四川大学化学学院
师资力量

李 峰     特聘研究员

研究方向:DNA纳米技术、生物分析化学、体外诊断试剂及辨析仪器开发

联系方式:15881094081          Email:windtalker_1205@scu.edu.cn

个人主页:点击进入

 

简历

教育背景:

2007.09 2013.02 University of Alberta,分析化学,博士, 导师:X. Chris Le院士

2002.09 2006.07,天津大学药学院,理学学士

工作及研究经历:

2018.05 至今,四川大学化学学院,特聘研究员,博导

2019.07 至今,Brock University,化学系、生物技术中心,兼职副教授(Tenured

2014.12 2019.07Brock University,化学系、生物技术中心,助理教授

2018.08 2018.08,中科院上海应用物理所,中加YSEP访问学者,Host:樊春海教授

2013.08 2013.12University of   California, Irvine,干细胞研究中心,访问学者

2013.02 2014.11University of Alberta,临床医学及病理学系,博士后

主要研究方向

Research at Analytical   DNA Nanotechnology Laboratory (ADNL) is at the interface of bioanalytical   chemistry and DNA nanotechnology. We consider DNA both as important   biomarkers for diverse biological processes and clinical diagnostics and also   as a class of highly programmable engineering material. As such, we are   interested in developing advanced tools for nucleic acid testing and protein   detection at decentralized conditions, such as for point-of-care diagnosis   and field-deployable tests. We are also interested in the fundamentals and   applications of DNA nanotechnology, where we program DNA into diverse   nanodevices and nanomachines with predictable behaviors and function.

主要工作业绩

2019 Young Investigators in Analytical and Bioanalytical ScienceAnalytical   and Bioanalytical ChemistrySpringer旗下期刊)

2019 山西省百人计划短期项目,山西省委组织部

2018 入选Ontario-China Young Scientist Exchange   Program,中国科技部与加拿大安大略政府共同资助

2018 Ontario Early Researcher Award,加拿大安大略省政府

2017 入选第十三批国家千人计划青年项目

2016 Emerging Investigator in Analytical ScienceAnalyst(英国皇家化学会旗下期刊)

2014 JDRF Postdoctoral Fellowshipdeclined),美国糖尿病协会

2013 Doctoral Dissertation Award(推荐人:Analytical   Chemistry主编Jonathan Sweedler教授),University of Alberta

2013 国家优秀自费留学生奖,中国教育部

2013 Bill Davidson Graduate Student Travel Award, 7th   International Symposium on Enabling Technologies

2012 Young Scientist Travel Award, 28th International Symposium   on Microscale Separations and Bioanalysis

2012 J. Gordin Kaplan Graduate Student Award, University of   Alberta

2012纳米技术创业大赛二等奖,University of Alberta

代表性成果 (获奖成果、专著、论文、专利)

完整文章列表见小组主页(*代表通讯作者; #代表共同一作)

1. Mason, S. D.; Wang, G.   A.; Yang, P.; Li, Y.; Li, F.* Probing and controlling dynamic interactions at   biomolecule-nanoparticle interfaces using stochastic DNA walkers. ACS   Nano, 2019, 13,   8106-8113.

2. Li, Y.; Mansour, H.; Wang, T.; Poojari, S.; Li, F.* Naked-eye detection of grapevine red-blotch viral infection using a   plasmonic CRISPR Cas12a Assay. Anal. Chem. 2019, 91, 11510-11513.

3. Li, Y.; Wang, G, A.; Mason, S. D.;   Yang, X.; Yu, Z.; Tang, Y.; Li,   F.* Simulation-guided engineering of an   enzyme-powered three-dimensional DNA nanomachine for discriminating single   nucleotide variants. Chem. Sci. 2018, 9,   6434-6439. 

4. Li, F.;* Lin, Y.; Lau, A.; Tang, Y.; Chen, J.; Le, X. C.* Binding-induced molecular amplifier as a universal detection platform for   biomolecules and biomolecular interaction. Anal. Chem. 2018,   90, 8651-8657.

5. Wang, G. A.;   Dong, T.; Mansour H.; Matamoros, G.; Sanchez, A. L.; Li,   F.* Paper-Based DNA Reader for   Visualized Quantification of Soil-Transmitted Helminth Infections. ACS   Sens. 2018, 3,   205-210.

6. Yang, X.;   Tang, Y.; Traynor, S. M.; Li, F.* Regulation of DNA   strand displacement using allosteric DNA toehold. J. Am. Chem. Soc. 2016138, 14076-14082.

7. Yang, X.;   Tang, Y.; Mason, S. D.; Chen, J.; Li, F.* Enzyme-powered   three dimensional DNA nanomachine for DNA walking, payload release, and   biosensingACS Nano 2016, 10, 2324-2330.

8. Li, F.*; Tang, Y.; Traynor, S. M.;   Li, X.-F.; Le, X. C.* Kinetics of proximity-induced intramolecular DNA strand   displacement. Anal. Chem. 2016, 88,   8152-8157.

9. Tang, Y.;   Wang, Z.; Yang, X.; Chen, J.; Liu,   L.; Zhao, W.; Le, X. C.; Li, F.* Constructing real-time, wash-free, and reiterative sensors for   cell surface proteins using binding-induced dynamic DNA assembly. Chem.   Sci. 20156, 5729-5733.

10. Tang, Y.;   Lin, Y; Yang, X.; Wang, Z.; Le, X.   C.; Li, F.* Universal strategy to engineer catalytic DNA hairpin assemblies for   protein analysisAnal.   Chem. 2015, 87,   8063-8066.

11. Li, F.;# Zhang, H.;# Wang, Z.; Newbigging, M. A.;   Reid, S. M..; Li, X.-F.; Le, X. C. Aptamers facilitate   amplified detection of biomoleculesAnal.   Chem. 2015, 87,   274-292.

12. Ali, M.M.; Li, F.; Zhang Z.; Zhang, K.; Kang, D.-K.; Ankrum, J.; Le, X. C.; Zhao, W. Rolling circle amplification: a versatile tool for chemical biology,   materials science and medicineChem. Soc. Rev. 2014, 43, 3324-3341.

13. Zhang, H.#; Li, F.#; Dever, B.; Li, X-F.; Le, X. C. DNA-mediated   homogeneous binding assays for nucleic acids and proteins. Chem. Rev. 2013, 113, 2812-2841.

14. Li, F.; Zhang, H.; Wang, Z.; Li, X.; Li, X.-F.; Le, X. C. Dynamic DNA   assemblies mediated by binding-induced DNA strand displacement. J. Am. Chem. Soc. 2013, 135, 2443-2446.

15. Li, F.; Lin, Y.; Le, X. C. Binding-induced formation of DNA three-way   junctions and its application in real-time protein detection and DNA strand   displacement. Anal. Chem. 2013,   85, 10835-10841. 

16. Zhang, H.; Li, F.; Dever, B.; Wang, C.; Li, X.-F.; Le, X.C. Assembling DNA through affinity binding to achieve ultrasensitive   protein detection. Angew.   Chem. Int. Ed. 2013, 52, 10698-10705.

17. Li, F.; Zhang, H.; Lai C.; Li, X-F.; Le, X. C. A molecular translator that acts by binding-induced DNA strand   displacement for a homogeneous protein assay. Angew. Chem. Int. Ed. 2012, 51, 9317-9320.

18. Li, F.; Dever, B.; Zhang, H.; Li, X-F.; Le, X. C. Mesoporous materials in peptidome analysis. Angew. Chem. Int. Ed. 2012, 51,   3518-3519.

19. Li, F.; Li, J.; Wang, C.; Zhang, J.; Li, X.-F.; Le, X. C. Competitive   protection of aptamer-functionalized gold nanoparticles by controlling DNA assembly. Anal. Chem. 2011, 83, 6464-6467.

20. Li, F.; Zhao, Q.; Wang, C.; Lu, X.;   Li, X.-F.; Le, X. C. Detection of E. coli O157: H7 using   gold nanoparticle labeling and inductively coupled plasma-mass spectrometry.   Anal. Chem. 2010, 82,   3399-3403.

 

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