主要研究方向

手性配体或催化剂的设计合成及其在不对称催化中的应用

金属有机化学

主要工作业绩

研究经历

董顺喜博士毕业于四川大学，师从冯小明教授，博士研究方向主要是手性胍类小分子催化剂的设计、合成及其在吖内酯参与的环化反应中的应用。2013作为洪堡学者赴德国亚琛工业大学Carsten Bolm教授课题组开展博士后研究工作，主要从事氨基酸衍生的pentathiepin设计合成以及手性氮杂环卡宾(NHC)催化不对称转化领域研究。2016年，加入德国明斯特大学Gerhard Erker课题组，开展主族元素有机化学研究，主要开展新型受阻Lewis酸碱对(FLP)的设计合成及其反应性研究。目前为止，已取得一系列创新性的研究成果, 在Chem. Soc. Rev., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Org. Lett., Chem. Commun., Chem. -Eur. J. 以及 Dalton. Trans. 等刊物发表 SCI 论文30余篇，多篇工作被Synfacts杂志刊登并给予高度评价。其中以第一作者身份发表 SCI 论文8篇，(共同)通讯作者论文10篇。

主要奖励及荣誉

2013年 获德国洪堡学者博士后奖学金

2019年 获四川省引进海内外高层次人才计划

2019年 获四川大学“双百人才工程” B计划

2019年 获教育部高等学校科学研究优秀成果奖自然科学一等奖(排名第四)

2020年 获四川大学青年科技学术带头人培育项目资助

代表性成果 (获奖成果、专著、论文、专利)

论文发表情况

1. Chen, Y. S.; Liu, Y.; Li, Z. J.; Dong, S. X.*; Liu, X. H.; Feng, X. M.* Tandem Insertion/[1,3]-Rearrangement: Highly Enantioselective Construction of a-Aminoketones, Angew. Chem. Int. Ed. 2020, 59, 8052.

2. Tang, Q.; Fu, K.; Ruan, P. R.; Dong, S. X.*; Su, Z. S; Liu, X. H.; Feng, X. M.* Asymmetric Catalytic Formal 1,4-Allylation of β,γ-Unsaturated α-Ketoesters via Allylboration/Oxy-Cope Rearrangement, Angew. Chem. Int. Ed. 2019, 58, 11846.

3. Dong, S. X.; Feng, X. M.; Liu, X. H.* Chiral Guanidine and Their Derivatives

in Asymmetric Synthesis, Chem. Soc. Rev. 2018, 47, 8525.

4. Wang, F.; Feng, L. L.; Dong, S. X.*; Liu, X. H.; Feng, X. M.* Chiral N,N′-Dioxide–Iron(III)-Catalyzed Asymmetric Sulfoxidation with Hydrogen Peroxide, Chem. Commun. 2020, 56, 3233.

5. Li, D. W.; Wang, S. J.; Ge, S. L.; Dong, S. X.*; Feng, X. M. Asymmetric Synthesis of Axially Chiral Anilides via Organocatalytic Atroposelective N-Acylation, Org. Lett. 2020, 22, DOI: 10.1021/acs.orglett.0c01581.

6. Dong, S. X.; Daniliuc, C. G.; Kehr, G.; Erker, G.* Formation of Active Cyclic Five-membered Frustrated Phosphane/Borane Lewis Pairs and their Cycloaddition Reactions, Chem. Eur. J. 2020, 26, 745.

7. Luo, Y.; Zhang, H.; Wang, S. Y.; Zhou, Y. Q.; Dong, S. X.*; Feng, X. M.* Asymmetric Catalytic Diverse Ring Opening/Cycloadditions of Cyclobutenones with (E)-Alkenyloxindoles and (E)-Dioxopyrrolidines, Org. Lett. 2020, 22, 2645.

8. Ge, S. L.; Zhang, Y. Y.; Tan, Z.; Li, D. W.; Dong, S. X.*; Liu, X. H.; Feng, X. M.*, Bimetallic Catalytic Tandem Reaction of Acyclic Enynones: Enantioselective Access to Tetrahydrobenzofuran Derivatives, Org. Lett. 2020, 22, 3551.

9. Xiong, Q. Li, G. L.; Dong, S. X.*; Liu, X. H.; Feng, X. M.*, Enantioselective Synthesis of Hydrothiazole Derivatives via an Isocyanide-Based Multicomponent Reaction, Org. Lett. 2019, 21, 8771.

10. Liu, W.; Zhou, P. F.; Lang, J. W.; Dong, S. X.*; Liu, X. H.; Feng, X. M.*, A nickel(II)-catalyzed asymmetric intramolecular Alder-ene reaction of 1,7-dienes, Chem. Commun. 2019, 55, 4479.

11. Li, X. Q.; Xiong, Q.; Guan, M. M.; Dong, S. X.*; Liu, X. H.; Feng, X. M.*, Divergent Synthesis of Enantioenriched β-Functional Amines via Desymmetrization of meso-Aziridines with Isocyanides, Org. Lett. 2019, 21, 6096.

12. Zhong, X.; Tang, Q., Zhou, P. F.; Zhong, Z. W. Dong, S. X.*; Liu, X. H.; Feng, X. M.*, Asymmetric Synthesis of Polysubstituted Methylenecyclobutanes via Catalytic [2+2] Cycloaddition Reaction of N-Allenamides, Chem. Commun. 2018, 54, 10511.

13. Dong, S. X.; Frings, M.; Cheng, H. C.; Wen, J.; Zhang, D.; Rabbe, G.; Bolm, C.* "Organocatalytic Kinetic Resolution of Sulfoximines" J. Am. Chem. Soc. 2016, 138, 2166. Highlight by Synfacts (2016, 634)

14. Dong, S. X.; Liu X. H*.; Zhu, Y.; He, P.; Lin, L. L.; Feng, X. M.* "Organocatalytic Oxyamination of Azlactones: Kinetic Resolution of Oxaziridines and Asymmetric Synthesis of Oxazolin-4-ones" J. Am. Chem. Soc. 2013, 135, 10026. Highlight by Synfacts (2013, 1006)

15. Dong, S. X.; Liu, X. H.; Chen, X. H.; Mei, F.; Gao, B.; Lin, L. L.; Feng, X. M.* "Chiral Bisguanidine-Catalyzed Inverse-Electron-Demand Hetero-Diels-Alder Reaction of Chalcones with Azlactones" J. Am. Chem. Soc. 2010, 132, 10650. Highlight by Synfacts (2010, 1105)

16. Dong, S. X.; Frings, M.; Zhang, D.; Guo. Q. Q.; Danilliuc, C. G.; Cheng, H. C.; Bolm, C.* "Organocatalytic Asymmetric Synthesis of trans-γ-Lactams" Chem. Eur. J. 2017, 23, 13888.

17. Dong, S. X.; Wang, L.; Wang, T.; Daniliuc, C. G.; Brinkkötter, M.; Eckert, H.; Kehra. G.; Erker, G. "Formation and Reactions of Active Five-membered Phosphane/borane Frustrated Lewis Pair Ring Systems" Dalton Trans. 2018, 47, 4449.

18. Dong, S. X.; Liu, X. H*.; Zhang, Y. L.; Lin, L. L.; Feng, X. M *. "Asymmetric Synthesis of 3,4-Diaminochroman-2-ones Promoted by Guanidine and Bisguanidium Salt" Org. Lett. 2011, 13, 5060.

19. Liu, X. H.; Dong, S. X.; Lin, L. L.; Feng, X. M.* " Chiral Amino Acids-Derived Catalysts and Ligands " Chin. J. Chem, 2018, 36, 791.

20. Guo, J.; Dong, S. X.; Zhang, Y. L.; Kuang, Y. L.; Feng, X. M.* "Chiral Scandium(III)-Catalyzed Enantioselective α-Arylation of N-Unprotected 3-Substituted Oxindoles with Diaryliodonium Salts" Angew. Chem., Int. Ed. 2013, 52, 10245. Highlight by Synfacts (2013, 1262)

21. Wang, L.; Dong, S. X.; Daniliuc, C. G.; Liu, L.; Grimme, S.; Knitsch, R.; Eckert, H.; Hansen, M. R.; Kehra. G.; Erker, G."Formation of Macrocyclic Ring Systems by Carbonylation of Trifunctional P/B/B Frustrated Lewis Pairs" Chem. Sci. 2018, 9, 1544.

22. Xu, X.; Zhang, J. L.; Dong, S. X.; Lin. L. L.; Lin, X. B.; Liu, X. H.; Feng, X. M.* "Nickel(II)-Catalyzed Asymmetric Propargyl [2,3]-Wittig Rearrangement of Oxindole Derivatives: A Remarkable Chiral Amplification Effect" Angew. Chem., Int. Ed. 2018, 57, 8734.

23. Zhu, Y.; Liu, X. H.;* Dong, S. X.; Zhou, Y. H.; Li, W.; Lin, L. L.; Feng, X. M.* "Asymmetric N-H Insertion of Secondary and Primary Anilines under the Catalysis of Palladium and Chiral Guanidine Derivatives" Angew. Chem., Int. Ed. 2014, 53, 1636.

24. Wen, J.; Cheng, H. C.; Dong, S. X.; Bolm, C.* "Copper-Catalyzed S-C/S-N Bond Interconversions" Chem. Eur. J. 2016, 22, 5547.

25. Chen, X. Y.; Bohmann, R. A.; Wang, L.; Dong, S. X.; Räuber, C.; Bolm, C.* "Palladium/Copper-Cocatalyzed Oxidative Amidobrominations of Alkenes" Chem. Eur. J. 2015, 21, 10330.

26. Cheng, H.; Dong, W.; Dannenberg, C. A.; Dong, S. X.; Guo, Q.; Bolm, C.* "Ruthenium-Catalyzed Hydroarylations of Oxa- and Azabicyclic Alkenes" ACS Cat. 2015, 5, 2770.

27. Yao, Q.; Yu, H.; Zhang, H.; Dong, S. X.; Chang, F. Z.; Lin, L. L.; Liu, X. H.; Feng, X. M.* "Lewis acid catalyzed asymmetric [4+2] cycloaddition of cyclobutenones to synthesize α,β-unsaturated δ-lactones" Chem. Commun. 2018, 54, 3375.

28. Chen, X. H.; Dong, S. X.; Qiao, Z.; Zhu, Y.; Xie, M. S.; Lin, L. L.; Liu, X. H.;* Feng, X. M.* "Guanidine Organocatalyst for Asymmetric Mannich-Type Reaction between α-Isothiocyanato Imide and Sulfonyl Imines" Chem. Eur. J. 2011, 17, 2583.

29. Zhang, Y. L.; Dong, S. X.; Liu, X. H.; Xie. M. S.; Zhu, Y.; Lin, L. L.; Feng, X. M.^* "Asymmetric Synthesis of cis-4-Aminobenzopyran Derivatives Catalyzed by N,N'-Dioxide-Sc(OTf)₃ Complex" Chem. Eur. J. 2011, 17, 13684.

30. Yang, Y.; Dong, S. X.; Liu, X. H.; Lin, L. L.; Feng, X. M.^* "Chiral guanidine-catalyzed asymmetric direct vinylogous Michael reaction of α,β-unsaturated γ-butyrolactams with alkylidene malonates" Chem. Commun., 2012, 48, 5040.

31. Xiao, X.; Liu X. H^*.; Dong, S. X.; Cai, Y. F.; Lin, L. L.; Feng, X. M.^* "Asymmetric Synthesis of 2,3-Dihydroquinolin-4-one Derivatives Catalyzed by Chiral Bisguanidium Salt" Chem. Eur. J. 2012, 18, 15922.

32. Zhu, Y.; Xie, M. S.; Dong, S. X.; Zhao, X. H.; Lin, L. L.; Liu, X. H.; Feng, X. M.^* "Asymmetric Cycloaddition of β,γ-Unsaturated α-Ketoesters with Electron-Rich Alkenes Catalyzed by a Chiral Er(OTf)₃/N,N′-Dioxide Complex: Highly Enantioselective Synthesis of 3,4-Dihydro-2H-pyrans" Chem. Eur. J. 2011, 17, 8202.

33. Wang, J.; Liu, X. H.;^* Dong, S. X.; Lin, L. L.; Feng, X. M.^* "Asymmetric Organocatalytic Cyclopropanation of Cinnamone Derivatives with Stabilized Sulfonium Ylides" J. Org. Chem., 2013, 78, 6322.

34. Xiong, Y.; Wang, F.; Dong, S. X.; Liu, X. H.; Feng, X. M.^* "Asymmetric Bisprolinamide-Catalyzed Cross-Aldol Reaction of Aldehydes" Synlett. 2008, 1, 73.

35. Zhu, Y.; Chen, X. H.; Xie, M. S.; Dong, S. X.; Qiao, Zhen.; Lin, L. L.; Liu, X. H.; Feng, X. M.^* "Asymmetric Diels–Alder and Inverse-Electron-Demand Hetero-Diels–Alder Reactions of β,γ-Unsaturated α-Ketoesters with Cyclopentadiene Catalyzed by N,N′-Dioxide Copper(II) Complex" Chem. Eur. J. 2010, 16, 11963.

36. Wen, Y. H.; Gao, B.; Fu, Y. Z.; Dong, S. X.; Liu, X. H.; Feng, X. M.^* "Asymmetric Three-Component Strecker Reactions Catalyzed by trans-4-Hydroxy-L-proline-Derived N,N′-Dioxides" Chem. Eur. J. 2008, 14, 6789.