The website of group：https://adnlab.mysxl.cn/
RESEARCH INTERESTS:
Bioanalytical chemistry; DNA nanotechnology; Techniques for in vitro disease diagnostics
EDUCATION AND ACADEMIC CAREER:
Education
Ph.D., University of Alberta, Canada 2007-2013, Analytical Chemistry, Department of Chemistry, Advisor: Dr. X. Chris Le
B.Sc., Tianjin University, China，2002-2006, Pharmaceutical Sciences, School of Pharmaceutical Science and Technology
Working Experience
2019/09-present, Professor, College of Chemistry, Sichuan University
2021/06-present, Adjunct Professor, Department of Chemistry and Centre for Biotechnology, Brock University
2019/07-2021/06, Associate Professor, Department of Chemistry and Centre for Biotechnology, Brock University
2014/12-2019/06, Assistant Professor, Department of Chemistry and Centre for Biotechnology, Brock University
2018/08-2018/08, YSEP Visiting Scholar, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, China, Host: Prof. Chunhai Fan
2013/02-2014/11, Postdoctoral Fellow, Department of Laboratory Medicine and Pathology, University of Alberta
2013/08-2013/12, Visiting Scholar, Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Advisor: Dr. Weian Zhao
HONORS AND AWARDS:
2021 Fred Beamish Award, Canadian Society for Chemistry
2019 Young Investigator in (Bio-)Analytical Chemistry, Analytical and Bioanalytical Chemistry (Springer Journal)
2018 Awardee of the Ontario-China Young Scientist Exchange Program, MRIS, Ontario, Canada
2018 Early Researcher Award, Ministry of Research, Innovation and Science, Government of Ontario
2016 Emerging Investigator in Analytical Science, Analyst (RSC Journal)
2014 JDRF Postdoctoral Fellowship (declined), Juvenile Diabetes Research Foundation, USA
2013 Doctoral Dissertation Award, Faculty of Science, University of Alberta
2013 Bill Davidson Graduate Student Travel Award, 7th International Symposium on Enabling Technologies
2013 Chinese Government Scholarship for Outstanding Self-financed Students Studying Abroad, Ministry of Education, China Scholarship Council
2012 Young Scientist Travel Award, 28th International Symposium on International Symposium on Microscale Separations and Bioanalysis
2012 J Gordin Kaplan Graduate Student Award, University of Alberta
2007 Provost Doctoral Entrance Award, University of Alberta
2004 Gilbert Stork Scholarship, Tianjin University
SELECTED PUBLICATIONS:
1. Tang, Y.#; Song, T.#; Gao, L.; Yin, S.; Ma, M.; Tan, Y.; Wu, L.; Yang, Y.; Wang, Y.; Lin, T.*; Li, F.* A CRISPR-based ultrasensitive assay detects attomolar concentrations of SARS-CoV-2 antibodies in clinical samples. Nature Communications, 2022, 13, 4667.
2. Wang, G.A.; Xu, J.; Traynor, S. M.; Chen, H.; Eljabu, F.; Wu, X.; Yan, H.; Li, F.* DNA balance for native characterization of chemically modified DNA. Journal of the American Chemical Society, 2021, 143, 13655–13663.
3. Wang, G.A.; Xie, X.; Mansour, H.; Chen, F.; Matamoros, G.; Sanchez, A. L.; Fan, C.; Li, F.* Expanding detection windows for discriminating single nucleotide variants using rationally designed DNA equalizer probes. Nature Communications, 2020,11, 5473.
4. Traynor, S. M.; Wang, G. A.; Pandey, R.; Li, F.*; Soleymani, L.* Dynamic Bio‐Barcode Assay Enables Electrochemical Detection of a Cancer Biomarker in Undiluted Human Plasma: A Sample‐In‐Answer‐Out Approach. Angewandte Chemie International Edition, 2020, 59, 22617-22622.
5. Wang, Y.; Yang, Q.; Lin, X.; Chen, D.; Wang, Z.; Chen, B.; Han, H.; Chen, H.; Cai, K.; Li, Q.; Yang, S.*; Tang, Y.*; Li, F.* G4LDB 2.2: a database for discovering and studying G-quadruplex and i-Motif ligands. Nucleic Acids Research, 2022, 50, D150-D160.
6. Yang, P.; Zhou, R.; Kong, C.; Fan, L.; Dong, C.; Chen, J.; Hou, X.*; Li, F.* Stimuli-Responsive Three-Dimensional DNA Nanomachines Engineered by Controlling Dynamic Interactions at Biomolecule-Nanoparticle Interfaces. ACS nano, 2021, 15, 16870-16877.
7. Mason, S. D.; Wang, G. A.; Yang, P.; Li, Y.; Li, F.* Probing and controlling dynamic interactions at biomolecule-nanoparticle interfaces using stochastic DNA walkers. ACS Nano, 2019, 13, 8106-8113.
8. Tang, Y.; Gao, L.; Feng, W.; Guo, C.; Yang, Q.; Li, F.*; Le, X. C. The CRISPR–Cas toolbox for analytical and diagnostic assay development. Chemical Society Reviews, 2021, 50, 11844-11869. (Inside Cover)
9. Yang, X.; Tang, Y.; Traynor, S. M.; Li, F.* Regulation of DNA strand displacement using allosteric DNA toehold. Journal of the American Chemical Society, 2016, 138, 14076-14082.
10. Yang, X.; Tang, Y.; Mason, S. D.; Chen, J.; Li, F.* Enzyme-powered three-dimensional DNA nanomachine for DNA walking, payload release, and biosensing. ACS Nano, 2016, 10, 2324-2331.
11. Li, Y.; Mansour, H.; Watson, C.; Tang, Y.*; MacNeild, A.; Li, F.* Amplified detection of nucleic acids and proteins using an isothermal proximity CRISPR Cas12a assay. Chemical Science, 2021, 12, 2133-2137.
12. Gao, L.; Liu, L.; Tian, Y.; Yang, Q.; Wu, P.; Fan, C.; Zhao, Q.*; Li, F.* Probing the Formation Kinetics and Thermodynamics with Rationally Designed Analytical Tools Enables One-Pot Synthesis and Purification of a Tetrahedral DNA Nanostructure. Analytical Chemistry, 2021, 93, 7045−7053.（Front Cover)
13. Dong, T.; Mansour, H.; Hu, H.; Wang, G. A.; Watson, C. J. F.; Yousef, M.; Matamoros, G.; Sanchez, A. L.; MacNeil, A. J.; Wu, P.;* Li, F.* Colorimetric polymerase chain reaction enabled by a fast light-activated substrate chromogenic (FLASH) detection platform. Analytical Chemistry, 2020, 92, 6456-6461.
14. Yang, P.; Li, Y.; Mason, S. D.; Chen, F.; Chen, J.;* Zhou, R.; Liu, J.; Hou, X.; Li, F.* A concentric DNA amplifier that streamlines in-solution biorecognition and on-particle biocatalysis. Analytical Chemistry, 2020, 92，3220-3227.
15. Li, Y.; Mansour, H.; Wang, T.; Poojari, S.; Li, F.* Naked-eye detection of grapevine red-blotch viral infection using a plasmonic CRISPR Cas12a Assay. Analytical Chemistry, 2019, 91, 11510-11513.
