picture
 
王 娜
职称与职务
副教授
专      业
化学生物学
电      话
028-85418580 (O)
E-Mail
简  历
1994.9-1998.7 贵州大学化学系理学学士
1998.7-2006.7 贵州大学基础科学部,助教,讲师
2001.7-2006.6 浙江大学化学系,理学博士
2006.7-2008.7 四川大学化学学院,讲师
2008.7-至今四川大学化学学院,副教授
2014.2-2016.2 瑞典皇家理工学院(KTH),生物技术部,博士后
主要研究方向
1. 生物催化与生物转化:非水介质中的酶促合成及水解酶催化非专一性的研究与应用;
2. 酶工程与蛋白质工程:定点突变,酶蛋白表达、固定化以及酶分子的生物改造,修饰等;
3. 功能化高分子材料:功能性聚合物的酶-化学法的合成及其在药物载体,药物释放中的相关应用。
主要工作业绩
以第一作者或通讯作者发表SCI论文40余篇,他引次数达350余次,2011,2012,2013连续三年获四川大学“优秀青年骨干教师”。
代表性成果 (获奖成果、专著、论文、专利)

参编论著:

[1]Na Wang, Xiao-Qi Yu, Hydrolase-Catalyzed Unconventional Reactions and Applications in Organic Synthesis. Green Chemistry2012, Chapter 8, P213-241. Editor: Rafael Luque. Nova Science Publishers, Inc.

[2]王娜,余孝其*,陈-林偶联反应(Chan-Lam Coupling Reaction),《现代有机反应:金属催化反应2(第6卷)》,2013年,胡跃飞,林国强主编,化学工业出版社

代表性论文(通讯作者):
[1] Zhang, W.; Wang, N.; Liu, Y.-H.; Jiao, S.-Y.; Zhang, W.-W.; Pu, X.-M.; Yu, X.-Q., 1,4-Dihydropyridines: discovery of minimal AIEEgens and their mitochondrial imaging applications. Journal Of Materials Chemistry B 2017, 5 (3), 464-469.
[2] Zhang, W.; Wang, N.; Yang, Z.-J.; Li, Y.-R.; Yu, Y.; Pu, X.-M.; Yu, X.-Q., Lipase-Initiated Tandem Biginelli Reactions via in situ-Formed Acetaldehydes in One Pot: Discovery of Single-Ring Deep Blue Luminogens . Advanced Synthesis & Catalysis 2017, DOI: 10.1002/adsc.201700599
[3] Liu, B.-Y.; Wu, W.-X.; Liu, Y.-H.; Jia, C.; Yang, X.-L.; Li, J.; Wang, N.; Yu, X.-Q., Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency. Polymer Chemistry 2017, 10.1039/C7PY01138E.
[4]Wu, W.-X.; Yang, X.-L.; Liu, B.-Y.; Deng, Q.-F.; Xun, M.-M.; Wang, N.; Yu, X.-Q., Lipase-catalyzed synthesis of oxidation-responsive poly(ethylene glycol)-b-poly(beta-thioether ester) amphiphilic block copolymers. Rsc Advances 2016, 6 (14), 11870-11879.
[5]Wu, W.-X.; Qu, L.; Liu, B.-Y.; Zhang, W.-W.; Wang, N.; Yu, X.-Q., Lipase-catalyzed synthesis of acid-degradable poly(beta-thioether ester) and poly(beta-thioether ester-co-lactone) copolymers. Polymer 2015, 59, 187-193.
[6]Liu, B.-Y.; Wu, W.-X.; Wang, N.; Yu, X.-Q., Novel biocompatible fluorescent polymeric micelles based on 1,8-naphthalimide derivatives for cell imaging. Polymer Chemistry 2015, 6 (3), 364-368.
[7]Hu, C.; Wang, N.; Zhang, W.; Zhang, S.; Meng, Y.; Yu, X., Immobilization of Aspergillus terreus lipase in self-assembled hollow nanospheres for enantioselective hydrolysis of ketoprofen vinyl ester. Journal Of Biotechnology 2015, 194, 12-18.
[8]Zhou, L.-H.; Wang, N.; Chen, G.-N.; Yang, Q.; Yang, S.-Y.; Zhang, W.; Zhang, Y.; Yu, X.-Q., Lipase-catalyzed highly diastereoselective direct vinylogous Michael addition reaction of alpha,alpha-dicyanoolefins to nitroalkenes. Journal Of Molecular Catalysis B-Enzymatic 2014, 109, 170-177.
[9]Xie, Z.-B.; Wang, N.; Wu, W.-X.; Le, Z.-G.; Yu, X.-Q., Trypsin-catalyzed tandem reaction: One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by in situ formed acetaldehyde. Journal Of Biotechnology 2014, 170, 1-5.
[10]Wu, W.-X.; Wang, N.; Liu, B.-Y.; Deng, Q.-F.; Yu, X.-Q., Lipase-catalyzed synthesis of azido-functionalized aliphatic polyesters towards acid-degradable amphiphilic graft copolymers. Soft Matter 2014, 10 (8), 1199-1213.
[11]Xie, Z.-B.; Wang, N.; Zhou, L.-H.; Wan, F.; He, T.; Le, Z.-G.; Yu, X.-Q., Lipase-Catalyzed Stereoselective Cross-Aldol Reaction Promoted by Water. Chemcatchem 2013, 5 (7), 1935-1940.
[12]Wang, H.-Y.; Zhang, W.-W.; Wang, N.; Li, C.; Li, K.; Yu, X.-Q., Biocatalytic Synthesis and in Vitro Release of Biodegradable Linear Polyesters with Pendant Ketoprofen. Biomacromolecules 2010, 11 (12), 3290-3293.
[13]Li, K.; He, T.; Li, C.; Feng, X.-W.; Wang, N.; Yu, X.-Q., Lipase-catalysed direct Mannich reaction in water: utilization of biocatalytic promiscuity for C-C bond formation in a "one-pot" synthesis. Green Chemistry 2009, 11 (6), 777-779.
[14]Feng, X.-W.; Li, C.; Wang, N.; Li, K.; Zhang, W.-W.; Wang, Z.; Yu, X.-Q., Lipase-catalysed decarboxylative aldol reaction and decarboxylative Knoevenagel reaction. Green Chemistry 2009, 11 (12), 1933-1936.
[15]Li, C.; Feng, X.-W.; Wang, N.; Zhou, Y.-J.; Yu, X.-Q., Biocatalytic promiscuity: the first lipase-catalysed asymmetric aldol reaction. Green Chemistry 2008, 10 (6), 616-618.

 

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