EDUCATION AND ACADEMIC CAREER:
1994/9–1998/7，College of Chemistry，Sichuan University，Bachelor
2000/9–2003/7，College of Chemistry，Sichuan University，Master (Mentor：Prof. Hua Chen)
2003/9–2006/7，College of Chemistry，Sichuan University，PhD，Master (Mentor：Prof. Hua Chen)
2011/4-2012/4，Institut Sciences Chimiques de Rennes，France，Visiting scholar, Director：Prof. Henri Doucet
2013/9-2015/3，The Scripps Research Institute，USA; Visiting scholar, Director：Prof. Jin-Quan Yu
2006/7-2009/7，College of Chemistry，Sichuan University，Lecturer
2009/7-2021/7, College of Chemistry，Sichuan University，Associate Professor
2021/7~ : College of Chemistry，Sichuan University，Professor
RESEARCH INTERESTS:
(1) Development of new heterocyclic compound construction and derivatization methods;
(2) Functionalization of deficient aromatic heterocycles;
(3) Direct C-H bond functionalization reaction;
(4) Hydroformylation reaction
SELECTED PUBLICATIONS:
1. Sun, R.; Yang, X.; Ge, Y.; Song, J.; Zheng, X.; Yuan, M.; Li, R.; Chen, H.; Fu, H.*, Visible-Light-Induced Oxazoline Formations from N-Vinyl Amides Catalyzed by an Ion-Pair Charge-Transfer Complex. ACS Catalysis 2021, 11 (18), 11762-11773
2. Li,W.; Li, S.; Luo L.; Ge, Y.; Xu, J.; Zheng, X.; Yuan, M.; Li, R.; Chen, H.; Fu, H.*,Visible-Light-Initiated Catalyst-Free Oxidative Cleavage of (Z)-Triaryl-Substituted Alkenes Containing Pyridyl Motif under Ambient Conditions, Green Chem. 2021, 23, 3649–3655
3. Zhao, J.; Zheng, X.; Tao, S.; Zhu, Y.; Yi, J.; Tang, S.; Li, R.; Chen, H.; Fu, H.*; Yuan, M.*, Selective Rhodium-Catalyzed Hydroformylation of Terminal Arylalkynes and Conjugated Enynes to (Poly)enals Enabled by a pi-Acceptor Biphosphoramidite Ligand. Org Lett 2021, 23 (15), 6067-6072
4. Jiang, Y.; Li, C.; Tang, S.; Tao, S.; Yuan, M.; Li, R.; Chen, H.; Fu, H.*; Zheng, X.*, Practical Synthesis of (Z)-alpha,beta-Unsaturated Nitriles via a One-Pot Sequential Hydroformylation/Knoevenagel Reaction. J. Org. Chem. 2021, 86 (21), 15413-15422
5. Hao, T.; Yang, Y.; Liang, W.; Fan, C.; Wang, X.; Wu, W.*; Chen, X.; Fu, H.*; Chen, H.; Yang, C.*, Trace mild acid-catalysed Z --> E isomerization of norbornene-fused stilbene derivatives: intelligent chiral molecular photoswitches with controllable self-recovery. Chem Sci 2020, 12 (7), 2614-2622
6. Tang, J.; Chen, X.; Zhao, C. Q.; Li, W. J.; Li, S.; Zheng, X. L.*; Yuan, M. L.; Fu, H. Y.*; Li, R. X.; Chen, H. Iodination/Amidation of the N-Alkyl (Iso)quinolinium Salts. J. Org. Chem. 2021, 86, 716
7. Li, S.; Li, W.-J.; Yang, X.; Sun, R.; Tang, J.; Zheng, X.-L.; Yuan, M.-L.; Li, R.-X.; Chen, H.; Fu, H.-Y. *, Selective direct C–H polyfluoroarylation of electron-deficient N-heterocyclic compounds. Org. Chem.Front.2020, 7 (23), 3887-3895;
8. Li, W.; Tang, J.; Li, S.; Zheng, X.; Yuan, M.; Xu, B.; Jiang, W.; F, H. *; Li, R.; Chen, H.*, Stereodivergent Synthesis of Alkenylpyridines via Pd/Cu Catalyzed C-H Alkenylation of Pyridinium Salts with Alkynes. Org.Lett. 2020, 22 (20), 7814-7819;
9. Nie, X.; Zheng, Y.; Ji, L.; Fu, H. *; Chen, H.; Li, R. *, Acceptorless dehydrogenation of amines to nitriles catalyzed by N-heterocyclic carbene-nitrogen-phosphine chelated bimetallic ruthenium (II) complex. J. Catal. 2020, 391, 378-385;
10. Xu, K.; Li, W.; Sun, R.; Luo, L.; Chen, X.; Zhang, C.; Zheng, X.; Yuan, M.; Fu, H. *; Li, R.; Chen, H., Synthesis of 2-Formylpyrroles from Pyridinium Iodide Salts. Org.Lett. 2020, 22 (15), 6107-6111;
11. Yang, X.; Sun, R.; Li, S.; Zheng, X.; Yuan, M.; Xu, B.; Jiang, W.; Chen, H.; Fu, H. *; Li, R. *, Regioselective Direct C-H Trifluoromethylation of Pyridine. Org.Lett. 2020, 22 (18), 7108-7112
12. Zheng, Y.; Nie, X.; Long, Y.; Ji, L.; Fu, H*.; Zheng, X.; Chen, H.; Li, R*. Ruthenium-catalyzed synthesis of N-substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines. Chem. Commun. 2019, 55,12384-12387
13. Liu, H. M.; Jian, L.; Li, C.; Zhang, C. C.; Fu, H.*; Zheng, X. L.; Chen, H.; Li, R. X.*, Dehydrogenation of Alcohols to Carboxylic Acid Catalyzed by in Situ-Generated Facial Ruthenium-CPP Complex. J. Org. Chem. 2019. 84(14): p. 9151-9160.
14. Li, W.; Liu, H.; Chen, X.; Li, S.; Zheng, R.; Zhang, C.; Zheng, X.; Yuan, M.; Li, R.; Fu, H.*; Chen, H*. Palladium-catalyzed direct ortho-alkynylation of aryl acetamides with low catalyst loading. Tetrahedron Lett. 2019, 60, 1875
15. Yang, X.; Sun, R.; Zhang, C.; Zheng, X.*; Yuan, M.; Fu, H.*; Li, R.; Chen, H., Iridium-Catalyzed Benzylamine C-H Alkenylation Enabled by Pentafluorobenzoyl as the Directing Group. Org Lett, 2019. 21(4): p. 1002-1006.
16. Hao, T. T.; Liang, H. R.; Ou-Yang, Y. H.; Yin, C. Z.; Zheng, X. L.; Yuan, M. L.; Li, R. X.; Fu, H.*; Chen, H.*, Palladium-Catalyzed Domino Reaction for Stereoselective Synthesis of Multisubstituted Olefins: Construction of Blue Luminogens. J. Org. Chem. 2018. 83(8): p. 4441-4454.
17. Jia, F.; Yin, C.; Zeng, Y.; Sun, R.; Ge, Y. C.; Xu, D.; Li, R.; Chen, H.; Zhang, C*.; Fu, H.*, Mechanism of Direct C-H Arylation of Pyridine via a Transient Activator Strategy: A Combined Computational and Experimental Study. J. Org. Chem. 2018. 83(17): p. 10389-10397.
18. Sun, R.; Yang, X.; Chen, X.; Zhang, C.; Zhao, X.; Wang, X.; Zheng, X.; Yuan, M.; Fu, H.*; Li, R.; Chen, H.*, Rh(III)-Catalyzed [4 + 2] Self-Annulation of N-Vinylarylamides. Org. Lett. 2018. 20(21): p. 6755-6759.
19. Yin, C.; Zhong, K.; Li, W.; Yang, X.; Sun, R.; Zhang, C.; Zheng, X.; Yuan, M.; Li, R.; Lan, Y.*; Fu, H*.; Chen, H*, C6-Selective Direct Arylation of 2-Phenylpyridine via an Activated N-methylpyridinium Salt: A Combined Experimental and Theoretical Study. Adv. Syn. & Catal. 2018. 360(20): p. 3990-3998
20. Zeng, Y.; Zhang, C.; Yin, C.; Sun, M.; Fu, H.*; Zheng, X.; Yuan, M.; Li, R.; Chen, H. *, Direct C-H Functionalization of Pyridine via a Transient Activator Strategy: Synthesis of 2,6-Diarylpyridines. Org. Lett. 2017, 19 (8), 1970-1973.
21. Huang, J.; Wang, W.; He, H.-Y.; Jian, L.; Fu, H.-Y. *; Zheng, X.-L.; Chen, H.; Li, R.-X.*, An Approach to the Synthesis of 1-Propenylnaphthols and 3-Arylnaphtho[2,1-b]furans. J. Org. Chem. 2017, 82 (5), 2523-2534.
22. Fu, H.; Shen, P. X.; He, J.; Zhang, F.; Li, S.; Wang, P.; Liu, T.; Yu, J. Q., Ligand-Enabled Alkynylation of C(sp3 )-H Bonds with Palladium(II) Catalysts. Angew. Chem. Int. Ed. 2017, 56 (7), 1873-1876.
23. Li, W.; Yin, C.; Yang, X.; Liu, H.; Zheng, X.; Yuan, M.; Li, R.; Fu, H.; Chen, H.Cu(ii)-Mediated keto C(sp(3))-H bond alpha-acyloxylation of N,N-dialkylamides with aromatic carboxylic acids. Org.Bio.Chem. 2017. 15(36): p. 7594-7599
24. Liu, H.; Han, W.; Li, C.; Ma, Z.; Li, R.; Zheng, X.; Fu, H. *; Chen, H. *, Practical Synthesis of Phenanthridinones by Palladium-Catalyzed One-Pot C-C and C-N Coupling Reaction: Extending the Substrate Scope too-Chlorobenzamides. Eur. J. Org. Chem. 2016, 2016 (2), 389-393.
25. Wang, W.; Huang, J.; Zhou, R.; Jiang, Z.-J.; Fu, H.-Y. *; Zheng, X.-L.; Chen, H.; Li, R.-X.*, A Simple and Efficient Access to Naphtho[b]furans by Claisen Rearrangement/Cyclization of Bromonaphthyl 3-Phenylallyl Ethers. Adv. Syn. & Catal. 2015, 357 (11), 2442-2446.
26. Ma, Z.; Liu, H.; Zhang, C.; Zheng, X.; Yuan, M.; Fu, H. *; Li, R.; Chen, H. *, One-Pot Synthesis of Symmetrical 2,6-DiarylpyridinesviaPalladium/Copper-Catalyzed Sequential Decarboxylative and Direct C-H Arylation. Adv. Syn. & Catal. 2015, 357 (6), 1143-1148.
27. Ge, Y.; Cheng, Y.; Fu, H.*; Zheng, X.; Li, R.; Chen, H.*; Li, X., Suzuki-Miyaura cross-coupling reaction catalyzed by a highly stable Pd(P-Phos)Cl-2 complex at room temperature under air. Chin. J. Catal. 2013, 34 (9), 1667-1673.
28. Fu, H.; Chen, H.; Doucet, H., Palladium-catalyzed selective decarboxylative coupling reaction versus direct C?H arylation for arylation of heteroaromatics. Appl. Organometal.Chem. 2013, 27 (10), 595-600.
29. Fu, H.; Zhao, L.; Bruneau, C.; Doucet, H., Palladium-Catalysed Direct Heteroarylations of Heteroaromatics Using Esters as Blocking Groups at C2 of Bromofuran and Bromothiophene Derivatives: A One-Step Access to Biheteroaryls. Synlett 2012, (14), 2077-2082.
30. Fu, H.; Chen, L.; Doucet, H., Phosphine-Free Palladium-Catalyzed Direct Arylation of Imidazo 1,2-a pyridines with Aryl Bromides at Low Catalyst Loading. J. Org. Chem. 2012, 77 (9), 4473-4478.
31. Pi, X.; Zhou, Y.; Zhou, L.; Yuan, M.; Li, R.; Fu, H.*; Chen, H.*, Dicyclopentadiene Hydroformylation in an Aqueous/Organic Two Phase System in the Presence of a Cationic Surfactant. Chin. J. Catal. 2011, 32 (4), 566-571.
32. Liu, H.; Yuan, M.; Guo, C.; Li, R.; Fu, H.*; Chen, H.*; Li, X., Selective Hydrogenation of Cinnamaldehyde to Cinnamyl Alcohol over Ru/ZrO2 center dot xH(2)O Catalyst. Chin. J. Catal. 2011, 32 (7), 1256-1261.
33. Fu, H.; Doucet, H., Methyl 2-Furoate: An Alternative Reagent to Furan for Palladium-Catalysed Direct Arylation. Eur.J.Org.Chem. 2011, (35), 7163-7173.
34. Fu, H.; Yuan, M.; Chen, H.; Li, R.; Li, X., Progress of Olefin Hydroformylation Catalyzed by Water-Soluble Rhodium-Phosphine Complexes. Chin. J. Catal. 2010, 31 (3), 251-260.
35. Mao, H.; Fu, H.*; Chen, H. *; Li, R.; Li, X., Synergistic Effect of TPPTS and TPPDS on the Regioselectivity for 1-Decene Hydroaminomethylation in a Two-Phase Catalytic System. Chin. J. Catal. 2009, 30 (12), 1192-1196.
36. Fu, H.; Li, M.; Mao, H.; Lin, Q.; Yuan, M.; Li, X.; Chen, H., Aqueous biphasic catalytic hydroformylation of higher olefins: Promotion effect of cationic gemini and trimeric surfactants. Catal. Commun. 2008, 9 (7), 1539-1544.
37. Fu, H.; Li, M.; Chen, J.; Zhang, R.; Jiang, W.; Yuan, M.; Chen, H.; Li, X., Application of a new amphiphilic phosphine in the aqueous biphasic catalytic hydroformylation of long chain olefins. J. Mol.Catal. A-Chem. 2008, 292 (1-2), 21-27.
38. Fu, H.; Li, M.; Chen, H.; Li, X., Higher olefin hydroformylation in organic/aqueous biphasic system accelerated by double long-chain cationic surfactants. J. Mol.Catal. A-Chem. 2006, 259 (1-2), 156-160.
39. Fu, H.; Guo, Y.; Lin, Q.; Chen, H.; Li, X., Cocatalytic effect of new surface-active phosphine in long-chain olefin hydroformylation. Chin. J. Catal. 2006, 27 (12), 1053-1058.
40. He, J.; Li, S.; Deng, Y.; Fu, H.; Laforteza, B. N.; Spangler, J. E.; Homs, A.; Yu，J.-Q. *, Ligand-controlled C(sp(3))-H arylation and olefination in synthesis of unnatural chiral alpha-amino acids. Science 2014, 343 (6176), 1216-1220.
41. Chan, K. S. L.; Fu, H.; Yu，J.-Q. *, Palladium (II)-catalyzed highly enantioselective C-H arylation of cyclopropylmethylamines. J. Am. Chem. Soc. 2015, 137 (5), 2042-6;
42. He, J.; Takise, R.; Fu, H.; Yu，J.-Q. *, Ligand-enabled cross-coupling of C(sp(3))-H bonds with arylsilanes. J. Am. Chem. Soc. 2015, 137 (14), 4618-21;
43. Zhu, R.; Tanaka, K.; Li, G.; He, J.; Fu, H.; Li, S.; Yu，J.-Q. * Ligand-Enabled Stereoselective beta-C(sp(3))-H Fluorination: Synthesis of Unnatural Enantiopure anti beta-Fluoro-alpha-am8ino Acids. J. Am. Chem. Soc. 2015, 137 (22), 7067-70
