四川大学化学学院
师资力量

高戈     教 授(博导)

研究方向:有机化学

联系方式:028-85418195          Email:gg2b@scu.edu.cn

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简历

简历:

19949 ~ 19987月,四川大学化学系,本科

19989 ~ 20047月,四川大学化学系,博士研究生

20047 ~ 20052月,四川大学化学学院,工作

20053 ~ 20085月,美国University of Virginia,博士后

20087 ~ 现在,四川大学化学学院,任教

学术任职:

《中国化学快报》青年编委,2014.10   ~ 现在

主要研究方向

主要研究方向:

基于芳杂环功能化修饰的有机合成方法学研究

开发基于芳杂环的新型有机功能分子

离子型的有机功能材料分子的设计合成

主要工作业绩

工作业绩:

主要围绕芳杂环,开发简洁高效的新反应对其进行合成和修饰,以用于构建新颖的功能型有机分子,特别是带有电荷的离子型有机功能分子。现已发展了高效的咪唑直接芳基季胺化构筑咪唑鎓的方法;发展了咪唑鎓分子的直接C–H芳基化的方法,开发了咪唑鎓电致变色新性能;发展了多个基于碳氢键串联环化的高效构筑离子型天然产物骨架的方法;发展了高活性吡喃鎓中间体的构筑与转化方法,发展了一锅法合成12-氮杂芘鎓盐的方法;首次合成了一种刚性四咪唑鎓大环,可在水中高效识别硫酸根阴离子;提出了铑催化反应中底物作为配体原位配位铑中心的过渡态新策略,成功实现含咪唑鎓单元的阳离子型三亚杂芳烃骨架的高效构筑;提出了构筑近红外Indazo-Fluor小分子荧光探针的D-HetED-HetER-A骨架模型。2013年入选教育部新世纪优秀人才计划。目前已在JACSACIEOLCCJOC等杂志上发表研究论文50余篇。

主持的主要科研项目:

1.国家自然科学基金面上项目,新型共轭多环杂芳烃的合成与性质研究,2018-2021

2.国家自然科学基金面上项目,联杂芳烃型小分子荧光骨架的构筑方法、性质与应用研究,2015-2018

3.教育部新世纪优秀人才计划,功能离子型有机材料的合成与应用,2014-2016

4.四川大学优秀青年学者基金,杂芳环鎓盐的功能化与应用,2014-2016

5.国家自然科学基金面上项目,新型荧光手性传感器的合成与应用,2012-2015

6.国家自然科学基金青年基金,刚性共轭多咪唑鎓的合成与应用研究,2010-2012

代表性成果 (获奖成果、专著、论文、专利)

代表性论著:

1.Kadam, V. D.; Feng, B.; Chen, X.; Liang, W.; Zhou, F.; Liu,   Y.; Gao, G.;* You J.* Cascade C-H Annulation Reaction of Benzaldehydes,   Anilines, and Alkynes toward Dibenzo[a,f]quinolizinium Salts: Discovery of   Photostable Mitochondrial Trackers at the Nanomolar-Level Org. Lett. 2018,   20, 7071.


 
 

2.She, Z.; Wang, Y.; Wang, D.; Zhao, Y.; Wang, T.; Zheng, X.;   Yu, Z.-X.;* Gao, G.;* You, J.* Two-Fold C-H/C-H Cross-Coupling Using   RhCl3·3H2O as the Catalyst: Direct Fusion of N-(Hetero)arylimidazolium Salts   and (Hetero)arenes J. Am. Chem. Soc. 2018, 140, 12566.


 
 

3.Zhao, Y.; Zheng, Q.; Yu, C.; Liu, Z.; Wang, D.; You, J.; Gao,   G.* Rh(III)-Catalyzed Regioselective C–H [4+2] C-Annulation of Vinyl   Enaminones with Alkynes to Form Polysubstituted Salicylaldehydes Org. Chem.   Front. 2018, 5, 2875.


 
 

4.Zhao, Y.; Yu, C.; Wang, T.; She, Z.; Zheng, X.; You, J. Gao,   G.* Tandem Rh-Catalyzed [4 + 2] Vinylic C-H O-Annulation of Exocyclic Enones   with Alkynes and 1,5-H Shift Org. Lett. 2018, 20, 1074.


 
 

5.Li, S.; Tang, J.; Zhao, Y.; Jiang, R.; Wang, T.; Gao, G.;*   You, J.* Cu-Catalyzed Selective C-H Mono-/Di-/Triarylation of Imidazolium   Salts for Ionic Functional Materials Chem. Commun. 2017, 53, 3489.


 
 

6.Zhao, Y.; Li, S.; Zheng, X.; Tang, J.; She, Z.; Gao, G.;* You,   J.* Rh/Cu-Catalyzed Cascade [4+2] Vinylic C–H O-Annulation and Ring   Contraction of ?-Aryl Enones with Alkynes in Air Angew. Chem. Int. Ed. 2017,   56, 4286.


 
 

7.Tang, J.; Li, S.; Liu, Z.; Zhao, Y.; She, Z.; Kadam, V. D.;   Gao, G.;* Lan, J.; You, J.* Cascade C-H Annulation of Aldoximes with Alkynes   using O2 as the Sole Oxidant: One-Pot Access to Multisubstituted   Protoberberine Skeletons Org. Lett. 2017, 19, 604.


 
 

8.He, Z.; Qi, X.; She, Z.; Zhao, Y. Li, S.; Tang, J.; Gao, G.;*   Lan, Y.;* You, J.* Room-Temperature Coupling/Decarboxylation Reaction of   α-Oxocarboxylates with α-Bromoketones: Solvent-Controlled Regioselectivity   for 1,2- and 1,3-Diketones J. Org. Chem. 2017, 82, 1403.


 
 

9.Feng, B.; Wan, D.; Yan, L.; Kadam, V. D.; You, J.; Gao, G.* A   Facile Access to Substituted Cationic 12-Azapyrene Salts by   Rhodium(III)-Catalyzed C–H Annulation of N-Arylpyridinium Salts RSC Adv.   2016, 6, 66407.


 
 

10.Cheng, Y.; Li, G.; Liu, Y.; Shi, Y.; Gao, G.;* Wu, D.; Lan,   J.; You, J.* Unparalleled Ease of Access to a Library of Biheteroaryl   Fluorophores via Oxidative Cross-Coupling Reactions: Discovery of Photostable   NIR Probe for Mitochondria J. Am. Chem. Soc. 2016, 138, 4730.


 
 

11.Zhao, Y.; He, Z.; Li, S.; Tang, J.; Gao, G.;* Lan, J.; You,   J.* An Air-stable Half-sandwich RuII Complex as Efficient Catalyst for [3+2]   Annulation of 2-Arylcyclo-2-enones with Alkynes Chem. Commun. 2016, 52, 4613.   (Cover story)


 
 

12.Qin, D.; Wang, J.; Qin, X.; Wang, C.; Gao, G.;* You, J.*   Rh(III)-catalyzed oxime ether-directed heteroarylation of arene through   oxidative C–H/C–H cross-coupling Chem. Commun. 2015, 51, 6190.


 
 

13.He, Z.; Qi, X.; Li, S.; Zhao, Y.; Gao, G.;* Lan, Y.;* Wu, Y.;   Lan, J.; You, J.* Transition-Metal-Free Formal Decarboxylative Coupling of   α-Oxocarboxylates with α-Bromoketones under Neutral Conditions: A Simple   Access to 1,3-Diketones Angew. Chem. Int. Ed. 2015, 54, 855.


 
 

14.Li, J.; Wang, Z.; Wu, N.; Gao, G.* You, J.* Radical Cascade   Cyanomethylation of Activated Alkenes to Construct Cyano Substituted   Oxindoles Chem. Commun., 2014, 50 (95), 15049.


 
 

15.Li, C.; Gao, C.; Lan, J.; You, J.; Gao, G.* An AIE Active   Y-shaped Diimidazolylbenzene: Aggregation and Disaggregation for Cd2+ and   Fe3+ Sensing in Aqueous Solution Org. Bio. Chem., 2014, 12, 9524.


 
 

16.Gao, C.; Gao, G.;* Lan, J.; You, J.* An AIE Active   Monoimidazolium Skeleton: High Selectivity and Fluorescence Turn-on for   H2PO4- in Acetonitrile and ClO4- in Water Chem. Commun. 2014, 50, 5623.


 
 

17.Li, S.; Yang, F.; Lv, T.; Lan, J.; Gao, G.;* You, J.*   Synthesis of Unsymmetrical Imidazolium Salts by Direct Quaternization of   N-Substituted Imidazoles with Arylboronic Acids Chem. Commun. 2014, 50, 3941.


 
 

18.Zhou, H.; Zhao, Y.; Gao, G.;* Li, S.; Lan, J.; You, J.*   Highly Selective Fluorescent Recognition of Sulfate in Water by Two Rigid   Tetrakisimidazolium Macrocycles with Peripheral Chains J. Am. Chem. Soc.   2013, 135, 14908.


 
 

19.Lv, T.; Yang, L.; Zhao, Y.; Song, F.; Lan, J.; You, J.;* Gao,   G.* One-pot Synthesis of Diarylimidazolium Salts from 1H-Imidazole Chin.   Chem. Lett. 2013, 24, 773.


 
 

20.王志,周红军,胡俊毅,游劲松*,高戈* 十字架型间二咪唑(鎓)苯的合成及对有机酸的识别 化学学报 2013, 71, 1257.


 
 

21.Hu, J.; He, Z.; Wang, Z.; Li, X.; You, J.; Gao, G.* A Simple   Approach to Aggregation-Induced Emission in Difluoroboron Dibenzoylmethane   Derivatives Tetrahedron Lett. 2013, 54, 4167.


 
 

22.Lv, T.; Wang, Z.; You, J.* Lan, J.; Gao, G.;*   Copper-Catalyzed Direct Aryl Quaternization of N-Substituted Imidazoles to   Form Imidazolium Salts J. Org. Chem. 2013, 78, 5723.


 
 

23.Zhou, H.; Wang, Z.; Gao, C.; You, J.; Gao, G.* Synthesis and   Characterization of a Luminescent and Fully Rigid Tetrakisimidazolium   Macrocycle Chem. Commun. 2013, 49, 1832.


 
 

24.Gao, C.; Zhou, H.; Wei, S.; Zhao, Y.; You, J.; Gao, G.* Novel   Bisimidazolium Pincers as Low Loading Ligands for in situ Palladium-Catalyzed   Suzuki-Miyaura Reaction in the Ambient Atmosphere Chem. Commun. 2013, 49,   1127.


 
 

25.Yang, S.; You, J.;* Lan, J.; Gao, G.* Facile Access to   Extremely E?cient Energy-Transfer Pairs via an Unexpected Reaction of   Squaraines with Ketones J. Am. Chem. Soc. 2012, 134, 11868.


 
 

26.Cheng, L.; Dong, J.; You, J.; Gao, G.;* Lan, J.* A Highly   syn-Selective Nitroaldol Reaction Catalyzed by CuII-Bisimidazoline Chem.   -Eur. J. 2010, 16(23), 6761.

 

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