Weichao Xue     

Research direction: Organic Chemistry, Inorganic Chemistry

Contact information: weichaoxue@scu.edu.cn

Email: weichaoxue@scu.edu.cn


1. Coordination Supramolecular Chemistry: We aim to conduct in-depth research on the precise and efficient construction of multi-level chiral coordination supramolecular frameworks. Our focus encompasses the investigation of mechanisms and rules governing chirality, as well as chiral transfer, amplification, and regulation. This research endeavor holds the potential to provide effective methods and inspiration for developing innovative chiral functional supramolecular assemblies and materials.

2. Organometallic Catalysis: We are dedicated to the efficient synthesis of novel chiral ligands and organometallic catalysts. Our focus includes uncovering the impact of various factors, such as the chiral ligand framework, coordinating atoms, non-covalent interactions, metal oxidation states, spin states, and confined environments, on catalyst performance. This may help to provide insights and methods for the preparation of highly active and cost-effective chiral organometallic catalysts.


2024now Professor, College of Chemistry, Sichuan University (SCU)

20232023 Walter Benjamin Postdoctoral Fellowship, Fakultät für Chemie und Chemische Biologie

Anorganische Chemie, Technische Universität Dortmund, Supervisor: Prof. Guido Clever

20192023 Walter Benjamin Postdoctoral Fellowship, Yusuf Hamied Department of Chemistry, University of Cambridge, Supervisor: Prof. Jonathan Nitschke

20152019 PhD, Institut für Chemie, Technische Universität Berlin, Supervisor: Prof. Martin Oestreich

20121015 M.S., Department of Chemistry, Shanghai University, Supervisor: Prof. Hegui Gong

20082012 B.S., College of Chemistry and Molecular Sciences, Henan University, Supervisor: Prof. Feng Shi


1. W. Xue, L. Pesce, B. Adinarayana, T. K. Ronson, K. Wu, D. Zhang, N. Vanthuyne, T. Brotin, A. Martinez, G. M. Pavan, J. R. Nitschke. Subtle Stereochemical Effects Influence Binding and Purification Abilities of an FeII4L4 Cage. J. Am. Chem. Soc. 2023, 145, 55705575.

2. W. Xue, K. Wu, N. Ouyang, T. Brotin, J. R. Nitschke. Allosterically Regulated Guest Binding Determines Framework Symmetry for an FeII4L4 Cage. Angew. Chem. Int. Ed. 2023, 62, e202301319.

3. W. Xue, T. K. Ronson, Z. Lu, J. R. Nitschke. Solvent Drives Switching between Λ and Δ Metal Center Stereochemistry of M8L6 Cubic Cages. J. Am. Chem. Soc. 2022, 144, 61366142.

4. W. Xue,* X. Jia, X. Wang, X. Tao, Z. Yin, H. Gong*. Nickel-Catalyzed Formation of Quaternary Carbon Centers Using Tertiary Alkyl Electrophiles. Chem. Soc. Rev. 2021, 50, 41624184.

5. W. Xue, M. Oestreich. Beyond Carbon: Enantioselective and Enantiospecific Reactions with Catalytically Generated Boryl- and Silylcopper Intermediates. ACS Cent. Sci. 2020, 6, 1070–1081.

6. W. Xue, W. Mao, L, Zhang, M. Oestreich. Mechanistic Dichotomy of Magnesium- and Zinc-Based Germanium Nucleophiles in the C(sp3)–Ge Cross-Coupling with Alkyl Electrophiles. Angew. Chem. Int. Ed. 2019, 58, 6440–6443.

7. W. Mao, W. Xue, E. Irran, M. Oestreich. Copper-Catalyzed Regio- and Enantioselective Addition of Silicon Grignard Reagents to Alkenes Activated by Azaaryl Groups. Angew. Chem. Int. Ed. 2019, 58, 10723–10726. (Highlighted as Hot Paper; Synfacts 2019, 15, 1024).

8. W. Xue, R. Shishido, M. Oestreich. Bench-Stable Stock Solutions of Silicon Grignard Reagents: Application to Iron- and Cobalt-Catalyzed Radical C(sp3)–Si Cross-Coupling Reactions. Angew. Chem. Int. Ed. 2018, 57, 12141–12145. (Highlighted as VIP Paper; Synfacts 2018, 14, 1174; Org. Process Res. Dev. 2018, 22 ,1687)

9. W. Xue, M. Oestreich. Copper-Catalyzed Decarboxylative Radical Silylation of Redox-Active Aliphatic Carboxylic Acid Derivatives. Angew. Chem. Int. Ed. 2017, 56, 1164911652.

10. W. Xue, Z.-W. Qu. S. Grimme, M. Oestreich. Copper-Catalyzed Cross-Coupling of Silicon Pronucleophiles with Unactivated Alkyl Electrophiles Coupled with Radical Cyclization. J. Am. Chem. Soc. 2016, 138, 1422214225.

11. W. Xue, M. Oestreich. Silicon Grignard Reagents as Nucleophiles in Transition-Metal-Catalyzed Allylic Substitution. Synthesis 2019, 51, 233–239.

12. W. Xue, H. Xu, Z. Liang, H. Gong. Nickel-Catalyzed Reductive Cyclization of Alkyl Dihalides.Org. Lett. 2014, 16, 49844987. (Highlighted by Synfacts, 2015, 11, 0076)

13. Z. Liang, W. Xue, K. Lin, H. Gong. Nickel-Catalyzed Reductive Reductive Methylation of Alkyl Halides and Acid Chlorides with Methyl p-Tosylate. Org. Lett. 2014, 16, 56205623.

14. Z. Zhao, Y. Gong, W. Tong, W. Xue*, H. Gong.* Ni-Catalyzed Cross-Electrophile Coupling of Aryl Triflates withThiocarbonates via C–O/C–O Bond Cleavage. Org. Lett. 2021, 23,21582163.

15. X. Tao, K. Yao,* W. Xue.* Ni-Catalyzed Cross-Electrophile Coupling of α-Hydroxy Carbonyl Compound-Derived Oxalates with Vinyl Triflates. Tetrahedron Lett. 2021, 73, 153129.

16. H. Zhu, L. Pesce, R. Chowdhury, W. Xue, K. Wu, T. K. Ronson, R. H. Friend, G. M. Pavan, J. R. Nitschke. Stereocontrolled Self-Assembly of a Helicate-Bridged CuI12L4 Cage That Emits Circularly Polarized Light. J. Am. Chem. Soc. 2024, 10.1021/jacs.3c11321.

17. K. Wu, T. K. Ronson, L. Goh, W. Xue, A. W. Heard, P. Su, X. Li, M. Vinković, J. R. Nitschke. A Diverse Array of Large Capsules Transform in Response to Stimuli. J. Am. Chem. Soc. 2023, 145, 11356–11363

18. S. Bähr, W. Xue, M. Oestreich. C(sp3)–Si Cross-Coupling. ACS Catal. 2019, 9, 16–24.

19. M. Zheng, W. Xue, T. Xue, H. Gong. Ester Formation via Nickel-Catalyzed Reductive Coupling of Alkyl Halides with Chloroformates. Org. Lett. 2016, 18, 61526155.

20. X. Wang, S. Wang, W. Xue, H. Gong. Nickel-Catalyzed Reductive Coupling of Aryl Bromides withTertiary Alkyl Halides. J. Am. Chem. Soc. 2015, 137, 1156211565.

21. J. Gu, X. Wang, W. Xue, H. Gong. Nickel-Catalyzed Reductive Coupling of Alkyl Halides with Other Electrophiles: Concept and Mechanistic Considerations. Org. Chem. Front. 2015, 2, 14111421. (ESI Highly Cited Paper)

22. P. Li, C. Wu, J. Zhao, Y. Li, W. Xue, F. Shi. One-Pot Synthesis of Dihydrobenzisoxazoles from Hydroxylamines, Acetylenedicarboxylates, and Arynes via in situ Generation of Nitrones. Can. J. Chem. 2013, 91, 4350.

23. C. Wu, P. Li, Y, Fang, J, Zhao, W. Xue, Y. Li, R. C. Larock, F. Shi. Pd-Catalyzed Oxidative Coupling of Monosubstituted Sydnones and Terminal Alkynes. Tetrahedron Lett. 2011, 52, 37973801.


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