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陈小川
职称与职务
教 授
专      业
有机化学
电      话
E-Mail
简  历
1992年9月-1996年6月,兰州大学化学系,理学学士;
1996年9月-1999年6月,兰州大学化学化工学院,理学硕士;
1999年9月-2002年6月,兰州大学化学化工学院,理学博士;
2003年1月-2007年8月;于法国国家科学研究中心,天然物质化学研究所,博士后;
2007年9月至今,四川大学化学学院任教。
主要研究方向
 活性天然产物合成研究
有机合成方法学研究

 

主要工作业绩
    近些年发展出一些新颖实用的路线,完成了一些具有抗癌、抗菌、抗HIV-1等重要活性的天然分子的不对称合成。特别是在合成jorunnamycins、jorumycin等高度抗癌、抗菌活性的海洋生物碱时,在策略和产率上取得了较大的突破,对发掘抗癌新药上具有重要价值和意义。同时设计了一些新型不对称Ugi反应,基于此有效合成几类复杂的手性杂环化合物,具有潜在的活性。已在各类SCI期刊上发表三十多篇学术论文,承担和参与了自然科学基金委、科技部、教育部等的多项研究项目。

 

代表性成果 (获奖成果、专著、论文、专利)
2.        Liang Xia, Sheng Li, Ruijiao Chen, Kai Liu, Xiaochuan Chen*, Catalytic Ugi-Type Condensation of α-Isocyanoacetamide and Chiral Cyclic Imine: Access to Asymmetric Construction of Several Heterocycles, J. Org. Chem.78(7), 3120-3131, 2013.
3.        Ruijiao Chen, Hao Liu, Xiaochuan Chen*, Asymmetric Total Synthesis of ()-Jorunnamycins A and C and ()-Jorumycin from L-Tyrosine, J. Nat. Prod.76(9), 1789-1795, 2013.
4.        Li Pan, Ruijiao Chen, Dongshun Ni, Liang Xia, Xiaochuan Chen*, An Approach to the Synthesis of Enantiopure Tetrahydroisoquinoline via a Key Asymmetric Ugi Reaction, Synlett24(2), 241-245, 2013.
5.        Ruijiao Chen, Hao Liu, Xiubing Liu, Xiaochuan Chen*, An efficient synthesis of L-3,4,5-trioxygenated phenylalanine compounds from l-tyrosine, Tetrahedron 69(17), 3565-3570, 2013.
6.        Sheng Li, Ruijiao Chen, Xiubing Liu, Li Pan, Liang Xia, Xiaochuan Chen*, An Ugi-type Condensation of α-Isocyanoacetamide and Chiral Cyclic Imine under a New Catalytic System, Synlett23(13), 1985-1989, 2012.
7.        Xiang Ma, Yuting Song, Hao Liu, Ruijiao Chen, Xiaochuan Chen*, First Syntheses of Lorneic Acids A and B with Potential PDE5 Inhibition Activity, Synlett23, 607-610, 2012.
8.        Deguang Zhu, Liang Xia, Li Pan, Sheng Li, Ruijiao Chen, Yongren Mou, Xiaochuan Chen*, An Asymmetric Ugi Three-Component Reaction Induced by Chiral Cyclic Imines: Synthesis of Morpholin- or Piperazine-Keto-carboxamide Derivatives, J. Org. Chem.77, 1386-1395, 2012.
9.        Ruijiao Chen, Deguang Zhu, Zuoqiang Hu, Zhiming Zheng, Xiaochuan Chen*, A new approach to synthesis of L-3-hydroxy-4-methoxy-5-methyl-phenylalanine derivatives from L-tyrosine, Tetrahedron: Asymmetry21(1), 39-42, 2010.
10.    Deguang Zhu, Ruijiao Chen, Haibo Liang, Sheng Li, Li Pan, Xiaochuan Chen*, An Efficient Procedure for the Synthesis of Morpholin-2-one-3-carboxamide Derivatives in Good Diastereoselectivity by the Ugi Reaction, Synlett 897-900, 2010.
11.    Xiaochuan Chen, Jieping Zhu, Total Synthesis of the Marine Natural Product (-)-Cribrostatin 4 (Renieramycin H), Angew. Chem. Int. Ed.46,3962-3965, 2007.
12.    Jinchun Chen, Xiaochuan Chen, Matthieu Willot, Jieping Zhu, Asymmetric Total Synthesis of Ecteinascidin 597 and Ecteinascidin 583, Angew. Chem. Int. Ed.45,8028-8032, 2006.
13.    Jinchun Chen, Xiaochuan Chen, Michele Bois-Choussy, Jieping Zhu, Total Synthesis of Ecteinascidin 743, J. Am. Chem. Soc.128(1),87-89, 2006.
14.    Xiaochuan Chen, Jinchun Chen, Jieping Zhu, Synthetic Studies on Ecteinascidin 743 (Et 743): Asymmetric Synthesis of a Highly Oxygenated Tetrahydroisoquinoline via a Key Phenolic Mannich Reaction, Synthesis(23),4081-4086, 2006.
15.    Xiaochuan Chen, Jinchun Chen, De Paolis Michael, Jieping Zhu, Synthetic Studies toward Ecteinascidin 743, J. Org. Chem.70(11),4397-4408, 2005.
16.    陈小川、陈瑞蛟,L-3-羟基-4-甲氧基-5-甲基-苯丙氨醇/酸化合物的合成,2012.6,中国,ZL200910059952.X。
 

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