RESEARCH INTERESTS:
DNA Nanotechnology and its applications in Bioanalysis
EDUCATION AND ACADEMIC CAREER:
2016.09-2021.06：Brock University, Canada，Ph.D.
2013.09-2016.06：Illinois Institute of Technology, U.S.A.，M.Sc.
2009.09-2013.06：East China University of Science and Technology, B.Sc.
HONORS AND AWARDS:
1. 2024 China Association for Instrumental Analysis Award (CAIA Award)
2. 2018 Jack M. Miller Excellence in Research Award, Brock University
SELECTED PUBLICATIONS:
1. Xu, J.;† Deng, H.;† Wu, L.; Song, J.; Feng, X.; Liu, Y.; Wang, G, A.*; Li, F.* Binder-Responsive DNA Strand Displacement Enables High-Throughput and High-Fidelity Discovering of Small Molecular DNA Binders. Anal. Chem., 2024, 96, 30, 12213–12216.
2. Wu, Y.;† Wang, G, A.;† Yang, Q.; Li, F.* Native Characterization of Noncanonical Nucleic Acid Thermodynamics via Programmable Dynamic DNA Chemistry. J. Am. Chem. Soc., 2024, 146(26), 18041–18049.
3. Wu, L.;† Wang, G, A.;† Li, F.* A plug-and-play module for reversible and continuous control of DNA strand displacement kinetics. J. Am. Chem. Soc., 2024, 146(10), 6516–6521.
4. Wang, G. A†; Wu, X. †; Chen, F.; Shen, C.; Yang, Q.; Li, F.* Toehold-exchange-based activation of aptamer switches enables high thermal robustness and programmability. J. Am. Chem. Soc., 2023, 145(5), 2750–2753.
5. Wang, G. A.; Kong, C.; Li, F.* Design and Bioanalytical Applications of Stochastic DNA Walkers. Chem. Commun., 2023, 59, 5492-5501.
6. Wang, G. A.; Xu, J.; Traynor, S. M.; Wu, X.; Yan, H.; Li, F.* DNA balance for native characterization of chemically modified DNA. J. Am. Chem. Soc., 2021, 143(34), 13655-13663.
7. Wang, G. A.; Xie, X.; Mansour, H.; Chen, F.; Matamoros, G.; Sanchez, A. L.; Fan, C.; Li, F.* Expanding detection windows for discriminating single nucleotide variants using rationally designed DNA equalizer probes. Nat. Commun. 2020, 11, 5473-5483.
8. Li, Y.;† Wang, G, A.;† Mason, S. D.; Yang, X.; Yu, Z.; Tang, Y.; Li, F.* Simulation-guided engineering of an enzyme-powered three-dimensional DNA nanomachine for discriminating single nucleotide variants. Chem. Sci. 2018, 9, 6434-6439. (†Equal Contribution)
9. Wang, G. A.;† Dong, T.;† Mansour H.; Matamoros, G.; Sanchez, A. L.; Li, F.* Paper-based DNA reader for visualized quantification of soil-transmitted helminth infections. ACS Sens. 2018, 3, 205-210. (†Equal Contribution)
10. Guo, C. †; Deng, H. †; Yang, Q. †; Huang, D.; Shen, C.; Wang, G.A.; Li, F.* Coding intrinsic disorder into DNA hybridization probes enables discrimination of single nucleotide variants over wide and tunable temperature ranges. Angew. Chem. Int. Ed., 2023, e202314386.
11. Huang, D.; † Deng, H.; † Zhou, J.; † Wang, G. A.; Lei, Q.; Guo, C.; Peng, W.; Liang, P.; Shen, C.; Ying, B.;* Li, W.;* Li, F.* Mismatch-Guided Deoxyribonucleic Acid Assembly Enables Ultrasensitive and Multiplex Detection of Low-Allele-Fraction Variants in Clinical Samples. J. Am. Chem. Soc., 2023, 145, 37, 20412–20421.
12. Xu, J.; Wang, G. A.; Gao, L.; Wu, L.; Lei, Q.; Deng, H.; Li, F. Enabling Programmable Dynamic DNA Chemistry Using Small-Molecule DNA Binders. Nat. Commun., 2023, 14 (1), 4248.
13. Traynor, S. M.; Wang, G. A.; Pandey, R.; Li, F.;* Soleymani, L.* Dynamic bio-barcode assay enables electrochemical detection of a cancer biomarker in undiluted human plasma: A sample-in-answer-out approach. Angew. Chem. Int. Ed. 2020, 132, 22806–22811.
14. Mason, S. D.; Wang, G. A.; Yang, P.; Li, Y.; Li, F.* Probing and controlling dynamic interactions at biomolecule-nanoparticle interfaces using stochastic DNA walkers. ACS Nano 2019, 13, 8106-8113.
15. Dong, T.; Mansour, H.; Hu, H.; Wang, G. A.; Watson, C. J. F.; Yousef, M.; Matamoros, G.; Sanchez, A. L.; MacNeil, A. J.; Wu, P.;* Li, F.* Colorimetric polymerase chain reaction enabled by a fast light-activated substrate chromogenic (FLASH) detection platform. Anal. Chem. 2020, 92, 6456-6461.
16. Tang, W.;† Zhong, W.;† Tan, Y.;† Wang, G. A.;† Li, F.;* Liu, Y.* DNA Strand displacement reaction: a powerful tool for discriminating single nucleotide variants. Topics in Current Chemistry 2020, 378, 10.
17. Dong, T.; Wang, G. A.; Li, F.* Shaping up field-deployable nucleic acid testing using microfluidic paper-based analytical devices. Anal. Bioanal. Chem., 2019, 411, 4401-4414.
18. Dong, T.; Wang, G. A.; Li, M. W.; Li, F.* Systematic investigation of a quantitative paper-based DNA reader (QPDR) for distance-based quantification of nucleic acids and mercury ions. Anal. Methods 2019, 11, 5376–5380.
