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曾小明
职称与职务
教 授
专      业
有机化学
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(+86)-18629294957
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2017.05—至今      四川大学化学学院从事教学与科研工作,教授、博士生导师
2012.01—2017.04   西安交通大学前沿科学技术研究院从事科研工作,教授、博士生导师
2010.04—2011.12   东京大学化学系,JSPS研究员,合作导师:Eiichi Nakamura 教授
2007.09—2009.09   加州大学河滨分校化学系,联合培养博士,导师:Guy Bertrand 教授
2004.09—2009.12   四川大学化学学院有机化学专业攻读博士学位,导师:罗美明教授
2002.09—2004.07   广东省新兴县华侨中学从事高中化学教学工作
1998.09—2002.07   四川师范大学化学学院应用化学专业本科学习
学术任职:任Elsevier数据库旗下期刊Heliyon的国际编委。
主要研究方向

(1)卡宾化学

开发新型的环状单胺基卡宾,研究卡宾在过渡金属催化中的配体行为和反应活性。

(2)第一过渡系金属铬和铁催化的合成化学研究
发展铬催化的区域选择性交叉偶联反应和氢化反应,探索金属铬的独特催化性能与化学活性,应用于合成功能化合物和药物中间体。
主要工作业绩

(1) 在单胺基卡宾配体的开发与应用方面:

开发了一类具有强亲电和亲核特性的单胺基卡宾–环状(芳基)(胺基)卡宾;以富电性的单胺基卡宾为配体,解决了均相催化芳香酮和苯酚的芳环化学选择性加氢难题,为化学工业上制备作为生产尼龙-66和液晶原材料的环已酮类化合物提供了高效、洁净的合成策略。
(2) 在铬和铁催化的合成化学研究方面:
发展了金属铬催化惰性碳–氧和碳–氮键的选择性功能化,稠环芳烃的区域选择性加氢还原反应,提示出低价铬在活化惰性碳-杂原子键方面具有独特的催化活性,有效地制备了芳香酮等活性中间体和稠环芳烃部分加氢产物;并实现了铁催化远程导向喹啉的烯丙基化反应,区域选择性地合成了具有生物活性的烯丙基喹啉杂环衍生物。
作为主要贡献人现已分别在Chem. Rev., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Common., Org. Lett., Organometallics, Synlett 等刊物上发表论文三十多篇,其中三篇论文他引超过一百次,三篇通讯作者论文成为ESI高引论文,被同行正面评价和推介近二十次。
主要奖励和荣誉
2016年入选西安交通大学青年拔尖人才计划A类
2015年获得美国化学会三年会员奖励
2010年获得日本学术振兴会外国人特别研究员奖学金
2007年获得中国留学基金委公派留学奖学金

代表性成果 (获奖成果、专著、论文、专利)

1. Xuefeng Cong,§ Fei Fan,§ Pengchen Ma,§ Meiming Luo, Hui Chen,* and  Xiaoming Zeng*
Low-Valent, High-Spin Chromium-Catalyzed Cleavage of Aromatic Carbon–Nitrogen Bonds at Room Temperature: A Combined Experimental and Theoretical Study
J. Am. Chem. Soc.  2017139, 15182?15190.  [Link]
2. Lei Jia,Qiang Tang, Meiming Luo,* and  Xiaoming Zeng*
Chin. J. Org. Chem. DOI: 10.6023/cjoc201707018  [Link]
3. Jinghua Tang, Meiming Luo,*and  Xiaoming Zeng *
Chromium-Catalyzed, Regioselective Cross-Coupling of C–O Bonds Using Organic Bromides as Reactants
Synlett,  201728, 2577–2580. (Invited for cluster of “C–O bond activation”) [Link]
4. Sen Gao, Liming Gao, Hong Meng, Meiming Luo,*and  Xiaoming Zeng *
Iron-Catalyzed Synthesis of Benzoxazoles by Oxidative Coupling/Cyclization of Phenol Derivatives with Benzoyl Aldehyde Oximes
Chem. Commun.,  201753, 9886–9889.  [Link]
5. Changpeng Chen, and  Xiaoming Zeng*
Ruthenium-Catalyzed Alkynylation of Benzoic Acids Mediated by a Weakly-Coordination Directing Auxiliary
Eur. J. rg. Chem.  2017, 4749–4752.  [Link]
6. Changpeng Chen, Pei Liu, Jinghua Tang, Gongda Deng, and  Xiaoming Zeng*
Iridium-Catalyzed, Weakly Coordination-Assisted  Ortho-Alkynylation of (Hetero)aromatic Carboxylic Acids without Cyclization
Org. Lett. 201719, 2474–2477.  [Link]
7. Pei Liu, Jinghua Tang, and  Xiaoming Zeng*
Site-Selective Silylation of Aliphatic C–H Bonds Mediated by [1,5]-Hydrogen Transfer: Synthesis of α-Sila Benzamides
Org. Lett. 201618, 5536–5539.  [Link]
8. Bin Rao, Jinghua Tang, and  Xiaoming Zeng*
Synthesis of 2-Benzylphenyl Ketones by Aryne Insertion into Unactivated C–C Bonds
Org. Lett. 201618, 1678–1681.  [Link]
9. Xuefeng Cong, Shengxian Zhai, and  Xiaoming Zeng*
Low-Valent Cobalt-Catalyzed C–H Allylation
Org. Chem. Front. 20163, 673–677. (Invited as “2015 Emerging Investigator by OCF”)  [Link]
10. Yuexuan Li, Gongda Deng, and  Xiaoming Zeng*
Chromium-Catalyzed Regioselective Hydropyridination of Styrenes
Organometallics 201635, 747–750.  [Link]
11. Bin Rao, Jinghua Tang, Yu Wei, and  Xiaoming Zeng*
Ring Expansion via Cleavage of Benzylic C–C Bonds Enabling Direct Synthesis of Medium Ring-fused Benzocarbocycles
Chem.–Asian J. 201611, 991–995.  [Link]
12. Xuefeng Cong, Huarong Tang, and  Xiaoming Zeng*
Regio- and Chemoselective Kumada–Tamao–Corriu Reaction of Aryl Alkyl Ethers Catalyzed by Chromium Under Mild Conditions
J. Am. Chem. Soc. 2015137, 14367–14372.  [Link]
(Highlights by  Synfacts201612, 0192;  ChemInform201647, 21-126)
13. Yu Wei, and  Xiaoming Zeng*
Catalytic Strategies toward Selective Hydrogenation of Aromatic Ketones and Phenols: Facile Synthesis of Cyclohexyl Ketones
Synlett. 201627, 650–655. (Invited  Synpacts article)
14. Bin Rao, Huarong Tang,  Xiaoming Zeng*, Liu Liu, Mohand Melaimi and Guy Bertrand* 
Cyclic (Amino)(aryl)carbenes (CAArCs) as Strong σ-Donating and π-Accepting Ligands for Transition Metals
Angew. Chem. Int. Ed. 201554, 14915–14919.  [Link]
15. Yu Wei, Bin Rao, Xuefeng Cong, and  Xiaoming Zeng*
Highly Selective Hydrogenation of Aromatic Ketones and Phenols Enabled by Cyclic (Amino)(alkyl)carbene Rhodium Complexes
J. Am. Chem. Soc. 2015, 137, 9250–9253. [Link]
(Highlights by  Chin. J. Org. Chem. 2015,  35, 2019;  ChemInform201647, 03-038)
16.  Xiaoming Zeng* and Xuefeng Cong
Chromium-Catalyzed Transformations Using Grignard Reagents: New Opportunities for Cross-Coupling Reactions
Org. Chem. Front. 20152, 69–72.  [Link]
17.  Xuefeng Cong, Yuexuan Li, Yu Wei, and  Xiaoming Zeng*
Nickel-Catalyzed C–H Coupling with Allyl Phosphates: A Site-Selective Synthetic Route to Linear Allylarenes
Org. Lett. 201416, 3926–3929. [Link]
 (Highlight by  ChemInform201546, 05-054)
18.  Xuefeng Cong and  Xiaoming Zeng*
Iron-Catalyzed, Chelation-Induced Remote C–H Allylation of Quinolines via 8-Amido Assistance
Org. Lett. 201416, 3716–3719.  [Link]
(Highlight by  ChemInform201546, 02-047)
19.  Yu WeiHuarong TangXuefeng CongBin RaoChao Wu* and  Xiaoming Zeng*
(§X.C. and H.T. contributed equally)
Pd(II)-Catalyzed Intermolecular Arylation of Unactivated C(sp3)–H Bonds with Aryl Bromides Enabled by 8-Aminoquinoline Auxiliary
Org. Lett. 201416, 2248–2251. [Link]
(Highlight by  ChemInform201445, 41-085)
20. Bin Rao and  Xiaoming Zeng*
Aminocyanation by the Addition of N–CN Bonds to Arynes: Chemoselective Synthesis of 1,2-Bifunctional Aminobenzonitriles
Org. Lett.201416, 314–317.  [Link]
 (Highlights by  ChemInform201445, 23-095;  Org. Chem. Highlights 2014, October 13)
21. Xuefeng Cong,§ Huarong Tang,§ Chao Wu*, and  Xiaoming Zeng*
(§X.C. and H.T. contributed equally)
Role of Mono-N-Protected Amino Acid Ligands in Pd(II)-Catalyzed Dehydrogenative Heck Reactions of Electron-Deficient (Hetero)Arenes: Experimental and Computational Studies
Organometallics201332, 6565–6575.  [Link]
22. Yu Wei, Jinghua Tang, Xuefeng Cong, and  Xiaoming Zeng*
Practical Metal-Free Synthesis of Chalcone Derivatives via a Tandem Cross-Dehydrogenative-Coupling/Elimination Reaction
Green Chem. 201315, 3165–3169.  [Link]
(Highlight by  ChemInform201445, 12-079)
23.  Xiaoming Zeng*
Recent Advances in Catalytic Sequential Reactions Involving Hydroelement Addition to Carbon–Carbon Multiple Bonds
Chem. Rev. 2013113, 6864–6900.  [Link]
( ESI highly cited paper)
24. Pei Guo,  Xiaoming Zeng, Si Chen, and Meiming Luo*
J. Organomet. Chem. 2013751, 438–442.  [Link]
25.  Xiaoming Zeng, Laurean Ilies, and Eiichi Nakamura*
Iron-Catalyzed Regio- and Stereoselective Chloro-sulfonylation of Terminal Alkynes with Aromatic Sulfonyl Chlorides
Org. Lett. 201214, 954–956. [Link]
(Highlight by  ChemInform201243, 23-088)
 26.   Xiaoming Zeng, Laurean Ilies, and Eiichi Nakamura*
Synthesis of Functionalized 1H-Indenes via Copper-Catalyzed Arylative Cyclization of Arylalkynes with Aromatic Sulfonyl Chlorides
J. Am. Chem. Soc. 2011133, 17638–17640. [Link]
 27.  Laurean Ilies, Quan Chen,  Xiaoming Zeng, and Eiichi Nakamura*
Cobalt-Catalyzed Chemoselective Insertion of Alkene into the  ortho-C–H Bond of Benzamide
J. Am. Chem. Soc. 2011133, 5221–5223. [Link]
 28.   Xiaoming Zeng, Rei Kinjo, Bruno Donnadieu, and Guy Bertrand*
Serendipitous Discovery of the Catalytic Hydroammoniumation and  Methylamination of Alkynes
Angew. Chem., Int. Ed . 201049, 942–945. [Link]
29.  Xiaoming Zeng,Guido D. Frey, Rei Kinjo, Bruno Donnadieu, and Guy Bertrand*
Synthesis of a Simplified Version of Stable Bulky and Rigid Cyclic (Alkyl)(amino)carbenes, and Catalytic Activity of the Ensuing Gold(I) Complex in the Three-Component Preparation of 1,2-Dihydroquinoline Derivatives
J. Am. Chem. Soc.  2009131, 8690–8696. [Link]
30.  Xiaoming Zeng Guido D. Frey, Shazia Kousar, and Guy Bertrand*
A Cationic Gold(I) Complex as a General Catalyst for the Intermolecular Hydroamination of Alkynes: Application to the One-Pot Synthesis of Allenes from Two Alkynes and a Sacrificial Amine
Chem.–Eur. J. 200915, 3056–3060. [Link]
31.  Xiaoming Zeng,Michele Soleilhavoup, and Guy Bertrand*
Gold-Catalyzed Intermolecular Markovnikov Hydroamination of Allenes with Secondary Amines
Org. Lett. 200911, 3166–3169. [Link]
32.  Xiaoming Zeng, Tongxin Zhang, Yuancheng Qin, Zhijun Wei, and Meiming Luo*
Synthesis of a Carbene Transfer Organometallic Polymer and Application to Forming a Recyclable Heterogeneous Catalyst for the Suzuki Reactions of Arylchlorides
Dalton Trans. 2009,8341–8348. [Link]
33. Sujuan Zhang,  Xiaoming Zeng Zhijun Wei, Dongbing Zhao, Tairan Kang, Weifeng Zhang, Mei Yan, and Meiming Luo *
Desulfitative Suzuki Cross-Couplings of Arylsulfonyl Chlorides and Boronic Acids Catalyzed by a Recyclable Polymer-Supported N-Heterocyclic Carbene-Palladium Complex Catalyst
Synlett 2006, 1891–1894.
34. Chun Yan,  Xiaoming Zeng,Weifeng Zhang, and Meiming Luo*
Polymer-Supported N-Heterocyclic Carbene–Rhodium Complex Catalyst for the Addition of Arylboronic Acids to Aldehydes

 

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