四川大学化学学院
师资力量

张 骥     教 授,化学生物学教研室主任

研究方向:化学生物学,有机化学

联系方式:028-85418580          Email:jzhang@scu.edu.cn

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简历

理学博士,博士生导师,2011年入选教育部“新世纪优秀人才支持计划”。

 

1993.9-1997.7: 四川大学化学系,本科学习,物理化学专业

1997.9-2002.6: 四川大学化学学院,硕-博连读,有机化学专业

2002.7-2007.6: 四川大学化学学院,讲师

2003.1-2005.1: 香港大学化学系,Research Assistant

2007.7-2013.6: 四川大学化学学院,副教授

2013.7- : 四川大学化学学院,教授

 

讲授本科生课程包括:

《有机化学I》(203112030 & 203113030, 省级精品课程)

《生物化学》(203080030, 双语课程)

《化学生物学实验》(203197020

《有机化学实验》

《应用化学设计实验》(203130020

主要研究方向

纳米生物材料:新型核酸和药物递送系统的设计、合成和建立,基因/药物载体的构效关系,以及相关基因治疗和免疫治疗研究。

主要工作业绩

2011年入选教育部“新世纪优秀人才支持计划”;

2010年教育部高等学校科学研究优秀成果奖(科学技术)自然科学奖一等奖(排名第三);

2015年四川大学首届“五粮春青年教师优秀教学奖”;

2015-16四川大学先进个人(优秀教师);

2012-13年度四川大学十佳青年教师教学奖;

多次获得四川大学本科课堂教学质量优秀奖;本科教学管理工作先进个人;大学生课外科技实践活动优秀指导教师;学术型社团指导教师标兵;以及四川大学“优秀青年骨干教师”称号。

代表性成果 (获奖成果、专著、论文、专利)

获奖成果:

简单金属盐催化的C-C键和C-N键形成反应,教育部高等学校科学研究优秀成果奖(科学技术)自然科学奖一等奖,2010,第三完成人。

主编著作:

1. 《有机化学基础》(第三版),2019,科学出版社。

2. <Macrocyclic Polyamines: Synthesis   and Applications>, 2018, Wiley-VCH, ISBN: 978-3-527-34187-0.

参编著作:

1. 《有机化学基础》(第二版),2008年,海洋出版社。

2. 《现代有机合成化学》,2007年第一版,华东理工大学出版社,十一五国家重点图书。

近年部分代表性论文:

1. He, X.; Luo, Q.; Zhang, J.*; Chen, P.; Wang, H.-J.;   Luo, K.; Yu, X.-Q.* “Gadolinium-doped Carbon Dots as   Nano-theranostic Agent for MR/FL Imaging and Gene Delivery” Nanoscale   2019, 11(27), 12973-12982.

2. He, X.; Chen, P.; Zhang, J.*; Luo, T.-Y.; Wang, H.-J.;   Liu, Y.-H.; Yu, X.-Q.* “Cationic Polymer-Derived Carbon Dots for   Enhanced Gene Delivery and Cell Imaging” Biomater. Sci. 2019, 7(5),   1940-1948.

3. Yu, Q.-Y.; Guo, Y.; Zhang, J.*; Huang, Z.; Yu, X.-Q.*   “Zn(II) coordination to cyclen-based polycations for enhanced gene delivery” J.   Mater. Chem. B 2019, 7(3), 451-459.

4. Zhang, Y.-M; Huang, Z.; Wu, X.-R.; Zhang, J.*; Liu,   Y.-H.; Yu, X.-Q.* “A small combinatorial library of lipidoids as   gene delivery vectors” ACS Appl. Nano Mater. 2018, 1(8),   3925-3934.

5. Wang, B.; Zhang, J.*; Liu, Y.-H.; Zhang, W.; Xiao,   Y.-P.; Zhao, R.-M.; Yu, X.-Q.* “A reduction-responsive liposomal   nanocarrier with self-reporting ability for efficient gene delivery” J.   Mater. Chem. B 2018, 6(18), 2860-2868.

6. Xiao, Y.-P., Zhang, J.*; Liu, Y.-H.; Chen, X.-C.; Yu,   Q.-Y.; Luan, C.-R.; Zhang, J.-H.; Wei, X.; Yu, X.-Q.*   “Ring-opening polymerization of diepoxides as an alternative method to   overcome PEG dilemma in gene delivery” Polymer 2018, 134,   53-62.

7. Wang, B.; Chen, P.; Zhang, J.*; Liu, Y.-H.; Huang, Z.;   Yu, Q.-Y.; Zhang, J.-H.; Zhang, W.; Yu, X.-Q.* “Self-assembled   core-shell-corona multifunctional AIE non-viral vector for efficient   hepatocytes targeting gene delivery” Polymer Chem. 2017, 8(48),   7486-7498.

9. Xiao, Y.-P.; Zhang, J.*; Liu, Y.-H.; Huang, Z.; Wang,   B.; Zhang, Y.-M.; Yu, X.-Q.* “Cross-linked polymers with   fluorinated bridge for efficient gene delivery” J. Mater. Chem. B 2017,   5(43), 8542-8553.

10. Wang, H.-J.; He, X.; Luo, T.-Y.; Zhang, J.*;   Liu, Y.-H.; Yu, X.-Q.* “Amphiphilic carbon dots as versatile   vector for nucleic acid and drug delivery” Nanoscale. 2017, 9(18),   5935-5947.

11. Zhang, Y.-M; Huang, Z.; Zhang, J.*; Wu,   W.-X.; Liu, Y.-H.; Yu, X.-Q.* “Amphiphilic polymers from   ring-opening polymerization: a strategy for the enhancement of gene delivery”   Biomater. Sci. 2017, 5(4), 718-729.

12. Huang, Z.; Zhang, Y.-M.; Cheng, Q.; Zhang, J.*;   Liu, Y.-H.; Wang, B.; Yu, X.-Q.* “Structure-activity relationship   studies of symmetrical cationic bolasomes as non-viral gene vectors” J.   Mater. Chem. B 2016, 4(33), 5575-5584.

13. Luan, C.-R.; Liu, Y.-H.; Zhang, J.*; Yu,   Q.-Y.; Huang, Z.; Wang, B.; Yu, X.-Q.* “Low molecular weight   oligomers with aromatic backbone as efficient non-viral gene vectors” ACS   Appl. Mater. Interf. 2016, 8(17), 10743-10751.

14. Xun, M.-M.; Xiao, Y.-P.; Zhang, J.*; Liu,   Y.-H.; Peng, Q.; Guo, Q.; Wu, W.-X.; Xu, Y.; Yu, X.-Q.* “Low   molecular weight PEI-based polycationic gene vectors via Michael addition   polymerization with improved serum-tolerance” Polymer 2015, 65,   45-54.

15. Guo, Q.; Liu, Y.-H.; Xun, M.-M.; Zhang, J.*;   Huang, Z.; Zhou, X.-D.; Yu, X.-Q.* “Diol glycidyl ether-bridged   low molecular weight PEI as potential gene delivery vehicles” J. Mater.   Chem. B 2015, 3(13), 2660-2670.

16. Zhang, Q.-F.; Yu, Q.-Y.; Geng, Y.; Zhang, J.*;   Wu, W.-X.; Wang, G.; Gu, Z.; Yu, X.-Q.* “Ring-opening   polymerization for hyperbranched polycationic gene delivery vectors with   excellent serum tolerance” ACS Appl. Mater. Interfaces 2014, 6(18),   15733-15742.

17. Yi, W.-J.; Yu, X.-C.; Wang, B.; Zhang, J.*;   Yu, Q.-Y.; Zhou, X.-D.; Yu, X.-Q.* “TACN-based oilgomers with   aromatic backbones for efficient nucleic acid delivery” Chem. Commun. 2014,   50(49), 6454-6457.

18. Yi, W.-J.; Zhang, Q.-F.; Zhang, J.*; Liu,   Q.; Ren, L.; Chen, Q.-M.; Guo, L.; Yu, X.-Q.* “Cyclen-based   lipidic oligomers as potential gene delivery vehicles” Acta Biomater. 2014,   10(3), 1412-1422.

19. Wang, H.-J.; Liu, Y.-H.; Zhang, J.*;   Zhang, Y.; Xia, Y.; Yu, X.-Q.* “Cyclen-based cationic lipids with   double hydrophobic tails for efficient gene delivery” Biomaterials Sci.   2014, 2(10), 1460-1470.

20. Zhang, Q.-F.; Yi, W.-J.; Wang, B.; Zhang, J.*;   Ren, L.; Chen, Q.-M.; Guo, L.; Yu, X.-Q.* “Linear polycations by   ring-opening polymerization as non-viral gene delivery vectors:   structure-activity relationship studies” Biomaterials 2013, 34(21),   5391-5401.

 

专利:

环氧化合物与阳离子聚合物及它们的制备方法,余孝其、张琴芳、张骥,专利号201210586561.5

 

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