picture
 
王 娜
职称与职务
副教授
专      业
化学生物学
电      话
028-85418580 (O)
E-Mail
简  历
1994.9-1998.7 贵州大学化学系理学学士
1998.7-2006.7 贵州大学基础科学部,助教,讲师
2001.7-2006.6 浙江大学化学系,理学博士
2006.7-2008.7 四川大学化学学院,讲师
2008.7-至今四川大学化学学院,副教授
2014.2-2016.2 瑞典皇家理工学院(KTH),生物技术部,博士后
主要研究方向
1.       生物催化与生物转化:非水介质中的酶促合成及水解酶催化非专一性研究;功能性高分子的酶-化学法的合成及相关应用。
2.       酶工程与蛋白质工程:蛋白表达,分离纯化,固定化以及酶分子的生物改造,修饰等。
主要工作业绩
2011、2012、2013连续三年获四川大学“优秀青年骨干教师” 
代表性成果 (获奖成果、专著、论文、专利)

参编论著:
[1]    Na Wang, Xiao-Qi Yu, Hydrolase-Catalyzed Unconventional Reactions and Applications in Organic Synthesis. Green Chemistry, 2012, Chapter 8, P213-241. Editor: Rafael Luque. Nova Science Publishers, Inc.
[2]    王娜,余孝其*,陈-林偶联反应(Chan-Lam Coupling Reaction),《现代有机反应:金属催化反应2(第6卷)》,2013年,胡跃飞,林国强主编,化学工业出版社
通讯作者或第一作者论文(自2008年后)
[1]     Wu, W.-X.; Qu, L.; Liu, B.-Y.; Zhang, W.-W.; Wang, N.*; Yu, X.-Q.*, Lipase-catalyzed synthesis of acid-degradable poly(beta-thioether ester) and poly(beta-thioether ester-co-lactone) copolymers. Polymer 2015,59, 187-193.
[2]     Liu, B.-Y.; Wu, W.-X.; Wang, N.*; Yu, X.-Q.*, Novel biocompatible fluorescent polymeric micelles based on 1,8-naphthalimide derivatives for cell imaging. Polymer Chemistry 2015,6 (3), 364-368.
[3]     Hu, C.; Wang, N.*; Zhang, W.; Zhang, S.; Meng, Y.; Yu, X., Immobilization of Aspergillusterreus lipase in self-assembled hollow nanospheres for enantioselective hydrolysis of ketoprofen vinyl ester. Journal of Biotechnology 2015,194, 12-18.
[4]     Zhou, L.-H.; Wang, N.*; Chen, G.-N.; Yang, Q.; Yang, S.-Y.; Zhang, W.; Zhang, Y.; Yu, X.-Q.*, Lipase-catalyzed highly diastereoselective direct vinylogous Michael addition reaction of alpha,alpha-dicyanoolefins to nitroalkenes. Journal of Molecular Catalysis B-Enzymatic 2014,109, 170-177.
[5]     Zhang, Y.; Wang, N.*;Xie, Z.-B.; Zhou, L.-H.; Yu, X.-Q.*, Ionic liquid as a recyclable and efficient medium for lipase-catalyzed asymmetric cross aldol reaction. Journal of Molecular Catalysis B-Enzymatic 2014,110, 100-110.
[6]     Zhang, W.-W.; Wang, N.*; Zhang, L.; Wu, W.-X.; Hu, C.-L.; Yu, X.-Q.*, Effects of Additives on Lipase Immobilization in Microemulsion-Based Organogels. Applied Biochemistry and Biotechnology 2014,172 (6), 3128-3140.
[7]     Zhang, W.-W.; Wang, N.*; Feng, X.-W.; Zhang, Y.; Yu, X.-Q.*, Biocatalytic Synthesis of Optically Active Hydroxyesters via Lipase-Catalyzed DecarboxylativeAldol Reaction and Kinetic Resolution. Applied Biochemistry and Biotechnology 2014,173 (2), 535-543.
[8]     Xie, Z.-B.; Wang, N.*; Wu, W.-X.; Le, Z.-G.; Yu, X.-Q.*, Trypsin-catalyzed tandem reaction: One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by in situ formed acetaldehyde. Journal of Biotechnology 2014,170, 1-5.
[9]     Wu, W.-X.; Wang, N.*; Liu, B.-Y.; Deng, Q.-F.; Yu, X.-Q.*, Lipase-catalyzed synthesis of azido-functionalized aliphatic polyesters towards acid-degradable amphiphilic graft copolymers. Soft Matter 2014,10 (8), 1199-1213.
[10]Zhou, Y.-J.; Hu, C.-L.; Wang, N.*; Zhang, W.-W.; Yu, X.-Q.*, Purification of porcine pancreatic lipase by aqueous two-phase systems of polyethylene glycol and potassium phosphate. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2013,926, 77-82.
[11]Zhou, L.-H.; Wang, N.*; Zhang, W.; Xie, Z.-B.; Yu, X.-Q.*, Catalytical promiscuity of alpha-amylase: Synthesis of 3-substituted 2H-chromene derivatives via biocatalytic domino oxa-Michael/aldol condensations. Journal of Molecular Catalysis B-Enzymatic 2013,91, 37-43.
[12]Xie, Z.-B.; Wang, N.*; Zhou, L.-H.; Wan, F.; He, T.; Le, Z.-G.; Yu, X.-Q.*, Lipase-Catalyzed Stereoselective Cross-Aldol Reaction Promoted by Water. Chemcatchem2013,5 (7), 1935-1940.
[13]Xie, Z.-B.; Wang, N.*; Jiang, G.-F.; Yu, X.-Q.*, Biocatalytic asymmetric aldol reaction in buffer solution. Tetrahedron Letters 2013,54 (8), 945-948.
[14]Wu, W.-X.; Wang, H.-Y.; Wang, N.*; Zhang, W.-W.; Lai, H.; Yu, X.-Q.*, Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen. Polymers 2013,5 (3), 1158-1168.
[15]Wang, N.*; Zhang, W.; Zhou, L.-H.; Deng, Q.-F.; Xie, Z.-B.; Yu, X.-Q.*, One-Pot Lipase-Catalyzed Aldol Reaction Combination of In Situ Formed Acetaldehyde. Applied Biochemistry and Biotechnology 2013,171 (7), 1559-1567.
[16]Zhang, W.-W.; Wang, N.*; Zhou, Y.-J.; He, T.; Yu, X.-Q.*, Enhancement of activity and stability of lipase by microemulsion-based organogels (MBGs) immobilization and application for synthesis of arylethyl acetate. Journal of Molecular Catalysis B-Enzymatic 2012,78, 65-71.
[17]Xie, Z.-B.; Wang, N.*; Wu, M.-Y.; He, T.; Le, Z.-G.; Yu, X.-Q.*, Catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to nitroalkenes by a grinding method. Beilstein Journal of Organic Chemistry 2012,8, 534-538.
[18]Wang, H.-Y.; Zhou, Y.-J.; Wang, Z.; Wang, N.*; Li, K.; Yu, X.-Q.*, Enzyme-Catalyzed Synthesis of a Novel Thermosensitive Polyester with Pendant Ketoprofen. Macromolecular Bioscience 2011,11 (5), 595-599.
[19]Wang, L.; Li, C.; Wang, N.*; Li, K.; Chen, X.; Yu, X.-Q.*, Enzyme-mediated domino synthesis of 2-alkylbenzimidazoles in solvent-free system: A green route to heterocyclic compound. Journal of Molecular Catalysis B-Enzymatic 2010,67 (1-2), 16-20.
[20]Wang, H.-Y.; Zhang, W.-W.; Wang, N.*; Li, C.; Li, K.; Yu, X.-Q.*, Biocatalytic Synthesis and in Vitro Release of Biodegradable Linear Polyesters with Pendant Ketoprofen. Biomacromolecules2010,11 (12), 3290-3293.
[21]Li, C.; Zhou, Y.-J.; Wang, N.*; Feng, X.-W.; Li, K.; Yu, X.-Q.*, Promiscuous protease-catalyzed aldol reactions: A facile biocatalytic protocol for carbon-carbon bond formation in aqueous media. Journal of Biotechnology 2010,150 (4), 539-545.
[22]Wang, H.-Y.; Li, C.; Wang, N.*; Li, K.; Feng, X.-W.; He, T.; Yu, X.-Q.*, Two-step enzymatic selective synthesis of water-soluble ketoprofen-saccharide conjugates in organic media. Bioorganic & Medicinal Chemistry 2009,17 (5), 1905-1910.
[23]Li, K.; He, T.; Li, C.; Feng, X.-W.; Wang, N.*; Yu, X.-Q.*, Lipase-catalysed direct Mannich reaction in water: utilization of biocatalytic promiscuity for C-C bond formation in a "one-pot" synthesis. Green Chemistry 2009,11 (6), 777-779.
[24]Feng, X.-W.; Li, C.; Wang, N.*; Li, K.; Zhang, W.-W.; Wang, Z.; Yu, X.-Q.*, Lipase-catalyseddecarboxylativealdol reaction and decarboxylativeKnoevenagel reaction. Green Chemistry 2009,11 (12), 1933-1936.
[25]Li, C.; Feng, X.-W.; Wang, N.*; Zhou, Y.-J.; Yu, X.-Q.*, Biocatalytic promiscuity: the first lipase-catalysed asymmetric aldol reaction. Green Chemistry 2008,10 (6), 616-618.
 
 
 

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