picture
 
郑 柯
职称与职务
教 授
专      业
有机化学
电      话
17760523883
E-Mail
简  历
学习经历:
2007.09~2012.07       四川大学       有机化学专业       理学博士学位
                       师从冯小明教授从事不对称催化的研究
2003.09~2007.07       四川大学       应用化学专业       理学学士学位
                       保送四川大学化学学院有机化学专业攻读博士研究生。
研究及工作经历:
2016.06~至今          四川大学化学学院 教授
2014.10~2016.05       密西根大学安娜堡分校癌症中心
                       研究员
                       合作导师: Dr. Shaomeng Wang
2012.07~2014.09       The Scripps Research Institute
                       研究助理
                       合作导师: Dr. Philip LoGrasso & Dr. Yangbo Feng
主要研究方向
手性药物及生物活性化合物的合成
绿色有机合成方法学
基于调节蛋白间相互作用的小分子抑制剂研究
靶向抗癌药物的理性设计合成
主要工作业绩

 研究经历

郑柯博士先后致力于不对称催化剂的设计合成, 手性药物合成,神经类药物及抗癌药物和抗癌新靶点等多个前沿性领域的研究,取得了一系列创新性的优秀成果;其丰富的跨学科研究经历,为今后的科研工作,特别是交叉学科和转化药学的研究打下了扎实的基础。目前郑柯博士已经在J. Am. Chem. Soc.Angew. Chem. Int. Ed.Chem. Commun.Chem. -Eur. J.ACS Med. Chem. Lett.以及 J. Med. Chem. 等本领域权威刊物发表 SCI 论文和专著 17 篇,并多次被 Synfacts 杂志刊登并给予了高度的评价。其中以第一作者身份发表 SCI 论文 9 篇,申请国际专利 1 篇、美国专利 2 篇。

主要奖励及荣誉

2013      四川省优秀博士学位论文
2012     “四川省优秀毕业研究生”称号
2012     “四川大学优秀毕业研究生”称号
2010      教育部自然科学奖一等奖(第九完成人)
2010      教育部第一届“博士研究生学术新人奖”
2011      唐敖庆化学奖
2007-2010    曾先后获得四川大学“振兴奖学金”(2007),“陶氏化学教育发展奖学金”    (2008),“宝钢优秀学生奖”(2009),“中石化奖学金”(2010)
2007-2011    连续4年获得四川大学创新人才一等奖
2007-2009   “四川大学双十佳优秀学生模范”
2007-2012    连续5年获得“四川大学研究生一等奖学金”及“四川大学优秀研究生”称号
2007     “四川省优秀本科毕业生”称号及“四川大学2007届本科优秀毕业生”称号
代表性成果 (获奖成果、专著、论文、专利)

 论文发表情况

1)       Ke Zheng, Chul Min Park, Sarah Iqbal, Pamela Hernandez, HaJeung Park, Philip V. LoGrasso,* and Yangbo Feng* “Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors” ACS Med. Chem. Lett., (2015), 6(4), 413-418.
2)       Ke Zheng, Sarah Iqbal, Pamela Hernandez, HaJeung Park, Philip V. LoGrasso,* and Yangbo Feng* “Design and Synthesis of Highly Potent and Selective JNK3 Inhibitors: SAR Studies on Aminopyrozal Derivatives” J. Med. Chem.  (2014), 57(23), 10013-10030
3)       Ke Zheng, Xiaohua Liu, Song Qin, Mingsheng Xie, Lili Lin, Changwei Hu, and Xiaoming Feng* “Completely OH-Selective FeCl3 Catalyzed Prins Cyclization: Highly Stereoselective Synthesis of 4-OH-Tetrahydropyrans” J. Am. Chem. Soc. Article (2012), 134, 17564−17573.
4)       Ke Zheng, Lili Lin and Xiaoming Feng* “Chiral N,N '-Dioxide-Ni(II) Complex Catalyzed Asymmetric Carbonyl-Ene Reaction of Ethyl Trifluoropyruvate” Acta Chim. Sinica (2012), 70, 1785-1790.
5)       Ke Zheng, Chengkai Yin, Xiaohua Liu, and Xiaoming Feng* “Catalytic Asymmetric Addition of Alkyl Enol Ethers to 1,2-Dicarbonyl Compounds: Highly Enantioselective Synthesis of Substituted 3-Alkyl-3-Hydroxyoxindoles” Angew. Chem. Int. Ed. (2011), 50, 2573.
6)       Ke Zheng, Xiaohua Liu, Jiannan Zhao, Yang Yang, Lili Lin and Xiaoming Feng* “Highly Enantioselective Aza-Ene-Type Reaction Catalyzed by Chiral N,N’-dioxide-nickel(II) Complex” Chem. Commun. (2010), 46, 3771–3773.
7)       Ke Zheng, Yang Yang, Jiannan Zhao, Chengkai Yin, Lili Lin, Xiaohua Liu and Xiaoming Feng*. “Magnesium(II)-Catalyzed Asymmetric Ketone-Ene Reaction: Stereocontrolled Access to Enantioenriched Trifluoromethyl-Substituted Compounds” Chem. Eur. J. (2010), 16, 9969.
8)       Ke Zheng, Jian Shi, Xiaohua Liu, and Xiaoming Feng*. “Asymmetric Carbonyl-Ene Reaction Catalyzed by Chiral N,N’-Dioxide -Nickel(II) Complex: Remarkably Broad Substrate Scope” J. Am. Chem. Soc. (2008), 130, 15770-15771.
9)       Ke Zheng, Bo Qin, Xiaohua Liu and Xiaoming Feng* “Highly Enantioselective Allylation of a-Ketoesters Catalyzed by N,N’-Dioxide-In(III) Complexes” J. Org. Chem. (2007), 72, 8478-8483.
10)    Y. Yan, K. Zheng, et al, Y. Feng* and P. LoGrasso*. “Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors” J. Med. Chem. (2015), 58(4), 1846-1861.
11)    X. Liu, K. Zheng, and X. M. Feng. “Advancements in the Catalytic Asymmetric Intermolecular Ene-Type Reactions” SYNTHESIS, 2014; 46(17): 2241-2257
12)    J. N. Zhao, K. Zheng, et al and X. M. Feng. “Asymmetric Mukaiyama Aldol Reaction Catalyzed by C2-Symmetric N,N’-Dioxide–Ni(II) Complex” Synlett, (2011), 903-906.
13)    Y. Yang, K. Zheng, et al and X. M. Feng. “Asymmetric Direct Vinylogous Aldol Reaction of Unactivated γ-Butenolide to Aldehydes” J. Org. Chem. (2010), 75, 5382-5384.
14)    P. HaJeung; I. Sarah; H. Pamela; M. Rudy; K. Zheng, et al, Y. Feng and P. LoGrasso. “Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles” Scientific reports (2015), 5, 8047
15)     K. Shen, X. H. Liu, K. Zheng, et al and X. M. Feng. “Catalytic Asymmetric Synthesis of 3-(a-Hydroxy-b-carbonyl) Oxindoles by a Sc(III)-Catalyzed Direct Aldol-Type Reaction” Chem. Eur. J. (2010), 16, 3736-3742.
16)    J. Shi, M. Wang, L. He, K. Zheng, et al and X. M. Feng. “Enantioselective Michael addition of malononitrile to chalcones catalyzed by a simple quinine-Al(OiPr)3 complex: a simple method for thesynthesis of a chiral 4H-pyran derivative” Chem. Commun. (2009), 45, 4711–4713.
17)     B. Qin, X. H. Liu, J. Shi, K. Zheng, et al and X. M. Feng. “Enantioselective Cyanosilylation of a,a-Dialkoxy Ketones Catalyzed by Proline-Derived in-Situ-Prepared N-Oxide as Bifunctional Organocatalys” J. Org. Chem. (2007), 72, 2374.
专利
1. Feng, Yangbo; LoGrasso, Philip V.; Zheng, Ke; Park, Chul Min.;“Novel compounds as jnk kinase inhibitors” WO 2015084936  (2015)
2. Feng, Yangbo; LoGrasso, Philip V.; Wu, Yuntao; Bibian, Mathieu; Park, Chul Min; Fei, Yi; Guo, Jia; Zheng, Ke; Yin, Yan. “Lim Kinase Inhibitors.” U.S. Serial No. 62/109,378.
3. Feng, Yangbo; LoGrasso, Philip V.; Zheng, Ke; Park, Chul Min. “Selective Modulators of JNK Isoforms 2 and 3.” US provisional Patent Appl. (2013), 61911741.