picture
 
刘 波
职称与职务
教 授、博士生导师、副院长
专      业
有机化学
电      话
028-85413712
E-Mail
简  历
1994.9.---1998.7.  在西南师范大学化学化工学院学习,环境学专业;获理学学士学位
1998.9.---2001.7.  在中科院成都有机化学研究所学习,有机合成专业,主要从事不对称催化反应研究;获理学硕士学位;导师:冯小明 研究员;蒋耀忠 研究员
2001.9.---2004.7.  在中科院上海有机化学研究所学习,有机合成专业,主要从事天然产物全合成研究;获理学博士学位;导师:周维善 研究员
2004.9.---2007.3.  在美国德克萨斯大学西南医学中心作博士后研究,主要从事过渡金属催化的反应研究及天然产物全合成;导师:Prof. Jef K. De Brabander
2007.6.---至今    四川大学化学学院从事教学和科研
主要研究方向
主要研究方向
1. 具有重要生物活性的复杂天然产物全合成
2. 天然产物分子探针的生物学功能开发
3. 合成导向的反应方法学研究
4. 药物合成
科研项目
1.基于去芳香化/[5+2] 环加成策略的二萜及其类天然产物合成研究,国家自然科学基金面上项目(2017-2020)
2.具有重要药用价值的多环天然产物的高效合成,国家自然科学基金重大项目(2013-2017)。
3.瑞香烷型二萜Trigoxyphin A的全合成研究,国家自然科学基金面上项目(2012-2015),项目负责人。
4.具有重要生物活性的天然产物的化学合成,国家重点基础研究计划(科技部973计划, 2010-2014)。
5.四川大学优秀青年学者科研基金(B类),2011-2014。
6.天然产物Chlorahololide A(钾离子通道抑制剂)的全合成研究,国家自然科学基金面上项目(2009-2011),项目负责人。
7.教育部新世纪优秀人才支持计划(2009-2011), 项目负责人。
8.抗真菌天然产物金粟兰内酯 A 的全合成研究,教育部留学回国人员基金(2009-2011),项目负责人。
9.抗结核天然产物 Hirsutellones A-F 的全合成研究,国家自然科学基金青年基金项目(2008-2010),项目负责人。
主要工作业绩
    完成了orostanal、palmerolide A、heliespirones A & C、cuevaene A、金粟兰内酯A&D、银线草内酯E、leucosceptroid B、bolivianine、crotobarin、shizukaol D和sarcandrolide J等天然产物在国际上的首次合成;完成了海洋天然产物Phorboxazoles的片段合成及Peloruside A的大环骨架的合成;同时,发展了贵金属催化炔烃的碳-杂原子键形成反应,以及碱性条件下缩酮的脱保护方法等。
    目前运用机理和构象分析为工具,结合前沿的串联反应、原子经济性、氧化-还原经济性、步骤经济性、无保护基合成、集合合成和可放大合成等高效策略,重点围绕以萜类为主的多环复杂天然产物开展工作。
    截止2017年5月,在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Org. Lett.,Chem. Commun., Eur. J. Chem.等专业期刊上发表SCI论文50多篇。一些研究成果被评选为Org. Lett.和J. Am. Chem. Soc.的most read articles, 被收录进入化学专业网站 Organic Chemistry Highlights,被化学博客brsmbog.com和chemblogs.net以及专业评述性杂志Synfacts收录和正面评价,被化学专业微信平台X-MOL报导。
  课题组成立以来,完成全合成的部分天然产物结构如下(2010-现在):

获得奖励
教育部新世纪优秀人才支持计划(2009)
国家自然科学基金委优秀青年基金(2013)
Thieme Chemistry Journal Award 2014
ACP Lectureship Awards to Japan & Malaysia (2014)
ACP Lectureship Awards to Taiwan (2015)
中国化学会维善天然产物合成奖(2015)
ACP Lectureship Awards to Singapore (2016)

代表性成果 (获奖成果、专著、论文、专利)
论著目录:
1. Heping Deng, Wei Cao, Rong Liu, Yanhui Zhang, and Bo Liu*, Asymmetric Total Synthesis of Hispidanin A, Angew. Chem. Int. Ed., 2017, 56, 5849-5852.
  • Selected as Hot paper
  • Highlighted by AdvancedScienceNews
2. Changchun Yuan, Biao Du, Heping Deng, Yi Man, Bo Liu*, Total Synthesis of Sarcandrolide J and Shizukaol D: Lindenane Sesquiterpenoid [4+2] Dimers, Angew. Chem. Int. Ed., 2017, 56, 637-640.
  • Highlighted by Synfacts (2017, 227)
  • Selected as Synfact of the month
  • Highlighted by X-MOL
  • Highlighted by Chin. J. Org. Chem.(有机化学,2017, 37, 774)
3. Liqiang Song, Guili Zhu, Yongjiang Liu, Bo Liu*, Song Qin, Total Synthesis of Atisane-type Diterpenoids: Application of Diels-Alder Cycloadditions of Podocarpane-type Unmasked ortho-Benzoquinones, J. Am. Chem. Soc.2015, 137, 13706-13714.
  • Highlighted by Synfacts (2016, 6)
  • Highlighted by X-MOL
4. Changchun Yuan, Biao Du, Li Yang, Bo Liu* Bioinspired Total Synthesis of Bolivianine: A Diels-Alder/ Intramolecular Hetero-Diels-Alder Cascade Approach, J. Am. Chem. Soc. 2013, 135, 9291-9294. 
  • One of Most Read Articles in J. Am. Chem. Soc.
  • Highlighted by Synfacts (2013, 915)
  • Selected as Synfact of the month
  • Highlighted by Chin. J. Org. Chem.(有机化学,2013, 33, 2028)
  • Highlighted by RSC/Chemistry World (2013-06-27)
5. Xuan Huang, Liqiang Song, Jiao Xu, Guili Zhu, Bo Liu* Asymmetric Total Synthesis of Leucosceptroid B, Angew. Chem. Int. Ed. 2013, 52, 952-955.
  • Highlighted by Synfacts (2013, 246)
  • Highlighted by Chin. J. Org. Chem.(有机化学,2013, 33, 654)
6. Yan-Hui Zhang, Rong Liu, Bo Liu*, Total Synthesis of Nannocystin Ax, Chem. Commun., 2017, 53, 5549-5552.
7. Yang Yang, Jinpeng Li, Biao Du, Changchun Yuan, Bo Liu*, Song Qin*, An Entry to Vinylcyclopropane through Palladium-catalyzed Intramolecular Cyclopropanation of Alkenes with Unstabilized Allylic tosylhydrazones, Chem. Commun.2015, 51, 6179-6182.
l Highlighted by Synfacts (2015, 744)
8. Biao Du, Changchun Yuan, Tianzi Yu, Li Yang, Yang Yang, Bo Liu*, Song Qin* Asymmetric Total Synthesis of Onoseriolide, Bolivianine and Isobolivianine, Chem. Eur. J.2014, 20, 2613-2622.
9. Guizhou Yue, Li Yang, Changchun Yuan, Xiaoling Jiang, Bo Liu* Total synthesis of chloranthalactone A, Org. Lett.2011, 13, 5406-5408.
  • One of Most Read Articles in Org. Lett.
  • Highlighted by Organic Chemistry Highlights (2012-12-31)
  • Highlighted in brsmblog.com and chemblogs.net
10. Mingzheng Huang, Liqiang Song, Bo Liu* Construction of the Cyclophane Core of
    the Hirsutellones via a RCM Strategy, Org. Lett.2010, 12, 2504-2507.
11. Chong Huang, Bo Liu* Asymmetric total synthesis ent-heliespirones A & C, Chem. Commun.2010, 46, 5280-5282
13. Guili Zhu, Sachin B. Wadavrao, Bo Liu*, Divergent total synthesis of atisane-type diterpenoids, Chem. Rec., in press, DOI: 10.1002/tcr.201600096.
14. Zhijiang Zhang, Bo Liu*, Total synthesis and confirmation of the revised structures of jiangrines A, C and D, Org. Biomol. Chem., 2017, 15, 207-212.
15. Jinpeng Li, Changchun Yuan, Biao Du, Bo Liu*, An Alternative Total Synthesis of Bolivianine , Chin. Chem. Lett.2017, 28, 113-116.
16. Zhijiang Zhang, Bo Liu*, Total Synthesis of Proposed Structures of Jiangrines C and D, Sci. Chin. Chem. 2016, 59, 1205-1210.
17. Hongli Yin, Zhe Meng, Bo Liu*, Construction of the Core Structure of Trichotomone , Synthesis, 2016,48, 3951-3956.
18. Heping Deng, Wei Cao, Zhijiang Zhang, Bo Liu*, Asymmetric Synthesis and Absolute Stereochemistry of A Labdane-type Diterpenoid Isolated from the Rhizomes of Isodan yuennanensis, Org. Biomol. Chem.2016, 14, 6225-6230.
19. Li Yang, Liqiang Song, Chong Huang, Mingzheng Huang, Bo Liu*, Exploiting Ortho- Substitution Effect on Formation of Oxygen-containing [10]Paracyclophane through Ring-Closing Metathesis, Org. Chem. Front.2016, 3, 319-323.
20. Rong Liu, Jing Feng, Bo Liu*, Synthetic Progress of Daphnane-type Diterpenoids, Acta Chim. Sinica2016, 74, 24-43.
21. Tianzi Yu, Bo Liu*, Asymmetric Total Synthesis of 3-Furanoeudesmene, A Metabolite from Antarctic Gorgonian and Determination of Its Absolute Configuration, Chin. J. Org. Chem.2015, 35, 2157-2161.
22. Jiao Xu, Bo Liu* Total synthesis of norleucosceptroids F and G, Chin. Chem. Lett. 2015, 26, 1341–1344.
23. Guili Zhu, Rong Liu, Bo Liu*, Total Synthesis of Atisane-type Diterpenoids and Related Diterpenoid Alkaloids , Synthesis2015, 47, 2691-2708. (Invited review)
24. Li Yang, Jing Feng, Jinpeng Li, Bo Liu*, Total synthesis of heliespirone B, Tetrahedron Lett.2015, 56, 4931-4933.
25. Liqiang Song, Chong Huang, Mingzheng Huang, Bo Liu*, Toward the synthesis of hirsutellone B via an intramolecular Diels-Alder /ketene-trapping strategy, Tetrahedron2015, 71, 3602-3607.
26. Jing Feng, Bo Liu*, Formal Carbo [3+3] Annulation and Its Application in Organic Synthesis, Tetrahedron Lett.2015, 56, 1474-1485.
27. Li Yang, Guizhou Yue, Changchun Yuan, Biao Du, Heping Deng, Bo Liu*, Synthetic Studies toward Lindenane-Type Sesquiterpenoid Dimers, Synlett2014, 25, 2471-2474.
28. Hai Tong, Bo Liu*, A Diels-Alder Approach toward the scaffolds of Polycyclic sesquiterpenoids with 2-Pyrone, Synlett2014, 25, 681-686.
29. Biao Du, Changchun Yuan, Langzhong Zhang, Li Yang, Bo Liu* Deprotection of 1,3-Oxathiolanes to Ketones Promoted by Base, Tetrahedron Lett.2013, 54, 2217-2220 .
30. Guizhou Yue, Xuan Huang, Bo Liu* Progress in the Total Synthesis of trans-Hydrindane- Containing Terpenoids, Chin. J. Org. Chem. 2013, 33, 1167-1185.
31. Jing Feng, Guili Zhu, Bo Liu*, Xiangdong Zhou* Expedient Synthesis of (R)-Curcuphenol: A Chiral Pool Strategy, Chin, J. Chem.2013, 31, 23-26.
32. Guizhou Yue, Li Yang, Changchun Yuan, Biao Du, Bo Liu* Progress in Total Syntheses of Lindenane-type Sesquiterpenoids and Their Dimers, Chin. J. Org. Chem. 2013, 33, 90-100.
33. Hang Su, Ting Zhou, Bo Liu* Total Synthesis of (±)-Spirobenzofuran, Synlett2013, 615-618.
34. Changchun Yuan, Li Yang, Biao Du, Bo Liu* A Base-promoted deprotection of 1,3-dioxolanes to ketones, Tetrahedron Lett.2012, 53, 6972-6976.
35. Guizhou Yue, Li Yang, Changchun Yuan, Biao Du, Bo Liu* Total Syntheses of Lindenane- type Sesquiterpenoids: (±)-Chloranthalactones A, B, F, (±)-9-Hydroxy Heterogorgiolide and (±)-Shizukanolide E, Tetrahedron, 2012, 68, 9624-9637.
36. Ting Zhou, Guili Zhu, Xuan Huang, Bo Liu* Zeise’s dimmer-catalyzed regioselective hydration of homopropargyl tertiary ether, Tetrahedron Lett.2012, 53, 4955-4958
37. Yongjiang Liu, Chong Huang, Bo Liu* Asymmetric total syntheses of heliannuol E and epi-heliannuol E, Tetrahedron Lett.2011, 52, 5802-5804.
38. Chong Huang, Wenhan Zhang, Bo Liu* Racemic and enantioselective total synthesis of heliespirones A & C, Sci. China. Chem.2011, 54, 43-55.
39. Daxing Yang, Jianfeng Huang, Bo Liu* Platinum-Catalyzed Regioselective Formation of β-Alkoxy Ketones from Internal Alkynes, Eur. J. Org. Chem.2010, 4185-4188.
40. Jianfeng Huang, Xuan Huang, Bo Liu* Gold-catalyzed synthesis of nitrogen-containing heterocycles from ε-N-protected propargylic esters, Org. Biomol. Chem. 2010, 8, 2697-2699.
41. Yunxiu Chen, Jianfeng Huang, Bo Liu* Total syntheses of the proposed structures of cuevaene A, Tetrahedron Lett.2010, 51, 4655-4657.
42. Mingzheng Huang, Chong Huang, Bo Liu* Studies toward the total synthesis of the hirsutellones, Tetrahedron Lett. 2009, 50, 2797-2800.
43. Jef K. De Brabander*, Bo Liu, Mingxing Qian Au(I)- and Pt(II)-Catalyzed Cycloetherification of ω-Hydroxy Propargylic Esters, Org. Lett. 2008, 10, 2533.
44. Xin Jiang, Bo Liu, Sylvain Lebreton, Jef K. De Brabander* Total Synthesis and Structure Revision of the Marine Metabolite Palmerolide A, J. Am. Chem. Soc.2007, 129, 6386. (One of the Most-Accessed Articles in 2007)
45. Bo Liu, Jef K. De Brabander* Metal-Catalyzed Regioselective Oxy-Functionalization of Internal Alkynes: An Entry into Ketones, Acetals, and Spiroketals, Org. Lett.2006, 8, 4907.
46. De-Run Li, Dong-Hui Zhang, Cai-Yun Sun, Ji-Wen Zhang, Li Yang, Jian Chen, Bo Liu, Ce Su, Wei-Shan Zhou*, Guo-Qiang Lin* Total Synthesis of Phorboxazole B, Chem. Eur. J.2006, 12, 1185.
47. Bo Liu, Wei-Shan Zhou* Towards the total synthesis of natural peloruside A: stereoselective synthesis of the backbone of the core, Org. Lett.2004, 6, 71.
48. Bo Liu, Wei-Shan Zhou*, Stereoselective synthesis of the C21-C27 fragment of the phorboxazoles, Tetrahedron Lett.2003, 44, 4933.
49. Bo Liu, Wei-Shan Zhou* The first stereoselective synthesis of orostanal, a novel abeo-sterol inducing apoptosis in leukemia cells, Tetrahedron2003, 59, 3379.
50. Zhigang Jiao, Xiaoming Feng * , Bo Liu , Fuxue Chen, Guolin Zhang, Yaozhong Jiang, Enantioselective Strecker reactions between aldimines and trimethylsilyl cyanide promoted by chiral N,N’51. Bo Liu, Wei-Shan Zhou* The first stereoselective synthesis of orostanal, a novel abeo-sterol inducing apoptosis in leukemia cells, Tetrahedron Lett.2002, 43, 4187.
52. Bo Liu, Xiaoming Feng*, Fuxue Chen, Guolin Zhang, Xin Cui, Yaozhong Jiang, Enantioselective Strecker reaction promoted by chiral N –oxides, Synlett2001, 1551.
53. 获准美国专利一项:Jef K. De Brabander, Xin Jiang, Bo Liu,Palmerolides: Methods of preparation and derivatives thereof, US patent, US2008249162-A1; WO2008124072-A1; TW200906387-A; US7838691-B2.

 

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