四川大学化学学院
师资力量

刘小华     教授

研究方向:主要从事新型手性催化剂的设计合成、不对称催化反应、手性药物和生理活性化合物的高效高选择性合成研究。

联系方式:028-85418249           Email:liuxh@scu.edu.cn

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简历

1996.9-2000.6 湖北师范学院化学系学习,获理学学士学位。

2000.9-2003.6 四川大学化学学院分析化学专业学习,获理学硕士学位。

2003.9-2006.6 四川大学化学学院有机化学专业学习,获理学博士学位。

2006.7-2010.6 四川大学化学学院副教授,硕士生导师。

2010.7-至今 四川大学化学学院教授,2012年担任博士生导师。

2011年获教育部新世纪优秀人才计划资助;2012年获国家自然科学基金委优秀青年基金资助;2013年入选四川省学术和技术带头人后备人选;获霍英东青年教师基金资助;2015年获第二届中组部青年拔尖人才资助,享受国务院政府特殊津贴专家;2016年获国家杰出青年科学基金资助;2017年国家百千万人才工程入选者和有突出贡献中青年专家。

Chinese Chemical Letter和《化学学报》编委委员,《高等学校化学学报》青年执行编委,中国化学会青年工作委员会委员、中国化学会手性化学专业委员会和中国化学会物理有机化学专业委员会委员。

主要研究方向

主要从事新型手性催化剂的设计合成、不对称催化反应、手性药物和生理活性化合物的高效高选择性合成研究。详见课题组主页http://chem01.scu.edu.cn/chem-asl

主要工作业绩

主要从事不对称合成方法学及生理活性化合物的合成研究。目前研究工作集中在新型手性含氮类配体和催化剂的设计合成、不对称催化反应、生理活性化合物合成及催化机理研究。

2009年获教育部高等学校科学研究优秀成果奖自然科学一等奖(第二完成人);2012年获国家自然科学奖二等奖(第二完成人);2013年获德国Thieme出版社Thieme Chemistry Journals Award 20132014年获四川大学唐立新青年科技之星奖一等奖;2016年获Asian Core Program / Advanced Research Network Lectureship Award2016年获四川大学青年科技人才奖;2018年获第六届中国化学会-英国皇家化学会青年化学奖;2019年获第十五届中国青年女科学家奖;2019年获教育部高等学校科学研究优秀成果奖自然科学一等奖(第二完成人)。

代表性成果 (获奖成果、专著、论文、专利)

1. Xiaobin Lin, Wei Yang, Wenkun Yang, Xiaohua Liu,* and Xiaoming Feng,* Asymmetric Catalytic [2,3] Stevens and Sommelet–Hauser Rearrangements of a-Diazo Pyrazoleamides with Sulfides, Angew. Chem. Int. Ed. 2019, 58, 13492–13498.

2. Qian Xiong, Shunxi Dong, Yushuang Chen, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of Tetrazole and Dihydroisoquinoline Derivatives by Isocyanidebased Multicomponent Reactions, Nat. Commun. 2019, 10, 2116.

3. Yu Zhang, Fengcai Zhang, Long Chen, Jian Xu, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of P-Stereogenic Compounds via Thulium(III)-Catalyzed Desymmetrization of Dialkynylphosphine Oxides, ACS Catal. 2019, 9, 4834−4840.

4. Wangbin Wu, Weidi Cao, Linfeng Hu, Zhishan Su, Xiaohua Liu,* and Xiaoming Feng,* Asymmetric Baeyer–Villiger Oxidation: Classical and Parallel Kinetic Resolution of 3-Substituted Cyclohexanones and Desymmetrization of meso-Disubstituted Cycloketones, Chem. Sci. 2019, 10, 7003−7008.

5. Jian Yang, Peiran Ruan, Wei Yang, Xiaoming Feng and Xiaohua Liu,* Enantioselective carbene insertion into the N–H bond of benzophenone imine, Chem. Sci. 2019, 10, DOI10.1039/c9sc03354h

6. Lihua Xie, Shunxi Dong, Qian Zhang, Xiaoming Feng, Xiaohua Liu,* Asymmetric Construction of Dihydrobenzofuran-2,5-dione Derivatives via Desymmetrization of p-Quinols with Azlactones, Chem. Commun. 2019, 55, 87−90.

7. Pengfei Zhou, Xiaohua Liu,* Wangbin Wu, Chaoran Xu, Xiaoming Feng,* Catalytic Asymmetric Construction of βAzido Amides and Esters via Haloazidation, Org. Lett. 2019, 21, 1170−1175.

8. Hang Zhang, Yao Luo, Dawei Li, Qian Yao, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Synthesis of 4-Hydroxy-dihydrocoumarins via Catalytic Ring Opening/Cycloaddition of Cyclobutenones, Org. Lett. 2019, 21, 2388–2392.

9. Jiawen Lang, Yi Li, Tengfei Kang, Xiaoming Feng, Xiaohua Liu,* Organocatalytic Asymmetric Michael/Dieckmann Cyclization Reaction of Alkynones To Construct Spirocyclopentene Oxindoles, Org. Lett. 2019, 21, 6897−6902.

10. Weidi Cao, Xiaoming Feng, Xiaohua Liu,* Reversal of enantioselectivity in chiral metal complex-catalyzed asymmetric reactions, Org. Biomol. Chem. 2019, 17, 6538−6550.

11. Shunxi Dong, Xiaoming Feng, Xiaohua Liu,* Chiral Guanidines and Their Derivatives in Asymmetric Synthesis, Chem. Soc. Rev. 2018, 47, 8525–8540.

12. Xiaobin Lin, Yu Tang, Wei Yang, Fei Tan, Lili Lin, Xiaohua Liu,* Xiaoming Feng,* Chiral Nickel(II) Complex Catalyzed Enantioselective Doyle-Kirmse Reaction of α-Diazo Pyrazoleamides, J. Am. Chem. Soc. 2018, 140, 3299–3305.

13. Yu Tang, Jian Xu, Jian Yang, Lili Lin, Xiaoming Feng, and Xiaohua Liu,* Asymmetric Three-Component Reaction for the Synthesis of Tetrasubstituted Allenoates via Allenoate-Copper Intermediates, Chem. 2018, 4, 16581672.

14. Haifeng Zheng, Yan Wang, Chaoran Xu, Xi Xu, Lili Lin, Xiaohua Liu,* Xiaoming Feng,* Stereodivergent Synthesis of Vicinal Quaternary-quaternary Stereocenters and Bioactive Hyperolactones, Nat. Commun. 2018, 1968−1974.

15. Yuhang Zhou, Lili Lin, Xiaohua Liu,* Xinyue Hu, Yan Lu, Xiying Zhang, Xiaoming Feng,* Catalytic Asymmetric Diels-Alder Reaction/[3,3] Sigmatropic Rearrangement Cascade of 1-Thiocyanatobutadienes, Angew. Chem. Int. Ed. 2018, 57, 9113–9116.

16. Fei Tan, Xiaohua Liu,* Yan Wang, Shunxi Dong, Han Yu, Xiaoming Feng,* Chiral Lewis Acid Catalyzed Reactions of a-Diazoester Derivatives: Construction of Dimeric Polycyclic Compounds, Angew. Chem. Int. Ed. 2018, 57, 16176–16179.

17. Xiaohua Liu, Xiaoming Feng,* Dual Nickel and Brnsted Acid Catalysis for Hydroalkenylation, Angew. Chem. Int. Ed. 2018, 57, 16604–16605.

18. Songsong Guo, Pei Dong, Yushuang Chen, Xiaoming Feng, Xiaohua Liu,* Chiral Guanidine/Copper Catalyzed Asymmetric Azide-Alkyne Cycloaddition/[2+2] Cascade Reaction, Angew. Chem. Int. Ed. 2018, 57, 16852–16856.

19. Yulong Kuang, Bin Shen, Li Dai, Qian Yao, Xiaohua Liu,* Lili Lin, Xiaoming Feng,* Diastereodivergent Asymmetric Michael-Alkylationreactions Using Chiral N,N′-Dioxide/Metal Complexes, Chem. Sci. 2018, 9, 688–692.

20. Quangang Chen, Lihua Xie, Zhaojing Li, Yu Tang, Peng Zhao, Lili Lin, Xiaoming Feng and Xiaohua Liu,* Copper/Guanidine-catalyzed Asymmetric Alkynylation of Isatin-Derived Ketimines, Chem. Commun. 2018, 54, 678−681.

21. Peng Zhao, Simeng Wu, Chaoqi Ke, Xiaohua Liu,* Xiaoming Feng,* Chiral Lewis Acid-Catalyzed Enantioselective Cyclopropanation and C–H Insertion Reactions of Vinyl Ketones with α-Diazoesters, Chem. Commun. 2018, 54, 9837–9840.

22. Jing Guo, Xiaohua Liu,* Changqiang He, Fei Tan, Shunxi Dong and Xiaoming Feng,* Nickel(II)-catalyzed Enantioselective α-Alkylation of b-Ketoamides with Phenyliodonium Ylide via a Radical Process, Chem. Commun. 2018, 54, 12254–12257.

23. Jian Yang, Chaoqi Ke, Dong Zhang, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Synthesis of 2,2,3-Trisubstituted Indolines via Bimetallic Relay Catalysis of α-Diazoketones with Enones, Org. Lett. 2018, 20, 4536–4539.

24. Li Dai, Lili Lin, Jianfeng Zheng, Dong Zhang, Xiaohua Liu,* Xiaoming Feng,* N,N′-Dioxide/Gd(OTf)3 Complex-Promoted Asymmetric Aldol Reaction of Silyl Ketene Imines with Isatins: Water Plays an Important Role, Org. Lett. 2018, 20, 53148–5318.

25. Tengfei Kang, Peng Zhao, Jian Yang, Lili Lin, Xiaoming Feng, and Xiaohua Liu,* Asymmetric Catalytic Double Michael Additions for the Synthesis of Spirooxindoles, Chem. Eur. J. 2018, 24, 3703−3706.

26. Jianlin Zhang, Wanlong Xiao, Haipeng Hu, Lili Lin, Xiaohua Liu,* Xiaoming Feng,* Catalytic Asymmetric [8+3] Annulation Reactions of Tropones or Azaheptafulvenes with meso-Aziridines, Chem. Eur. J., 2018, 24, 13428–13431.

27. Han Yu, Shunxi Dong, Qian Yao, Long Chen, Dong Zhang, Xiaohua Liu,* Xiaoming Feng,* N,N¢-Dioxide-Metal Complexes Mediated Enantioselective [2+2] Photocycloadditions of Enones and Olefins with Visible Light, Chem. Eur. J. 2018, 24, 19361–19367.

28. Sai Ruan, Xiaobin Lin, Lihua Xie, Lili Lin, Xiaoming Feng and Xiaohua Liu,* Asymmetric Synthesis of 3-Aminodihydrocoumarins via the Chiral Guanidine Catalyzed Cascade Reaction of Azlactones, Org. Chem. Front. 2018, 5, 32–35.

29. Yong Xia, Fenzhen Chang, Lili Lin, Yali Xu, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Ring-Opening of Cyclopropyl Ketones with β-Naphthols Catalyzed by a Chiral N,N′-Dioxide-Scandium(III) Complex, Org. Chem. Front. 2018, 5, 1293–1296.

30. Jianlin Zhang, Xiaohua Liu,* Songsong Guo, Changqiang He, Wanlong Xiao, Lili Lin, Xiaoming Feng,* Enantioselective Formal [4 + 2] Annulation of ortho-Quinone Methides with ortho-Hydroxyphenyl α,β-Unsaturated Compounds, J. Org. Chem. 2018, 83, 10175–10185.

31. Xiaohua Liu, Shunxi Dong, Lili Lin, Xiaoming Feng,* Chiral Amino Acids-Derived Catalysts and Ligands, Chin. J. Chem. 2018, 36, 791–797.

32. Weidi Cao, Xiaohua Liu,* Xiaoming Feng, Chiral Organobases: Properties and Applications in Asymmetric Catalysis, Chin. Chem. Lett. 2018, 29, 1201−1208.

33. Xiaohua Liu, Haifeng Zheng, Yong Xia, Lili Lin, and Xiaoming Feng,* Asymmetric Cycloaddition and Cyclization Reactions Catalyzed by Chiral N,N¢-Dioxide−Metal Complexes, Acc. Chem. Res. 2017, 50, 2621−2631

34. Jianfeng Zheng, Lili Lin, Li Dai, Qiong Tang, Xiaohua Liu,* and Xiaoming Feng,* Nickel-Catalyzed Conjugate Addition of Silyl Ketene Imines to In Situ Generated Indol-2-ones: Highly Enantioselective Construction of Vicinal All-Carbon Quaternary Stereocenters, Angew. Chem. Int. Ed. 2017, 56, 13107–13111.

35. Jun Li, Lili Lin, Bowen Hu, Pengfei Zhou, Tianyu Huang, Xiaohua Liu,* and Xiaoming Feng,* Gold(I)/Chiral N,N¢-Dioxide–Nickel(II) Relay Catalysis for Asymmetric Tandem Intermolecular Hydroalkoxylation/Claisen Rearrangement, Angew. Chem. Int. Ed. 2017, 56, 885–888.

36. Tianyu Huang, Xiaohua Liu,* Jiawen Lang, Jian Xu, Lili Lin, and Xiaoming Feng,* Asymmetric Aerobic Oxidative Cross-Coupling of Tetrahydroisoquinolines with Alkynes, ACS Catal. 2017, 7, 5654−5660.

37. Yuting Liao, Baixin Zhou, Yong Xia, Xiaohua Liu,* Lili Lin, and Xiaoming Feng,* Asymmetric [3 + 2] Cycloaddition of 2,2′-Diester Aziridines To Synthesize Pyrrolidine Derivatives, ACS Catal. 2017, 7, 3934−3939.

38. Yu Zhang, Yuting Liao, Xiaohua Liu,* Xi Xu, Lili Lin and Xiaoming Feng,* Catalytic Asymmetric Hydroxylative Dearomatization of 2-Naphthols: Synthesis of Lacinilene Derivatives, Chem. Sci., 2017, 8, 6645−6649.

39. Weiwei Luo, Lili Lin, Yu Zhang, Xiaohua Liu,* and Xiaoming Feng,* Construction of Distant Stereocenters by Enantioselective Desymmetrizing Carbonyl-Ene Reaction, Org. Lett. 2017, 19, 3374−3377.

40. Qian Zhang, Songsong Guo, Jian Yang, Kunru Yu, Xiaoming Feng, Lili Lin, and Xiaohua Liu,* Asymmetric Formal [3 + 2]-Cycloaddition of Azomethine Imines with Azlactones To Synthesize Bicyclic Pyrazolidinones, Org. Lett. 2017, 19, 5826−5829.

41. Baiwei Ma, Weiwei Luo, Lili Lin, Xiaohua Liu* and Xiaoming Feng,* A Chiral Cobalt(II) Complex Catalyzed Asymmetric Formal [3+2] Cycloaddition for the Synthesis of 1,2,4-Triazolines, Chem. Commun. 2017, 53, 4077−4079.

42. Chaoran Xu, Haifeng Zheng, Bowen Hu, Xiaohua Liu,* Lili Lin and Xiaoming Feng,* Chiral Cobalt(II) Complex Catalyzed Friedel–Crafts Aromatization for the Synthesis of Axially Chiral Biaryldiols, Chem. Commun. 2017, 53, 9741−9744.

43. Guojin Wang, Yu Tang, Yu Zhang, Xiaohua Liu,* Lili Lin, and Xiaoming Feng,* Enantioselective Synthesis of N-H-Free 1,5-Benzothiazepines, Chem. Eur. J. 2017, 23, 554–557.

44. Baiwei Ma, Xiaobin Lin, Lili Lin, Xiaoming Feng,* and Xiaohua Liu,* Chiral N,N¢Dioxide Organocatalyzed Asymmetric Electrophilic αCyanation of βKeto Esters and βKeto Amides, J. Org. Chem. 2017, 82, 701−708.

45. Yushuang Chen, Xiaohua Liu,* Weiwei Luo, Lili Lin, Xiaoming Feng, Asymmetric Organocatalytic Michael/Michael/Henry Sequence to Construct Cyclohexanes with Six Vicinal Stereogenic Centers, Synlett, 2017, 28, 966–969.

46. Yong Xia, Lili Lin, Fenzhen Chang, Yuting Liao, Xiaohua Liu,* and Xiaoming Feng,* Asymmetric Ring Opening/Cyclization/Retro-Mannich Reaction of Cyclopropyl Ketones with Aryl 1,2-Diamines for the Synthesis of Benzimidazole Derivatives, Angew. Chem. Int. Ed. 2016, 55, 12228–12232.

47. Haipeng Hu, Yangbin Liu, Lili Lin, Yuheng Zhang, Xiaohua Liu,* and Xiaoming Feng*, Kinetic Resolution of 2H-Azirines by Asymmetric Imine Amidation, Angew. Chem. Int. Ed. 2016, 55, 10098–10101.

48. Qian Yao, Yuting Liao, Lili Lin, Xiaobin Lin, Jie Ji, Xiaohua Liu,* and Xiaoming Feng,* Efficient Synthesis of Chiral Trisubstituted 1,2-Allenyl Ketones by Catalytic Asymmetric Conjugate Addition of Malonic Esters to Enynes, Angew. Chem. Int. Ed. 2016, 55, 1859–1863.

49. Yangbin Liu, Xiaohua Liu,* Haipeng Hu, Jing Guo, Yong Xia, Lili Lin, and Xiaoming Feng,* Synergistic Kinetic Resolution and Asymmetric Propargyl Claisen Rearrangement for the Synthesis of Chiral Allenes, Angew. Chem. Int. Ed. 2016, 55, 4054–4058.

50. Quangang Chen, Yu Tang, Tianyu Huang, Xiaohua Liu,* Lili Lin, and Xiaoming Feng, Copper/Guanidine-Catalyzed Asymmetric Alkynylation of Isatins, Angew. Chem. Int. Ed. 2016, 55, 5286–5289.

51. Tengfei Kang, Shulin Ge, Lili Lin, Yan Lu, Xiaohua Liu,* and Xiaoming Feng,* A Chiral N,N′-Dioxide–ZnII Complex Catalyzes the Enantioselective [2+2] Cycloaddition of Alkynones with Cyclic Enol Silyl Ethers, Angew. Chem. Int. Ed. 2016, 55, 5541–5544.

52. Jun Li, Lili Lin, Bowen Hu, Xiangjin Lian, Gang Wang, Xiaohua Liu,* and Xiaoming Feng,* Bimetallic Gold(I)/Chiral N,N′-Dioxide Nickel(II) Asymmetric Relay Catalysis: Chemo- and Enantioselective Synthesis of Spiroketals and Spiroaminals, Angew. Chem. Int. Ed. 2016, 55, 6075–6078.

53. Fei Tan, Xiaohua Liu,* Xiaoyu Hao, Yu Tang, Lili Lin, and Xiaoming Feng, Asymmetric Catalytic Insertion of α-Diazo Carbonyl Compounds into O−H Bonds of Carboxylic Acids, ACS Catal. 2016, 6, 6930−6934.

54. Gang Wang, Xiaohua Liu,* Yushuang Chen, Jian Yang, Jun Li, Lili Lin, and Xiaoming Feng,* Diastereoselective and Enantioselective Alleno-aldol Reaction of Allenoates with Isatins to Synthesis of Carbinol Allenoates Catalyzed by Gold, ACS Catal. 2016, 6, 2482−2486.

55. Jing Guo, Yangbin Liu, Xiangqiang Li, Xiaohua Liu,* Lili Lin and Xiaoming Feng,* Nickel(II)-Catalyzed Enantioselective Cyclopropanation of 3-Alkenyl-oxindoles with Phenyliodonium Ylide via Free Carbine, Chem. Sci. 2016, 7, 2717–2721.

56. Yuting Liao, Xiaohua Liu,* Yu Zhang, Yali Xu, Yong Xia, Lili Lin and Xiaoming Feng,* Asymmetric [3 + 2] Cycloaddition of Donor–Acceptor Aziridines with Aldehydes via Carbon–Carbon Bond Cleavage, Chem. Sci. 2016, 7, 3775–3779.

57. Weiwei Luo, Xiao Yuan, Lili Lin, Pengfei Zhou, Xiaohua Liu* and Xiaoming Feng,* A N,N′-Dioxide/Mg(OTf)2 Complex Catalyzed Enantioselective α-Addition of Isocyanides to Alkylidene Malonates, Chem. Sci. 2016, 7, 4736–4740.

58. Jing Guo, Lili Lin, Yangbin Liu, Xiangqiang Li, Xiaohua Liu,* and Xiaoming Feng,* Nickel(II)-Catalyzed Enantioselective α-Vinylation of β-Keto Amides/Esters with Hypervalent Iodine Salts, Org. Lett. 2016, 18, 5540−5543.

59. Xiaobin Lin, Sai Ruan, Qian Yao, Chengkai Yin, Lili Lin, Xiaoming Feng, and Xiaohua Liu,* Kinetic Resolution of Oxaziridines via Chiral Bifunctional Guanidine-Catalyzed Enantioselective α-Hydroxylation of β-Keto Esters, Org. Lett. 2016, 18, 3602−3605.

60. Songsong Guo, Xiaohua Liu,* Bin Shen, Lili Lin, and Xiaoming Feng, Organocatalytic Asymmetric Cascade Reaction of 2-Hydroxyphenyl-Substituted Enones and Isocyanates To Construct 1,3-Benzoxazin-2-ones, Org. Lett. 2016, 18, 5070–5073.

61. Yangbin Liu, Haipeng Hu, Lili Lin, Xiaoyu Hao, Xiaohua Liu* and Xiaoming Feng,* Enantioselective Construction of Branched 1,3-Dienyl Substituted Quaternary Carbon Stereocenters by Asymmetric Allenyl Claisen Rearrangement, Chem. Commun. 2016, 52, 11963–11966.

62. Yu Zhang, Yuting Liao, Xiaohua Liu,* Qian Yao, Yuhang Zhou, Lili Lin, and Xiaoming Feng,* Catalytic Michael/Ring-Closure Reaction of α,β-Unsaturated Pyrazoleamides with Amidomalonates: Asymmetric Synthesis of (-)-Paroxetine, Chem. Eur. J. 2016, 22, 15119–15124.

63. Yong Xia, Lili Lin, Fenzhen Chang, Xuan Fu, Xiaohua Liu*, Xiaoming Feng,* Asymmetric Ring-Opening of Cyclopropyl Ketones with Thiol, Alcohol, and Carboxylic Acid Nucleophiles Catalyzed by a Chiral N,N′-Dioxide–Scandium(III) Complex, Angew. Chem. Int. Ed. 2015, 54, 13748–13752.

64. Haifeng Zheng, Xiaohua Liu,* Chaoran Xu, Yong Xia, Lili Lin, Xiaoming Feng,* Regio- and Enantioselective Aza-Diels–Alder Reactions of 3-Vinylindoles: A Concise Synthesis of the Antimalarial Spiroindolone NITD609, Angew. Chem. Int. Ed., 2015, 54, 10958−10962.

65. Yu Tang, Quangang Chen, Xiaohua Liu,* Gang Wang, Lili Lin, and Xiaoming Feng, Direct Synthesis of Chiral Allenoates from the Asymmetric C-H Insertion of α-Diazoesters into Terminal Alkynes, Angew. Chem. Int. Ed., 2015, 54, 9512−9516.

66. Xiaohu Zhao, Xiaohua Liu,* Hongjiang Mei, Jing Guo, Lili Lin, Xiaoming Feng,* Asymmetric Dearomatization of Indoles through Michael/Friedel–Crafts-Type Cascade to Construct Polycyclic Spiroindolines, Angew. Chem. Int. Ed. 2015, 54, 4032−4035.

67. Yong Xia, Xiaohua Liu,* Haifeng Zheng, Lili Lin, Xiaoming Feng,* Asymmetric Synthesis of 2,3-Dihydropyrroles by Ring-Opening/Cyclization of Cyclopropyl Ketones Using Primary Amines, Angew. Chem. Int. Ed. 2015, 54, 227230.

68. Kunru Yu, Xiaohua Liu,* Xiaobin Lin, Lili Lin and Xiaoming Feng, Organocatalytic Dynamic Kinetic Resolution of Azlactones to Construct Chiral N-Acyl Amino Acid Oxime Esters; Chem. Commun., 2015, 51, 14897−14900.

69. Bing Fang, Xiaohua Liu,* Jiannan Zhao, Yu Tang, Lili Lin, Xiaoming Feng,* Chiral Bifunctional Guanidine-Catalyzed Enantioselective Aza-Henry Reaction of Isatin-Derived Ketimines, J. Org. Chem. 2015, 80, 3332−3338

70. Yan Lu, Min, Wang, Xiaohu Zhao, Xiaohua Liu,* Lili Lin, Xiaoming Feng*, Reaction of Isatin-Derived Ketimines Iso- Reaction of Isatin-Derived Ketimines, Synlett 2015, 26, 1545−1548.

71. Yin Zhu, Xiaohua Liu,* Shunxi Dong, Yuhang Zhou, Wei Li, Lili Lin, and Xiaoming Feng,* Asymmetric N-H Insertion of Secondary and Primary Anilines under the Catalysis of Palladium and Chiral Guanidine Derivatives, Angew. Chem. Int. Ed. 2014, 53, 1636–1640.

72. Xiaohua Liu, Lili Lin and Xiaoming Feng,* Chiral N,N¢-Dioxide Ligands: Synthesis, Coordination Chemistry and Asymmetric Catalysis, Org. Chem. Front. 2014, 1, 298–302.

73. Zuliang Zhang, Xiaohua Liu,* Zhen Wang, Xiaohu Zhao, Lili Lin, Xiaoming Feng,* Chiral Co(II) Complex Catalyzed Asymmetric Michael Reactions of β-Ketoamides to Nitroolefins and Alkynones, Tetrahedron Lett. 2014, 55, 3797−3801.

74. Xiaohua Liu, Ke Zheng, Xiaoming Feng,* Advancements in Catalytic Asymmetric Intermolecular Ene-Type Reactions, Synthesis 2014; 46, 2241−2257.

75. Shunxi Dong, Xiaohua Liu,* Yin Zhu, Peng He, Lili Lin, Xiaoming Feng,* Organocatalytic Oxyamination of Azlactones: Kinetic Resolution of Oxaziridines and Asymmetric Synthesis of Oxazolin-4-ones, J. Am. Chem. Soc. 2013, 135, 10026‒10029.

76. Min Wang, Xiaohua Liu,* Peng He, Lili Lin, Xiaoming Feng,* Enantioselective Synthesis of 1,2,4-Triazolines by Chiral Iron(II)-Complex Catalyzed Cyclization of α-Isocyano Esters and Azodicarboxylates, Chem. Commun. 2013, 49, 2572–2574.

77. Jingjing Yao, Xiaohua Liu*, Peng He, Yin Zhu, Xiangjin Lian, Lili Lin, Xiaoming Feng,* Chiral-Zn(NTf2)2-Complex-Catalyzed Diastereo- and Enantioselective Direct Conjugate Addition of Arylacetonitriles to Alkylidene Malonates, Chem. Eur. J. 2013, 19, 16424−16430.

78. Zhenling Chen, Lili Lin, Min Wang, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of trans-β-Lactams by a Kinugasa Reaction on Water, Chem. Eur. J. 2013, 19, 7561–7567.

79. Jing Wang, Xiaohua Liu,* Shunxi Dong, Lili Lin, Xiaoming Feng,* Asymmetric Organocatalytic Cyclopropanation of Cinnamone Derivatives with Stabilized Sulfonium Ylides, J. Org. Chem. 2013, 78, 6322‒6327.

80. Yang Yang, Shunxi Dong, Xiaohua Liu,* Lili Lin, Xiaoming Feng,* Chiral Guanidine-Catalyzed Asymmetric Direct Vinylogous Michael Reaction of α,β-Unsaturated γ-Butyrolactams with Alkylidene Malonates, Chem. Commun. 2012, 48, 5040–5042.

81. Xiao Xiao, Xiaohua Liu,* Shunxi Dong, Yunfei Cai, Lili Lin, Xiaoming Feng,* Asymmetric Synthesis of 2,3-Dihydroquinolin-4-one Derivatives Catalyzed by Chiral Bisguanidium Salt, Chem. Eur. J. 2012, 18, 15922–15925.

82. Yangbin Liu, Xiaohua Liu*, Min Wang, Peng He, Lili Lin, Xiaoming Feng*, Enantioselective Synthesis of 3,4-Dihydropyran Derivatives via Organocatalytic Michael Reaction of α,β-Unsaturated Enones, J. Org. Chem. 2012, 77, 4136–4142.

83. Xiaohua Liu, Lili Lin, Xiaoming Feng,* Chiral N,N¢-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions, Acc. Chem. Res. 2011, 44, 574–587.

84. Shunxi Dong, Xiaohua Liu,* Yulong Zhang, Lili Lin, and Xiaoming Feng,* Asymmetric Synthesis of 3,4-Diaminochroman-2-ones Promoted by Guanidine and Bisguanidium Salt, Org. Lett. 2011, 13, 5060–5063.

85. Jing Wang, Wentao Wang, Xiaohua Liu,* Zongrui Hou, Lili Lin, Xiaoming Feng,* Highly Enantioselective Direct Michael Addition of 1H-Benzotriazole to Chalcones Catalyzed by Sc(OTf)3/N,N¢-Dioxide Complex, Eur. J. Org. Chem. 2011, 2039–2042.

86. Xiaohong Chen, Shunxi Dong, Zhen Qiao, Yin Zhu, Mingsheng Xie, Lili Lin, Xiaohua Liu,* Xiaoming Feng,* Guanidine Organocatalyst for the Asymmetric Mannich-Type Reaction between α-Isothiocyanato Imide and Sulfonyl Imines, Chem. Eur. J. 2011, 17, 2583–2586.

87. Min Wang, Lili Lin, Jian Shi, Xiaohua Liu,* Yulong Kuang, Xiaoming Feng,* Asymmetric Crossed-Conjugate Addition of Nitroalkenes to Enones by a Chiral Bifunctional Diamine Organocatalyst, Chem. Eur. J. 2011, 17, 2365–2368.

88. Peng He, Xiaohua Liu,* Jian Shi, Lili Lin, Xiaoming Feng,* Organocatalytic Sequential Michael Reactions: Stereoselective Synthesis of Multifunctionalized Tetrahydroindan Derivatives, Org. Lett. 2011, 13, 936−939.

89. Zhenhua Dong, Xiaohua Liu,* Juhua Feng, Min Wang, Lili Lin, Xiaoming Feng,* Efficient Asymmetric Synthesis of 4H-Chromene Derivatives through a Tandem Michael Addition–Cyclization Reaction Catalyzed by a Salen–Cobalt(II) Complex, Eur. J. Org. Chem. 2011, 137–142.

90. Xuan Fu, Juhua Feng, Zhenhua Dong, Lili Lin, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Synthesis of 2-Substituted-1,5-Benzodiazepines through Domino Reaction of o-Phenylenediamine and Chalcone Derivatives, Eur. J. Org. Chem. 2011, 5233–5236.

91. Yonghai Hui, Weiliang Chen, Wentao Wang, Jun Jiang, Yunfei Cai, Lili Lin, Xiaohua Liu,* and Xiaoming Feng,* Highly Enantioselective Zinc-Catalyzed Friedel–Crafts Alkylation of Indoles with Ethyl Trifluoropyruvate, Adv. Synth. Catal. 2010, 352, 3174–3178.

92. Xiaohua Liu, Lili Lin, Xiaoming Feng,* Amide-Based Bifunctional Organocatalysts in Asymmetric Reactions, Chem. Commun. 2009, 45, 6145−6158.

93. Xiaohua Liu, Bo Qin, Bin He, Xiaoming Feng,* Catalytic Asymmetric Cyanosilylation of Ketones by a Chiral Amino Acid Salt, J. Am. Chem. Soc. 2005, 127, 12224−12225.

 

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