picture
 
冯小明
职称与职务
教 授(博导)
专      业
有机化学、绿色化学
电      话
86-28-8541 8249
E-Mail
课题组网站:
简  历

1981-1988  兰州大学化学系有机化学专业学习,分获理学学士学位和理学硕士学位。

1993-1996  中国科学院化学研究所学习,获理学博士学位。

1988-1993  西南师范大学化学系从事有机化学教学和科研工作,历任助教和副教授。

1996-2000  中国科学院成都有机化学研究所从事不对称催化反应研究,历任副研究员和研究员,不对称合成联合开放实验室副主任,于1999被评聘为博士生导师。

1998-1999  美国Colorado State University化学系做博士后研究。

2000-至今  四川大学化学学院教授,博士生导师;2013年当选中国科学院院士

2002年获国家杰出青年科学基金资助,四川省有突出贡献优秀专家称号;2004年入选四川省学术与技术带头人和获国务院政府特殊津贴;2005年入选教育部长江学者特聘教授;2007年获宝钢优秀教师奖,人事部“新世纪百千万人才工程”国家级人选;2008年获教育部“长江学者和创新团队发展计划”创新团队资助(学术带头人);2010年获国家创新研究群体资助(学术带头人);2013年当选中国科学院院士。

担任国际刊物Adv. Synth. Catal.Curr. Org. Synth.Asian J. Org. Chem.SynlettSynthesis顾问编委,Chem.-Asian J.编委, 有机化学、无机化学编委,任应用化学、Chin. Chem. Letts.顾问编委。

主要研究方向

主要从事新型手性催化剂的设计合成、不对称催化反应、手性药物和生理活性化合物的高效高选择性合成研究。详见课题组主页http://chem.scu.edu.cn/chem-asl

主要工作业绩

针对不对称合成中发展新型优势手性催化剂、新反应和新策略等核心问题,进行系统深入的研究。以廉价易得的氨基酸为原料,设计合成多种新型手性配体和催化剂,获得了具有原创性和特色的优势手性催化剂,实现了一些重要不对称反应,如第一例不对称催化α-取代重氮酯与醛的反应,被国外人名反应专著冠名为Roskamp-Feng反应,为一些重要生理活性手性化合物的合成提供有效方法。现已在Acc. Chem. Res., Chem. Rev., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Sci.,等刊物上发表论文300多篇。研究成果入选了“2011年中国高等学校十大科技进展”,中科院2012《科学发展报告》和《国家自然科学基金资助项目优秀成果选编》。

2009年获教育部高等学校科学研究优秀成果奖自然科学一等奖(第一完成人);2010年获国家自然科学基金委创新研究群体资助(学术带头人);2010年获药明康德“生命化学奖”二等奖;2011年获“中国高等学校十大科技进展”,获中国化学会有机化学委员会颁发的“有机合成创造奖”、获全国优秀博士学位论文指导教师荣誉称号;2012年获国家自然科学奖二等奖(第一完成人);2013年 当选中国科学院院士;2015年获四川大学基础研究年度卓越奖一等奖;2016年获中国化学会“手性化学奖”,四川大学-东土学术创新奖一等奖。

代表性成果 (获奖成果、专著、论文、专利)
1.Ke Zheng, Xiaohua Liu, Xiaoming Feng*, Recent Advances in Metal-Catalyzed Asymmetric 1,4-Conjugate Addition (ACA) of Nonorganometallic Nucleophiles, Chem. Rev. 2018, 118, 7586-7656. 
2.Haifeng Zheng, Yan Wang, Chaoran Xu, Xi Xu, Lili Lin, Xiaohua Liu*, Xiaoming Feng*, Stereodivergent Synthesis of Vicinal Quaternary-quaternary Stereocenters and Bioactive Hyperolactones, Nat. Commun. 2018, 1968-1973. 
3.Xiaobin Lin, Yu Tang, Wei Yang, Fei Tan, Lili Lin, Xiaohua Liu*, Xiaoming Feng*, Chiral Nickel(II) Complex Catalyzed Enantioselective Doyle-Kirmse Reaction of α Diazo Pyrazoleamides, J. Am. Chem. Soc. 2018, 140, 3299-3305. 
4.Dong Zhang, Lili Lin, Jian Yang, Xiaohua Liu, Xiaoming Feng*, Asymmetric Synthesis of Tetrahydroindolizines by Bimetallic Relay Catalyzed Cycloaddition of Pyridinium Ylides, Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201806630. 
5.Xi Xu, Jianlin Zhang, Shunxi Dong, Lili Lin, Xiaobin Lin, Xiaohua Liu, Xiaoming Feng*, Nickel(II)-Catalyzed Asymmetric Propargyl [2,3] Wittig Rearrangement of Oxindole Derivatives: A Chiral Amplification Effect, Angew. Chem. Int. Ed. 2018, 57, 8734-8738. 
6.Yuhang Zhou, Lili Lin, Xiaohua Liu*, Xinyue Hu, Yan Lu, Xiying Zhang, Xiaoming Feng*, Catalytic Asymmetric Diels-Alder Reaction/[3,3] Sigmatropic, Angew. Chem. Int. Ed. 2018, 57, 9113-9116. 
7.Yulong Kuang, Bin Shen, Li Dai, Qian Yao, Xiaohua Liu*, Lili Lin, Xiaoming Feng*, Diastereodivergent Asymmetric Michael-Alkylationreactions Using Chiral N,N′-Dioxide/Metal Complexes, Chem. Sci. 2018, 9, 688-692. 
8.Xiaohua Liu, Haifeng Zheng, Yong Xia, Lili Lin, Xiaoming Feng,* Asymmetric Cycloaddition and Cyclization Reactions Catalyzed by Chiral N,N′ Dioxide-Metal Complexes, Acc. Chem. Res. 2017, 50, 2621-2631.
9.Pengfei Zhou, Lili Lin, Long Chen, Xia Zhong, Xiaohua Liu, Xiaoming Feng,* Iron-Catalyzed Asymmetric Haloazidation of α,β-Unsaturated Ketones: Construction of Organic Azides with Two Vicinal Stereocenters, J. Am. Chem. Soc. 2017, 139, 13414-13419.
10.Jianfeng Zheng, Lili Lin, Li Dai, Qiong Tang, Xiaohua Liu,* Xiaoming Feng,* Nickel-Catalyzed Conjugate Addition of Silyl Ketene Imines to In Situ Generated Indol-2-ones: Highly Enantioselective Construction of Vicinal All-Carbon Quaternary Stereocenters, Angew. Chem. Int. Ed. 2017, 56, 13107-13111.
11.Jun Li, Lili Lin, Bowen Hu, Pengfei Zhou, Tianyu Huang, Xiaohua Liu,* Xiaoming Feng,* Gold(I)/Chiral N,N’-Dioxide–Nickel(II) Relay Catalysis for Asymmetric Tandem Intermolecular Hydroalkoxylation/Claisen Rearrangement, Angew. Chem. Int. Ed. 2017, 56, 885-888.
12.Tianyu Huang, Xiaohua Liu,* Jiawen Lang, Jian Xu, Lili Lin, Xiaoming Feng,* Asymmetric Aerobic Oxidative Cross-Coupling of Tetrahydroisoquinolines with Alkynes, ACS Catal. 2017, 7, 5654-5660. 
13.Jie Ji, Lili Lin, Qiong Tang, Tengfei Kang, Xiaohua Liu, Xiaoming Feng,* Highly Efficient Asymmetric Synthesis of Chiral γ Alkenyl Butenolides Catalyzed by Chiral N,N′ Dioxide-Scandium(III) Complexes, ACS Catal. 2017, 7, 3763-3767.
14.Yuting Liao, Baixin Zhou, Yong Xia, Xiaohua Liu,* Lili Lin, Xiaoming Feng,* Asymmetric [3 + 2] Cycloaddition of 2,2′-Diester Aziridines To Synthesize Pyrrolidine Derivatives, ACS Catal. 2017, 7, 3934-3939.
15.Xiangjin Lian, Lili Lin, Kai Fu, Baiwei Ma, Xiaohua Liu, Xiaoming Feng,* A new approach to the asymmetric Mannich reaction catalyzed by chiral N,N’-dioxide-metal complexes, Chem. Sci., 2017, 8, 1238-1242.
16.Yu Zhang, Yuting Liao, Xiaohua Liu,* Xi Xu, Lili Lin, Xiaoming Feng,* Catalytic asymmetric hydroxylative dearomatization of 2-naphthols: synthesis of lacinilene derivatives, Chem. Sci. 2017, 8, 6645-6649.
17.Yong Xia, Lili Lin, Fenzhen Chang, Yuting Liao, Xiaohua Liu,* and Xiaoming Feng*, Asymmetric Ring Opening/Cyclization/Retro-Mannich Reaction of Cyclopropyl Ketones with Aryl 1,2-Diamines for the Synthesis of Benzimidazole Derivatives, Angew. Chem. Int. Ed. 2016, 55, 12228-12232.
18.Haipeng Hu, Yangbin Liu, Lili Lin, Yuheng Zhang, Xiaohua Liu,* and Xiaoming Feng*, Kinetic Resolution of 2H-Azirines by Asymmetric Imine Amidation, Angew. Chem. Int. Ed. 2016, 55, 10098-10101.
19.Qian Yao, Yuting Liao, Lili Lin, Xiaobin Lin, Jie Ji, Xiaohua Liu,* and Xiaoming Feng*, Efficient Synthesis of Chiral Trisubstituted 1,2-Allenyl Ketones by Catalytic Asymmetric Conjugate Addition of Malonic Esters to Enynes, Angew. Chem. Int. Ed. 2016, 55, 1859-1863.
20.Yangbin Liu, Xiaohua Liu,* Haipeng Hu, Jing Guo, Yong Xia, Lili Lin, and Xiaoming Feng*, Synergistic Kinetic Resolution and Asymmetric Propargyl Claisen Rearrangement for the Synthesis of Chiral Allenes, Angew. Chem. Int. Ed. 2016, 55, 4054-4058.
21.Quangang Chen, Yu Tang, Tianyu Huang, Xiaohua Liu,* Lili Lin, and Xiaoming Feng; Copper/Guanidine-Catalyzed Asymmetric Alkynylation of Isatins, Angew. Chem. Int. Ed. 2016, 55, 5286-5289.
22.Tengfei Kang, Shulin Ge, Lili Lin, Yan Lu, Xiaohua Liu,* and Xiaoming Feng*, A Chiral N,N′-Dioxide–ZnII Complex Catalyzes the Enantioselective [2+2] Cycloaddition of Alkynones with Cyclic Enol Silyl Ethers, Angew. Chem. Int. Ed. 2016, 55, 5541-5544.
23.Jun Li, Lili Lin, Bowen Hu, Xiangjin Lian, Gang Wang, Xiaohua Liu,* and Xiaoming Feng*, Bimetallic Gold(I)/Chiral N,N′-Dioxide Nickel(II) Asymmetric Relay Catalysis: Chemo- and Enantioselective Synthesis of Spiroketals and Spiroaminals, Angew. Chem. Int. Ed. 2016, 55, 6075-6078.
24.Pengfei Zhou, Yunfei Cai, Xia Zhong, Weiwei Luo, Tengfei Kang, Jun Li, Xiaohua Liu,* Lili Lin, and Xiaoming Feng*, Catalytic Asymmetric Intra- and Intermolecular Haloetherification of Enones: An Efficient Approach to (-)-Centrolobine, ACS Catal. 2016, 6, 7778-7783.
25.Gang Wang, Xiaohua Liu,*, Yushuang Chen, Jian Yang, Jun Li, Lili Lin, and Xiaoming Feng*, Diastereoselective and Enantioselective Alleno-aldol Reaction of Allenoates with Isatins to Synthesis of Carbinol Allenoates Catalyzed by Gold, ACS Catal. 2016, 6, 2482-2486.
26.Yali Xu, Yuting Liao, Lili Lin, Yuhang Zhou, Jun Li, Xiaohua Liu, and Xiaoming Feng*, Catalytic Asymmetric Inverse-Electron Demand 1,3-Dipolar Cycloaddition of Isoquinolinium Methylides with Enecarbamates by a Chiral N,N′-Dioxide/Ag(I) Complex, ACS Catal. 2016, 6, 589-592.
27.Jing Guo, Yangbin Liu, Xiangqiang Li, Xiaohua Liu,* Lili Lin and Xiaoming Feng*, Nickel(II)-catalyzed enantioselective cyclopropanation of 3-alkenyl-oxindoles with phenyliodonium ylide via free carbine, Chem. Sci. 2016, 7, 2717-2721.
28.Yuting Liao, Xiaohua Liu,* Yu Zhang, Yali Xu, Yong Xia, Lili Lin and Xiaoming Feng*, Asymmetric [3 + 2] cycloaddition of donor–acceptor aziridines with aldehydes via carbon–carbon bond cleavage, Chem. Sci. 2016, 7, 3775-3779.
29.Weiwei Luo, Xiao Yuan, Lili Lin, Pengfei Zhou, Xiaohua Liu* and Xiaoming Feng*, A N,N′-dioxide/Mg(OTf)2 complex catalyzed enantioselective a-addition of isocyanides to alkylidene malonates, Chem. Sci. 2016, 7, 4736-4740.
30.Yong Xia, Xiaohua Liu*, Haifeng Zheng, Lili Lin, Xiaoming Feng*, A symmetric Synthesis of 2,3-Dihydropyrroles by Ring-Opening/Cyclization of Cyclopropyl Ketones Using Primary Amines, Angew. Chem. Int. Ed. 2015, 54, 227-230.
31.Yong Xia, Lili Lin, Fenzhen Chang, Xuan Fu, Xiaohua Liu*, Xiaoming Feng*, Asymmetric Ring-Opening of Cyclopropyl Ketones with Thiol, Alcohol, and Carboxylic Acid Nucleophiles Catalyzed by a Chiral N,N′-Dioxide–Scandium(III) Complex, Angew. Chem. Int. Ed. 2015, 54, 13748-13752.
32.Haifeng Zheng, Xiaohua Liu*, Chaoran Xu, Yong Xia, Lili Lin, Xiaoming Feng*, Regio- and Enantioselective Aza-Diels–Alder Reactions of 3-Vinylindoles: A Concise Synthesis of the Antimalarial Spiroindolone NITD609, Angew.Chem.Int. Ed. 2015, 54, 10958-10962.
33.Jiannan Zhao, Bing Fang, Weiwei Luo, Xiaoyu Hao, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Enantioselective Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Silyl Ketene Imines with Isatin-Derived Ketimines, Angew. Chem. Int. Ed. 2015, 54, 241-244.
34.Wei Li, Fei Tan, Xiaoyu Hao, Gang Wang, Yu Tang, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric Intramolecular Homologation of Ketones with α-Diazoesters: Synthesis of Cyclic α-Aryl/Alkyl β-Ketoesters, Angew. Chem. Int. Ed. 2015, 54, 1608-1611.
35.Xiaohu Zhao, Xiaohua Liu*, Hongjiang Mei, Jing Guo, Lili Lin, Xiaoming Feng*, Asymmetric Dearomatization of Indoles through a Michael/Friedel-Crafts-Type Cascade To Construct Polycyclic Spiroindolines, Angew. Chem. Int. Ed. 2015, 54, 4032-4035.
36.Yin Zhu, Xiaohua Liu,* Shunxi Dong, Yuhang Zhou, Wei Li, Lili Lin, Xiaoming Feng*, Asymmetric NH Insertion of Secondary and Primary Anilines under the Catalysis of Palladium and Chiral Guanidine Derivatives, Angew. Chem. Int. Ed. 2014, 53, 1636-1640.
37.Yangbin Liu, Haipeng Hu, Haifeng Zheng, Yong Xia, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Nickel(II)-Catalyzed Asymmetric Propargyl and Allyl Claisen Rearrangements to Allenyl- and Allyl-Substituted β-Ketoesters, Angew. Chem. Int. Ed. 2014, 53, 11579-11582.
38.Xie Mingsheng, Wu Xiaoxia, Wang Gang, Lin Lili, Feng Xiaoming*, Catalytic Asymmetric [8+2] Cycloaddition for the Construction of Cycloheptatriene-Fused Pyrrolidin-3,3’-Oxindoles, Acta Chimica Sinica 2014, 72, 856-861. 
39.Xiaohua Liu, Lili Lin and Xiaoming Feng*, Chiral N,N′-Dioxide Ligands: Synthesis, Coordination Chemistry and Asymmetric Catalysis, Org. Chem. Front., 2014, 1, 298-302.
40.Jiannan Zhao, Xiaohua Liu, Weiwei Luo, Mingsheng Xie, Lili Lin, Xiaoming Feng*, Asymmetric Synthesis of β-Amino Nitriles through a ScIII-Catalyzed Three-Component Mannich Reaction of Silyl Ketene Imines, Angew. Chem. Int. Ed. 2013, 52, 3473-3477.
41.Mingsheng Xie, Xiaohua Liu, Xiaoxia Wu, Yunfei Cai, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric [8+2] Cycloaddition: Synthesis of Cycloheptatriene-Fused Pyrrole Derivative, Angew. Chem. Int. Ed. 2013, 52, 5604-5607.
42.Jing Guo, Shunxi Dong, Yulong Zhang, Yulong Kuang, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Chiral Scandium(III)-Catalyzed Enantioselective α-Arylation of N-Unprotected 3-Substituted Oxindoles with Diaryliodonium Salts, Angew. Chem. Int. Ed. 2013, 52, 10245-10249. 
43.Wei Li, Xiaohua Liu, Fei Tan, Xiaoyu Hao, Jianfeng Zheng, Lili Lin, Xiaoming Feng*, Catalytic Homologation of α-Ketoesters with α-Diazoesters: Enantioselective Synthesis of Succinate Derivatives with Chiral Quaternary Centers, Angew. Chem. Int. Ed. 2013, 52, 10883-10886. 
44.Shunxi Dong, Xiaohua Liu*, Yin Zhu, Peng He, Lili Lin, Xiaoming Feng*, Organocatalytic Oxyamination of Azlactones: Kinetic Resolution of Oxaziridines and Asymmetric Synthesis of Oxazolin-4-ones, J. Am. Chem. Soc. 2013, 135, 10026-10029. 
45.Ke Zheng, Xiaohua Liu, Song Qin, Mingsheng Xie, Lili Lin, Changwei Hu, Xiaoming Feng*, Completely OH-Selective FeCl3-Catalyzed Prins Cyclization: Highly Stereoselective Synthesis of 4-OH-Tetrahydropyrans, J. Am. Chem. Soc. 2012, 134, 17564-17573. 
46.Lin Zhou, Xiaohua Liu, Jie Ji, Yuheng Zhang, Lili Lin, Xiaoming Feng*, Enantioselective Baeyer?Villiger Oxidation: Desymmetrization of Meso Cyclic Ketones and Kinetic Resolution of Racemic 2?Arylcyclohexanones, J. Am. Chem. Soc. 2012, 134, 17023-17026.  
47.Wei Li, Xiaohua Liu, Xiaoyu Hao, Yunfei Cai, Lili Lin, Xiaoming Feng*, A Catalytic Asymmetric Ring-Expansion Reaction of Isatins and α-Alkyl-α-Diazoesters: Highly Efficient Synthesis of Functionalized 2-Quinolone Derivatives, Angew. Chem. Int. Ed. 2012, 51, 8644-8647.
48.Zhen Wang, Zhenling Chen, Sha Bai, Wei Li, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Highly Z-Selective Asymmetric Conjugate Addition of Alkynones with Pyrazol-5-ones Promoted by N,N′-Dioxide–Metal Complexes, Angew. Chem. Int. Ed. 2012, 51, 2776-2779.
49.Ke Shen, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Recent Progress in Enantioselective Synthesis of C3-functionalized Oxindoles: Rare Earth Metals Take Action, Chem. Sci. 2012, 3, 327-334.    
50.Yangyang Chu, Xiaohua Liu, Wei Li, Xiaolei Hu, Lili Lin and Xiaoming Feng*, Asymmetric Catalytic Epoxidation of α,β-Unsaturated Carbonyl Compounds with Hydrogen Peroxide: Additive-free and Wide Substrate Scope, Chem. Sci. 2012, 3, 1996-2000.
51.Ke Zheng, Lili Lin, Xiaoming Feng*, Chiral N,N′-Dioxide-Ni(II) Complex Catalyzed Asymmetric Carbonyl-Ene Reaction Of Ethyl Trifluoropyruvate, Acta Chim. Sinica 2012, 70, 1785-1790.
52.Xiaohua Liu, Lili Lin, Xiaoming Feng*, Chiral N,N′-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions, Acc. Chem. Res. 2011, 44, 574-587.
53.Jun Wang, Xiaohua Liu, Xiaoming Feng*, Asymmetric Strecker Reactions, Chem. Rev. 2011, 111, 6947-6983.
54.Wei Li, Xiaohua Liu, Xiaoyu Hao, Xiaolei Hu, Yangyang Chu, Weidi Cao, Song Qin, Changwei Hu, Lili Lin, Xiaoming Feng*, New Electrophilic Addition of α-Diazoesters with Ketones for Enantioselective C-N Bond Formation, J. Am. Chem. Soc. 2011, 133, 15268-15271.
55.Yunfei Cai, Xiaohua Liu, Jun Jiang, Weiliang Chen, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric Chloroamination Reaction of α,β-Unsaturated γ-Keto Esters and Chalcones, J. Am. Chem. Soc. 2011, 133, 5636-5639. 
56.Yunfei Cai, Xiaohua Liu, Jun Li, Weiliang Chen, Wentao Wang, Lili Lin, Xiaoming Feng* Asymmetric Iodoamination of Chalcones and 4-Aryl-4-oxobutenoates Catalyzed by a Complex Based on Scandium (III) and a N,N′-Dioxide Ligand, Chem. Eur. J. 2011, 17, 14916-14921.
57.Ke Shen, Xiaohua Liu, Gang Wang, Lili Lin, and Xiaoming Feng*, Facile and Efficient Enantioselective Hydroxyamination Reaction: Synthesis of 3-Hydroxyamino-2-Oxindoles Using Nitrosoarenes, Angew. Chem. Int. Ed. 2011, 50, 4684-4688. 
58.Zhen Wang, Zhigang Yang, Donghui Chen, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Highly Enantioselective Michael Addition of Pyrazolin-5-ones Catalyzed by Chiral N,N′-dioxide-Lanthanide(III) Complex: Metal Directed Reversal of Enantioselectivity, Angew. Chem. Int. Ed. 2011, 50, 4928-4932.
59.Ke Zheng, Chengkai Yin, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric Addition of Alkyl Enol Ethers to 1,2-Dicarbonyl Compounds: Highly Enantioselective Synthesis of Substituted 3-Alkyl-3-Hydroxyoxindoles, Angew. Chem. Int. Ed. 2011, 50, 2573-2577.
60.Yunfei Cai, Xiaohua Liu, Yonghai Hui, Jun Jiang, Wentao Wang, Weiliang Chen, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric Bromoamination of Chalcones: Highly Efficient Synthesis of Chiral α-Bromo-β-Amino Ketone Derivatives, Angew. Chem. Int. Ed. 2010, 49, 6160-6164. 
61.Wei Li, Jun Wang, Xiaolei Hu, Ke Shen, Wentao Wang, Yangyang Chu, Lili Lin, Xiaohua Liu, Xiaoming Feng*, Catalytic Asymmetric Roskamp Reaction of α-Alkyl-α-diazoesters with Aromatic Aldehydes: Highly Enantioselective Synthesis of α-Alkyl-β-keto Esters, J. Am. Chem. Soc. 2010, 132, 8532-8533. 
62.Zongrui Hou, Jun Wang, Peng He, Jing Wang, Bo Qin, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Highly Enantioselective Insertion of Carbenoids into N-H Bonds Catalyzed by Copper(I) Complexes of Rigid BINOL Derivatives, Angew. Chem. Int. Ed. 2010, 49, 4763-4766. 
63.Yonghai Hui, Jun Jiang, Wentao Wang, Weiliang Chen, Yunfei Cai, Lili Lin, Xiaohua Liu, Xiaoming Feng*, Highly Enantioselective Conjugate Addition of Thioglycolate to Enones Using Mild Lanthanum Catalysis: Lower Catalyst Loading and Remarkably Chiral Amplification, Angew. Chem. Int. Ed. 2010, 49, 4290-4293. 
64.Mingsheng Xie, Xiaohong Chen, Yin Zhu, Bo Gao, Lili Lin, Xiaohua Liu, Xiaoming Feng*. Asymmetric Three-Component Inverse Electron-Demand Aza-Diels-Alder Reaction: Efficient Synthesis of Ring-Fused Tetrahydroquinolines, Angew. Chem. Int. Ed. 2010, 49, 3799-3802. 
65.Ke Shen, Xiaohua Liu, Wentao Wang, Gang Wang, Weidi Cao, Wei Li, Xiaolei Hu, Lili Lin, Xiaoming Feng*, Highly Enantioselective Synthesis of 1,3-Bis(hydroxymethyl)-2-oxindoles from Unprotected Oxindoles and Formalin Using a Chiral Nd(III) Complex, Chem. Sci. 2010, 1, 590-595. 
66.Shunxi Dong, Xiaohua Liu, Xiaohong Chen, Fang Mei, Yulong Zhang, Bo Gao, Lili Lin, Xiaoming Feng*, Chiral Bisguanidine-Catalyzed Inverse-Electron-Demand Hetero-Diels-Alder Reaction of Chalcones with Azlactones, J. Am. Chem. Soc. 2010, 132, 10650-10651. 
67.Jun Wang, Wentao Wang, Wei Li, Xiaolei Hu, Ke Shen, Cheng Tan, Xiaohua Liu, Xiaoming Feng*, Asymmetric Cyanation of Aldehydes, Ketones, Aldimines, and Ketimines Catalyzed by a Versatile Catalyst Generated from Cinchona Alkaloid, Achiral Substituted 2,2’-Biphenol and Tetraisopropyl Titanate, Chem. Eur. J. 2009, 15, 11642-11659. 
68.Zhipeng Yu, Xiaohua Liu, Lin Zhou, Lili Lin, Xiaoming Feng*, Bifunctional Guanidine via an Amino Amide Skeleton for Asymmetric Michael Reactions of β-Ketoesters with Nitroolefins: A Concise Synthesis of Bicyclic β-Amino Acids, Angew. Chem. Int. Ed. 2009, 48, 5195-5198. 
69.Xiaohua Liu, Lili Lin, Xiaoming Feng*, Amide-Based Bifunctional Organocatalysts in Asymmetric Reactions, Chem. Commun. 2009, 6145-6158. 
70.Ke Zheng, Jian Shi, Xiaohua Liu, Xiaoming Feng*, Asymmetric Carbonyl-Ene Reaction Catalyzed by Chiral N,N′-Dioxide-Nickel(II) Complex: Remarkably Broad Substrate Scope, J. Am. Chem. Soc. 2008, 130, 15770-15771. 
71.Lijia Wang, Xiaohua Liu, Zhenhua Dong, Xuan Fu, Xiaoming Feng*, Asymmetric Intramolecular Oxa-Michael Addition of Activated α,β-Unsaturated Ketones Catalyzed by a Chiral N,N′-Dioxide Nickel(II) Complex: Highly Enantioselective Synthesis of Flavanones, Angew. Chem., Int. Ed. 2008, 47, 8670-8673. 
72.Xu Yang, Xin Zhou, Lili Lin, Lu Chang, Xiaohua Liu, Xiaoming Feng*, Highly Enantioselective Direct Michael Addition of Nitroalkanes to Nitroolefins Catalyzed by La(OTf)3/N,N′-Dioxide Complexes, Angew. Chem. Int. Ed. 2008, 47, 7079-7081 
73.Yuehong Wen, Bo Gao, Yingzi Fu, Shunxi Dong, Xiaohua Liu, Xiaoming Feng*, Asymmetric Three-Component Strecker Reactions Catalyzed by trans-4-Hydroxy-L-proline-Derived N,N′-Dioxides, Chem. Eur. J. 2008, 14, 6789-6795. 
74.Zongrui Hou, Jun Wang, Xiaohua Liu, Xiaoming Feng*, Highly Enantioselective Strecker Reaction of Ketoimines Catalyzed by an Organocatalyst from (S)-BINOL and L-Prolinamide, Chem. Eur. J. 2008, 14, 4484-4486. 
75.Zhipeng Yu, Xiaohua Liu, Zhenhua Dong, Mingsheng Xie, Xiaoming Feng*, An N,N′-Dioxide/In(OTf)3 Catalyst for the Asymmetric Hetero-Diels-Alder Reaction Between Danishefsky's Dienes and Aldehydes: Application in the Total Synthesis of Triketide, Angew. Chem., Int. Ed. 2008, 47, 1308-1311. 
76.Xin Zhou, Xiaohua Liu, Xu Yang, Deju Shang, Junguo Xin, Xiaoming Feng*, Highly Enantioselective Hydrophosphonylation of Aldehydes Catalyzed by Tridentate Schiff Base Aluminum(III) Complexes, Angew. Chem. Int. Ed. 2008, 47, 392-394. 
77.Jie Liu, Zhigang Yang, Zhen Wang, Fei Wang, Xiaohong Chen, Xiaohua Liu, Xiaoming Feng*, Zhishan Su, Changwei Hu*, Asymmetric Direct Aldol Reaction of Functionalized Ketones Catalyzed by Amine Organocatalysts Based on Bispidine, J. Am. Chem. Soc. 2008, 130, 5654-5655.  
78.Jun Wang, Xiaolei Hu, Jun Jiang, Shaohua Gou, Xiao Huang, Xiaohua Liu, Xiaoming Feng*, Asymmetric Activation of tropos 2,2'-Biphenol with Cinchonine Generating a Remarkably Effective Catalyst for the Asymmetric Strecker Reaction of N-Ts Protected Aldimines and Ketoimines, Angew. Chem. Int. Ed. 2007, 46, 8468-8470.
79.Yuehong Wen, Yan Xiong, Lu Chang, Jinglun Huang, Xiaohua Liu, Xiaoming Feng*, Chiral Bisformamides as Effective Organocatalysts for Asymmetric One-pot, Three-Component Strecker Reaction, J. Org. Chem. 2007, 72, 7715-7719.
80.Xin Zhang, Donghui Chen, Xiaohua Liu, Xiaoming Feng*, Enantioselective Allylation of Ketones Catalyzed by N,N′-Dioxide and Indium(III) Complex, J. Org. Chem. 2007, 72, 5227-5233.
81.Bo Qin, Xiaohua Liu., Jian Shi, Ke Zheng, Haitao Zhao, Xiaoming Feng*, Enantioselective Cyanosilylation of α,α-Dialkoxy Ketones Catalyzed by Proline-Derived in Situ Prepared N-Oxides as Bifunctional Organocatalysts, J. Org. Chem. 2007, 72, 2374-2378.
82.Jinglun Huang, Xiaohua Liu, Yuehong Wen, Bo Qin, Xiaoming Feng*, Enantioselective Strecker Reaction of Phosphinoyl Ketoimines Catalyzed by in situ Prepared Chiral N,N′-Dioxides, J. Org. Chem. 2007, 72, 204-208.
83.Xiao Huang, Jinglun Huang, Yuehong Wen, Xiaoming Feng*, Asymmetric Strecker Reaction of Ketoimines Catalyzed by a Novel Chiral Bifunctional N,N′-Dioxide, Adv. Synth. Catal. 2006, 348, 2579-2584.
84.Yuehong Wen, Xiao Huang, Jinglun Huang, Yan Xiong, Bo Qin, Xiaoming Feng*, Asymmetric Cyanosilylation of Aldehydes Catalyzed by Novel Organocatalysts, Synlett 2005, 2445-2448.
85.Xiaohua Liu, Bo Qin, Bin He, Xiaoming Feng*, Catalytic Asymmetric Cyanosilylation of Ketones by a Chiral Amino Acid Salt,J. Am. Chem. Soc. 2005, 127, 12224-12225.
86.Fu-Xue Chen, Hui Zhou, Xiaohua Liu,Bo Qin, Xiaoming Feng*,  Guolin Zhang, Yaozhong Jiang, Enantioselective Cyanosilylation Of Ketones by a Catalytic Double-Activation Method Using Aluminum Complex and N-oxide, Chem. Eur. J. 2004, 10, 4790-4797.
87.Xiaoming Feng, Lianhe Shu, Yian Shi*, Complete Conversion of Racemic Enol Ester Epoxides into Optically Active a-Acyloxy Ketones, J. Am. Chem. Soc. 1999, 121, 11002-11003.

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