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董顺喜     教 授、博导

研究方向：不对称合成，稀土金属催化、自由基化学、手性药物和生物活性化合物合成

联系方式：          Email：dongs@scu.edu.cn

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研究方向：不对称合成，稀土金属催化、自由基化学、手性药物和生物活性化合物合成

简历：

教育经历

2004.09～2008.06 四川大学  化学专业  理学学士学位

2008.09～2013.06 四川大学  有机化学  理学博士学位  导师：冯小明

研究及工作经历

2013.11～2016.02 德国亚琛工业大学，洪堡学者 (Carsten Bolm教授)

2016.07～2017.12 德国明斯特大学，博士后 (Gerhard Erker教授)

2018.01～2021.08 四川大学，化学学院，特聘研究员

2021.09～至今 四川大学，化学学院，教授

通讯地址：四川省成都市九眼桥望江路29号四川大学化学学院

主要研究方向

新型手性配体和催化剂的设计合成

稀土金属有机配合物催化

生物活性分子的高效合成

主要工作业绩

研究经历

董顺喜博士毕业于四川大学，师从冯小明教授，博士研究方向主要是手性胍类小分子催化剂的设计、合成及其在吖内酯参与的环化反应中的应用。2013作为洪堡学者赴德国亚琛工业大学Carsten Bolm教授课题组开展博士后研究工作，主要从事氨基酸衍生的pentathiepin设计合成以及手性氮杂环卡宾(NHC)催化不对称转化领域研究。2016年，加入德国明斯特大学Gerhard Erker课题组，开展新型受阻Lewis酸碱对(FLP)的设计合成及其反应性研究。2018年加入四川大学化学学院，主要从事（1）手性双氮氧/金属配合物催化；（2）新型手性稀土金属有机配合物催化剂设计合成及其在不对称C-H官能化、氢元素化等反应中的应用研究。截至目前，已取得一系列创新性的研究成果,在Acc. Chem. Res., Chem. Soc. Rev., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nat. Commun., CCS Chem., ACS Catal., Sci. China Chem., Chem. Sci., J. Med. Chem.等刊物发表SCI论文40余篇，多篇工作被Synfacts杂志专题亮点评述。

主要奖励和荣誉

2013年 获德国洪堡学者博士后奖学金

2019年 四川省引进海内外高层次人才计划

2019年 四川大学“双百人才工程” B计划

2019年 教育部高等学校科学研究优秀成果奖自然科学一等奖(排名第四)

2020年 四川大学青年科技学术带头人培育项目资助

2020年 四川大学 大学生创新创业教育优秀指导教师

2020年 四川大学 基于智慧教学环境“探究式—小班化“教学质量优秀奖

2020 年 四川大学学术新人奖

2021年 Thieme Chemistry Journals Award

2021 年 第十三批四川省学术与技术带头人后备人选

2023年 参与主讲的《手性技术》被认定为四川省首批高等学校课程思政典型案例（第四主讲人）

2024年The Distinguished Lectureship Award of The CSJ Asian International Symposium

学术任职

2022年～2025年 Chinese Chemical Letters 第四届青年编委会委员

代表性成果（获奖成果、专著、论文、专利）

代表性论文：

  1. Wang, S. Y. #; Ning L. C.#; Mao, T.; Zhou, Y. Q.; Pu, M. P.; Feng, X. M.; Dong, S. X.* Anti-Markovnikov Hydroallylation Reaction of Alkenes via Scandium-catalyzed Allylic C‒H activation. Nat. Commun. 2025, 16, 1423.

  2. Liu, Z. Z. #; Wu, H. L. #; Zhang, H. L.; Wang, F.; Liu, X. H.; Dong, S. X. *; Hong, X. *; Feng, X. M. * Iron-Catalyzed Asymmetric Imidation of Sulfides via Sterically Biased Nitrene Transfer, J. Am. Chem. Soc. 2024, 146, 18050.

  3. Tan, Z.; Chen, L.; Li, L. Y.; Li, Y. Z.; Luo, Y.; Wang, F.; Dong, S. X.*; Feng, X M.* Asymmetric Synthesis of α-Methylene-γ-butyrolactones via Tandem Allylboration/Lactonization: a Kinetic Resolution Process, Angew. Chem. Int. Ed. 2023, 62, e202306146.

     

  4. Dong, S. X.; Liu, X. H.*; Feng, X. M.* Asymmetric Catalytic Rearrangements with a-Diazocarbonyl Compounds, Acc. Chem. Res. 2022, 55, 415. (封面论文).

  5. Lin, Q. C.; Zheng, S. J.; Chen, L.; Wu, J.; Li, Z. J.; Liu, P. Z.; Dong, S. X.*; Liu, X. H.; Peng, Q.*; Feng, X. M.* Catalytic Regio- and Enantioselective Protonation for the Synthesis of Chiral Allenes: Synergistic Effect of the Counterion and Water, Angew. Chem. Int. Ed. 2022, 61, e202203650 (封面论文).

  6. Chen, Y. S.; Liu, Y.; Li, Z. J.; Dong, S. X.*; Liu, X. H.; Feng, X. M.* Tandem Insertion/[1,3]-Rearrangement: Highly Enantioselective Construction of α-Aminoketones, Angew. Chem. Int. Ed. 2020, 59, 8052.

  7. Tang, Q.; Fu, K.; Ruan, P. R.; Dong, S. X.*; Su, Z. S; Liu, X. H.; Feng, X. M.* Asymmetric Catalytic Formal 1,4-Allylation of β,γ-Unsaturated α-Ketoesters via Allylboration/Oxy-Cope Rearrangement, Angew. Chem. Int. Ed. 2019, 58, 11846.

  8. Dong, S. X.; Feng, X. M.; Liu, X. H.* Chiral Guanidine and Their Derivatives in Asymmetric Synthesis, Chem. Soc. Rev. 2018, 47, 8525.

  9. Zhu, C. H.#; Zhou, Y. Q.#; Zhang, J.; Li, J. F.; Zhang, Y. X.; Wang, F.; Feng, X. M.*; Dong, S. X.* Rare-Earth Metal Catalyzed Asymmetric Addition/Hydroamidination of Nitriles and Allylamines for the Concise Synthesis of Chiral Imidazolines, CCS Chem. 2025, 7, 148.

  10. Luo, Q. L.; Zhou, Y. Q.; Zhang, J.; Dong, S. X.*; Feng, X. M*. Asymmetric Catalytic (3+2) Cyclization and Sequential Reaction to Construct Dihydrofuran- and Azepine-Based Spirooxindoles. Org. Lett. 2025. DOI: 10.1021/acs.orglett.5c00182.

  11. Li,W. Y. R.; Yang, L. Q.; Tang, X. X.; Yan, W. J.; Wu, Z.; Wang, F.; Dong, S. X.*; Feng, X. M*. Asymmetric α-Selective Allylation of Amide Unit of Maleimides and Alkenyloxindoles by Dual-functional InIII/N,N'-dioxide Complex. Org. Chem. Front. 2025, DOI: 10.1039/D4QO02320J.

  12. Zeng, Z.#; Yang, L. Q. #; Xiao, Z. J.; Chen, L.; Zhong, Z. W.; Wang, F.; Liu, X. H.; Dong, S. X.*; Feng, X. M.* A Remarkable Influence of La(III)/N,N'‑Dioxide Structure on Asymmetric Formal Substitution of 3‑Bromo-3-substituted Oxindoles with TMSCN, ACS Catal. 2024, 14, 2908.

  13. Mo, Y. H.; Ning, L. C.; Luo, Z.; Yang, L. K.; Tang, S.; Dong, S. X.* Zhou, Q. L.; Feng, X. M.* Asymmetric Photoenolization/Diels-Alder Reaction of 2-Methylbenzaldehydes and 2-Alkylbenzophenones with Chromones, ACS Catal. 2024, 14, 6687.

  14. Luo, Q. L.; Mao, T.; Luo, Y.; Zhang, Y. X.; Wang, F.; Dong, S. X.*; Feng, X. M*. Enantioselective Synthesis of Spiro[cyclopentane-1,3’-oxindole] Scaffolds with Five Consecutive Stereocenters. Org. Lett. 2024, 26, 6402.

  15. Tan, Z.; YiHuo, A. Y.; Wu, Z. Wang, F.; Dong, S. X.*; Feng, X. M. Concise Synthesis of Chiral γ-Butenolides via an Allylation/Lactonization Cascade Reaction, Chem. Commun. 2024, 60, 7926.

  16. Zhu, C. H.; Mao, T.; Feng, X. M.; Dong, S. X*. Rare-Earth-Metal-Catalyzed Regioselective Hydrosilylation of Internal Alkenes and Alkynes. Synthesis 2024, 56, 3903.

  17. Li, D.; Wang, Y. J.; Wang, S. Y..; Dong, S. X.* The Effect of Basic Ligands and Alkenes on the Regioselectivity of C–H Additions of Tertiary Amines to Alkenes, Chem. Eur. J. 2024, 30, e202401014.

  18. Cao, D. Y.; Xi, R. Y.; Li, H. Y.; Zhang, Z. H.; Shi, X. K.; Li, S. S.; Jin, Y. J.; Liu, W. L.; Zhang, G. L.; Liu, X. H.; Dong, S. X.*; Feng, X. M.*; Wang, F.* Discovery of a Covalent Inhibitor of Pro-Caspase-1 Zymogen Blocking NLRP3 Inflammasome Activation and Pyroptosis, J. Med. Chem. 2024, DOI: 10.1021/acs.jmedchem.4c01558.

  19. Dong, S. X.; Cao, W. D.; Pu, M. P.; Liu, X. H.*; Feng, X. M.* Ligand Acceleration in Chiral Lewis Acid Catalysis, CCS Chem. 2023, 5, 2717.

  20. Li, D. W.; Ning, L. C.; Luo, Q. L.; Wang, S. Y.; Feng, X. M.; Dong, S. X.*. C-H alkylation of pyridines with olefins catalyzed by imidazolin-2-iminato-ligated rare-earth alkyl complexes, Sci. China. Chem. 2023, 66, 1804.

  21. Wang. S. Y.; Zhu, C. H.; Ning, L. C.; Li, D. W.; Feng, X. M; Dong, S. X.* Regioselective C-H alkylation of anisoles with olefins by cationic imidazolin-2-iminato scandium(III) alkyl complexes, Chem. Sci. 2023, 14. 3132 (cover picture).

  22. Zhu, C. H.; Zhou, Y. Q.; Yang, J.; Feng, X. M.; Dong, S. X.* Lanthanide-catalyzed regio- and enantioselective hydrosilylation of aryl-substituted terminal and internal alkenes, Org. Chem. Front. 2023, 10, 1263.

  23. Wang, S. J.; Zhang, C.; F.; Li, D.; Zhou, Y. Q.; Su, Z. S.; Feng, X. M.; Dong, S. X.* New Chiral N-Heterocyclic Olefin Bifunctional Organocatalysis in α-Functionalization of β-Ketoesters, Sci. China. Chem. 2023, 66, 147.

  24. Wang, S. J.; Yang, J.; Zeng, H. H.; Zhou, Y. Q.; Wang, F.; Feng, X. M.; Dong, S. X.* Asymmetric Formal Coupling of β-Ketoesters with Quinones Promoted by a Chiral Bifunctional N-Heterocyclic Olefin, Org. Lett. 2023, 25, 7247.

  25. Wang, Y.; Yihuo, A. Y.; Wang, L. F. Dong, S. X.*; Feng, X. M.* Catalytic Asymmetric Synthesis of Chiral Azo Compounds via Interrupted Japp–Klingemann Reaction with Aryldiazonium Salts, Sci. China Chem. 2022, 65, 546.

  26. Dong, P.; Li, Z. J.; Liu, X. H.; Dong, S. X.*; Feng, X. M.* Asymmetric Synthesis of Polycyclic Spiroindolines via the Dy-catalyzed Cascade Reaction of 3-(2-Isocyanoethyl)indoles with Aziridines, Org. Chem. Front. 2022, 9, 4591.

  27. Tang, X. X.; Su, Z. S.; Lin, Q. C.; Lin, L. L.; Dong, S. X.*; Feng, X. M.* Asymmetric Catalytic α-Selective Allylation of Ketones with Allyltrifluoroborates using Dual-functional Chiral InIII/N,N′-dioxide Complex, Chin. J. Chem. 2022, 40, 1793.

  28. Zhong, X.; Tan, J. Q.; Qiao, J. L.; Zhou, Y. Q.; Lv, C. D.; Su, Z. S.; Dong, S. X.*; Feng, X. M.* Catalytic Asymmetric Synthesis of Spirocyclobutyl Oxindoles and Beyond via [2+2] Cycloaddition and Sequential Transformations, Chem. Sci. 2021, 12, 9991.

  29. Xu, C. R.; Qiao, J. L.; Dong, S. X.*; Zhou, Y. Q.; Liu, X. H.; Feng, X. M.* Asymmetric Synthesis of Dihydro-1,3-Dioxepines by Rh(II)/Sm(III) Relay Catalytic Three-Component Tandem [4+3]-Cycloaddition, Chem. Sci. 2021, 12, 5458. This article is part of the themed collection: 2021 Chemical Science HOT Article Collection. Highlighted by Synfacts 2021, 17, 0518.

  30. Xiao, W. L.; Mo, Y. H.; Guo, J.; Su, Z. S.; Dong, S. X.*; Liu, X. H.; Feng, X. M.* Catalytic Enantioselective Synthesis of Macrodiolides and their Application in Chiral Recognition, Chem. Sci., 2021, 12, 2940.

  31. Xiong, Q.; Luo, Q. L.; Zhang, T. H.; Dong, S. X.*; Liu, X. H.; Feng, X. M.* Catalytic Asymmetric Multicomponent Reaction of Isocyanide, Isothiocyanate and Alkylidene Malonates, Chem. Commun. 2021, 57, 7288.

  32. Tang, X. X.; Su, Z. S., Yan, L. Q.; Tang, Q.; Dong, S. X.*; Lin, L. L. Xiaoming Feng, X. M.* Diastereo- and Enantioselective Synthesis of 3-Allyl-3-hydroxyoxindoles via Allylation of Isatins, Org. Lett. 2021, 23, 8419.

  33. Dong, P.; Chen, L.; Yang, Z. D.; Dong, S. X.*; Feng, X. M.* Asymmetric Cycloisomerization/[3+2] Cycloaddition for Synthesis of Chiral Spiroisobenzofuran-1,3'-pyrrolidine Derivatives, Org. Chem. Front. 2021, 8, 6874.

  34. Wang, F.; Feng, L. L.; Dong, S. X.*; Liu, X. H.; Feng, X. M.* Chiral N,N′-Dioxide-Iron(III)-Catalyzed Asymmetric Sulfoxidation with Hydrogen Peroxide, Chem. Commun. 2020, 56, 3233.

  35. Li, D. W.; Wang, S. J.; Ge, S. L.; Dong, S. X.*; Feng, X. M. Asymmetric Synthesis of Axially Chiral Anilides via Organocatalytic Atroposelective N-Acylation, Org. Lett. 2020, 22, 5331.

  36. Dong, S. X.; Daniliuc, C. G.; Kehr, G.; Erker, G.* Formation of Active Cyclic Five-membered Frustrated Phosphane/Borane Lewis Pairs and their Cycloaddition Reactions, Chem. Eur. J. 2020, 26, 745.

  37. Luo, Y.; Zhang, H.; Wang, S. Y.; Zhou, Y. Q.; Dong, S. X.*; Feng, X. M.* Asymmetric Catalytic Diverse Ring Opening/Cycloadditions of Cyclobutenones with (E)-Alkenyloxindoles and (E)-Dioxopyrrolidines, Org. Lett. 2020, 22, 2645.

  38. Ge, S. L.; Zhang, Y. Y.; Tan, Z.; Li, D. W.; Dong, S. X.*; Liu, X. H.; Feng, X. M.*, Bimetallic Catalytic Tandem Reaction of Acyclic Enynones: Enantioselective Access to Tetrahydrobenzofuran Derivatives, Org. Lett. 2020, 22, 3551. Highlighted by Synfacts, 2020, 16, 0820.

  39. Xiong, Q. Li, G. L.; Dong, S. X.*; Liu, X. H.; Feng, X. M.*, Enantioselective Synthesis of Hydrothiazole Derivatives via an Isocyanide-Based Multicomponent Reaction, Org. Lett. 2019, 21, 8771.

  40. Liu, W.; Zhou, P. F.; Lang, J. W.; Dong, S. X.*; Liu, X. H.; Feng, X. M.*, A Nickel(II)-Catalyzed Asymmetric Intramolecular Alder-ene Reaction of 1,7-Dienes, Chem. Commun. 2019, 55, 4479.

  41. Li, X. Q.; Xiong, Q.; Guan, M. M.; Dong, S. X.*; Liu, X. H.; Feng, X. M.*, Divergent Synthesis of Enantioenriched β-Functional Amines via Desymmetrization of meso-Aziridines with Isocyanides, Org. Lett. 2019, 21, 6096.

  42. Zhong, X.; Tang, Q., Zhou, P. F.; Zhong, Z. W. Dong, S. X.*; Liu, X. H.; Feng, X. M.*, Asymmetric Synthesis of Polysubstituted Methylenecyclobutanes via Catalytic [2+2] Cycloaddition Reaction of N-Allenamides, Chem. Commun. 2018, 54, 10511. Highlighted by Synfacts 2018, 14, 1154.

    书籍章节：

  43. Dong, S. X.; Zhao, J. N.; Feng, X. M.* Comprehensive Chirality, Second Edition, Volume 6, Chapter 1. Introduction and Remarks, Elsevier, 2023.

  44. Zhao, J. N.; Dong, S. X.; Feng, X. M.* Comprehensive Chirality, Second Edition, Volume 6, Chapter 9. [4+2]-Cycloadditions (Inverse-Electron-Demand Hetero-Diels–Alder Reaction), Elsevier, 2023.

  45. Wang, S. J.; Feng, X. M.; Dong, S. X.* Electronic Encyclopedia of Reagents for Organic Synthesis, 1H-Imidazole,2,3-dihydro-1,3-bis[4-methyl-2,6-bis[(1R)-1-phenylethyl] phenyl]-2-methylidene, Wiley, 2024, accepted, ID: RN02602.

Before SCU:

  1. Dong, S. X.; Frings, M.; Cheng, H. C.; Wen, J.; Zhang, D.; Rabbe, G.; Bolm, C.* Organocatalytic Kinetic Resolution of Sulfoximines. J. Am. Chem. Soc. 2016, 138, 2166. Highlight by Synfacts 2016, 12, 634.

  2. Dong, S. X.; Liu X. H.*; Zhu, Y.; He, P.; Lin, L. L.; Feng, X. M.* Organocatalytic Oxyamination of Azlactones: Kinetic Resolution of Oxaziridines and Asymmetric Synthesis of Oxazolin-4-ones. J. Am. Chem. Soc. 2013, 135, 10026. Highlight by Synfacts (2013, 1006).

  3. Dong, S. X.; Liu, X. H.; Chen, X. H.; Mei, F.; Gao, B.; Lin, L. L.; Feng, X. M.* Chiral Bisguanidine-Catalyzed Inverse-Electron-Demand Hetero-Diels-Alder Reaction of Chalcones with Azlactones. J. Am. Chem. Soc. 2010, 132, 10650. Highlight by Synfacts (2010, 1105).

  4. Dong, S. X.; Frings, M.; Zhang, D.; Guo. Q. Q.; Danilliuc, C. G.; Cheng, H. C.; Bolm, C.* Organocatalytic Asymmetric Synthesis of trans-γ-Lactams. Chem. Eur. J. 2017, 23, 13888.

  5. Dong, S. X.; Wang, L.; Wang, T.; Daniliuc, C. G.; Brinkkötter, M.; Eckert, H.; Kehra. G.; Erker, G. Formation and Reactions of Active Five-membered Phosphane/borane Frustrated Lewis Pair Ring Systems. Dalton Trans. 2018, 47, 4449.

  6. Dong, S. X.; Liu, X. H*.; Zhang, Y. L.; Lin, L. L.; Feng, X. M *. Asymmetric Synthesis of 3,4-Diaminochroman-2-ones Promoted by Guanidine and Bisguanidium Salt. Org. Lett. 2011, 13, 5060.

  7. Liu, X. H.; Dong, S. X.; Lin, L. L.; Feng, X. M.* Chiral Amino Acids-Derived Catalysts and Ligands. Chin. J. Chem, 2018, 36, 791.

  8. Guo, J.; Dong, S. X.; Zhang, Y. L.; Kuang, Y. L.; Feng, X. M.* Chiral Scandium(III)-Catalyzed Enantioselective α-Arylation of N-Unprotected 3-Substituted Oxindoles with Diaryliodonium Salts. Angew. Chem., Int. Ed. 2013, 52, 10245. Highlight by Synfacts (2013, 1262).

  9. Wang, L.; Dong, S. X.; Daniliuc, C. G.; Liu, L.; Grimme, S.; Knitsch, R.; Eckert, H.; Hansen, M. R.; Kehra. G.; Erker, G. Formation of Macrocyclic Ring Systems by Carbonylation of Trifunctional P/B/B Frustrated Lewis Pairs. Chem. Sci. 2018, 9, 1544.

 

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