiao J. Gao, Huarong Tang,* and Xiaoming Zeng*

Dioxygen activation   with stable N-heterocyclic carbenes

Chem. Commun. 2019,   55(11), 1584–1587.

11. Pei Liu, Changpeng   Chen, Xuefeng Cong, Jinghua Tang, and Xiaoming Zeng*

Chromium-catalyzed para-selective   formation of quaternary carbon centers by alkylation of benzamide derivatives

Nat. Commun. 2018,   9, 4637.

12. Jinghua Tang, Pei   Liu, and Xiaoming Zeng*

N-Heterocyclic   carbene–chromium-catalyzed alkylative cross-coupling of benzamide derivatives   with aliphatic bromides

Chem. Commun. 2018, 54(67),   9325–9328.

13. Fei Fan, Jinghua   Tang, Meiming Luo,* and Xiaoming Zeng*

Chromium-Catalyzed   Regioselective Kumada Arylative Cross-Coupling of C(aryl)–O Bonds with a   Traceless Activation Strategy

J. Org. Chem. 2018,   83(21), 13549–13559.

14. Changpeng Chen, Pei   Liu, Meiming Luo, and Xiaoming Zeng*

Kumada Arylation of   Secondary Amides Enabled by Chromium Catalysis for Unsymmetric Ketone Synthesis   under Mild Conditions

ACS Catal. 2018,   8(7), 5864–5868.

15. Yuan He, Jinghua   Tang, Meiming Luo,* and Xiaoming Zeng*

Regioselective and   Chemoselective Reduction of Naphthols Using Hydrosilane in Methanol: Synthesis   of the 5,6,7,8-Tetrahydronaphthol Core

Org. Lett. 2018,   20(14), 4159–4163.

16. Lei Jia, Qiang   Tang, Meiming Luo,* and Xiaoming Zeng*

Direct ortho-Selective   Amination of 2-Naphthol and Its Analogues with Hydrazines

J. Org. Chem. 2018,   83(9), 5082–5091.


17. Xuefeng Cong, Fei   Fan, Pengchen Ma, Meiming Luo, Hui Chen,* and Xiaoming Zeng*

Low-Valent, High-Spin   Chromium-Catalyzed Cleavage of Aromatic Carbon–Nitrogen Bonds at Room   Temperature: A Combined Experimental and Theoretical Study

J. Am. Chem. Soc.   2017, 139(42), 1518215190.

18. Lei Jia, Qiang Tang, Meiming   Luo,* and Xiaoming Zeng*

One-Step Synthesis of   Unsymmetric 1,1’-Biaryl-2,2'-diamines by the Reaction of 2-Naphthols with   Aryl Hydrazines

Chin. J. Org. Chem. 2018, 38, 443–450.


19. Jinghua Tang,   Meiming Luo,* and Xiaoming Zeng*

Chromium-Catalyzed, Regioselective   Cross-Coupling of C–O Bonds Using Organic Bromides as Reactants

Synlett,   2017, 28(19), 2577–2580. (Invited for cluster of “C–O bond activation”)


20. Sen   Gao, Liming Gao, Hong Meng, Meiming Luo,* and Xiaoming Zeng*

Iron-Catalyzed   Synthesis of Benzoxazoles by Oxidative Coupling/Cyclization of Phenol   Derivatives with Benzoyl Aldehyde Oximes

Chem.   Commun., 2017, 53(71),   9886–9889.


21. Changpeng Chen,   and Xiaoming Zeng*

Ruthenium-Catalyzed   Alkynylation of Benzoic Acids Mediated by a Weakly-Coordination Directing   Auxiliary

Eur. J. Org. Chem. 2017, 2017(32),   4749–4752.


22. Changpeng Chen, Pei   Liu, Jinghua Tang, Gongda Deng, and Xiaoming Zeng*

Iridium-Catalyzed,   Weakly Coordination-Assisted Ortho-Alkynylation of (Hetero)aromatic   Carboxylic Acids without Cyclization

Org. Lett. 2017,   19(10), 2474–2477.


23. Pei Liu, Jinghua   Tang, and Xiaoming Zeng*

Site-Selective   Silylation of Aliphatic C–H Bonds Mediated by [1,5]-Hydrogen Transfer: Synthesis   of α-Sila Benzamides

Org. Lett. 2016,   18(21), 5536–5539.


24. Bin Rao, Jinghua   Tang, and Xiaoming Zeng*

Synthesis of   2-Benzylphenyl Ketones by Aryne Insertion into Unactivated C–C Bonds

Org. Lett. 2016,   18(7), 1678–1681.


25. Xuefeng Cong,   Shengxian Zhai, and Xiaoming Zeng*

Low-Valent   Cobalt-Catalyzed C–H Allylation

Org. Chem. Front. 2016,   3(6), 673–677. (Invited as “2015 Emerging Investigator by OCF”)


26. Yuexuan Li, Gongda   Deng, and Xiaoming Zeng*

Chromium-Catalyzed   Regioselective Hydropyridination of Styrenes

Organometallics 2016,   35(5), 747–750.

27. Bin Rao, Jinghua   Tang, Yu Wei, and Xiaoming Zeng*

Ring Expansion via   Cleavage of Benzylic C–C Bonds Enabling Direct Synthesis of Medium Ring-fused   Benzocarbocycles

Chem.–Asian J. 2016, 11(7),   991–995.


28. Xuefeng Cong,   Huarong Tang, and Xiaoming Zeng*

Regio- and   Chemoselective Kumada–Tamao–Corriu Reaction of Aryl Alkyl Ethers Catalyzed by   Chromium Under Mild Conditions

J. Am. Chem. Soc. 2015,   137(45), 14367–14372. (Highlights by Synfacts, 2016, 12,   0192; ChemInform, 2016, 47, 21-126)

29. Yu Wei, and Xiaoming   Zeng*

Catalytic Strategies   toward Selective Hydrogenation of Aromatic Ketones and Phenols: Facile   Synthesis of Cyclohexyl Ketones

Synlett 2016,   27(5), 650–655. (Invited Synpacts article)

30. Bin Rao, Huarong   Tang, Xiaoming Zeng*, Liu Liu, Mohand Melaimi and Guy Bertrand*

Cyclic   (Amino)(aryl)carbenes (CAArCs) as Strong σ-Donating and π-Accepting Ligands   for Transition Metals

Angew. Chem. Int. Ed. 2015,   54(49), 14915–14919.

31. Yu Wei, Bin Rao,   Xuefeng Cong, and Xiaoming Zeng*

Highly Selective   Hydrogenation of Aromatic Ketones and Phenols Enabled by Cyclic   (Amino)(alkyl)carbene Rhodium Complexes

J. Am. Chem. Soc. 2015,   137(29), 9250–9253.

(Highlights by Chin.   J. Org. Chem. 2015, 35, 2019; ChemInform, 2016,   47, 03-038)

32. Xiaoming   Zeng* and Xuefeng Cong

Chromium-Catalyzed   Transformations Using Grignard Reagents: New Opportunities for Cross-Coupling   Reactions

Org. Chem. Front. 2015,   2(1), 69–72.


33. Xuefeng Cong, Yuexuan   Li, Yu Wei, and Xiaoming Zeng*

Nickel-Catalyzed C–H   Coupling with Allyl Phosphates: A Site-Selective Synthetic Route to Linear   Allylarenes

Org. Lett. 2014,   16(15), 3926–3929. (Highlight by ChemInform, 2015, 46,   05-054)


34. Xuefeng Cong and Xiaoming   Zeng*

Iron-Catalyzed,   Chelation-Induced Remote C–H Allylation of Quinolines via 8-Amido Assistance

Org. Lett. 2014,   16(14), 3716–3719. (Highlight by ChemInform, 2015, 46,   02-047)


35. Yu Wei, Huarong Tang, Xuefeng Cong, Bin Rao, Chao Wu* and Xiaoming   Zeng*

Pd(II)-Catalyzed   Intermolecular Arylation of Unactivated C(sp3)–H Bonds with Aryl   Bromides Enabled by 8-Aminoquinoline Auxiliary

Org. Lett. 2014,   16(8), 2248–2251. (Highlight by ChemInform, 2014, 45,   41-085)


36. Bin Rao and Xiaoming   Zeng*

Aminocyanation by the   Addition of N–CN Bonds to Arynes: Chemoselective Synthesis of   1,2-Bifunctional Aminobenzonitriles

Org. Lett., 2014,   16(1), 314–317. (Highlights by ChemInform, 2014, 45,   23-095; Org. Chem. Highlights 2014, October 13)


37. Xuefeng Cong,   Huarong Tang, Chao Wu*, and Xiaoming Zeng*

Role of Mono-N-Protected   Amino Acid Ligands in Pd(II)-Catalyzed Dehydrogenative Heck Reactions of   Electron-Deficient (Hetero)Arenes: Experimental and Computational Studies

Organometallics, 2013,   32(21), 6565–6575.


38. Yu Wei, Jinghua   Tang, Xuefeng Cong, and Xiaoming Zeng*

Practical Metal-Free   Synthesis of Chalcone Derivatives via a Tandem Cross-Dehydrogenative-Coupling/Elimination   Reaction

Green Chem. 2013,   15(11), 3165–3169. (Highlight by ChemInform, 2014, 45,   12-079)


39. Xiaoming   Zeng*

Recent Advances in   Catalytic Sequential Reactions Involving Hydroelement Addition to Carbon–Carbon   Multiple Bonds

Chem. Rev. 2013,   113(8), 6864–6900.  (ESI highly cited paper)

40. Pei Guo, Xiaoming   Zeng, Si Chen, and Meiming Luo*

Au(I)–N-heterocyclic   carbene complex-catalyzed synthesis of 1-substituted benzo[b][1,4]diazepines   from N-substituted o-phenylenediamines and terminal alkynes

J. Organomet. Chem. 2013,   751, 438–442.


41. Xiaoming   Zeng, Laurean Ilies, and Eiichi Nakamura*

Iron-Catalyzed Regio-   and Stereoselective Chloro-sulfonylation of Terminal Alkynes with Aromatic   Sulfonyl Chlorides

Org. Lett. 2012,   14(3), 954–956. (Highlight by ChemInform, 2012, 43,   23-088)


42. Xiaoming   Zeng, Laurean Ilies, and Eiichi Nakamura*

Synthesis of   Functionalized 1H-Indenes via Copper-Catalyzed Arylative Cyclization of   Arylalkynes with Aromatic Sulfonyl Chlorides

J. Am. Chem. Soc. 2011,   133(44), 17638–17640.


43. Laurean Ilies,   Quan Chen, Xiaoming Zeng, and Eiichi Nakamura*

Cobalt-Catalyzed   Chemoselective Insertion of Alkene into the ortho-C–H Bond of   Benzamide

J. Am. Chem. Soc. 2011,   133(14), 5221–5223.


44. Xiaoming   Zeng, Rei Kinjo, Bruno Donnadieu, and Guy Bertrand*

Serendipitous   Discovery of the Catalytic Hydroammoniumation and  Methylamination of   Alkynes

Angew. Chem. Int. Ed.   2010, 49(5), 942–945.


45. Xiaoming   Zeng, Guido D. Frey, Rei Kinjo, Bruno Donnadieu, and   Guy Bertrand*

Synthesis of a   Simplified Version of Stable Bulky and Rigid Cyclic (Alkyl)(amino)carbenes,   and Catalytic Activity of the Ensuing Gold(I) Complex in the Three-Component   Preparation of 1,2-Dihydroquinoline Derivatives

J. Am. Chem. Soc. 2009, 131(24),   8690–8696.


46. Xiaoming   Zeng, Guido D. Frey, Shazia Kousar, and Guy Bertrand*

A Cationic Gold(I) Complex   as a General Catalyst for the Intermolecular Hydroamination of Alkynes:   Application to the One-Pot Synthesis of Allenes from Two Alkynes and a   Sacrificial Amine

Chem.–Eur. J. 2009,   15(13), 3056–3060.


47. Xiaoming   Zeng, Michele Soleilhavoup, and Guy Bertrand*

Gold-Catalyzed   Intermolecular Markovnikov Hydroamination of Allenes with Secondary Amines

Org. Lett. 2009,   11(15), 3166–3169.


48. Xiaoming   Zeng, Tongxin Zhang, Yuancheng Qin, Zhijun Wei, and Meiming Luo*

Synthesis of a   Carbene Transfer Organometallic Polymer and Application to Forming a   Recyclable Heterogeneous Catalyst for the Suzuki Reactions of Arylchlorides

Dalton Trans. 2009, 2009(39), 8341–8348.  


49. Sujuan Zhang, Xiaoming   Zeng, Zhijun Wei, Dongbing Zhao, Tairan Kang, Weifeng Zhang, Mei   Yan, and Meiming Luo*

Desulfitative Suzuki   Cross-Couplings of Arylsulfonyl Chlorides and Boronic Acids Catalyzed by a   Recyclable Polymer-Supported N-Heterocyclic Carbene-Palladium Complex   Catalyst

Synlett 2006,   18(12), 1891–1894.


50. Chun Yan, Xiaoming   Zeng, Weifeng Zhang, and Meiming Luo*

Polymer-Supported   N-Heterocyclic Carbene–Rhodium Complex Catalyst for the Addition of   Arylboronic Acids to Aldehydes

J. Organomet. Chem. 2006,   691(15), 3391–3396.


二.授权专利

1.  曾小明、韩波、罗美明;一种铬盐/甲基溴化镁选择性催化氢化多环芳烃的方法,中国,专利号:ZL 2017 1   0396279.3,授权日期2019-07-09,申请日期2017-05-31.

2.  曾小明、韩波、罗美明;基于钴盐选择性催化氢化多环芳烃的方法,中国,专利号:ZL 2017 1   0396265.1,授权日期2019-07-09,申请日期2017-05-31.

 

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