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张 骥
职称与职务
教 授,化学生物学教研室主任
专      业
化学生物学,有机化学
电      话
028-85418580
E-Mail
简  历
理学博士,博士生导师,2011年入选教育部“新世纪优秀人才支持计划”。

1993.9-1997.7: 四川大学化学系,本科学习,物理化学专业
1997.9-2002.6: 四川大学化学学院,硕-博连读,有机化学专业
2002.7-2007.6: 四川大学化学学院,讲师
2003.1-2005.1: 香港大学化学系,Research Assistant
2007.7-2013.6: 四川大学化学学院,副教授
2013.7- : 四川大学化学学院,教授

目前讲授本科生课程包括:
《有机化学I》(203112030 & 203113030, 省级精品课程)
《生物化学》(203080030, 双语课程)
《化学生物学实验》(203197020)
《有机化学实验》
《应用化学设计实验》(203130020)

主要研究方向
生物纳米材料:新型核酸和药物递送系统的设计、合成和建立,基因载体/药物载体的构效关系研究;
有机合成化学:高效、高选择性的绿色合成方法学的研究,微波促进的有机反应方法学研究。
主持国家自然科学基金面上项目、青年基金以及973子课题等多个项目。

主要工作业绩
2011年入选教育部“新世纪优秀人才支持计划”;
2010年教育部高等学校科学研究优秀成果奖(科学技术)自然科学奖一等奖(排名第三);
2015年四川大学首届“五粮春青年教师优秀教学奖”;
2015-16四川大学先进个人(优秀教师);
2012-13年度四川大学十佳青年教师教学奖;
2011、2013、2014、2015年度四川大学本科课堂教学质量优秀奖;
2014年度本科教学管理工作先进个人;
2013年度大学生课外科技实践活动优秀指导教师;
2009、2011、2014年度四川大学“优秀青年骨干教师”。
代表性成果 (获奖成果、专著、论文、专利)
获奖成果:
简单金属盐催化的C-C键和C-N键形成反应,教育部高等学校科学研究优秀成果奖(科学技术)自然科学奖一等奖,2010,第三完成人。
部分代表性论文:
1. Wang, H.-J.; He, X.; Luo, T.-Y.; Zhang, J.*; Liu, Y.-H.; Yu, X.-Q.* “Amphiphilic carbon dots as versatile vector for nucleic acid and drug delivery” Nanoscale. 2017, 9, DOI: 10.1039/C7NR01029J.
2. Zhang, Y.-M; Huang, Z.; Zhang, J.*; Wu, W.-X.; Liu, Y.-H.; Yu, X.-Q.* “Amphiphilic polymers from ring-opening polymerization: a strategy for the enhancement of gene delivery” Biomater. Sci. 2017, 5(4), 718-729.
3. Huang, Z.; Zhang, Y.-M.; Cheng, Q.; Zhang, J.*; Liu, Y.-H.; Wang, B.; Yu, X.-Q.* “Structure-activity relationship studies of symmetrical cationic bolasomes as non-viral gene vectors” J. Mater. Chem. B 2016, 4(33), 5575-5584.
4. Luan, C.-R.; Liu, Y.-H.; Zhang, J.*; Yu, Q.-Y.; Huang, Z.; Wang, B.; Yu, X.-Q.* “Low molecular weight oligomers with aromatic backbone as efficient non-viral gene vectors” ACS Appl. Mater. Interf. 2016, 8(17), 10743-10751.
5. Xun, M.-M.; Xiao, Y.-P.; Zhang, J.*; Liu, Y.-H.; Peng, Q.; Guo, Q.; Wu, W.-X.; Xu, Y.; Yu, X.-Q.* “Low molecular weight PEI-based polycationic gene vectors via Michael addition polymerization with improved serum-tolerance” Polymer 2015, 65, 45-54.
6. Guo, Q.; Liu, Y.-H.; Xun, M.-M.; Zhang, J.*; Huang, Z.; Zhou, X.-D.; Yu, X.-Q.* “Diol glycidyl ether-bridged low molecular weight PEI as potential gene delivery vehicles” J. Mater. Chem. B 2015, 3(13), 2660-2670.
7. Zhang, Q.-F.; Yu, Q.-Y.; Geng, Y.; Zhang, J.*; Wu, W.-X.; Wang, G.; Gu, Z.; Yu, X.-Q.* “Ring-opening polymerization for hyperbranched polycationic gene delivery vectors with excellent serum tolerance” ACS Appl. Mater. Interfaces 2014, 6(18), 15733-15742.
8. Yi, W.-J.; Yu, X.-C.; Wang, B.; Zhang, J.*; Yu, Q.-Y.; Zhou, X.-D.; Yu, X.-Q.* “TACN-based oilgomers with aromatic backbones for efficient nucleic acid delivery” Chem. Commun. 2014, 50(49), 6454-6457.
9. Yi, W.-J.; Zhang, Q.-F.; Zhang, J.*; Liu, Q.; Ren, L.; Chen, Q.-M.; Guo, L.; Yu, X.-Q.* “Cyclen-based lipidic oligomers as potential gene delivery vehicles” Acta Biomater. 2014, 10(3), 1412-1422.
10. Wang, H.-J.; Liu, Y.-H.; Zhang, J.*; Zhang, Y.; Xia, Y.; Yu, X.-Q.* “Cyclen-based cationic lipids with double hydrophobic tails for efficient gene delivery” Biomaterials Sci. 2014, 2(10), 1460-1470.
11. Li, C.-Y.; Wang, H.-J.; Cao, J.-M; Zhang, J.*; Yu, X.-Q.* “Bioreducible cross-linked polymers based on G1 peptide dendrimer as potential gene delivery vectors” Eur. J. Med. Chem. 2014, 87, 413-420.
12. Zhang, Q.-F.; Yi, W.-J.; Wang, B.; Zhang, J.*; Ren, L.; Chen, Q.-M.; Guo, L.; Yu, X.-Q.* “Linear polycations by ring-opening polymerization as non-viral gene delivery vectors: structure-activity relationship studies” Biomaterials 2013, 34(21), 5391-5401.
13. Xun, M.-M.; Zhang, X.-C.; Zhang, J.*; Jiang, Q.-Q.; Yi, W.-J.; Zhu, W.; Yu, X.-Q.* “Low molecular weight PEI-based biodegradable lipopolymers as gene delivery vectors” Org. Biomol. Chem. 2013, 11(7), 1242-1250.
14. Wang, J.; Wang, S.; Wang, G.; Zhang, J.*; Yu, X.-Q.* “Iron-Mediated Direct Arylation with Arylboronic Acids through an Aryl Radical Transfer Pathway” Chem. Commun. 2012, 48(96), 11769-11771.
15. Huang, Q.-D.; Ren, J.; Chen, H.; Ou, W.-J.; Fu, Y.; Zhang, J.*; Zhu, W.; Yu, X.-Q.* “Cyclen based-cationic lipids containing carbamate linkages as efficient gene delivery vector with low toxicity” ChemPlusChem 2012, 77(7), 584-591.
16. Feng, J.; Liang, S.; Chen, S.-Y.; Zhang, J.*; Fu, S.-S.; Yu, X.-Q.* “A Metal-Free Oxidative Esterification of Benzyl C-H Bond” Adv. Synth. Catal. 2012, 354(7), 1287-1292.
17. Wen, J.; Zhang, R.-Y.; Chen, S.-Y.; Zhang, J.*; Yu, X.-Q.* “Transition Metal-Free Direct Arylation of Arene and N-Heteroarenes with Diaryliodonium Salts” J. Org. Chem. 2012, 77(1), 766-771.
18. Wang, J.; Hou, J.-T.; Wen, J.; Zhang, J.*; Yu, X.-Q.* “Iron-catalyzed direct amination of azoles using formamides or amines as nitrogen sources in air” Chem. Commun. 2011, 47(12), 3652-3654.
19. Huang, Q.-D.; Zhong, G.-X.; Zhang, Y.; Ren, J.; Fu, Y.; Zhang, J.*; Zhu, W.; Yu, X.-Q.* “Cyclen-based cationic lipids for highly efficient gene delivery towards tumor cells” PLoS One 2011, 6(8), e23134.
20. Huang, Q.-D.; Ou, W.-J.; Chen, H.; Feng, Z.-H.; Wang, J.-Y.; Zhang, J.*; Zhu, W.; Yu, X.-Q.* “Novel cationic lipids possessing protonated cyclen and imidazolium salt for gene delivery” Eur. J. Pharm. Biopharm. 2011, 78(3), 326-335.
21. Li, S.; Wang, Y.; Zhang, J.*; Yang, W.-H.; Dai, Z.-H.; Zhu, W.; Yu, X.-Q.* “Biodegradable cross-linked poly(amino alcohol esters) based on LMW PEI for gene delivery” Mol. Biosyst. 2011, 7(3), 1254-1262.
22. Zhang, J.; Meng, X.-G.; Zeng, X.-C.; Yu, X.-Q.* “Metallomicellar Supramolecular Systems and Their Applications in Catalytic Reactions” Coordin. Chem. Rev. 2009, 253(17-18), 2166-2177.
参编著作:
1. 《有机化学基础》,2008年第二版,海洋出版社,统编教材,参编者。
2. 《现代有机合成化学》,2007年第一版,华东理工大学出版社,“十一五”国家重点图书,参编者。
专利:
环氧化合物与阳离子聚合物及它们的制备方法,余孝其、张琴芳、张骥,专利号201210586561.5。
 

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