四川大学化学学院
师资力量

林丽丽     教 授

研究方向:有机化学

联系方式:          Email:lililin@scu.edu.cn

个人主页:点击进入

简历

1999–2003,四川大学,化学学院应用化学专业,本科

2003–2008,四川大学,化学学院有机化学专业,博士

2008–2011,四川大学,化学学院有机化学专业,讲师

2011–2016,四川大学,化学学院有机化学专业,副教授,硕导

2016–至今 四川大学,化学学院有机化学专业,教授

2018-至今 四川大学,化学学院有机化学专业,博导

主要研究方向

不对称催化反应及其在天然产物合成中的应用。

主要工作业绩

从事不对称合成领域的科研工作。近年来已经在Chem.   Eur. J.Chem. Commun., Org. Lett.等刊物上发表多篇论文。目前承担国家自然科学基金面上项目两项:催化不对称反电子需求环化反应合成双杂原子环状化合物研究(批准号:21572136), 直接经费65万元,执行时间:2016.01-2019.12;双哌啶骨架手性催化剂的设计合成及在不对称反应中的应用(批准号:21871188),直接经费65万元,执行时间:2019.01-2022.12

作为第三完成人获得2009年教育部自然科学奖一等奖和2012年国家自然科学奖二等奖。

代表性成果 (获奖成果、专著、论文、专利)

1.Jingchuan Zhang, Kai Fu, Lili Lin,* Yan Lu, Xiaohua Liu, Xiaoming   Feng,* Efficient Catalytic Enantioselective Hydroxyamination of ?-Aryl-?-Cyanoacetates   with 2-Nitrosopyridines, Chem. Eur. J. 2018, 24, 4289–4293.

2.Yan Lu, Yuhang Zhou, Jingchuan Zhang, Lili Lin,* Xiaohua Liu, Xiaoming   Feng*, Highly Regio- and Enantioselective Nitroso Diels-Alder Reaction of   1,3-Diene-1-carbamates Catalyzed by Chiral N,N’-Dioxide/Copper(II) Complex.   Adv. Synth. Catal. 2018, 360, 186–191.

3.Jianlin Zhang, Lili Lin,* Changqiang He, Qian Xiong, Xiaohua Liu,   Xiaoming Feng,* A Chiral Scandium-Complex-Catalyzed Asymmetric Inverse-Electron-Demand   oxa-Diels–Alder Reaction of o-Quinone Methides with Fulvenes. Chem. Commun.   2018, 54, 74–77.

4.Qiong Tang, Lili Lin,* Jie Ji, Haipeng Hu, Xiaohua Liu, Xiaoming   Feng*, Catalytic Asymmetric Direct Vinylogous Aldol Reaction of Isatins with   β,γ-Unsaturated Butenolides, Chem. Eur. J. 2017, 23, 16447–16451.

5.Yuhang Zhou, Yan Lu, Xinyue Hu, Hongjiang Mei, Lili Lin,*   Xiaohua Liu, Xiaoming Feng*, Highly diastereo- and enantioselective synthesis   of spirooxindole-cyclohexaneamides through N,N’-dioxide/Ni(II)-catalyzed Diels–Alder   reactions, Chem. Commun., 2017, 53, 2060–2063.

6.Hongjiang Mei, Lili Lin, * Lifeng Wang, Li Dai, Xiaohua Liu, Xiaoming   Feng*, Highly regio-, diastereo- and enantioselective deracemization of   axially chiral 3-alkylideneoxindoles, Chem. Commun., 2017, 53, 8763–8766.

7.Zhengmeng Wang, Lili Lin,* Pengfei Zhou, Xiaohua Liu, Xiaoming   Feng*, Chiral N,N’-dioxide-Sc(NTf2)3 complex-catalyzed asymmetric bromoamination   of chalones with N-bromosuccinimide as both bromine and amide source, Chem.   Commun., 2017, 53, 3462–3465.

8.Dong Zhang, Chengkai Yin, Yuhang Zhou, Yali Xu, Lili Lin,* Xiaohua   Liu, Xiaoming Feng*, Chiral N,N’-dioxide/Co(II)-promoted asymmetric 1,3-dipolar   cycloaddition of nitrones with methyleneindolinones, Chem. Commun., 2017, 53,   7925–7928.

9.Shulin Ge, Tengfei Kang, Lili Lin,* Xiying Zhang, Peng Zhao, Xiaohua   Liu, Xiaoming Feng*, Chiral N,N’-dioxide/Sc(OTf)3 complex-catalyzed asymmetric   dearomatization of β-naphthols, Chem. Commun., 2017, 53, 11759–11762.

10.Hang Zhang, Qian Yao, Lili Lin,* Chaoran Xu, Xiaohua Liu, Xiaoming   Feng*, Catalytic Asymmetric Epoxidation of Electron-Deficient Enynes Promoted   by Chiral N,N’-Dioxide-Scandium(III) Complex, Adv. Synth. Catal. 2017, 359,   3454–3459.

11.Xiangqiang Li, Jing Guo, Lili Lin,* Haipeng Hu, Fenzhen Chang,   Xiaohua Liu, Xiaoming Feng*, Chiral Magnesium(II) Complex-Catalyzed Enantioselective   Desymmetrization of meso-Aziridines with Pyrazoles, Adv. Synth. Catal. 2017,   359, 3532–3537.

12.Yuheng Zhang, Lili Lin,* Yushuang Chen, Xiaohua Liu, Xiaoming   Feng*, N,N’-Dioxide–Lanthanum(III)-Catalyzed Asymmetric Cyclopropanation of 2-Cyano-3-arylacrylates   with 2-Bromomalonates, Adv. Synth. Catal. 2017, 359, 1831–1836.

13.Xiaoyu Hao, Lili Lin,* Fei Tan, Shulin Ge, Xiaohua Liu, Xiaoming   Feng*, Asymmetric synthesis of chromans via the Friedel–Crafts alkylation–hemiketalization   catalysed by an N,N’-dioxide scandium(III) complex, Org. Chem. Front. 2017,   4, 1647–1650.

14.Qian Yao, Lili Lin,* Hang Zhang, Han Yu, Qian Xiong, Xiaohua Liu,   Xiaoming Feng*, The asymmetric synthesis of multisubstituted diquinanes via   the domino reaction of electrondeficient enynes, Org. Chem. Front. 2017, 4,   2012–2015.

15.Lili Lin, Xiaoming Feng*, Catalytic Strategies for Diastereodivergent   Synthesis, Chem. Eur. J. 2017, 23, 6464–6482.

16.Wangbin Wu, Sijia Zou, Lili Lin,* Jie Ji, Yuheng Zhang, Baiwei   Ma, Xiaohua Liu, Xiaoming Feng*, Catalytic asymmetric Meerwein–Ponndorf–Verley   reduction of glyoxylates induced by a chiral N,N’-dioxide/Y(OTf)3 complex,   Chem. Commun., 2017, 53, 3232-3235.

17.Kai Fu, Jingchuan Zhang, Lili Lin,* Jun Li, Xiaohua Liu, and Xiaoming   Feng*, Chiral N,N’-Dioxide/Lanthanide(III) Complex Catalyzed Asymmetric   Bisvinylogous Mukaiyama Aldol Reactions, Org. Lett. 2017, 19, 332?335.

18.Juhua Feng, Xiao Yuan, Weiwei Luo, Lili Lin,* Xiaohua Liu, Xiaoming   Feng*, Chiral N,N’-Dioxide-Organocatalyzed Regio-, Diastereo- and Enantioselective   Michael Addition–Alkylation Reaction, Chem. Eur. J. 2016, 22, 15650–15653.

19.Jianfeng Zheng, Lili Lin,* Li Dai, Xiao Yuan, Xiaohua Liu, Xiaoming   Feng*, Chiral N,N′-Dioxide–Scandium(III) Complex-Catalyzed Asymmetric   Friedel-Crafts Alkylation Reaction of ortho-Hydroxybenzyl Alcohols with   C3-Substitued N-Protected Indoles, Chem. Eur. J. 2016, 22, 18254-18258

20.Xiaohu Zhao, Hongjiang Mei, Qian Xiong, Kai Fu, Lili Lin,* Xiaohua   Liu, Xiaoming Feng*, Highly enantioselective construction of carbazole   derivatives via [4+2] cycloaddition of silyloxyvinylindoles and ?,γ-unsaturated   a-ketoesters, Chem. Commun., 2016, 52,10692–10695

21.Yan Lu, Yuhang Zhou, Lili Lin,* Haifeng Zheng, Kai Fu, Xiaohua   Liu, Xiaoming Feng*, N,N’-Dioxide/nickel(II)-catalyzed asymmetric Diels–Alder   reaction of cyclopentadiene with 2,3-dioxopyrrolidines and 2-alkenoyl   pyridines, Chem. Commun., 2016, 52, 8255—8258.

22.Kai Fu, Jianfeng Zheng, Lili Lin,* Xiaohua Liu and Xiaoming Feng*,   Chiral N,N’-dioxide–In(OTf)3-catalyzed asymmetric vinylogous Mukaiyama aldol   reactions, Chem. Commun., 2015, 51, 3106—3108.

23.Xiying Zhang, Jianlin Zhang, Lili Lin,* Haifeng Zheng, Wangbin   Wu, Xiaohua Liu, Xiaoming Feng*, Chiral N,N’-Dioxide-Zinc(II) Complex-Catalyzed   Asymmetric Aza-Friedel–Crafts Reaction of Isatin-Derived Ketimines with   Indoles, Adv. Synth. Catal. 2016, 358, 3021-3026.

24.Xiao Xiao, Lili Lin,* Xiangjin Lian, Xiaohua Liu, Xiaoming Feng*,   Catalytic asymmetric α-amination of β-ketoesters and β-keto amides with a   chiral N,N’-dioxide–copper(I) complex, Org. Chem. Front., 2016, 3, 809–812

25.Xiao Yuan, Lili Lin,* Weiliang Chen, Wangbin Wu, Xiaohua Liu,   Xiaoming Feng*, Synthesis of Chiral Tetrahydrofurans via Catalytic Asymmetric   [3 + 2] Cycloaddition of Heterosubstituted Alkenes with Oxiranes, J. Org. Chem.   2016, 81, 1237?1243.

26.Ruixue Peng, Lili Lin,* Yuheng Zhang, Wangbin Wu, Yan Lu, Xiaohua   Liu, Xiaoming Feng*, The assignment of the configuration for α-hydroxy acid   esters using a CEC strategy, Org. Biomol. Chem., 2016, 14, 5258–5262.

27.Xuan Fu, Lili Lin,* Yong Xia, Pengfei Zhou, Xiaohua Liu, Xiaoming   Feng*, Catalytic asymmetric [3 + 3] annulation of cyclopropanes with mercaptoacet   aldehyde, Org. Biomol. Chem., 2016, 14, 5914–5917.

28.Jianfeng Zheng, Lili Lin*, Kai Fu, Haifeng Zheng, Xiaohua Liu,   Xiaoming Feng*, Synthesis of Optically Pure Spiro[cyclohexane-oxindoline] Derivatives   via Catalytic Asymmetric Diels?Alder Reaction of Brassard-Type Diene with   Methyleneindolines, J. Org. Chem. 2015, 80, 8836?8842

29.Ruixue Peng, Lili Lin*, Weidi Cao, Jing Guo, Xiaohua Liu, Xiaoming   Feng*, A racemic N,N’-dioxide-iron(III) complex chemosensor for determination   of enantiomeric excess, concentration and identity of hydroxy carboxylic   acids with circular dichroism and ?uorescence responses, Tetrahedron Letters   2015, 56, 3882–3885.

30.Hongjiang Mei, Xiao Xiao, Xiaohu Zhao, Bing Fang, Xiaohua Liu,   Lili Lin,* Xiaoming Feng*, Catalytic Asymmetric Henry Reaction of Nitroalkanes   and Aldehydes Catalyzed by a Chiral N,N’-Dioxide/Cu(I) Complex, J. Org. Chem.   2015, 80, 2272?2280.

31.Lili Lin, Yulong Kuang, Xiaohua Liu, Xiaoming Feng*, Indium(III)-Catalyzed   Asymmetric Hetero-Diels–Alder Reaction of Brassard-Type Diene with Aliphatic   Aldehydes, Org. Lett, 2011, 13, 3868-3871.

32.Lili Lin, Zhenling Chen, Xu Yang, Xiaohua Liu, and Xiaoming Feng*,   An Efficient Enantioselective Hetero-Diels-Alder Reaction of Brassard’s   Dienes with Aliphatic Aldehydes: A One-Step Synthesis of (R)-(+)-Kavain and   (S)-(+)-Dihydrokavain, Org. Lett. 2008, 10, 1311-1314.

33.Lili Lin, Qian Fan, Bo Qin, and Xiaoming Feng*, Highly Enantio-   and Diasteroselective Brassard Type Hetero-Diels-Alder Approach to 5-Methyl-Containing   α,β-Unsaturated δ-Lactones, J. Org. Chem. 2006, 71, 4141-4146.

34.Lili Lin, Xiaohua Liu, Xiaoming Feng, Asymmetric Hetero-Diels–Alder   Reactions of Danishefsky’s and Brassard’s Dienes with Aldehydes, Synlett   2007, 14, 2147-2157.

35.Zhenhua Dong, Juhua Feng, Weidi Cao, Xiaohua Liu, Lili Lin*, Xiaoming   Feng*, N,N’-Dioxide–nickel(II) complex catalyzed asymmetric Michael addition   of cyclic 1,3-dicarbonyl compounds to ?β,γ-unsaturated α-ketoesters, Tetrahedron   Lett, 2011, 52, 3433-3436.

 

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