四川大学化学学院
师资力量

付海燕     副教授

研究方向:过渡金属催化的方法学研究

联系方式:028-85412904          Email:haijianfu@163.com

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简历

教育经历

1994/9-1998/7,四川大学化学学院,学士

2000/9-2003/7,四川大学化学学院,硕士,导师:陈华

2003/9-2006/7,四川大学化学学院,博士,导师:陈华

科研与学术工作经历

2006/7-2009/7,四川大学化学学院,任教

2009/7-至今,四川大学化学学院,副教授

2011/4-2012/4,法国雷恩一大,访问学者,师从Henri Doucet教授

2013/9-2015/3,美国Scripps研究所,访问学者,师从余金权教授

主要研究方向

1. 过渡金属催化的新型碳-碳,碳-杂偶联反应研究,包括HeckSuzukiSonagashira等传统交叉偶联反应等;

2. 发展新的杂环化合物的构建及衍生方法;

3. 缺电芳杂环的官能化反应研究;

4. 导向C-H键官能化反应;

5. 不对称氢甲酰化反应研究

主要工作业绩

1. 国家自然科学基金面上项目,21871187,   缺电杂芳环的C-H官能化反应—惰性C-H键活化新策略研究, 2019/01-2022/12 65万,主持

2. 四川省科技计划项目,2018GZ0312,缺电杂芳环的C-H官能化反应,2018.1-2019.12 20万,主持

3. 四川大学-泸州合作项目,2018CDLZ-13,基于C-H活化方法的吡啶药物分子合成研究及生物活性测试,2019.1-2020.1230万,主持

4. 绿色催化四川省高校重点实验室开放基金项目,LZJ1901,基于联吡啶骨架新型膦配体的合成和应用研究,2019.07-2021.065万,主持

5. 国家自然科学基金面上项目,21072138, 负载金属催化剂表面羟基和溶剂水对羧基加氢的作用机理研究,2011/01-2014/1236万,已结题,主研

6. 国家自然科学基金青年基金项目, 21202104 含氮四膦配体及其钯配合物的合成,表征及其催化Heck反应研究,2013/01--2015/12, 25万元,已结题,主持

ScienceJ.   Am. Chem. Soc.Angew.Chem. Int. Ed.Org. Lett.Chem.Commun.J. Org.   Chem.Adv. Synth.Catal.Eur. J. Org. Chem.J. Mol. Catal. A: Chem.;   Appl. Catal. A: General等杂志上发表论文100多篇,申请发明专利5,授权2项;主持和参研自然科学基金及企业合作项目10余项。

代表性成果 (获奖成果、专著、论文、专利)

代表性论文

1. Zheng,   Y.; Nie, X.; Long, Y.; Ji, L.; Fu, H*.; Zheng, X.; Chen, H.; Li, R*. Ruthenium-catalyzed   synthesis of N-substituted lactams by acceptorless dehydrogenative coupling   of diols with primary amines. Chem Commun 2019, 55,12384-12387

2. Liu,   H. M.; Jian, L.; Li, C.; Zhang, C. C.; Fu, H. Y.*; Zheng, X. L.; Chen, H.;   Li, R. X.*, Dehydrogenation of Alcohols to Carboxylic Acid Catalyzed by in   Situ-Generated Facial Ruthenium-CPP Complex. J Org Chem, 2019. 84(14):   p. 9151-9160.

3. Li,   W.; Liu, H.; Chen, X.; Li, S.; Zheng, R.; Zhang, C.; Zheng, X.; Yuan, M.; Li,   R.; Fu, H.*; Chen, H*. Palladium-catalyzed direct ortho-alkynylation of   aryl acetamides with low catalyst loading. Tetrahedron Letters.   2019, 60, 1875

4. Yang,   X.; Sun, R.; Zhang, C.; Zheng, X.*; Yuan, M.; Fu, H.*; Li, R.; Chen, H., Iridium-Catalyzed   Benzylamine C-H Alkenylation Enabled by Pentafluorobenzoyl as the Directing   Group. Org Lett, 2019. 21(4): p. 1002-1006.

5. Hao,   T. T.; Liang, H. R.; Ou-Yang, Y. H.; Yin, C. Z.; Zheng, X. L.; Yuan, M. L.;   Li, R. X.; Fu, H. Y.*; Chen, H.*, Palladium-Catalyzed Domino Reaction for   Stereoselective Synthesis of Multisubstituted Olefins: Construction of Blue   Luminogens. J Org Chem, 2018. 83(8): p. 4441-4454.

6. Jia,   F.; Yin, C.; Zeng, Y.; Sun, R.; Ge, Y. C.; Xu, D.; Li, R.; Chen, H.; Zhang, C*.;   Fu, H.*, Mechanism of Direct C-H Arylation of Pyridine via a Transient   Activator Strategy: A Combined Computational and Experimental Study. J   Org Chem, 2018. 83(17): p. 10389-10397.

7. Sun,   R.; Yang, X.; Chen, X.; Zhang, C.; Zhao, X.; Wang, X.; Zheng, X.; Yuan, M.;   Fu, H.*; Li, R.; Chen, H.*, Rh(III)-Catalyzed [4 + 2] Self-Annulation of   N-Vinylarylamides. Org Lett, 2018. 20(21): p. 6755-6759.

8. Yin,   C.; Zhong, K.; Li, W.; Yang, X.; Sun, R.; Zhang, C.; Zheng, X.; Yuan, M.; Li,   R.; Lan, Y.; Fu, H*.; Chen, H*, C6-Selective Direct Arylation of   2-Phenylpyridine via an Activated N-methylpyridinium Salt: A Combined   Experimental and Theoretical Study. Advanced Synthesis & Catalysis,   2018. 360(20): p. 3990-3998

9. Zeng,   Y.; Zhang, C.; Yin, C.; Sun, M.; Fu, H.*; Zheng, X.; Yuan, M.; Li, R.; Chen,   H. *, Direct C-H Functionalization of Pyridine via a Transient Activator   Strategy: Synthesis of 2,6-Diarylpyridines. Org Lett 2017, 19   (8), 1970-1973.

10.Huang, J.; Wang, W.; He, H.-Y.; Jian,   L.; Fu, H.-Y. *; Zheng, X.-L.; Chen, H.; Li, R.-X.*, An Approach to the   Synthesis of 1-Propenylnaphthols and 3-Arylnaphtho[2,1-b]furans. The   Journal of Organic Chemistry 2017, 82 (5), 2523-2534.

11.Fu, H.; Shen, P. X.; He, J.; Zhang, F.; Li,   S.; Wang, P.; Liu, T.; Yu, J. Q., Ligand-Enabled Alkynylation of C(sp3 )-H   Bonds with Palladium(II) Catalysts. Angewandte Chemie 2017, 56 (7),   1873-1876.

12.Li, W.; Yin, C.; Yang, X.; Liu, H.;   Zheng, X.; Yuan, M.; Li, R.; Fu, H.; Chen, H.Cu(ii)-Mediated keto C(sp(3))-H   bond alpha-acyloxylation of N,N-dialkylamides with aromatic carboxylic acids.   Org Biomol Chem, 2017. 15(36): p. 7594-7599

13.Liu, H.; Han, W.; Li, C.; Ma, Z.; Li,   R.; Zheng, X.; Fu, H. *; Chen, H. *, Practical Synthesis of Phenanthridinones   by Palladium-Catalyzed One-Pot C-C and C-N Coupling Reaction: Extending the   Substrate Scope too-Chlorobenzamides. European Journal of Organic   Chemistry 2016, 2016 (2), 389-393.

14.Wang, W.; Huang, J.; Zhou, R.; Jiang,   Z.-J.; Fu, H.-Y. *; Zheng, X.-L.; Chen, H.; Li, R.-X.*, A Simple and   Efficient Access to Naphtho[b]furans by Claisen Rearrangement/Cyclization of   Bromonaphthyl 3-Phenylallyl Ethers. Advanced Synthesis & Catalysis 2015,   357 (11), 2442-2446.

15.Ma, Z.; Liu, H.; Zhang, C.; Zheng, X.; Yuan,   M.; Fu, H. *; Li, R.; Chen, H. *, One-Pot Synthesis of Symmetrical 2,6-DiarylpyridinesviaPalladium/Copper-Catalyzed   Sequential Decarboxylative and Direct CH Arylation. Advanced Synthesis   & Catalysis 2015, 357 (6), 1143-1148.

16.Ge, Y.; Cheng, Y.; Fu, H. *; Zheng, X.;   Li, R.; Chen, H. *; Li, X., Suzuki-Miyaura cross-coupling reaction catalyzed   by a highly stable Pd(P-Phos)Cl-2 complex at room temperature under air. Chinese   Journal of Catalysis 2013, 34 (9), 1667-1673.

17.Fu, H.; Chen, H.; Doucet, H., Palladium-catalyzed   selective decarboxylative coupling reaction versus direct C?H arylation for   arylation of heteroaromatics. Applied Organometallic Chemistry 2013, 27   (10), 595-600.

18.Fu, H. Y.; Zhao, L.; Bruneau, C.;   Doucet, H., Palladium-Catalysed Direct Heteroarylations of Heteroaromatics   Using Esters as Blocking Groups at C2 of Bromofuran and Bromothiophene   Derivatives: A One-Step Access to Biheteroaryls. Synlett 2012, (14),   2077-2082.

19.Fu, H. Y.; Chen, L.; Doucet, H.,   Phosphine-Free Palladium-Catalyzed Direct Arylation of Imidazo 1,2-a   pyridines with Aryl Bromides at Low Catalyst Loading. Journal of Organic   Chemistry 2012, 77 (9), 4473-4478.

20.Pi, X.; Zhou, Y.; Zhou, L.; Yuan, M.;   Li, R.; Fu, H. *; Chen, H.*, Dicyclopentadiene Hydroformylation in an Aqueous/Organic   Two Phase System in the Presence of a Cationic Surfactant. Chinese Journal   of Catalysis 2011, 32 (4), 566-571.

21.Liu, H.; Yuan, M.; Guo, C.; Li, R.; Fu,   H. *; Chen, H. *; Li, X., Selective Hydrogenation of Cinnamaldehyde to   Cinnamyl Alcohol over Ru/ZrO2 center dot xH(2)O Catalyst. Chinese Journal   of Catalysis 2011, 32 (7), 1256-1261.

22.Fu, H. Y.; Doucet, H., Methyl 2-Furoate:   An Alternative Reagent to Furan for Palladium-Catalysed Direct Arylation. European   Journal of Organic Chemistry 2011, (35), 7163-7173.

23.Fu, H.; Yuan, M.; Chen, H.; Li, R.; Li, X.,   Progress of Olefin Hydroformylation Catalyzed by Water-Soluble Rhodium-Phosphine   Complexes. Chinese Journal of Catalysis 2010, 31 (3), 251-260.

24.Mao, H.; Fu, H. *; Chen, H. *; Li, R.;   Li, X., Synergistic Effect of TPPTS and TPPDS on the Regioselectivity for 1-Decene   Hydroaminomethylation in a Two-Phase Catalytic System. Chinese Journal of   Catalysis 2009, 30 (12), 1192-1196.

25.Fu, H.; Li, M.; Mao, H.; Lin, Q.; Yuan,   M.; Li, X.; Chen, H., Aqueous biphasic catalytic hydroformylation of higher   olefins: Promotion effect of cationic gemini and trimeric surfactants. Catalysis   Communications 2008, 9 (7), 1539-1544.

26.Fu, H.; Li, M.; Chen, J.; Zhang, R.;   Jiang, W.; Yuan, M.; Chen, H.; Li, X., Application of a new amphiphilic   phosphine in the aqueous biphasic catalytic hydroformylation of long chain   olefins. Journal of Molecular Catalysis a-Chemical 2008, 292   (1-2), 21-27.

27.Fu, H.; Li, M.; Chen, H.; Li, X., Higher   olefin hydroformylation in organic/aqueous biphasic system accelerated by double   long-chain cationic surfactants. Journal of Molecular Catalysis a-Chemical   2006, 259 (1-2), 156-160.

28.Fu, H.; Guo, Y.; Lin, Q.; Chen, H.; Li,   X., Cocatalytic effect of new surface-active phosphine in long-chain olefin   hydroformylation. Chinese Journal of Catalysis 2006, 27 (12),   1053-1058.

 

授权专利:

1. 一种菲类化合物及其制备工艺,付海燕,浩涛涛,陈华,中国专利,ZL   2016106247098 (2018)

2. 一种吡啶类化合物双碳氢活化芳基化的方法,付海燕, 曾阳,陈华,郑学丽,袁茂林,李瑞祥,中国专利,ZL201610624803.3   (2018)

 

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