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陈小川
职称与职务
教 授
专      业
有机化学
电      话
E-Mail
简  历
1992年9月-1996年6月,兰州大学化学系,理学学士;
1996年9月-1999年6月,兰州大学化学化工学院,理学硕士;
1999年9月-2002年6月,兰州大学化学化工学院,理学博士;
2003年1月-2007年8月;于法国国家科学研究中心,天然物质化学研究所,博士后;
2007年9月至今,四川大学化学学院任教。
主要研究方向
活性天然产物合成研究
有机合成方法学研究

主要工作业绩
    近些年发展出一些新颖实用的路线,完成了一些具有抗癌、抗菌、抗HIV-1等重要活性的天然分子的不对称合成。特别是在合成jorunnamycins、 jorumycin 等高度抗癌、抗菌活性的海洋生物碱时,在策略和产率上取得了较大的突破,对发掘抗癌新药上具有重要价值和意义。同时设计了一些新型不对称Ugi反应,基于此有效合成几类复杂的手性杂环化合物,具有潜在的活性。已在各类SCI期刊上发表三十多篇学术论文,承担和参与了自然科学基金委、科技部、教育部等的多项研究项目。

代表性成果 (获奖成果、专著、论文、专利)
1. Xiaojing Liu, Junhao Jia, Yuanliang Jia, He Gu, Jingwen Luo, Xiaochuan Chen*, A flexible and divergent strategy to flavonoids with chiral A ring featuring intramolecular Michael addition. Stereoselective synthesis of (+)-cryptocaryone, (+)-cryptogione F, (+)-cryptocaryanones A and B, (+)-cryptochinones A and C, Org. Lett. 2018, 20(7), 1945–1948.
2. Yi Wang, Zaixiang Fang, Xiaochuan Chen*, Yuanhua Wang*, Mild Dirhodium(II)-Catalyzed Chemo- and Regioselective Azidation of Arenes, Org. Lett. 2018, 20(18), 5732–5736.
3. Xiong Li, Lingling Hu, Junhao Jia, He Gu, Yuanliang Jia, Xiaochuan Chen*, A Stereoselective Approach toward (-)-Lepadins A–C, Org. Lett. 2017, 19(19), 5372–5375.
4. Po Yuan, Xiaojing Liu, Xing Yang, Yanli Zhang, Xiaochuan Chen*, Total Syntheses of (+)-Gabosine P, (+)-Gabosine Q, (+)-Gabosine E, (–)-Gabosine G, (–)-Gabosine I, (–)-Gabosine K, (+)-Streptol and (–)-Uvamalol A by a Diversity-Oriented Approach Featuring Tunable Deprotection Manipulation, J. Org. Chem. 2017, 82 (7), 3692–3701.
5. Lizhen Jiang, Xiaojing Liu, Po Yuan, Yanli Zhang, Xiaochuan Chen*, Stereoselective Synthesis of (+)-Annuionone A and (-)-Annuionone B, J. Nat. Prod. 2017, 80(4), 805–812.
6. Xiaojing Liu, Ruijiao Chen, Feixia Duan, Junhao Jia, Yuqin Zhou, Xiaochuan Chen*, A concise synthesis of (+)-botryolide-E and its C-7 epimer, Tetrahedron Lett. 2017, 58(42), 3947–3950.
7. Junhao Jia, Ruijiao Chen, Hao Liu, Xiong Li, Yuanliang Jia, Xiaochuan Chen*, Asymmetric Synthesis of (–)-Renieramycin T, Org. Biomol. Chem. 2016, 14, 7334–7344.
8. Xiaojing Liu, Lingling Hu, Lizhen Jiang, Junhao Jia, Di Zhang, Xiaochuan Chen*, Asymmetric Synthesis of Concentricolide, Eur. J. Org. Chem. 2015, 10, 2291–2296.
9. Yuting Song, Lingling Hu, Ruijiao Chen, Xiaochuan Chen*, Research Progress in Synthesis of Renieramycin-Type Alkaloids, Chin. J. Org. Chem.(有机化学)2015, 35, 1627–1640.
10. Xiubing Liu, Lingling Hu, Xiaojing Liu, Junhao Jia, Lizhen Jiang, Jiangfeng Lin, Xiaochuan Chen*, A New Approach to Asymmetric Synthesis of Infectocaryone, Org. Biomol. Chem. 2014, 12, 7603–7611.
11. Hao Liu, Ruijiao Chen, Xiaochuan Chen*, A Rapid and Efficient Access to Renieramycin-Type Alkaloids Featuring a Temperature-Dependent Stereoselective Cyclization, Org. Biomol. Chem. 2014, 12, 1633–1640.
12. Liang Xia, Sheng Li, Ruijiao Chen, Kai Liu, Xiaochuan Chen*, Catalytic Ugi-Type Condensation of α -Isocyanoacetamide and Chiral Cyclic Imine: Access to Asymmetric Construction of Several Heterocycles, J. Org. Chem. 2013, 78(7), 3120–3131.
13. Ruijiao Chen, Hao Liu, Xiaochuan Chen*, Asymmetric Total Synthesis of (-)-Jorunnamycins A and C and (-)-Jorumycin from L-Tyrosine, J. Nat. Prod. 2013, 76(9), 1789–1795. 
14. Li Pan, Ruijiao Chen, Dongshun Ni, Liang Xia, Xiaochuan Chen*, An Approach to the Synthesis of Enantiopure Tetrahydroisoquinoline via a Key Asymmetric Ugi Reaction, Synlett 2013, 24(2), 241–245.
15. Ruijiao Chen, Hao Liu, Xiubing Liu, Xiaochuan Chen*, An efficient synthesis of L-3,4,5-trioxygenated phenylalanine compounds from L-tyrosine, Tetrahedron 2013, 69(17), 3565–3570.
16. Sheng Li, Ruijiao Chen, Xiubing Liu, Li Pan, Liang Xia, Xiaochuan Chen*, An Ugi-type Condensation of α-Isocyanoacetamide and Chiral Cyclic Imine under a New Catalytic System, Synlett 2012, 23(13), 1985-1989. 
17. Xiang Ma, Yuting Song, Hao Liu, Ruijiao Chen, Xiaochuan Chen*, First Syntheses of Lorneic Acids A and B with Potential PDE5 Inhibition Activity, Synlett 2012, 23, 607-610.
18. Deguang Zhu, Liang Xia, Li Pan, Sheng Li, Ruijiao Chen, Yongren Mou, Xiaochuan Chen*, An Asymmetric Ugi Three-Component Reaction Induced by Chiral Cyclic Imines: Synthesis of Morpholin- or Piperazine-Keto-carboxamide Derivatives, J. Org. Chem. 2012, 77, 1386-1395.
19. Ruijiao Chen, Deguang Zhu, Zuoqiang Hu, Zhiming Zheng, Xiaochuan Chen*, A new approach to synthesis of L-3-hydroxy-4-methoxy-5-methyl-phenylalanine derivatives from L-tyrosine, Tetrahedron: Asymmetry 2010, 21(1), 39-42.
20. Deguang Zhu, Ruijiao Chen, Haibo Liang, Sheng Li, Li Pan, Xiaochuan Chen*, An Efficient Procedure for the Synthesis of Morpholin-2-one-3-carboxamide Derivatives in Good Diastereoselectivity by the Ugi Reaction, Synlett 2010, 897-900. 
21. Xiaochuan Chen, Jieping Zhu, Total Synthesis of the Marine Natural Product (-)-Cribrostatin 4 (Renieramycin H), Angew. Chem. Int. Ed. 2007, 46, 3962-3965.
22. Jinchun Chen, Xiaochuan Chen, Matthieu Willot, Jieping Zhu, Asymmetric Total Synthesis of Ecteinascidin 597 and Ecteinascidin 583, Angew. Chem. Int. Ed. 2006, 45, 8028-8032.
23. Jinchun Chen, Xiaochuan Chen, Michele Bois-Choussy, Jieping Zhu, Total Synthesis of Ecteinascidin 743, J. Am. Chem. Soc. 2006, 128(1), 87-89.
24. Xiaochuan Chen, Jinchun Chen, Jieping Zhu, Synthetic Studies on Ecteinascidin 743 (Et 743): Asymmetric Synthesis of a Highly Oxygenated Tetrahydroisoquinoline via a Key Phenolic Mannich Reaction, Synthesis 2006, (23), 4081-4086.
25. Xiaochuan Chen, Jinchun Chen, De Paolis Michael, Jieping Zhu, Synthetic Studies toward Ecteinascidin 743, J. Org. Chem. 2005,70(11), 4397-4408.
26. 陈小川、贾俊豪、陈瑞蛟、刘好,一类 renieramycin G 的合成中间体及其制备方法,中国发明专利,2016.6,ZL201310699230.7。
27. 陈小川、宋玉廷、陈瑞蛟,一类合成 renieramycins 型生物碱的中间体及其制备方法,中国发明专利,2016.4,ZL201310266099.5。
28. 陈小川、胡玲玲、陈瑞蛟、刘修兵,L-3,4,5-三氧代-苯丙氨酸/醛化合物的合成,中国发明专利,2015.11,ZL201210403651.6。
29. 陈小川、陈瑞蛟,L-3-羟基-4-甲氧基-5-甲基-苯丙氨醇/酸化合物的合成,中国发明专利,2012.6,ZL200910059952.X。
 

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