Xiaoming Feng

xmfeng@scu.edu.cn

Professor, Chinese Academy of Sciences Academician


EDUCATION AND ACADEMIC CAREER
2000-present Professor, College of Chemistry, Sichuan University, Chengdu, China
1998-1999 Postdoctoral research, Colorado State University, USA (with Prof. Yian Shi)
1997-2000 Professor, Chengdu Institute of Organic Chemistry, CAS, China
1988-1993 Assistant/associate professor, Southwest Normal University, Chongqin, China
1993-1996 Ph.D., Institute of Chemistry, CAS (with Prof. Zhitang Huang & Yao-Zhong Jiang)
1985-1988 M.Sc., Dept. of Chemistry, Lanzhou University, China (with Prof. Ziyi Zhang)
1981-1985 B.Sc., Dept. of Chemistry, Lanzhou University, China


HONORS AND AWARDS
2002 the National Science Fund for Distinguished Young Scholars (China)
2005 the Special Professor of the Chang Jiang Scholars by the Ministry of Education of China
2009 Higher Education Outstanding Scientific Research Output Awards (Science and Technology) from the Ministry of Education (First class, China)
2011 SciFinder Award for Creative Work in Synthetic Organic Chemistry, CCS
2012 the State Natural Science Award, P.R. China (Second class, China)
2013 a Chinese Academy of Sciences Academician
2015 a Fellow of the Royal Society of Chemistry
2016 Chiral Chemistry Award, CCS
2018 Physical Science Prize of Future Science Prize

 

EDITORIAL BOARDS
2012-2015 Member, Associate Editor of Chinese Chemical Letters
2008-present Member, Editorial Advisory Board of Science China: Chemistry
2011-present Member, Academic Advisory Board of Advanced Synthesis & Catalysis
2011-present Member, Advisory Board of Current Organic Synthesis
2012-present Member, International Advisory Board of Asian Journal of Organic Chemistry
2014-present Member, Advisory Board of Synlett/Synthesis

 

RESEARCH INTERESTS

Design and synthesis of chiral organocatalysts and ligand-metal complex catalysts, asymmetric catalytic reaction, the synthesis of bioactive compounds


We dedicated to develop new chiral catalysts and asymmetric catalytic systems. Based on the strategies of bifunctional catalysis and C2-symmetry, we designed and synthesized a new family of N,N'-dioxide amide compounds as chiral ligands and catalysts for the first time. Novel C2-symmetric N,N'-dioxides were readily prepared by the connection of two N-oxide amide subunits via a linker with variable conformation. The structural modify to fit the targeted enantioselective reactions could be easily established by using different chiral backbone, linker units, and amines with varied steric and electronic nature. In addition to acting as bifunctional organocatalysts, N,N'-dioxide amides were developed into useful neutral ligands for Lewis acidic metals, such as rare earth metals, alkaline earth metals, group IV metals, group XIII metals. Numerous chiral tetradentate ligand-metal complexes have been established as effective catalysts (see Acc. Chem. Rev. 2011, 44, 574; Acc. Chem. Res. 2017, 50, 2621; Chin. J. Chem. 2018, 36, 791 for details). Additionally, we also developed a useful combined catalyst, and new bifunctional organocatalysts, such as guanidine-amide, bispidine-based diamine.



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SELECTITED PUBLICATIONS

1.  Ke Zheng, Xiaohua Liu, Xiaoming Feng,* Recent Advances in Metal-Catalyzed Asymmetric 1,4-Conjugate Addition (ACA) of Nonorganometallic Nucleophiles, Chem. Rev. 2018, 118, 75867656.

2. Xiaobin Lin, Yu Tang, Wei Yang, Fei Tan, Lili Lin, Xiaohua Liu,* Xiaoming Feng,* Chiral Nickel(II) Complex Catalyzed Enantioselective Doyle-Kirmse Reaction of α-Diazo Pyrazoleamides, J. Am. Chem. Soc. 2018, 140, 3299–3305.

3. Haifeng Zheng, Yan Wang, Chaoran Xu, Xi Xu, Lili Lin, Xiaohua Liu,* Xiaoming Feng,* Stereodivergent Synthesis of Vicinal Quaternary-quaternary Stereocenters and Bioactive Hyperolactones, Nat. Commun. 2018, 1968.

4. Xi Xu, Jianlin Zhang, Shunxi Dong, Lili Lin, Xiaobin Lin, Xiaohua Liu, Xiaoming Feng,* Nickel(II)-Catalyzed Asymmetric Propargyl [2,3] Wittig Rearrangement of Oxindole Derivatives: A Chiral Amplification Effect, Angew. Chem. Int. Ed. 2018, 57, 8734–8738.

5. Yuhang Zhou, Lili Lin, Xiaohua Liu,* Xinyue Hu, Yan Lu, Xiying Zhang, Xiaoming Feng,* Catalytic Asymmetric Diels-Alder Reaction/[3,3] Sigmatropic Rearrangement Cascade of 1-Thiocyanatobutadienes, Angew. Chem. Int. Ed. 2018, 57, 9113–9116.

6. Dong Zhang, Lili Lin, Jian Yang, Xiaohua Liu, Xiaoming Feng,* Asymmetric Synthesis of Tetrahydroindolizines by Bimetallic Relay Catalyzed Cycloaddition of Pyridinium Ylides, Angew. Chem. Int. Ed. 2018, 57, 12323–12327.

7. Fei Tan, Xiaohua Liu,* Yan Wang, Shunxi Dong, Han Yu, Xiaoming Feng,* Chiral Lewis Acid Catalyzed Reactions of a-Diazoester Derivatives: Construction of Dimeric Polycyclic Compounds, Angew. Chem. Int. Ed. 2018, 57, 16176–16179.

8. Yushuang Chen, Shunxi Dong, Xi Xu, Xiaohua Liu, Xiaoming Feng,* Bimetallic Rhodium(II)/Indium(III) Relay Catalysis for Tandem Insertion/Asymmetric Claisen Rearrangement, Angew. Chem. Int. Ed. 2018, 57, 16554–16558.

9.  Xiaohua Liu, Xiaoming Feng,* Dual Nickel and Br?nsted Acid Catalysis for Hydroalkenylation, Angew. Chem. Int. Ed. 2018, 57, 16604–16605

10. Yali Xu, Fenzhen Chang, Weidi Cao, Xiaohua Liu, and Xiaoming Feng,* Catalytic Asymmetric Chemodivergent C2 Alkylation and [3 + 2]-Cycloaddition of 3-Methylindoles with Aziridines, ACS Catal. 2018, 8, 10261–10266.

11. Yulong Kuang, Bin Shen, Li Dai, Qian Yao, Xiaohua Liu,* Lili Lin, Xiaoming Feng,* Diastereodivergent Asymmetric Michael-Alkylationreactions Using Chiral N,N'-Dioxide/Metal Complexes, Chem. Sci. 2018, 9, 688–692.

12. Xiaohua Liu, Shunxi Dong, Lili Lin, Xiaoming Feng,* Chiral Amino Acids-Derived Catalysts and Ligands, Chin. J. Chem. 2018, 36, 791–797.

13.  Xiaohua Liu, Haifeng Zheng, Yong Xia, Lili Lin, Xiaoming Feng,* Asymmetric Cycloaddition and Cyclization Reactions Catalyzed by Chiral   N,N'-Dioxide–Metal Complexes, Acc. Chem. Res. 2017, 50, 26212631.

14.  Pengfei Zhou, Lili Lin, Long Chen, Xia Zhong, Xiaohua Liu, Xiaoming Feng,* Iron-Catalyzed Asymmetric Haloazidation of α,β-Unsaturated Ketones: Construction of Organic Azides with Two Vicinal Stereocenters, J. Am. Chem. Soc. 2017, 139, 1341413419.

15. Jianfeng Zheng, Lili Lin, Li Dai, Qiong Tang, Xiaohua Liu,* Xiaoming Feng,* Nickel-Catalyzed Conjugate Addition of Silyl Ketene Imines to In Situ Generated Indol-2-ones: Highly Enantioselective Construction of Vicinal All-Carbon Quaternary Stereocenters, Angew. Chem. Int. Ed. 2017, 56, 1310713111.

16. Jun Li, Lili Lin, Bowen Hu, Pengfei Zhou, Tianyu Huang, Xiaohua Liu,* Xiaoming Feng,* Gold(I)/Chiral   N,N'-Dioxide–Nickel(II) Relay Catalysis for Asymmetric Tandem Intermolecular Hydroalkoxylation/Claisen Rearrangement, Angew. Chem. Int. Ed. 2017, 56, 885888.

17. Tianyu Huang, Xiaohua Liu,* Jiawen Lang, Jian Xu, Lili Lin, Xiaoming Feng,* Asymmetric Aerobic Oxidative Cross-Coupling of Tetrahydroisoquinolines with Alkynes, ACS Catal. 2017, 7, 56545660.

18. Jie Ji, Lili Lin, Qiong Tang, Tengfei Kang, Xiaohua Liu, Xiaoming Feng,* Highly Efficient Asymmetric Synthesis of Chiral γ-Alkenyl Butenolides Catalyzed by Chiral N,N'-Dioxide–Scandium(III) Complexes, ACS Catal. 2017, 7, 37633767.

19. Yuting Liao, Baixin Zhou, Yong Xia, Xiaohua Liu,* Lili Lin, Xiaoming Feng,* Asymmetric [3 + 2] Cycloaddition of 2,2'-Diester Aziridines To Synthesize Pyrrolidine Derivatives, ACS Catal. 2017, 7, 39343939.

20. Xiangjin Lian, Lili Lin, Kai Fu, Baiwei Ma, Xiaohua Liu, Xiaoming Feng,* A new approach to the asymmetric Mannich reaction catalyzed by chiral   N,N'-dioxide–metal complexes, Chem. Sci., 2017, 8, 12381242.

21. Yu Zhang, Yuting Liao, Xiaohua Liu,* Xi Xu, Lili Lin, Xiaoming Feng,* Catalytic asymmetric hydroxylative dearomatization of 2-naphthols: synthesis of lacinilene derivatives, Chem. Sci. 2017, 8, 66456649.

22. Yong Xia, Lili Lin, Fenzhen Chang, Yuting Liao, Xiaohua Liu,* and Xiaoming Feng*, Asymmetric Ring Opening/Cyclization/Retro-Mannich Reaction of Cyclopropyl Ketones with Aryl 1,2-Diamines for the Synthesis of Benzimidazole Derivatives, Angew. Chem. Int. Ed. 2016, 55, 1222812232.

23. Haipeng Hu, Yangbin Liu, Lili Lin, Yuheng Zhang, Xiaohua Liu,* and Xiaoming Feng*, Kinetic Resolution of 2H-Azirines by Asymmetric Imine Amidation, Angew. Chem. Int. Ed. 2016, 55, 1009810101.

24. Qian Yao, Yuting Liao, Lili Lin, Xiaobin Lin, Jie Ji, Xiaohua Liu,* and Xiaoming Feng*, Efficient Synthesis of Chiral Trisubstituted 1,2-Allenyl Ketones by Catalytic Asymmetric Conjugate Addition of Malonic Esters to Enynes, Angew. Chem. Int. Ed. 2016, 55, 18591863.

25. Yangbin Liu, Xiaohua Liu,* Haipeng Hu, Jing Guo, Yong Xia, Lili Lin, and Xiaoming Feng*, Synergistic Kinetic Resolution and Asymmetric Propargyl Claisen Rearrangement for the Synthesis of Chiral Allenes, Angew. Chem. Int. Ed. 2016, 55, 40544058.

26. Quangang Chen, Yu Tang, Tianyu Huang, Xiaohua Liu,* Lili Lin, and Xiaoming Feng; Copper/Guanidine-Catalyzed Asymmetric Alkynylation of Isatins, Angew. Chem. Int. Ed. 2016, 55, 52865289.

27. Tengfei Kang, Shulin Ge, Lili Lin, Yan Lu, Xiaohua Liu,* and Xiaoming Feng*, A Chiral   N,N'-Dioxide–Zn(II) Complex Catalyzes the Enantioselective [2+2] Cycloaddition of Alkynones with Cyclic Enol Silyl Ethers, Angew. Chem. Int. Ed. 2016, 55, 55415544.

28. Jun Li, Lili Lin, Bowen Hu, Xiangjin Lian, Gang Wang, Xiaohua Liu,* and Xiaoming Feng*, Bimetallic Gold(I)/Chiral   N,N'-Dioxide Nickel(II) Asymmetric Relay Catalysis: Chemo- and Enantioselective Synthesis of Spiroketals and Spiroaminals, Angew. Chem. Int. Ed. 2016, 55, 60756078.

29. Pengfei Zhou, Yunfei Cai, Xia Zhong, Weiwei Luo, Tengfei Kang, Jun Li, Xiaohua Liu,* Lili Lin, and Xiaoming Feng*, Catalytic Asymmetric Intra- and Intermolecular Haloetherification of Enones: An Efficient Approach to (-)-Centrolobine, ACS Catal. 2016, 6, 77787783.

30. Gang Wang, Xiaohua Liu,*, Yushuang Chen, Jian Yang, Jun Li, Lili Lin, and Xiaoming Feng*, Diastereoselective and Enantioselective Alleno-aldol Reaction of Allenoates with Isatins to Synthesis of Carbinol Allenoates Catalyzed by Gold, ACS Catal. 2016, 6, 24822486.

31. Yali Xu, Yuting Liao, Lili Lin, Yuhang Zhou, Jun Li, Xiaohua Liu, and Xiaoming Feng*, Catalytic Asymmetric Inverse-Electron Demand 1,3-Dipolar Cycloaddition of Isoquinolinium Methylides with Enecarbamates by a Chiral   N,N'-Dioxide/Ag(I) Complex, ACS Catal. 2016, 6, 589592.

32. Jing Guo, Yangbin Liu, Xiangqiang Li, Xiaohua Liu,* Lili Lin and Xiaoming Feng*, Nickel(II)-catalyzed enantioselective cyclopropanation of 3-alkenyl-oxindoles with phenyliodonium ylide via free carbine, Chem. Sci. 2016, 7, 27172721.

33. Yuting Liao, Xiaohua Liu,* Yu Zhang, Yali Xu, Yong Xia, Lili Lin and Xiaoming Feng*, Asymmetric [3 + 2] cycloaddition of donor–acceptor aziridines with aldehydes via carbon–carbon bond cleavage, Chem. Sci. 2016, 7, 37753779.

34. Weiwei Luo, Xiao Yuan, Lili Lin, Pengfei Zhou, Xiaohua Liu* and Xiaoming Feng*, A   N,N'-dioxide/Mg(OTf)2 complex catalyzed enantioselective α-addition of isocyanides to alkylidene malonates, Chem. Sci. 2016, 7, 47364740.

35. Yong Xia, Xiaohua Liu*, Haifeng Zheng, Lili Lin, Xiaoming Feng*, A symmetric Synthesis of 2,3-Dihydropyrroles by Ring-Opening/Cyclization of Cyclopropyl Ketones Using Primary Amines, Angew. Chem. Int. Ed. 2015, 54, 227230.

36. Yong Xia, Lili Lin, Fenzhen Chang, Xuan Fu, Xiaohua Liu*, Xiaoming Feng*, Asymmetric Ring-Opening of Cyclopropyl Ketones with Thiol, Alcohol, and Carboxylic Acid Nucleophiles Catalyzed by a Chiral   N,N'-Dioxide–Scandium(III) Complex, Angew. Chem. Int. Ed. 2015, 54, 1374813752.

37. Haifeng Zheng, Xiaohua Liu*, Chaoran Xu, Yong Xia, Lili Lin, Xiaoming Feng*, Regio- and Enantioselective Aza-Diels–Alder Reactions of 3-Vinylindoles: A Concise Synthesis of the Antimalarial Spiroindolone NITD609, Angew. Chem. Int. Ed. 2015, 54, 1095810962.

38. Jiannan Zhao, Bing Fang, Weiwei Luo, Xiaoyu Hao, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Enantioselective Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Silyl Ketene Imines with Isatin-Derived Ketimines, Angew. Chem. Int. Ed. 2015, 54, 241244.

39. Wei Li, Fei Tan, Xiaoyu Hao, Gang Wang, Yu Tang, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric Intramolecular Homologation of Ketones with α-Diazoesters: Synthesis of Cyclic α-Aryl/Alkyl β-Ketoesters, Angew. Chem. Int. Ed. 2015, 54, 16081611.

40. Xiaohu Zhao, Xiaohua Liu*, Hongjiang Mei, Jing Guo, Lili Lin, Xiaoming Feng*, Asymmetric Dearomatization of Indoles through a Michael/Friedel-Crafts-Type Cascade to Construct Polycyclic Spiroindolines, Angew. Chem. Int. Ed. 2015, 54, 40324035.

41. Yin Zhu, Xiaohua Liu,* Shunxi Dong, Yuhang Zhou, Wei Li, Lili Lin, Xiaoming Feng*, Asymmetric NH Insertion of Secondary and Primary Anilines under the Catalysis of Palladium and Chiral Guanidine Derivatives, Angew. Chem. Int. Ed. 2014, 53, 16361640.

42. Yangbin Liu, Haipeng Hu, Haifeng Zheng, Yong Xia, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Nickel(II)-Catalyzed Asymmetric Propargyl and Allyl Claisen Rearrangements to Allenyl- and Allyl-Substituted β-Ketoesters, Angew. Chem. Int. Ed. 2014, 53, 1157911582.

43. Xie Mingsheng, Wu Xiaoxia, Wang Gang, Lin Lili, Feng Xiaoming*, Catalytic Asymmetric [8+2] Cycloaddition for the Construction of Cycloheptatriene-Fused Pyrrolidin-3,3’-Oxindoles, Acta Chimica Sinica 2014, 72, 856861.

44. Xiaohua Liu, Lili Lin and Xiaoming Feng*, Chiral N,N'-Dioxide Ligands: Synthesis, Coordination Chemistry and Asymmetric Catalysis, Org. Chem. Front., 2014, 1, 298302.

45. Jiannan Zhao, Xiaohua Liu, Weiwei Luo, Mingsheng Xie, Lili Lin, Xiaoming Feng*, Asymmetric Synthesis of β-Amino Nitriles through a Sc(III)-Catalyzed Three-Component Mannich Reaction of Silyl Ketene Imines, Angew. Chem. Int. Ed. 2013, 52, 34733477.

46. Mingsheng Xie, Xiaohua Liu, Xiaoxia Wu, Yunfei Cai, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric [8+2] Cycloaddition: Synthesis of Cycloheptatriene-Fused Pyrrole Derivative, Angew. Chem. Int. Ed. 2013, 52, 56045607.

47.  Jing Guo, Shunxi Dong, Yulong Zhang, Yulong Kuang, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Chiral Scandium(III)-Catalyzed Enantioselective α-Arylation of N-Unprotected 3-Substituted Oxindoles with Diaryliodonium Salts, Angew. Chem. Int. Ed. 2013, 52, 1024510249.

48. Wei Li, Xiaohua Liu, Fei Tan, Xiaoyu Hao, Jianfeng Zheng, Lili Lin, Xiaoming Feng*, Catalytic Homologation of α-Ketoesters with α-Diazoesters: Enantioselective Synthesis of Succinate Derivatives with Chiral Quaternary Centers, Angew. Chem. Int. Ed. 2013, 52, 1088310886.

49. Shunxi Dong, Xiaohua Liu*, Yin Zhu, Peng He, Lili Lin, Xiaoming Feng*, Organocatalytic Oxyamination of Azlactones: Kinetic Resolution of Oxaziridines and Asymmetric Synthesis of Oxazolin-4-ones, J. Am. Chem. Soc. 2013, 135, 1002610029.

50. Ke Zheng, Xiaohua Liu, Song Qin, Mingsheng Xie, Lili Lin, Changwei Hu, Xiaoming Feng*, Completely OH-Selective FeCl3-Catalyzed Prins Cyclization: Highly Stereoselective Synthesis of 4-OH-Tetrahydropyrans, J. Am. Chem. Soc. 2012, 134, 1756417573.

51. Lin Zhou, Xiaohua Liu, Jie Ji, Yuheng Zhang, Lili Lin, Xiaoming Feng*, Enantioselective Baeyer-Villiger Oxidation: Desymmetrization of Meso Cyclic Ketones and Kinetic Resolution of Racemic 2-Arylcyclohexanones, J. Am. Chem. Soc. 2012, 134, 1702317026.

52. Wei Li, Xiaohua Liu, Xiaoyu Hao, Yunfei Cai, Lili Lin, Xiaoming Feng*, A Catalytic Asymmetric Ring-Expansion Reaction of Isatins and α-Alkyl-α-Diazoesters: Highly Efficient Synthesis of Functionalized 2-Quinolone Derivatives, Angew. Chem. Int. Ed. 2012, 51, 86448647.

53.  Zhen Wang, Zhenling Chen, Sha Bai, Wei Li, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Highly Z-Selective Asymmetric Conjugate Addition of Alkynones with Pyrazol-5-ones Promoted by   N,N'-Dioxide-Metal Complexes, Angew. Chem. Int. Ed. 2012, 51, 27762779.

54.  Ke Shen, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Recent Progress in Enantioselective Synthesis of C3-functionalized Oxindoles: Rare Earth Metals Take Action, Chem. Sci. 2012, 3, 327334.

55. Yangyang Chu, Xiaohua Liu, Wei Li, Xiaolei Hu, Lili Lin and Xiaoming Feng*, Asymmetric Catalytic Epoxidation of α,β-Unsaturated Carbonyl Compounds with Hydrogen Peroxide: Additive-free and Wide Substrate Scope, Chem. Sci. 2012, 3, 19962000.

56. Ke Zheng, Lili Lin, Xiaoming Feng*, Chiral N,N'-Dioxide-Ni(II) Complex Catalyzed Asymmetric Carbonyl-Ene Reaction Of Ethyl Trifluoropyruvate, Acta Chim. Sinica 2012, 70, 17851790.

57. Xiaohua Liu, Lili Lin, Xiaoming Feng*, Chiral N,N'-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions, Acc. Chem. Res. 2011, 44, 574587.

58. Jun Wang, Xiaohua Liu, Xiaoming Feng*, Asymmetric Strecker Reactions, Chem. Rev. 2011, 111, 69476983.

59.   Wei Li, Xiaohua Liu, Xiaoyu Hao, Xiaolei Hu, Yangyang Chu, Weidi Cao, Song Qin, Changwei Hu, Lili Lin, Xiaoming Feng*, New Electrophilic Addition of α-Diazoesters with Ketones for Enantioselective C-N Bond Formation, J. Am. Chem. Soc. 2011, 133, 1526815271.

60. Yunfei Cai, Xiaohua Liu, Jun Jiang, Weiliang Chen, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric Chloroamination Reaction of α,β-Unsaturated γ-Keto Esters and Chalcones, J. Am. Chem. Soc. 2011, 133, 56365639.

61. Yunfei Cai, Xiaohua Liu, Jun Li, Weiliang Chen, Wentao Wang, Lili Lin, Xiaoming Feng* Asymmetric Iodoamination of Chalcones and 4-Aryl-4-oxobutenoates Catalyzed by a Complex Based on Scandium(III) and a   N,N'-Dioxide Ligand, Chem. Eur. J. 2011, 17, 1491614921.

62. Ke Shen, Xiaohua Liu, Gang Wang, Lili Lin, and Xiaoming Feng*, Facile and Efficient Enantioselective Hydroxyamination Reaction: Synthesis of 3-Hydroxyamino-2-Oxindoles Using Nitrosoarenes, Angew. Chem. Int. Ed. 2011, 50, 46844688.

63. Zhen Wang, Zhigang Yang, Donghui Chen, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Highly Enantioselective Michael Addition of Pyrazolin-5-ones Catalyzed by Chiral N,N'-dioxide-Lanthanide(III) Complex: Metal Directed Reversal of Enantioselectivity, Angew. Chem. Int. Ed. 2011, 50, 49284932.

64. Ke Zheng, Chengkai Yin, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric Addition of Alkyl Enol Ethers to 1,2-Dicarbonyl Compounds: Highly Enantioselective Synthesis of Substituted 3-Alkyl-3-Hydroxyoxindoles, Angew. Chem. Int. Ed. 2011, 50, 25732577.

65. Yunfei Cai, Xiaohua Liu, Yonghai Hui, Jun Jiang, Wentao Wang, Weiliang Chen, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric Bromoamination of Chalcones: Highly Efficient Synthesis of Chiral α-Bromo-β-Amino Ketone Derivatives, Angew. Chem. Int. Ed. 2010, 49, 61606164.

66.  Wei Li, Jun Wang, Xiaolei Hu, Ke Shen, Wentao Wang, Yangyang Chu, Lili Lin, Xiaohua Liu, Xiaoming Feng*, Catalytic Asymmetric Roskamp Reaction of α-Alkyl-α-diazoesters with Aromatic Aldehydes: Highly Enantioselective Synthesis of α-Alkyl-β-keto Esters, J. Am. Chem. Soc. 2010, 132, 85328533.

67.  Zongrui Hou, Jun Wang, Peng He, Jing Wang, Bo Qin, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Highly Enantioselective Insertion of Carbenoids into N-H Bonds Catalyzed by Copper(I) Complexes of Rigid BINOL Derivatives, Angew. Chem. Int. Ed. 2010, 49, 47634766.

68. Yonghai Hui, Jun Jiang, Wentao Wang, Weiliang Chen, Yunfei Cai, Lili Lin, Xiaohua Liu, Xiaoming Feng*, Highly Enantioselective Conjugate Addition of Thioglycolate to Enones Using Mild Lanthanum Catalysis: Lower Catalyst Loading and Remarkably Chiral Amplification, Angew. Chem. Int. Ed. 2010, 49, 42904293.

69.  Mingsheng Xie, Xiaohong Chen, Yin Zhu, Bo Gao, Lili Lin, Xiaohua Liu, Xiaoming Feng*. Asymmetric Three-Component Inverse Electron-Demand Aza-Diels-Alder Reaction: Efficient Synthesis of Ring-Fused Tetrahydroquinolines, Angew. Chem. Int. Ed. 2010, 49, 37993802.

70. Ke Shen, Xiaohua Liu, Wentao Wang, Gang Wang, Weidi Cao, Wei Li, Xiaolei Hu, Lili Lin, Xiaoming Feng*, Highly Enantioselective Synthesis of 1,3-Bis(hydroxymethyl)-2-oxindoles from Unprotected Oxindoles and Formalin Using a Chiral Nd(III) Complex, Chem. Sci. 2010, 1, 590595.

71. Shunxi Dong, Xiaohua Liu, Xiaohong Chen, Fang Mei, Yulong Zhang, Bo Gao, Lili Lin, Xiaoming Feng*, Chiral Bisguanidine-Catalyzed Inverse-Electron-Demand Hetero-Diels-Alder Reaction of Chalcones with Azlactones, J. Am. Chem. Soc. 2010, 132, 1065010651.

72. Jun Wang, Wentao Wang, Wei Li, Xiaolei Hu, Ke Shen, Cheng Tan, Xiaohua Liu, Xiaoming Feng*, Asymmetric Cyanation of Aldehydes, Ketones, Aldimines, and Ketimines Catalyzed by a Versatile Catalyst Generated from Cinchona Alkaloid, Achiral Substituted 2,2’-Biphenol and Tetraisopropyl Titanate, Chem. Eur. J. 2009, 15, 1164211659.

73.  Zhipeng Yu, Xiaohua Liu, Lin Zhou, Lili Lin, Xiaoming Feng*, Bifunctional Guanidine via an Amino Amide Skeleton for Asymmetric Michael Reactions of β-Ketoesters with Nitroolefins: A Concise Synthesis of Bicyclic β-Amino Acids, Angew. Chem. Int. Ed. 2009, 48, 51955198.

74. Xiaohua Liu, Lili Lin, Xiaoming Feng*, Amide-Based Bifunctional Organocatalysts in Asymmetric Reactions, Chem. Commun. 2009, 61456158.

75. Ke Zheng, Jian Shi, Xiaohua Liu, Xiaoming Feng*, Asymmetric Carbonyl-Ene Reaction Catalyzed by Chiral   N,N'-Dioxide-Nickel(II) Complex: Remarkably Broad Substrate Scope, J. Am. Chem. Soc. 2008, 130, 1577015771.

76. Lijia Wang, Xiaohua Liu, Zhenhua Dong, Xuan Fu, Xiaoming Feng*, Asymmetric Intramolecular Oxa-Michael Addition of Activated α,β-Unsaturated Ketones Catalyzed by a Chiral  N,N'-Dioxide Nickel(II) Complex: Highly Enantioselective Synthesis of Flavanones, Angew. Chem., Int. Ed. 2008, 47, 86708673.

77.  Xu Yang, Xin Zhou, Lili Lin, Lu Chang, Xiaohua Liu, Xiaoming Feng*, Highly Enantioselective Direct Michael Addition of Nitroalkanes to Nitroolefins Catalyzed by La(OTf)3/N,N'-Dioxide Complexes, Angew. Chem. Int. Ed. 2008, 47, 70797081

78.  Yuehong Wen, Bo Gao, Yingzi Fu, Shunxi Dong, Xiaohua Liu, Xiaoming Feng*, Asymmetric Three-Component Strecker Reactions Catalyzed by trans-4-Hydroxy-L-proline-Derived N,N'-Dioxides, Chem. Eur. J. 2008, 14, 67896795.

79. Zongrui Hou, Jun Wang, Xiaohua Liu, Xiaoming Feng*, Highly Enantioselective Strecker Reaction of Ketoimines Catalyzed by an Organocatalyst from (S)-BINOL and L-Prolinamide, Chem. Eur. J. 2008, 14, 44844486.

80. Zhipeng Yu, Xiaohua Liu, Zhenhua Dong, Mingsheng Xie, Xiaoming Feng*, An  N,N'-Dioxide/In(OTf)3 Catalyst for the Asymmetric Hetero-Diels-Alder Reaction Between Danishefsky's Dienes and Aldehydes: Application in the Total Synthesis of Triketide, Angew. Chem., Int. Ed. 2008, 47, 13081311.

81. Xin Zhou, Xiaohua Liu, Xu Yang, Deju Shang, Junguo Xin, Xiaoming Feng*, Highly Enantioselective Hydrophosphonylation of Aldehydes Catalyzed by Tridentate Schiff Base Aluminum(III) Complexes, Angew. Chem. Int. Ed. 2008, 47, 392394.

82.  Jie Liu, Zhigang Yang, Zhen Wang, Fei Wang, Xiaohong Chen, Xiaohua Liu, Xiaoming Feng*, Zhishan Su, Changwei Hu*, Asymmetric Direct Aldol Reaction of Functionalized Ketones Catalyzed by Amine Organocatalysts Based on Bispidine, J. Am. Chem. Soc. 2008, 130, 56545655.

83.  Jun Wang, Xiaolei Hu, Jun Jiang, Shaohua Gou, Xiao Huang, Xiaohua Liu, Xiaoming Feng*, Asymmetric Activation of tropos 2,2'-Biphenol with Cinchonine Generating a Remarkably Effective Catalyst for the Asymmetric Strecker Reaction of N-Ts Protected Aldimines and Ketoimines, Angew. Chem. Int. Ed. 2007, 46, 84688470.

84. Yuehong Wen, Yan Xiong, Lu Chang, Jinglun Huang, Xiaohua Liu, Xiaoming Feng*, Chiral Bisformamides as Effective Organocatalysts for Asymmetric One-pot, Three-Component Strecker Reaction, J. Org. Chem. 2007, 72, 77157719.

85. Xin Zhang, Donghui Chen, Xiaohua Liu, Xiaoming Feng*, Enantioselective Allylation of Ketones Catalyzed by N,N-Dioxide and Indium(III) Complex, J. Org. Chem. 2007, 72, 52275233.

86. Bo Qin, Xiaohua Liu., Jian Shi, Ke Zheng, Haitao Zhao, Xiaoming Feng*, Enantioselective Cyanosilylation of α,α-Dialkoxy Ketones Catalyzed by Proline-Derived in Situ Prepared N-Oxides as Bifunctional Organocatalysts, J. Org. Chem. 2007, 72, 23742378.

87.  Jinglun Huang, Xiaohua Liu, Yuehong Wen, Bo Qin, Xiaoming Feng*, Enantioselective Strecker Reaction of Phosphinoyl Ketoimines Catalyzed by in situ Prepared Chiral   N,N'-Dioxides, J. Org. Chem. 2007, 72, 204208.

88.   Xiao Huang, Jinglun Huang, Yuehong Wen, Xiaoming Feng*, Asymmetric Strecker Reaction of Ketoimines Catalyzed by a Novel Chiral Bifunctional   N,N'-Dioxide, Adv. Synth. Catal. 2006, 348, 25792584.

89.   Yuehong Wen, Xiao Huang, Jinglun Huang, Yan Xiong, Bo Qin, Xiaoming Feng*, Asymmetric Cyanosilylation of Aldehydes Catalyzed by Novel Organocatalysts, Synlett 2005, 24452448.

90. Xiaohua Liu, Bo Qin, Bin He, Xiaoming Feng*, Catalytic Asymmetric Cyanosilylation of Ketones by a Chiral Amino Acid Salt, J. Am. Chem. Soc. 2005, 127, 1222412225.

91. Fu-Xue Chen, Hui Zhou, Xiaohua Liu, Bo Qin, Xiaoming Feng*, Guolin Zhang, Yaozhong Jiang, Enantioselective Cyanosilylation Of Ketones by a Catalytic Double-Activation Method Using Aluminum Complex and N-oxide, Chem. Eur. J. 2004, 10, 47904797.

92. Xiaoming Feng, Lianhe Shu, Yian Shi*, Complete Conversion of Racemic Enol Ester Epoxides into Optically Active α-Acyloxy Ketones, J. Am. Chem. Soc. 1999, 121, 1100211003.