Chen, Xiaochuan     

Research direction: Organic Synthesis

Contact information:

Email: chenxc@scu.edu.cn

RESEARCH INTERESTS: Natural product synthesis; Organic synthesis methodology


Since 2007.09   Professor, College of Chemstry, Sichuan University

2003.01—2007.08   Research Fellow (Postdoctoral Fellow) in Organic Chemistry, Institut de Chimie des Substances Naturelles, CNRS, France

1999.09---2002.06   Ph.D. in Organic Chemistry, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University

1996.09---1999.06   MA.Sc in Organic Chemistry, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University

1992.09---1996.06   B.S., College of Chemistry and Chemical Engineering, Lanzhou University


1.  He Gu, Yue Hu, Yuanliang Jia, Qin Zhou, Guiyin Luo, Xiaochuan Chen*, Total Synthesis of ()-Lepadin F based on a Stereoselective Diels–Alder Reaction Controlled by a Ketolactone-type Dienophile, Chem. Eur. J. 2021, 27(12), 4141–4149.

2.  Feng Shui, Junhao Jia, Xing Yang, Qin Zhou, Yimin Jiang, Xiaochuan Chen*, Synthesis of (+)-Epoxydon, (-)-Phyllostine, (-)-RKTS 33, and (-)-Parasitenone Featuring Selective Sulfonylation and Oxirane Ring Closure of Aldol Cyclization Products, Eur. J. Org. Chem. 2020, 2021(26), 3981–3988.

3.  Yi Wang, Zaixiang Fang, Xiaochuan Chen, Yuanhua Wang*, Dirhodium(II)‐Catalyzed C(sp2)H Azidation of Benzaldehydes, Chem. Eur. J. 2020, 26, 6805–6811.

4.  Junhao Jia, Ruijiao Chen, Yuanliang Jia, He Gu, Qin Zhou, Xiaochuan Chen*Convergent Formal Synthesis of Ecteinascidin 743, J. Org. Chem. 2019, 84, 13696–13706.

5.  Xing Yang, Po Yuan, Feng Shui, Yuqin Zhou, Xiaochuan Chen*, A divergent strategy to synthesize gabosines featuring a switchable two-way aldol cyclization, Org. Biomol. Chem. 2019, 17, 4061–4072.

6.  Yi Wang, Xiaochuan Chen, Hong Jin*, Yuanhua Wang*, Mild and Practical Dirhodium(II)/NHPI-Mediated Allylic and Benzylic Oxidations with Air as the Oxidant, Chem. Eur. J. 2019, 25, 14273–14277.

7.  Xiaojing Liu, Junhao Jia, Yuanliang Jia, He Gu, Jingwen Luo, Xiaochuan Chen*, A flexible and divergent strategy to flavonoids with chiral A ring featuring intramolecular Michael addition. Stereoselective synthesis of (+)-cryptocaryone, (+)-cryptogione F, (+)-cryptocaryanones A and B, (+)-cryptochinones A and C, Org. Lett. 2018, 20(7), 1945–1948.

8.  Yi Wang, Zaixiang Fang, Xiaochuan Chen*, Yuanhua Wang*, Mild Dirhodium(II)-Catalyzed Chemo- and Regioselective Azidation of Arenes, Org. Lett. 2018, 20(18), 5732–5736.

9.  Xiong Li, Lingling Hu, Junhao Jia, He Gu, Yuanliang Jia, Xiaochuan Chen*, A Stereoselective Approach toward (-)-Lepadins A–C, Org. Lett. 2017, 19(19), 5372–5375.

10.  Po Yuan, Xiaojing Liu, Xing Yang, Yanli Zhang, Xiaochuan Chen*, Total Syntheses of (+)-Gabosine P, (+)-Gabosine Q, (+)-Gabosine E, (–)-Gabosine G, (–)-Gabosine I, (–)-Gabosine K, (+)-Streptol and (–)-Uvamalol A by a Diversity-Oriented Approach Featuring Tunable Deprotection Manipulation, J. Org. Chem. 2017, 82(7), 3692–3701.

11.  Lizhen Jiang, Xiaojing Liu, Po Yuan, Yanli Zhang, Xiaochuan Chen*, Stereoselective Synthesis of (+)-Annuionone A and (-)-Annuionone B, J. Nat. Prod. 2017, 80(4), 805–812.

12.  Junhao Jia, Ruijiao Chen, Hao Liu, Xiong Li, Yuanliang Jia, Xiaochuan Chen*, Asymmetric Synthesis of (–)-Renieramycin T, Org. Biomol. Chem. 2016, 14, 7334–7344.

13.  Xiaojing Liu, Lingling Hu, Lizhen Jiang, Junhao Jia, Di Zhang, Xiaochuan Chen*, Asymmetric Synthesis of Concentricolide, Eur. J. Org. Chem. 2015, 10, 2291–2296.

14.  Xiubing Liu, Lingling Hu, Xiaojing Liu, Junhao Jia, Lizhen Jiang, Jiangfeng Lin, Xiaochuan Chen*, A New Approach to Asymmetric Synthesis of Infectocaryone, Org. Biomol. Chem. 2014, 12, 7603–7611.

15.  Hao Liu, Ruijiao Chen, Xiaochuan Chen*, A Rapid and Efficient Access to Renieramycin-Type Alkaloids Featuring a Temperature-Dependent Stereoselective Cyclization, Org. Biomol. Chem. 2014, 12, 1633–1640.

16.  Liang Xia, Sheng Li, Ruijiao Chen, Kai Liu, Xiaochuan Chen*, Catalytic Ugi-Type Condensation of α -Isocyanoacetamide and Chiral Cyclic Imine: Access to Asymmetric Construction of Several Heterocycles, J. Org. Chem. 2013, 78(7), 3120–3131.

17.  Ruijiao Chen, Hao Liu, Xiaochuan Chen*, Asymmetric Total Synthesis of (-)-Jorunnamycins A and C and (-)-Jorumycin from L-Tyrosine, J. Nat. Prod. 2013, 76(9), 1789–1795. 

18.  Deguang Zhu, Liang Xia, Li Pan, Sheng Li, Ruijiao Chen, Yongren Mou, Xiaochuan Chen*, An Asymmetric Ugi Three-Component Reaction Induced by Chiral Cyclic Imines: Synthesis of Morpholin- or Piperazine-Keto-carboxamide Derivatives, J. Org. Chem. 2012, 77, 1386-1395.

19.  Ruijiao Chen, Deguang Zhu, Zuoqiang Hu, Zhiming Zheng, Xiaochuan Chen*, A new approach to synthesis of L-3-hydroxy-4-methoxy-5-methyl-phenylalanine derivatives from L-tyrosine, Tetrahedron: Asymmetry 2010, 21(1), 39-42.

21.  Xiaochuan Chen, Jieping Zhu*, Total Synthesis of the Marine Natural Product (-)-Cribrostatin 4 (Renieramycin H), Angew. Chem. Int. Ed. 2007, 46, 3962-3965.

22.  Jinchun Chen, Xiaochuan Chen, Michele Bois-Choussy, Jieping Zhu*, Total Synthesis of Ecteinascidin 743, J. Am. Chem. Soc. 2006, 128(1), 87-89.

23.  Jinchun Chen, Xiaochuan Chen, Matthieu Willot, Jieping Zhu*, Asymmetric Total Synthesis of Ecteinascidin 597 and Ecteinascidin 583, Angew. Chem. Int. Ed. 2006, 45, 8028-8032.

24.  Xiaochuan Chen, Jinchun Chen, De Paolis Michael, Jieping Zhu*, Synthetic Studies toward Ecteinascidin 743, J. Org. Chem. 2005,70(11), 4397-4408.


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