四川大学化学学院
师资力量

杨宇东     副教授

研究方向:有机金属化学、有机合成化学

联系方式:028-85418887          Email:yangyudong@scu.edu.cn

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简历

2016.10—至今 四川大学化学学院,副教授

2014.7—2016.10 四川大学化学学院,讲师,合作导师:游劲松教授

2011.4—2014.3 名古屋工业大学,未来材料创成工学专业,博士,导师:Norio Shibata教授

2007.7—2010.7 北京化工大学,化学工程与技术专业,硕士,导师:杜洪光教授

2003.9—2007.7 北京化工大学,应用化学专业,学士

主要研究方向

主要致力于过渡金属催化的有机合成反应及方法学研究,包括:

1)碳碳键及碳杂原子键的构筑新策略与新反应;

2)联(杂)芳环及稠(杂)芳环的高效、高选择性构建;

3)新型有机光电功能分子的开发

主要工作业绩

主要学术成果:

主要从事过渡金属催化C–H键直接高效、高选择性转化方面的研究,发展了多种基于过渡金属催化CH键活化构筑有机π共轭骨架的新方法和新策略,并开发它们在有机光电转化材料、分子探针以及细胞、组织成像等领域的应用。目前,已在Chem. Rev., J. Am.   Chem. Soc., Angew. Chem. Int. Ed., ACS Catal., Chem.   Sci., Chem. Commun.Org. Lett.等期刊发表SCI论文30余篇,多篇工作入选高被引论文和热点论文,或被Synfacts等国际著名化学评论期刊推介;参与编写专著2部;承担了国家重点研发计划(子课题),国家自然科学基金,四川大学优秀青年学者基金和国家重点实验室开放基金等支持的各级项目,入选第十三批四川省学术与技术带头人后备人选,四川省海外高层次留学人才。

主要奖励和荣誉:

2021.1

入选第十三批四川省学术与技术带头人后备人选

2020.9

《有机化学实验(I)-1》被认定为四川大学2019年课程思政榜样课程(5/11

2020.7

四川大学化学学院2019-2020年度“优秀共产党员”

2018.11

四川大学化学学院首届“探究式-小班化”教学竞赛三等奖

2018.6

四川大学2017-2018年度本科优秀实习指导教师二等奖

2018.6

四川大学2017-2018年度本科优秀生产实习队三等奖

2017.12

四川大学2016年度本科教学课堂教学质量优秀奖

2017.6

四川大学2016-2017年度化学专业优秀生产实习队二等奖

2016.1

四川大学优秀青年学者基金获得者

2010.10-2014.03

日本文部科学省奖学金

2008.11

第六届中国挑战杯创业计划竞赛国家级银奖

2008.06

第五届挑战杯首都大学生创业计划竞赛特等奖

2008.04

北京化工大学第四届寰球杯创业计划与科技创新大赛一等奖

2007.06

北京市优秀毕业生

代表性成果 (获奖成果、专著、论文、专利)

一、代表性论文:

1.  Cascade Oxidative C−H Annulation of Thiophenes: Heck-Type Pathway Enables Concise Access to Thienoacenes.

Xingyu Chen, Yudong Yang,* Weiguo Han, Quan Huang, Zhenmei Huang, and Jingsong You*

Angew. Chem. Int. Ed., 2021, 60(22), 12371−12375, DOI: 10.1002/anie.202103160.

(Publication   Date: 2021-05-25)

2.  Palladium-Catalyzed   Cascade Dearomative Spirocyclization and CH Annulation of Aromatic Halides with Alkynes.

Xingrong Liao, Fulin Zhou, Zhengyang Bin, Yudong Yang*, and Jingsong You

Org. Lett., 2021, in press. DOI: https://doi.org/10.1021/acs.orglett.1c01736

(Publication Date on line: 2021-06-16)

3.  Triple Oxa[7]helicene   with Circularly Polarized Luminescence: Enhancing the Dissymmetry Factors via Helicene Subunit Multiplication.

Fulin Zhou, Zhenmei Huang, Zhongyan Huang, Rui Cheng, Yudong Yang,* Jingsong You

Org. Lett., 2021, 23 (12), 4559−4563. DOI: https://doi.org/10.1021/acs.orglett.1c01212 (Publication Date: 2021-06-18)

4.  Palladium-catalyzed C8–H arylation and annulation of 1-naphthalene carboxylic acid derivatives with aryl iodides.

Min Zhang, Zhangyi Fu, Anping Luo, Xingwen Pu, Menglei Wang, Ying Huang, Yudong Yang*

Org. Chem. Front., 2021, advanced article, DOI: 10.1039/d1qo00428j

5.  基于螯合导向C–H/C–H氧化交叉偶联/环化反应策略构筑稠杂芳烃化合物.(黄乃正先生七十周岁庆祝专辑)

杨宇东, 游劲松*

化学进展, 2020, 32 (11), 18241834. DOI: 10.7536/PC200568. (Publication Date: 2020-09-01)

6.  Switchable cascade C−H   annulation to polycyclic pyryliums and pyridiniums: discovering   mitochondria-targeting fluorescent probes.

Xingyu Chen, Lipeng Yan, Yanhong Liu, Yudong Yang,* Jingsong You*

Chem. Commun., 2020, 56 (95), 1508015083. DOI: https://doi.org/10.1039/D0CC06997C. (Publication Date   (online): 2020-11-10)

Highlighted by Synfacts

7.  Rh(III)-Catalyzed Oxidative   C−H Activation/Domino Annulation of Anilines with 1,3-Diynes: A Rapid Access   to Blue-Emitting Tricyclic N,O-Heteroaromatics.

Shengyou Qian, Xingwen Pu, Guanjun Chang, Ying Huang, Yudong Yang*

Org. Lett., 2020, 22 (14), 5309−5313. DOI: https://doi.org/10.1021/acs.orglett.0c01465. (Publication Date: 2020-06-30)

8.  Build-Up of Double Carbohelicenes Using Nitroarenes: Dual Role of the Nitro Functionality as Activation and Leaving Group.

Fulin Zhou, Fujian Zhou, Rongchuan Su, Yudong Yang,* Jingsong You*

Chem. Sci., 2020, 11 (28), 7424−7428. DOI: https://doi.org/10.1039/D0SC02058C. (Publication Date: 2020-07-28)

Highlighted by Synfacts

9.  Methylation Platform of Unconventional Inert Aryl Electrophiles: Trimethylboroxine as a Universal Methylating Reagent.

Boya Feng, Yudong Yang,* Jingsong You.*

Chem. Sci., 2020, 11 (23), 6031−6035. DOI: https://doi.org/10.1039/D0SC01641A. (Publication Date: 2020-06-21)

Highlighted in InfoMat

10.  Palladium-catalyzed   denitrative Sonogashira-type cross-coupling of nitrobenzenes with terminal   alkynes.

Boya   Feng, Yudong Yang,* Jingsong You*

Chem. Commun. 2020, 56 (5), 790–793. (Publication Date: 2020-01-16)

11.  F+ Reagent-Promoted Pd-Catalyzed C7−H Arylation of 1-Naphthamides.

Min Zhang, Anping Luo, Yang Shi, Rongchuan Su, Yudong Yang,* Jingsong You*

ACS  Catal. 2019, 9 (12), 11802–11807. (Publication Date: 2019-12-06)

12.  C2/C4 Regioselective   Heteroarylation of Indoles by Tuning C–H Metalation Modes.

Shuyou Chen, Min Zhang, Rongchuan Su, Xingyu Chen, Boya Feng, Yudong Yang,* and   Jingsong You*

ACS Catal. 2019, 9 (7), 6372–6379. (Publication Date: 2019-07-05).  

Selected as the most read article

13.  Cascade intramolecular   imidoylation and C–H activation/annulation of benzimidoyl chlorides with   alkynes: one-pot synthesis of 7H-dibenzo[de,h]quinoline   analogues.

Jiao Liu, Hao Fang, Rui Cheng, Zhishuo Wang, Yudong Yang,* and Jingsong You*

Chem. Commun. 2019, 55 (49), 7097–7100. (Publication Date: 2019-06-21).

14.  General   rhodium-catalyzed oxidative cross-coupling reactions between anilines: synthesis   of unsymmetrical 2,2’-diaminobiaryls.

Yang   Shi, Jiahui Liu, Yudong Yang,* and Jingsong You*

Chem. Commun. 2019, 55 (38), 5475–5478. (Publication Date: 2019-05-11).

15.   Highly Chemo-, Regio- and E/Z-Selective Intermolecular Heck-Type Dearomative [2+2+1] Spiroannulation of Alkyl Bromoarenes with Internal Alkynes.

Xingrong Liao, Deping Wang, Yueyuan Huang, Yudong Yang,* and Jingsong You*

Org. Lett. 2019, 21 (4), 1152–1155. (Publication Date: 2019-02-15).

16.  Ir(III)-Catalyzed Oxidative Annulation of Phenylglyoxylic Acids with Benzo[b]thiophenes.

Zhigang Wang, Mufan Yang, and Yudong Yang*

Org. Lett. 2018, 20 (10), 3001–3005. (Publication Date: 2018-05-18).

17.  Experimental and Theoretical Studies on Ru(II)-Catalyzed Oxidative C−H/C−H Coupling of Phenols with Aromatic Amides Using Air as Oxidant: Scope, Synthetic Applications, and Mechanistic Insights.

Luoqiang Zhang, Lei Zhu, Yuming Zhang, Yudong Yang, Yimin Wu, Weixin Ma, Yu Lan,* Jingsong   You*

ACS Catal. 2018, 8 (9), 8324−8335. (Publication Date: 2018-08-06).

18.  RhCl3-Catalyzed Oxidative C−H/C−H Cross-Coupling of (Hetero)aromatic Sulfonamides with (Hetero)arenes.

You Ran, Yudong Yang, Huansha You, Jingsong You*

ACS Catal. 2018, 8 (3),   1796-1801. (Publication Date: 2018-01-25)

19.  Rh(III)-Catalyzed Direct ortho-Chalcogenation of Phenols and Anilines.

Shiping Yang, Boya Feng, Yudong Yang*

J. Org. Chem. 2017,   82 (23), 12430–12438. (Publication Date: 2017-12-01)

20.  Oxidative C–H/C–H Coupling Reactions between Two (Hetero)arenes.

Yudong Yang, Jingbo Lan, Jingsong You*

Chem. Rev. 2017, 117 (13), 8787–8863.

ESI高被引论文,热点论文

21.  Rh(III)-Catalyzed [4+1]-Annulation of Azoxy Compounds with Alkynes: A Regioselective Approach to 2H-Indazoles.

Zhen Long, Yudong Yang, and Jingsong You*

Org. Lett., 2017, 19 (11), 2781–2784. (Publication Date (Web): 2017-05-17)

22.  Rhodium(III)-Catalyzed Annulation of Pyridinones with Alkynes via Double C−H Activation: A Route to Functionalized Quinolizinones.

Juan Li, Yudong Yang, Zhigang Wang, Boya Feng, and Jingsong You.*

Org. Lett., 2017, 19 (12), 3083–3086.   (Publication Date (Web): 2017-05-30)

23.  Rhodium-catalyzed annulation of arenes with alkynes through weak chelation-assisted C–H   activation.

Yudong Yang, Kaizhi Li, Yangyang Cheng, Danyang Wan, Mingliang Li, Jingsong You*

Chem. Commun. 2016, 52, 2872–2884.

Most cited Features from 2016, 2017

24.  Rhodium-Catalyzed Oxidative Coupling of Benzoic Acids with Terminal Alkynes: An Efficient Access to 3-Ylidenephthalides.

Yang Liu, Yudong Yang*, Yang Shi, Xiaojie   Wang, Luoqiang Zhang, Yangyang Cheng, Jingsong You*

Organometallics 2016, 35 (10), 13501353.

25.  Radical Cyclization of Arenesulfonyl Chlorides and Alkynes: A Rapid Access to π-Conjugated Benzothiophenes.

Danyang Wan, Yudong Yang,* Xingyan Liu,  Mingliang Li, Siling Zhao, Jingsong You*

Eur. J. Org. Chem. 2016, 55–59.

Most Accessed paper

26.  Copper-Catalyzed Intramolecular Dehydrogenative Amidation of Unactivated C(sp3)–H   Bonds Using O2 as the Sole Oxidant.

Chunxia Wang, Yudong Yang*, Dekun Qin, Zhen He, Jingsong You*

J. Org. Chem., 2015, 80 (16),   8424–8429.

27.   Bis(pentafluorosulfanyl)phenyl Azide as an Expeditious Tool for Click Chemistry toward Antitumor Pharmaceuticals.

Yu-Dong Yang, Etsuko Tokunaga, Hidehiko   Akiyama, Norimichi Saito, Norio Shibata*

ChemMedChem 2014, 9 (5), 913917.

28.  Trifluoromethanesulfonyl hypervalent iodonium ylide for copper-catalyzed trifluoromethylthiolation of   enamines, indoles, and β-keto esters.

Yu-Dong Yang, Ayaka Azuma, Etsuko Tokunaga,   Mikio Yamasaki, Motoo Shiro, Norio Shibata*

J. Am. Chem. Soc. 2013, 135 (24), 87828785.

ESI高被引论文

29.  Transition-metal-free oxidative trifluoromethylation of unsymmetrical biaryls with   trifluoromethanesulfinate.

Yu-Dong Yang, Kanji Iwamoto, Etsuko Tokunaga,   Norio Shibata*

Chem. Commun. 2013, 49, 55105512.

30.  Cation versus radical: studies on the C/O regioselectivity in electrophilic tri-,   di, and monofluoromethylations of β-keto esters

Yu-Dong Yang, Xu Lu, Guokai Liu, Etsuko Tokunaga, Seiji Tsuzuki, Norio   Shibata*

ChemistryOpen 2012, 1 (5), 221226.

二、专著:

31.  Thiophenes and their Benzo Derivatives:   Reactivity.

Yudong Yang, Jingsong You.

Five-membered Rings with one Heteroatom, and their Benzo and   other Carbocyclic-fused Derivatives, Chapter   3.10, section editor: Henry N.C. Wong, Elsevier, 2020, DOI: https://doi.org/10.1016/B978-0-12-409547-2.14771-7.  

32.  Pd-Catalyzed Synthesis of Oxygen-Containing Heterocycles.

Yudong Yang, Jingsong You

Transition Metal-Catalyzed Heterocycle   Synthesis via C–H Activation, Chapter 3, Editor: Xiao-Feng. Wu, Wiley, Weinheim, Germany, 2016, pp65–89.

 

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