个人简介
教授，博士生导师。2002年于四川大学化学学院获理学博士学位，师从谢如刚教授。之后历任香港大学Research Assistant、四川大学化学学院讲师、副教授、教授。2011年入选教育部“新世纪优秀人才支持计划”，第十三批四川省学术和技术带头人后备人选，中国化学会高级会员。从事有机化学、化学生物学教学科研工作，国家级一流本科课程《有机化学（I）》负责人，四川大学“探究式-小班化”教学示范教师及示范课程负责人，主编本科教材1部。科研方向为纳米生物材料，获多项国家自然科学基金、重点研发项目子课题、省应用基础项目等资助，以第一/通讯作者发表SCI论文80余篇，主编英文专著1部。
教学科研概况
讲授本科课程：
《有机化学（I）》（203112030 & 203113030, 国家级一流本科课程）
《生物化学》（203080030, 双语课程）
《化学生物学实验》（203197020）
《有机化学实验》
《应用化学设计实验》（203130020）
讲授研究生课程：
《生物材料化学》（M0703Z202）
科研方向：
纳米生物材料：新型核酸和药物递送系统的设计和构建，基因/药物载体的构效关系，以及相关基因治疗和免疫治疗研究。
主要工作业绩
教育部“新世纪优秀人才支持计划”（2011）；
国家级一流线下本科课程《有机化学（I）》负责人（2023）；
四川省学术和技术带头人后备人选（第十三批，2021）；
教育部高等学校科学研究优秀成果奖（科学技术）自然科学奖一等奖（2010，排名第三）；
四川大学第七届“姜维平优秀教学奖”（2021）；
四川大学第四届“探究式-小班化”教学竞赛一等奖、四川大学“探究式-小班化”教学示范教师/课程（有机化学I）（2021）；
四川大学首届“五粮春青年教师优秀教学奖”（2015）；
四川大学先进个人（优秀教师）（2015~16）；
四川大学十佳青年教师教学奖（2012~13）；
及其它各类校级教学奖励20余项。
代表性成果 （获奖成果、专著、论文、专利）
获奖成果：
简单金属盐催化的C-C键和C-N键形成反应，教育部高等学校科学研究优秀成果奖(科学技术)自然科学奖一等奖，2010，第三完成人。
主编著作：
1. 《有机化学基础》（第三版），2020，科学出版社。ISBN: 978-7-03-064996-6.
2. <Macrocyclic Polyamines: Synthesis and Applications>, 2018, Wiley-VCH, ISBN: 978-3-527-34187-0.
近年部分代表性论文：
1. Chen, P.; He, X.; Hu, Y.; Tian, X.-L.; Yu, X.-Q.; Zhang, J. “Spleen-targeted mRNA delivery based on polyamine carbon dots for tumor immunotherapy” ACS Appl. Mater. Interf. 2023, 15(16), 19937-19950.
2. Yang, H.-Z.; Guo, Y.; Pu, L.; Yu, X.-Q.; Zhang, J. “Fluorescent self-reporting lipid nanoparticles for NO / gene co-delivery and combination therapy” Mol. Pharm. 2023, 20(2), 1404-1414.
3. Zhan, Y.-R.; Chen, P.; He, X.; Hei, M.-W.; Zhang, J.; Yu, X.-Q. “Sodium alginate-doping cationic nanoparticle as dual gene delivery system for genetically bimodal therapy” Biomacromolecules 2022, 23(12), 5312-5321.
4. Guo, Y.; He, X.; Zhao, R.-M.; Yang, H.-Z.; Huang, Z.; Zhang, J.; Yu, X.-Q. “Zn-dipicolylamine-based reactive oxygen species-responsive lipids for siRNA delivery and in vivo colitis treatment” Acta Biomater. 2022, 147, 287-298.
5. Zhan, Y.-R.; Tan, J.; Hei, M.-W.; Zhang, S.-Y.; Zhang, J.; Yu, X.-Q. “Construction of GSH-triggered cationic fluoropolymer as two-in-one nanoplatform for combined chemo/gene therapy” J. Mater. Chem. B 2022, 10(8), 1308-1318.
6. Chen, P.; He, X.; Zhang, J.; Tian, X.-L.; Yu, X.-Q. “One-Step Fabrication of Functional Carbon Dots with Long Wavelength Emission for Gene Delivery and Bio-imaging” J. Mater. Chem. B 2021, 9(40), 8518-8529.
7. Chen, P.; Zhang, J.; He, X.; Liu, Y.-H.; Yu, X.-Q. “Hydrophobically Modified Carbon Dots as Multifunctional Platform for Serum-Resistant Gene Delivery and Cell Imaging” Biomater. Sci. 2020, 8(13), 3730-3740.
8. Xiao, Y.-P.; Zhang, J.; Liu, Y.-H.; Huang, Z.; Guo, Y.; Yu, X.-Q. “Bioinspired pyrimidine-contained cationic polymers as effective nano-carriers for DNA and protein delivery” J. Mater. Chem. B 2020, 8(11), 2275-2285.
9. He, X.; Luo, Q.; Zhang, J.; Chen, P.; Wang, H.-J.; Luo, K.; Yu, X.-Q. “Gadolinium-doped Carbon Dots as Nano-theranostic Agent for MR/FL Imaging and Gene Delivery” Nanoscale 2019, 11(27), 12973-12982.
10. He, X.; Chen, P.; Zhang, J.; Luo, T.-Y.; Wang, H.-J.; Liu, Y.-H.; Yu, X.-Q. “Cationic Polymer-Derived Carbon Dots for Enhanced Gene Delivery and Cell Imaging” Biomater. Sci. 2019, 7(5), 1940-1948.
11. Yu, Q.-Y.; Guo, Y.; Zhang, J.; Huang, Z.; Yu, X.-Q. “Zn(II) coordination to cyclen-based polycations for enhanced gene delivery” J. Mater. Chem. B 2019, 7(3), 451-459.
12. Zhang, Y.-M; Huang, Z.; Wu, X.-R.; Zhang, J.; Liu, Y.-H.; Yu, X.-Q. “A small combinatorial library of lipidoids as gene delivery vectors” ACS Appl. Nano Mater. 2018, 1(8), 3925-3934.
13. Wang, B.; Zhang, J.; Liu, Y.-H.; Zhang, W.; Xiao, Y.-P.; Zhao, R.-M.; Yu, X.-Q. “A reduction-responsive liposomal nanocarrier with self-reporting ability for efficient gene delivery” J. Mater. Chem. B 2018, 6(18), 2860-2868.
14. Xiao, Y.-P., Zhang, J.; Liu, Y.-H.; Chen, X.-C.; Yu, Q.-Y.; Luan, C.-R.; Zhang, J.-H.; Wei, X.; Yu, X.-Q. “Ring-opening polymerization of diepoxides as an alternative method to overcome PEG dilemma in gene delivery” Polymer 2018, 134, 53-62.
15. Wang, B.; Chen, P.; Zhang, J.; Liu, Y.-H.; Huang, Z.; Yu, Q.-Y.; Zhang, J.-H.; Zhang, W.; Yu, X.-Q. “Self-assembled core-shell-corona multifunctional AIE non-viral vector for efficient hepatocytes targeting gene delivery” Polymer Chem. 2017, 8(48), 7486-7498.
16. Xiao, Y.-P.; Zhang, J.; Liu, Y.-H.; Huang, Z.; Wang, B.; Zhang, Y.-M.; Yu, X.-Q. “Cross-linked polymers with fluorinated bridge for efficient gene delivery” J. Mater. Chem. B 2017, 5(43), 8542-8553.
17. Wang, H.-J.; He, X.; Luo, T.-Y.; Zhang, J.; Liu, Y.-H.; Yu, X.-Q. “Amphiphilic carbon dots as versatile vector for nucleic acid and drug delivery” Nanoscale. 2017, 9(18), 5935-5947.
18. Zhang, Y.-M; Huang, Z.; Zhang, J.; Wu, W.-X.; Liu, Y.-H.; Yu, X.-Q. “Amphiphilic polymers from ring-opening polymerization: a strategy for the enhancement of gene delivery” Biomater. Sci. 2017, 5(4), 718-729.
19. Huang, Z.; Zhang, Y.-M.; Cheng, Q.; Zhang, J.; Liu, Y.-H.; Wang, B.; Yu, X.-Q. “Structure-activity relationship studies of symmetrical cationic bolasomes as non-viral gene vectors” J. Mater. Chem. B 2016, 4(33), 5575-5584.
20. Luan, C.-R.; Liu, Y.-H.; Zhang, J.; Yu, Q.-Y.; Huang, Z.; Wang, B.; Yu, X.-Q. “Low molecular weight oligomers with aromatic backbone as efficient non-viral gene vectors” ACS Appl. Mater. Interf. 2016, 8(17), 10743-10751.
21. Xun, M.-M.; Xiao, Y.-P.; Zhang, J.; Liu, Y.-H.; Peng, Q.; Guo, Q.; Wu, W.-X.; Xu, Y.; Yu, X.-Q. “Low molecular weight PEI-based polycationic gene vectors via Michael addition polymerization with improved serum-tolerance” Polymer 2015, 65, 45-54.
22. Guo, Q.; Liu, Y.-H.; Xun, M.-M.; Zhang, J.; Huang, Z.; Zhou, X.-D.; Yu, X.-Q. “Diol glycidyl ether-bridged low molecular weight PEI as potential gene delivery vehicles” J. Mater. Chem. B 2015, 3(13), 2660-2670.
23. Zhang, Q.-F.; Yu, Q.-Y.; Geng, Y.; Zhang, J.; Wu, W.-X.; Wang, G.; Gu, Z.; Yu, X.-Q. “Ring-opening polymerization for hyperbranched polycationic gene delivery vectors with excellent serum tolerance” ACS Appl. Mater. Interfaces 2014, 6(18), 15733-15742.
24. Yi, W.-J.; Yu, X.-C.; Wang, B.; Zhang, J.; Yu, Q.-Y.; Zhou, X.-D.; Yu, X.-Q. “TACN-based oilgomers with aromatic backbones for efficient nucleic acid delivery” Chem. Commun. 2014, 50(49), 6454-6457.
25. Yi, W.-J.; Zhang, Q.-F.; Zhang, J.; Liu, Q.; Ren, L.; Chen, Q.-M.; Guo, L.; Yu, X.-Q. “Cyclen-based lipidic oligomers as potential gene delivery vehicles” Acta Biomater. 2014, 10(3), 1412-1422.
26. Wang, H.-J.; Liu, Y.-H.; Zhang, J.; Zhang, Y.; Xia, Y.; Yu, X.-Q. “Cyclen-based cationic lipids with double hydrophobic tails for efficient gene delivery” Biomaterials Sci. 2014, 2(10), 1460-1470.
27. Zhang, Q.-F.; Yi, W.-J.; Wang, B.; Zhang, J.; Ren, L.; Chen, Q.-M.; Guo, L.; Yu, X.-Q. “Linear polycations by ring-opening polymerization as non-viral gene delivery vectors: structure-activity relationship studies” Biomaterials 2013, 34(21), 5391-5401.
