四川大学化学学院
师资力量

王天利     教授(国家青千)

研究方向:

联系方式:13540294716          Email:wangtl@scu.edu.cn

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简历

2016.09——至今,四川大学化学学院,教授

2012.06—2016.08National  University of Singapore,博后研究员,合作导师:Prof.   Lu Yixin

2011.08—2012.05,中国科学院化学研究所,助理研究员

2006.09—2011.07,中国科学院化学研究所,有机化学,理学博士,导师:范青华研究员

2002.09—2006.07,四川大学,应用化学,理学学士,导师:冯小明教授,范青华研究员

主要研究方向

有机催化方法学

绿色有机合成化学

有机反应机理研究

生物活性化合物合成新方法研究

课题组诚招副研究员、博士后、研究助理、硕博生以及联合培养学生!热烈欢迎本科生加入本课题组开展大创项目和本科毕业设计!

 

主要工作业绩

承担科研项目及基金

国家千人计划青年项目(2017获批)

国家自然科学基金委青年基金项目(2017获批)

四川省千人计划青年项目(2017获批)

国家自然科学基金委面上基金项目(2019获批)

科技部合成生物学重大专项(青年)项目(2019获批)

基金委创新群体项目子课题(2019获批)

主要工作业绩

不对称催化合成是化学学科、乃至药物和材料领域的前沿和研究热点,手性化合物尤其是具有潜在生理活性的手性分子的精准构筑是当前合成化学们关注的重点。王天利博士先后在金属不对称催化(主要是过渡金属催化芳香杂环不对称氢化)和有机小分子不对称催化(主要是有机膦()催化不对称合成)这两个大的不对称催化领域开展了系统深入的研究,取得了系列开拓性的重要创新成果。

回国入职四川大学开始独立工作之后,王天利博士主要围绕 五价鏻 / 膦催化的不对称合成化学开展独立研究工作,基于廉价易得的天然氨基酸手性骨架,发展了结构新颖和多样的手性双功能季鏻盐催化剂,率先建立了手性催化剂库,重点开展基于季鏻催化的不对称合成化学前沿研究,在国际上率先展开了在多功能手性季鏻催化领域的集中系统性研究。设计发展的多功能手性季鏻盐催化剂在多种不对称催化反应中表现出了优秀的催化效果,成功实现了许多传统催化剂(如季铵盐、三级胺及手性磷酸等)不能实现的催化反应,解决了不对称催化和手性合成领域的研究难题。课题组重点发展潜在生理活性分子的精准高效构筑新方法,已经实现了多种手性杂环(比如三、四、五、六元环状分子,七元杂环分子等)、手性螺环、手性桥环、以及多种手性共存的复杂有机分子的精准不对称合成。最近,我们基于C-X键的不对称构建策略,精准构筑了一系列不同杂原子取代的手性季碳类有机分子,为手性季碳类化合物尤其是手性药物等开发提供了新的合成思路。

王天利博士已经在 Acc.   Chem. Res. J. Am.   Chem. Soc. Angew.   Chem. Int. Ed. Chem.   Sci. 以及   Chem. Commun. 等国际顶级及权威刊物上发表SCI论文近30篇。部分研究成果(如 J. Am. Chem. Soc. 2011)已被多篇综述和多本专著收录,并被选作相关领域的重要进展被重点评述( Chem.   Soc. Rev. 2014, 43, 1660; Chem.   Rev. 2012, 112, 2557; “Organic Reaction Mechanisms” (Wiley,   2011)“Progress in   Heterocyclic Chemistry” (Elsevier, 2012)“Comprehensive Organic Synthesis II” (Elsevier, 2014));部分论文(如 Angew. Chem. Int. Ed. 2019; Angew. Chem. Int. Ed. 2013; J. Am.   Chem. Soc. 2016)被   Synfacts , X-mol以及 Chin. J. Org. Chem. 等专业评述杂志或网站作亮点推荐。

荣誉及获奖情况

2018年, 四川大学优秀本科毕业设计指导奖

2017年, 科学中国人2017年度人物奖(青年)

2017年, 四川大学青年科技人才奖

2017年, 四川大学好未来优秀学者奖

2016年, Gold   Award of Outstanding Mentor for “Singapore   Science and Engineering Fair (SSEF) 2016”(金奖,新加坡教育部)

2011年, 中国科学院化学研究所研究生系列报告奖

2010年, 中国科学院化学研究所青年科学特别奖

2010年, 第三届 “CCME-IOC &   ICCAS-LMRSS” Alfa Aesa 研究生学术研讨会优秀报告奖

2009年, 中国科学院化学研究所青年科学优秀奖

2009年, The Third   ChemComm International Symposium “The Three Best Poster Prize”(英国皇家化学会)

2009年, 中国科学院研究生院三好学生

2008年, 中国科学院化学研究所青年科学优秀奖

2007年, 中国科学院研究生院三好学生

2007年, 中国科学院研究生院优秀学生干部

2002-2006,国家一等奖学金(2003),四川大学优秀毕业论文一等奖(2006),并多次获得四川大学一等奖学金、优秀学生干部、三好学生、优秀学生等荣誉。

代表性成果 (获奖成果、专著、论文、专利)

 1. Jianke   Pan; Jia-Hong Wu; Hongkui Zhang; Xiaoyu Ren; Jian-Ping Tan; Lixiang Zhu;   Hong-Su Zhang; Chunhui Jiang; Tianli Wang,* “Highly   Enantioselective Synthesis of Fused Tri- and Tetrasubstituted Aziridines:   aza-Darzens Reaction of Cyclic Imines with α-Halogenated Ketones Catalyzed by   Bifunctional Phosphonium Salt”, Angew. Chem. Int. Ed. 2019, 58,   7425 –7430. ( Highlighted by Synfacts 2019, and X-mol)

2. Jian-Ping Tan, Peiyuan Yu,   Jia-Hong Wu, Yuan Chen, Jianke Pan, Chunhui Jiang, Xiaoyu Ren, Hong-Su Zhang,   Tianli Wang,* “Bifunctional Phosphonium Salt Directed   Enantioselective Formal [4 + 1] Annulation of Hydroxyl-Substituted para-Quinone   Methides with α-Halogenated Ketones”, Org. Lett. 2019, DOI:   10.1021/acs.orglett.9b02560.

3. Chunhui Jiang, Yayun Chen,   Hongkui Zhang, Jian-Ping Tan, Tianli Wang,* “Catalyst-Free   Synthesis of α-Functionalized 2H-Chromenes in Water: A Tandem Self-Promoted   pseudo-Substitution and Decarboxylation Process”, Chem. Asian J. 2019,   14, 2938?2944.

4. Guofei Huang, Xiaoyu Ren,   Chunhui Jiang, Jia-Hong Wu, Guowei Gao, Tianli Wang,* “Efficient   synthesis of (E)-2-nitromethylcinnamates via phosphine-catalyzed tandem   α-addition and 1,3-rearrangement”, Org. Chem. Front., 2019, 6,   2872–2876.

5. Jia-Hong Wu, Jianke Pan, Tianli   Wang,* “Dipeptide-Based Phosphonium Salt Catalysis: Application to   Enantioselective Synthesis of Fused Tri- and Tetrasubstituted Aziridines”, Synlett.,   2019, DOI: 10.1055/s-0039-1690192.

6.  Tianli Wang,   Xiaoyu Han, Fangrui Zhong, Weijun Yao, and Yixin Lu,* “Amino Acid-derived   Bifunctional Phosphines for Enantioselective Transformations”, Acc. Chem.   Res., 2016, 49, 1369?1378 .

7.  Tianli Wang,   Zhaoyuan Yu, Ding Long Hoon, Claire Yan Phee, Yu Lan, and Yixin Lu,*   “Regiodivergent Enantioselective γ-Additions of Oxazolones to   2,3-Butadienoates Catalyzed by Phosphines: Synthesis of α,α-Disubstituted   α-Amino Acids and N, O-Acetal Derivatives”, J. Am. Chem.   Soc. 2016, 138, 265?271. ( Highlighted by Synfacts 2016,   12, 309)

8.  Tianli Wang, Ya   Chen, Guanghui Ouyang, Yan-Mei He,* Zhiyan Li and Qing-Hua Fan* “Solvent   Regulated Asymmetric Hydrogenation of Quinoline Derivatives in Oligo(ethylene   glycol)s via Host-Guest Interactions”, Chem. Asian J. 2016,   11, 2773?2777.

9.  Tianli Wang,   Zhaoyuan Yu, Ding Long Hoon, Kuo-Wei Huang, Yu Lan,* Yixin Lu,* “Highly   Enantioselective Construction of Tertiary Thioethers and Alcohols via   Phosphine-Catalyzed Asymmetric g-Addition reactions of 5 H-Thiazol-4-ones   and 5 H-Oxazol-4-ones: Scope and Mechanistic Understandings”, Chem.   Sci. 2015, 6, 4912 ?4922.  

10.  Tianli Wang,   Ding Long Hoon, and Yixin Lu,* “Enantioselective Synthesis of   3-Fluoro-3-allyl-oxindoles via Phos-phine-Catalyzed Asymmetric g-addition of   3-Fluoro-Oxindoles to 2,3-Butadienoates”, Chem. Commun. 2015, 51,   10186?10189.

11.  Tianli Wang,   Weijun Yao, Fangrui Zhong, Guo Hao Pang, Yixin Lu,* “Phosphine-Catalyzed   Enantioselective g-Addition of 3-Substituted Oxindoles to 2,3-Butadienoates   and 2-Butynoates: Use of Prochiral Nucleophiles”, Angew. Chem. Int. Ed.   2014, 53, 2964?2968.

12.  Tianli Wang, Fei   Chen, Jie Qin, Yan-Mei He, Qing-Hua Fan,* “Asymmetric Ruthenium-Catalyzed   Hydrogenation of 2- and 2,9-Substituted 1,10-Phenanthrolines”, Angew.   Chem. Int. Ed. 2013, 52, 7172?7176. (Highlighted by Chin.   J. Org. Chem. 2013, 33, 2028)

13.  Tianli Wang,   Lian-Gang Zhuo, Zhi Wei Li, Fei Chen, Zi Yuan Ding, Yanmei He, Qing-Hua Fan,*   Jun Feng Xiang, Zhi-Xiang Yu,* Albert S. C. Chan, “Highly Enantioselective   Hydrogenation of Quinolines Using Phosphine-Free Chiral Cationic Ruthenium   Catalysts: Scope, Mechanism and Origin of Enantioselectivity”, J. Am.   Chem. Soc. 2011, 133, 9878?9891.

14.  Tianli Wang ,   Guanghui Ouyang, Yan-Mei He and Qing-Hua Fan,*“Asymmetric Tandem   Reduction of 2-(Aroylmethyl)quinolines with Phosphine-Free Ru-TsDPEN   Catalyst”, Synlett. 2011, 7, 939? 942.

15. Zhen Wang, Tianli Wang,   Weijun Yao, Yixin Lu,* “Phosphine-Catalyzed Enantioselective [4 + 2]   Annulation of o-Quinone Methides with Allene Ketones”, Org. Lett. 2017,   19, 4126?4129.

16. Xiaoyu Han, Weijun Yao, Tianli   Wang, Yong Ren Tan, Ziyu Yan, Jacek. Kwiatkowski, Yixin. Lu,* “Asymmetric   Synthesis of Spiropyrazolones through Phosphine-Catalyzed [4+1] Annulation”, Angew.   Chem. Int. Ed. 2014, 53, 5643 ?5647.  

17. Zi-Yuan Ding, Tianli Wang,   Yan-Mei He, Fei Chen, Hai-Feng Zhou, Qing-Hua Fan,* Qingxiang Guo,* and   Albert S. C. Chan, “Highly Enantioselective Synthesis of Chiral   Tetrahydroquinolines and Tetrahydroisoquinolines by Ruthenium-Catalyzed   Asymmetric Hydrogenation in Ionic Liquid”, Adv. Synth. Catal. 2013,   355, 3727?3735.

18. Fei Chen, Tianli Wang,   Yanmei He, Ziyuan Ding, Zhiwei Li, Lijin Xu and Qing-Hua   Fan,*"Asymmetric Hydrogenation of N-Alkyl Ketimines with   Phosphine-Free, Chiral, Cationic Ru-MsDPEN Catalysts",  Chem. Eur. J.2011, 17,   1109?1113.

19. Zhi-Wei Li, Tianli Wang,   Yan-Mei He, Zhi-Jian Wang, Qing-Hua Fan,*Jie Pan and Li-Jin Xu,*   "Air-Stable and Phosphine-Free Iridium Catalysts for Highly   Enantioselective Hydrogenation of Quinoline Derivatives",  Org. Lett.2008, 10,   5265?5268.

20. Haifeng Zhou, Zhiwei Li, Zhijian   Wang, Tianli Wang, Lijin Xu, Yanmei He, Qing-Hua Fan,*Jie   Pan, Lianquan Gu and Albert S. C. Chan,* "Hydrogenation of Quinolines   Using a Recyclable Phosphine-Free Chiral Cationic Ruthenium Catalyst:   Enhancement of Catalyst Stability and Selectivity in an Ionic Liquid", Angew. Chem. Int. Ed.2008, 47,   8464?8467.

21. Zhi-Jian Wang, Hai-Feng Zhou, Tianli   Wang, Yan-Mei He, Qing-Hua Fan,* "Highly Enantioselective   Hydrogenation of Quinolines under Solvent-Free or Highly Concentrated   Conditions",  Green Chem.2009,11, 767?769.  

22. Fei Chen, Ziyuan Ding, Jie Qin, Tianli   Wang, Yanmei He and Qing-Hua Fan,*"Highly Effective   Asymmetric Hydrogenation of Cyclic N-Alkyl Imines with Chiral Cationic   Ru-MsDPEN Catalysts",  Org. Lett, 2011, 13,   4348?4351.

23. Weijun Tang, Yawei Sun, Lijin Xu,* Tianli   Wang, Qing-Hua Fan,Kim-Hung Lam and Albert S. C. Chan,   "Highly Efficient and Enantioselective Hydrogenation of Quinolines and   Pyridines with Ir-Difluorphos Catalyst",  Org. Biomol. Chem.2010, 8,   3464?3471.

24.    Fei Chen, Ziyuan Ding, Yanmei He, Jie Qin, Tianli Wang   and Qing-Hua Fan,*"Asymmetric Hydrogenation of N-Alkyl   and N-Aryl Ketimines using Chiral CationicRu(Diamine) Complexes as   Catalysts: The Counteranion and Solvent Effects, and Substrate   Scope",  Tetrahedron2012, 68,   5248?5257.

 

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