picture
 
杨千帆
职称与职务
副教授
专      业
分析化学
电      话
17780501019
E-Mail
简  历
2000.9-2004.7 北京化工大学高分子材料科学与工程 学士
2005.9-2010.7 中国科学院化学研究所 博士
2010.7-2015.11 中国科学院化学研究所 助理研究员、副研究员
2011.1-2011.8 澳大利亚University of Western Sydney 访问学者
2013.11-2015.4 美国University of California, Los Angels 访问学者
2015.11-至今 四川大学化学学院 特聘副研究员

 

主要研究方向
1)生物识别
2)细胞荧光标记

3)肿瘤检测与诊断 

主要工作业绩

     本人主要从事DNA结构识别及其在重大疾病检测中的应用,已发表SCI论文30余篇,累计影响因子超过120。相关工作多次被《Nature China》、《Analyst》等国际高影响力杂志评选为研究亮点。相关成果已获得2014年北京市科学技术奖三等奖,中国分析测试协会科学技术奖(2009年一等奖、2012年一等奖、2014年二等奖)。本人已主持承担国家自然科学基金青年基金、教育部留学回国人员科研启动基金等国家级科研项目,并参与中国科学院知识创新工程、“973”等项目。于2013年入选中国科学院青年创新促进会会员。在成果转化方面,已授权国家发明专利14项,申请国际PCT专利3项。在人才培养方面,指导的博士生获得2013年的博士研究生国家奖学金。

代表性成果 (获奖成果、专著、论文、专利)

 通讯作者论文

1.Yu, L., Yang, Q.*, Xiang, J., Sun, H., Wang, L., Li, Q., Guan, A., Tang, Y.* (2015) Targeting of parallel c-myc G-quadruplex by dimeric cyanine dye supramolecular assembly: dependence on the linker length. Analyst. 140(5), 1637-46.
2.Gai, W., Yang, Q.*, Xiang, J., Jiang, W., Li, Q., Sun, H., Guan, A., Shang, Q., Zhang, H. and Tang, Y.*, (2013) A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex [d(TGGGGT)]4 and cyanine dye 2, 2¢-diethyl-9-methyl-selenacarbocyanine bromide. Nucleic Acids Res., 41 (4), 2709-2722.
3.Gai, W., Yang, Q.*, Xiang, J., Yu, L., Guan, A., Li, Q., Sun, H., Shang, Q., Jiang, W., Zhang, H., Liu, Y., Wang, L., Tang, Y.* (2013) Novel Dual-Functional Regulation of a Chair-Like Antiparallel G-quadruplex on Inducing Assembly/Disassembly of Cyanine Dye. Phys. Chem. Chem. Phys., 15, 5758-5761.
4.Gai, W., Yang, Q.*, Xiang, J., Jiang, W., Li, Q., Sun, H., Yu, L., Shang, Q., Guan, A., Zhang, H. and Tang, Y.*, (2013) A novel signal-amplified strategy based on assembly reactivation for highly specific and sensitive detection of chair-like antiparallel G-quadruplex. Analyst, 138 (3), 798-804. (Hot Article)
5.Gai, W., Yang, Q.*, Xiang, J., Sun, H., Shang, Q., Li, Q., Jiang, W., Guan, A., Zhang, H., Tang, Y.* and Xu, G., (2013) Roles of flanking sequences in the binding between unimolecular parallel-stranded G-quadruplexes and ligands. Chin. Sci. bull., 58, 731-740. (Cover Article)
第一作者论文
6.Yang, Q., Xiang, J., Yang, S., Li, Q., Zhou, Q., Guan, A., Lin, L., Zhang, X., Zhang, H., Tang, Y. and Xu, G. (2010) Verification of Intramolecular Hybrid/Parallel G-quadruplex Structure under Physiological Condition by Using Novel Cyanine Dye H-aggregates: both in Solution and on Au Film. Anal. Chem., 82 (22), 9135–9137.
7.Yang, Q., Xiang, J., Yang, S., Li, Q., Zhou, Q., Guan, A., Zhang, X., Zhang, H., Tang, Y. and Xu, G. (2010) Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: II. The binding characterization with specific intramolecular G-quadruplex and the recognizing mechanism. Nucleic Acids Res., 38, 1022-1033.
8.Yang, Q.; Xiang, J.; Yang, S.; Li, Q.; Zhou, Q.; Guan, A.; Zhang, X.; Zhang, H.; Tang, Y.; Xu, G.; (2010) Recognizing hybrid/mixed G-quadruplex in human telomeres by using a cyanine dye supramolecule with confocal laser scanning microscopy. Chin. J. Chem., 28 (7), 1126-1132.
9.Yang, Q., Xiang, J., Yang, S., Zhou, Q., Li, Q., Tang, Y. and Xu, G. (2009) Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: I. Recognizing mixed G-quadruplex in human telomeres. Chem. Commun., 1103-1105.
10.Yang, Q., Xiang, J., Li, Q., Yan, W., Zhou, Q., Tang, Y. and Xu, G. (2008) Chiral Transformation of Cyanine Dye Aggregates Induced by Small Peptides. J. Phys. Chem. B, 112, 8783-8787.