picture
 
李 峰(2016年)
职称与职务
青年千人计划
专      业
分析化学
电      话
E-Mail
简  历

 教育背景:

2007.09 – 2013.02, University of Alberta,分析化学,博士, 导师:X. Chris Le院士
2002.09 – 2006.07,天津大学药学院,理学学士
工作及研究经历:
2018.05 – 至今,四川大学化学学院,特聘研究员,博导
2014.12 – 至今,Brock University (加拿大)化学系、生物技术中心,助理教授(Tenure-Track)
2018.08 – 2018.08,中科院上海应用物理所,中加YSEP访问学者,Host:樊春海教授
2013.08 – 2013.12,University of California, Irvine干细胞研究中心,访问学者
2013.02 – 2014.11,University of Alberta临床医学及病理学系,博士后
主要研究方向

 DNA纳米技术、生物纳米技术、生物分析化学、体外诊断试剂及便携仪器开发

课题组主页:www.ligroupbrocku.com
主要工作业绩

2019 Young Investigators in Analytical and Bioanalytical Science,Analytical and Bioanalytical Chemistry(Springer旗下期刊)

2018 入选Ontario-China Young Scientist Exchange Program,中国科技部与加拿大安大略政府共同资助
2018 Ontario Early Researcher Award,加拿大安大略政府
2017 入选第十三批国家千人计划青年项目
2016 Emerging Investigator in Analytical Science,Analyst(英国皇家化学会旗下期刊)
2014 JDRF Postdoctoral Fellowship(declined),美国糖尿病协会
2013 Doctoral Dissertation Award(推荐人:Analytical Chemistry主编Jonathan Sweedler教授),University of Alberta
2013 国家优秀自费留学生奖,中国教育部
2013 Bill Davidson Graduate Student Travel Award, 7th International Symposium on Enabling Technologies
2012 Young Scientist Travel Award, 28th International Symposium on Microscale Separations and Bioanalysis
2012 J. Gordin Kaplan Graduate Student Award, University of Alberta
2012纳米技术创业大赛二等奖,University of Alberta
代表性成果 (获奖成果、专著、论文、专利)
1.Mason, S. D.; Tang, Y.; Li, Y.; Xie, X.; Li, F.* Emerging bioanalytical applications of DNA walkers. Trends in Analytical Chemistry, 2018, 107, 212-221. 
2.Li, Y.; Wang, A. G.; Mason, S. D.; Yang, X.; Yu, Z.; Tang, Y.; Li, F.* Simulation-guided engineering of an enzyme-powered three-dimensional DNA nanomachine for discriminating single nucleotide variants. Chemical Science, 2018, 9, 6434-6439.
This work was featured at Brock News, X-Mol, Newsweek, Business Standard, India Today, Digital Trends, and St. Catharines Standard.
3.Li, F.;* Lin, Y.; Lau, A.; Tang, Y.; Chen, J.; Le, X. C.* Binding-induced molecular amplifier as a universal detection platform for biomolecules and biomolecular interaction. Analytical Chemistry, 2018, 90, 8651-8657.
4.Wang, G. A.; Dong, T.; Mansour, H.; Matamoros, G.; Sanchez, A. L.; Li, F.* Paper-based DNA reader for visualized quantification of soil-transmitted helminth infections. ACS Sensors, 2018, 3, 205-210. 
This work was featured at Brock News, Lab Manager, Genomeweb, 360Dx, Niagara Now, and St. Catharines Standard.
5.Soleymani, L.;* Li, F.* The mechanistic challenges and advantages of biosensor miniaturization into the nanoscale. ACS Sensors, 2017, 2, 458-467. 
6.Li, F.;* Li, J.; Tang, Y.; Wang, C.; Li, X.-F.; Le, X. C.* Targeted enlargement of aptamer functionalized gold nanoparticles for quantitative protein analysis. Proteomes, 2017, 5, 1.
Invited contribution in the special issue of “Approaches to Top-Down Proteomics: In Honor of Prof. Patrick H. O’Farrell”.
7.Yang, X.; Tang, Y.; Traynor, S. M.; Li, F.* Regulation of DNA strand displacement using allosteric DNA toehold. Journal of the American Chemical Society, 2016, 138, 14076-14082.
This work was featured at Brock News and St. Catharines Standard.
8.Li, F.*; Tang, Y.; Traynor, S. M.; Li, X.-F.; Le, X. C.* Kinetics of Proximity-Induced Intramolecular DNA Strand Displacement. Analytical Chemistry, 2016, 88, 152-8157.
9.Yang, X.; Tang, Y.; Mason, S. D.; Chen, J.; Li, F.* Enzyme-powered three dimensional DNA nanomachine for DNA walking, payload release, and biosensing. ACS Nano, 2016, 10, 2324-2330. 
This work was featured at Popular Science, Brock News, MDT News, ZDNet, Catalyst (Carleton University), GyartasTrend (Hungary), and MedPortal (Russia).
10.Yang, X.; Tang, Y.; Alt, R. R.; Xie, X.; Li, F.* Emerging techniques for ultrasensitive protein analysis. Analyst, 2016, 141, 3473-3481. 
Invited Review in “Emerging Investigator” theme issue and selected as part of the “Recent Hot review articles” collection. 
11.Tang, Y.; Xu, Y.; Li, F.; Jamiff, L.; Steve, E. Hrudey; Li, X.-F. Non-targeted identification of peptides and disinfection byproducts in water. Journal of Environmental Sciences, 2016, 42, 259-266
12.Chen, J.; Deng B.; Wu, P.; Li, F.; Li, X.-F.; Le, X. C.; Zhang, H.; Hou, X. Amplified binding-induced homogeneous assay through catalytic cycling of analyte for ultrasensitive protein detection. Chemical Communication, 2016, 52, 1816-1819.
13.Tang, Y.; Wang, Z.; Yang, X.; Chen, J.; Liu, L.; Zhao, W.; Le, X. C.; Li, F.* Constructing real-time, wash-free, and reiterative sensors for cell surface proteins using binding-induced dynamic DNA assembly. Chemical Science, 2015, 6, 5729-5733. 
14.Tang, Y.; Lin, Y.; Yang, X.; Wang, Z.; Le, X. C.; Li, F.* Universal strategy to engineer catalytic DNA hairpin assemblies for protein analysis. Analytical Chemistry, 2015, 87, 8063-8066. 
15.Li, F.; Zhang, H.; Wang, Z.; Newbigging, M. A.; Reid, S. M.; Li, X.-F.; Le, X. C. Aptamers facilitating amplified detection of biomolecules. Analytical Chemistry, 2015, 87, 274-292. 
16.Paliwoda, E. R.;# Li, F.;# Reid, S. M.; Lin, Y.; Le, X. C. Sequential strand displacement beacon for detection of DNA coverage on functionalized gold nanoparticles. Analytical Chemistry, 2014, 86, 6138-6143. (# These authors contributed equally to this paper)
17.Ali, M.M.; Li, F.; Zhang Z.; Zhang, K.; Kang, D.-K.; Ankrum, J.; Le, X. C.; Zhao, W. Rolling circle amplification: a versatile tool for chemical biology, materials sciences and medicine. Chemical Society Reviews, 2014, 43, 3324-3341.
18.Deng, B.; Lin, Y.; Wang, C.; Li, F.; Wang, Z.; Zhang, H.; Li, X.-F.; Le, X. C. Aptamer binding assays for proteins: the thrombin example-a review. Analytica Chimica Acta, 2014, 837, 1-15.
19.Zhang, H.;# Li, F.;# Dever, B.; Li, X-F.; Le, X. C. DNA-mediated homogeneous binding assays for nucleic acids and proteins. Chemical Reviews, 2013, 113, 2812-2841. (# These authors contributed equally to this paper) 
20.Li, F.; Zhang, H.; Wang, Z.; Li, X.; Li, X.-F.; Le, X. C. Dynamic DNA assemblies mediated by binding-induced DNA strand displacement. Journal of the American Chemical Society, 2013, 135, 2443-2446.
21.Zhang, H.; Li, F.; Dever, B.; Wang, C.; Li, X.-F.; Le, X.C. Assembling DNA through affinity binding to achieve ultrasensitive protein detection. Angewante Chemie International Edition, 2013, 52, 10698-10705.
22.Li, F.; Lin, Y.; Le, X. C. Binding-induced formation of DNA three-way junctions and its application in real-time protein detection and DNA strand displacement. Analytical Chemistry, 2013, 85, 10835-10841.  
23.Li, F.; Zhang, H.; Dever, B.; Li, X.-F.; Le, X. C. Thermal stability of DNA functionalized gold nanoparticles. Bioconjugate Chemistry, 2013, 24, 1790-1797. 
24.Zhang, H.; Li, F.; Li, X.-F.; Le, X. C. Yoctomole detection of proteins using solid phase binding-induced DNA assembly. Methods, 2013, 64, 322-330.
25.Liu, Y.; Wang, C.; Li, F.; Shen, S.; Le, X. C.; Li, X-F. DNase-mediated single-cycle selection of aptamers for blotted proteins on a membrane. Analytical Chemistry, 2012, 84, 7603-7606. 
26.Li, F.; Zhang, H.; Lai C.; Li, X-F.; Le, X. C. A molecular translator that acts by binding-induced DNA strand displacement for a homogeneous protein assay. Angewante Chemie International Edition, 2012, 51, 9317-9320. 
27.Li, F.; Dever, B.; Zhang, H.; Li, X-F.; Le, X. C. Mesoporous materials in peptidome analysis. Angewandte Chemie International Edition, 2012, 51, 3518-3519. 
28.Li, F.; Li, J.; Wang, C.; Zhang, J.; Li, X.-F.; Le, X. C. Competitive protection of aptamer-functionalized gold nanoparticles by controlling DNA assembly. Analytical Chemistry, 2011, 83, 6464-6467. 
29.Hamula, C.L.A.; Zhang, H.; Li, F.; Wang, Z.; Le, X. C.; Li, X.-F. Selection and analytical applications of aptamers binding microbial pathogens. Trends in Analytical Chemistry, 2011, 30, 1587-1597. 
30.Li, F.; Zhao, Q.; Wang, C.; Lu, X.; Li, X.-F.; Le, X. C. Detection of E. coli O157: H7 using gold nanoparticle labeling and inductively coupled plasma-mass spectrometry. Analytical Chemistry, 2010, 82, 3399-3403. 
31.Wagner, M.K.; Li, F.; Li, J.; Li, X.-F.; Le, X. C. Use quantum dots in the development of assays for cancer biomarkers. Analytical and Bioanalytical Chemistry, 2010, 397, 3213-3224. 
32.Goulko, A.A.; Li, F.; Le, X. C. Bioanalytical applications of aptamer and molecular beacon probes in fluorescence affinity assays. Trends in Analytical Chemistry, 2009, 28, 878-892. 
33.Wang, Y.; Zhang, Z.; Zhang, L.; Li, F.; Chen, L.; Wan, Q. H. Magnetically immobilized beds for capillary electrochromatography. Analytical Chemistry, 2007, 79, 5082-5086.
Book Chapter
1.Tang, X.; Li, F.; Huang, G.; Li, X.-F., Mass spectrometry analysis of peptides distributed in environment, Encyclopedia of Analytical Chemistry, Wiley, 2016
2.Li, F.; Aeran, R.; Pone, E. J.; Kang D.-K.; Liu L.; Le X.C.; Zhao W. Probe and control of cell-cell interactions using bioengineered tools. In “Miro and Nanoengineering of the Cell Surface”, edited by Weian Zhao and Jeffery M. Karp. Elsevier. 2014
专利
1.Li, F.; Wang, A. G.; Dong, T. Paper-based device for nucleic acid testing. PCT, 2018, No. PCT/IB2018/056384.
2.Le, X.C.; Li, F. Binding-induced formation of DNA three-way junctions. U.S. Patent, 2015, No. US 20150219652 A1.
3.Zhao, W.; Kang, DK; Zhang, K.; Ali, M. M.; Eckert, M. A.; Li, F.; Gratton, E.; Digman, M. A.; Labanieh, L.; Lu, M. Encapsulated sensors and sensing systems for bioassays and diagnostics and methods for making and using them. World Pate
 

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