四川大学化学学院
师资力量

郑 柯     教 授

研究方向:有机化学

联系方式:17760523883          Email:kzheng@scu.edu.cn

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简历

 

学习经历: 

2007 ~ 2012   四川大学 有机化学专业 理学博士学位

   师从冯小明教授从事不对称催化的研究

2003 ~ 2007   四川大学 应用化学专业 理学学士学位

   保送四川大学化学学院有机化学专业攻读博士研究生。

研究及工作经历: 

2016 ~至今    四川大学化学学院 教授 博士生导师

2014 ~ 2016   密西根大学安娜堡分校癌症中心 研究员

   合作导师 : Dr. Shaomeng Wang

2012 ~ 2014   The Scripps Research Institute  研究助理

   合作导师 : Dr. Philip LoGrasso & Dr. Yangbo Feng

 

主要研究方向

 

主要研究方向: 

1. 绿色有机合成方法学(可见光催化或电化学产生的可控自由基反应及其合成应用)

2. 发展小分子催化的高选择性、高效性的自由基(光化学或电化学)参与的不对称合成方法学

3. 手性药物及靶向抗癌药物的理性设计合成及相关应用

热烈欢迎硕博生,交流生及研究助理加入我们课题组!

 

主要工作业绩

 

主要工作业绩:

郑柯博士先后致力于不对称催化剂的设计合成,手性药物合成,神经类药物及抗癌药物和抗癌新靶点等多个前沿性领域的研究,取得了一系列创新性的优秀成果;其丰富的跨学科研究经历,为今后的科研工作,特别是交叉学科和转化药学的研究打下了扎实的基础。回国入职四川大学开始独立工作之后,郑柯博士主要围绕以药物分子为导向的绿色有机合成方法学的研究。重点开展基于利用小分子的弱相互作用来稳定光催化和电催化反应中的高活性中间体,利用产生的高活性的自由基物种来实现以前传统历程不能实现的反应,实现新反应的拓展。同时引入具有手性结构的小分子催化剂来实现一系列自由基参与的不对称催化反应,实现一些以前较难实现的反应,为合成复杂分子和手性药物分子提供一个更绿色、高效的合成方法。最后,我们利用这些方法自身特点和流动化学相结合,为后续大规模的生产创造了便利的条件。

郑柯博士已经在 Chem. Rev. J. Am. Chem. Soc.  Angew. Chem. Int. Ed.  Chem. Commun.  Chem. -Eur. J.  ACS Med. Chem. Lett. 以及 J. Med. Chem. 等本领域权威刊物发表 SCI 论文和专著近 30 篇,国际专利 1 篇、美国专利 2 篇,并多次被 Synfacts 杂志刊登并给予了高度的评价。

主要奖励及荣誉 

2016   四川省千人计划专家

2013   四川省优秀博士学位论文

2012  “ 四川省优秀毕业研究生 ” 称号

2012  “ 四川大学优秀毕业研究生 ” 称号

2010   教育部自然科学奖一等奖(第九完成人)

2010   教育部第一届 “ 博士研究生学术新人奖 ”

2011   唐敖庆化学奖

2007-2010   曾先 后获得四川大学振兴奖学金2007),陶氏化学教育发展奖学金2008),宝钢优秀学生奖2009),中石化奖学金2010 

2007-2011 连续 4 年获得四川大学创新人才一等奖

2007-2009 “ 四川大学双十佳优秀学生模范 ”

2007-2012 连续 5 年获得 “ 四川大学研究生一等奖学金 ” 及 “ 四川大学优秀研究生 ” 称号

2007 “四川省优秀本科毕业生”称号及“四川大学2007届本科优秀毕业生”称号

代表性成果 (获奖成果、专著、论文、专利)

 

1. Dong Jing, ‡ Cong Lu, ‡ Zhuo Chen, Songyang Jin, Lijuan Xie, Ziyi Meng, Zhishan Su, Ke Zheng* “Light-Driven Intramolecular C-N Cross-Coupling via a Long-Lived Photoactive Photoisomer Complex” Angew. Chem. Int. Ed. 2019, 58, 7425 –7430. 

 


2. Cong Lu,‡ Zhishan Su, Dong Jing, Songyang Jin, Lijuan Xie, Liangrui, Li and Ke Zheng*

 “Intramolecular Reductive Cyclization of o-Nitroarenes via Biradical Recombination” Org. Lett. 2019, 21, 1438−1443.

 


3. Yujun Li, Qi Yang, Liquan Yang, Ning Lei and Ke Zheng* “A scalable electrochemical dehydrogenative cross-coupling of P(O)H compounds with RSH/ROH” Chem. Commun., 2019, 55, 4981-4984.

 


4. Angelo Aguilar, Ke Zheng, et al. and Shaomeng Wang * “Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction” J. Med. Chem. 2019, 62, 6015−6034. 

 


5. Lijuan Xie, Cong Lu, Dong Jing, Xinrui Ou, and Ke Zheng* “Metal-Free Synthesis of Polycyclic Quinazolinones Enabled by a (NH4)2S2O8-Promoted Intramolecular Oxidative Cyclization” Eur. J. Org. Chem. 2019, 36493653.

 


6. Ke Zheng, Xiaohua Liu, and Xiaoming Feng* “Recent Advances in Metal-Catalyzed Asymmetric 1,4-Conjugate Addition (ACA) of Nonorganometallic Nucleophiles” Chem. Rev. 2018, 118, 7586−7656. 

 

7. Shilin Xu, Angelo Aguilar, Tianfeng Xu, Ke Zheng, et al. and Shaomeng Wang * “Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL ProteinProtein Interaction” Angew. Chem. Int. Ed. 2018, 57, 1601−1605. 

 

8. Ke Zheng, Chul Min Park, Sarah Iqbal, Pamela Hernandez, HaJeung Park, Philip V. LoGrasso,* and Yangbo Feng* “Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors” ACS Med. Chem. Lett., 2015, 6, 413-418. 

 

9. Yan Yin, Ke Zheng, Nibal Eid, et al, Philip V. LoGrasso,* and Yangbo Feng*“Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors” J. Med. Chem. 2015, 58(4), 1846-1861. 

 


10. Ke Zheng, Sarah Iqbal, Pamela Hernandez, HaJeung Park, Philip V. LoGrasso,* and Yangbo Feng* “Design and Synthesis of Highly Potent and Selective JNK3 Inhibitors: SAR Studies on Aminopyrozal Derivatives” J. Med. Chem. 2014, 57, 10013-10030 

 


11. Ke Zheng, Xiaohua Liu, Song Qin, Mingsheng Xie, Lili Lin, Changwei Hu, and Xiaoming Feng* “Completely OH-Selective FeCl3 Catalyzed Prins Cyclization: Highly Stereoselective Synthesis of 4-OH-Tetrahydropyrans” J. Am. Chem. Soc. 2012, 134, 17564−17573. 

 

12. Ke Zheng, Lili Lin and Xiaoming Feng* “Chiral N,N '-Dioxide-Ni(II) Complex Catalyzed Asymmetric Carbonyl-Ene Reaction of Ethyl Trifluoropyruvate” Acta Chim. Sinica 2012, 70, 1785-1790.

13. Ke Zheng, Chengkai Yin, Xiaohua Liu, and Xiaoming Feng* “Catalytic Asymmetric Addition of Alkyl Enol Ethers to 1,2-Dicarbonyl Compounds: Highly Enantioselective Synthesis of Substituted 3-Alkyl-3-Hydroxyoxindoles” Angew. Chem. Int. Ed. 2011, 50, 2573. 

 


14. Ke Zheng, Xiaohua Liu, Jiannan Zhao, Yang Yang, Lili Lin and Xiaoming Feng* “Highly Enantioselective Aza-Ene-Type Reaction Catalyzed by Chiral N,N’-dioxide-nickel(II) Complex” Chem. Commun. 2010, 46, 3771–3773.

15. Ke Zheng, Yang Yang, Jiannan Zhao, Chengkai Yin, Lili Lin, Xiaohua Liu and Xiaoming Feng*. “Magnesium(II)-Catalyzed Asymmetric Ketone-Ene Reaction: Stereocontrolled Access to Enantioenriched Trifluoromethyl-Substituted Compounds” Chem. Eur. J. 2010, 16, 9969.

16. Ke Zheng, Jian Shi, Xiaohua Liu, and Xiaoming Feng*. “Asymmetric Carbonyl-Ene Reaction Catalyzed by Chiral N,N’-Dioxide -Nickel(II) Complex: Remarkably Broad Substrate Scope” J. Am. Chem. Soc. 2008, 130, 15770-15771.

17. Ke Zheng, Bo Qin, Xiaohua Liu and Xiaoming Feng* “Highly Enantioselective Allylation of a-Ketoesters Catalyzed by N,N’-Dioxide-In(III) Complexes” J. Org. Chem. 2007, 72, 8478-8483.

18. Ke Zheng, Bo Qin, Xiaohua Liu and Xiaoming Feng* “Highly Enantioselective Allylation of a-Ketoesters Catalyzed by N,N’-Dioxide-In(III) Complexes” J. Org. Chem. 2007, 72, 8478-8483.

19. Y. Yan, K. Zheng, et al, Y. Feng* and P. LoGrasso*. “Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors” J. Med. Chem. 2015, 58(4), 1846-1861.

20. X. Liu, K. Zheng, and X. M. Feng. “Advancements in the Catalytic Asymmetric Intermolecular Ene-Type Reactions” SYNTHESIS, 2014; 46: 2241-2257

21. J. N. Zhao, K. Zheng, et al and X. M. Feng. “Asymmetric Mukaiyama Aldol Reaction Catalyzed by C2-Symmetric N,N’-Dioxide–Ni(II) Complex” Synlett, 2011, 903-906.

22. P. HaJeung; I. Sarah; H. Pamela; M. Rudy; K. Zheng, et al, Y. Feng and P. LoGrasso. “Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles” Scientific reports 2015, 5, 8047

23. K. Shen, X. H. Liu, K. Zheng, et al and X. M. Feng. “Catalytic Asymmetric Synthesis of 3-(a-Hydroxy-b-carbonyl) Oxindoles by a Sc(III)-Catalyzed Direct Aldol-Type Reaction” Chem. Eur. J. 2010, 16, 3736-3742.

24. J. Shi, M. Wang, L. He, K. Zheng, et al and X. M. Feng. “Enantioselective Michael addition of malononitrile to chalcones catalyzed by a simple quinine-Al(OiPr)3 complex: a simple method for thesynthesis of a chiral 4H-pyran derivative” Chem. Commun. 2009, 45, 4711–4713.

25. B. Qin, X. H. Liu, J. Shi, K. Zheng, et al and X. M. Feng. “Enantioselective Cyanosilylation of a,a-Dialkoxy Ketones Catalyzed by Proline-Derived in-Situ-Prepared N-Oxide as Bifunctional Organocatalys” J. Org. Chem. 2007, 72, 2374.

 

 

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