Na Wang

Na Wang

Tel028-85418580 O



Associate Professor, College of Chemistry, Sichuan University, Chengdu, China


Post Doc, School of Biotechnology, Royal Institute of Technology (KTH), Stockholm, Sweden.


Lecture, College of Chemistry, Sichuan University, Chengdu, China


Lecture, College of Science, Guizhou University, Guiyang, China


Ph. D., Chemical Biology,Department of Chemistry, Zhejiang University, Hangzhou, China


A teaching assistant, College of Science, Guizhou University, Guiyang, China


BS., Analytic Chemistry, Department of Chemistry, Guizhou University, Guiyang, China



1.      Biocatalysis and Biotransformation: Enzyme-catalyzed organic reaction and biocatalytic promiscuityChemo-Enzymatic synthesis of functional polymers and application

2.      Enzyme engineering and protein engineering: Expression, purification , modification and immobilization of enzyme protein.

&   PUBLICATIONS  (Since 2008)

[1]     Na Wang, Xiao-Qi Yu*, Hydrolase-Catalyzed Unconventional Reactions and Applications in Organic Synthesis. Green Chemistry, 2012, Chapter 8, P213-241. Editor: Rafael Luque. Nova Science Publishers, Inc.

[2]     Wu, W.-X.; Qu, L.; Liu, B.-Y.; Zhang, W.-W.; Wang, N.*; Yu, X.-Q.*, Lipase-catalyzed synthesis of acid-degradable poly(beta-thioether ester) and poly(beta-thioether ester-co-lactone) copolymers. Polymer 2015,59, 187-193.

[3]     Liu, B.-Y.; Wu, W.-X.; Wang, N.*; Yu, X.-Q.*, Novel biocompatible fluorescent polymeric micelles based on 1,8-naphthalimide derivatives for cell imaging. Polymer Chemistry 2015,6 (3), 364-368.

[4]     Hu, C.; Wang, N.*; Zhang, W.; Zhang, S.; Meng, Y.; Yu, X., Immobilization of Aspergillusterreus lipase in self-assembled hollow nanospheres for enantioselective hydrolysis of ketoprofen vinyl ester. Journal of Biotechnology 2015,194, 12-18.

[5]     Zhou, L.-H.; Wang, N.*; Chen, G.-N.; Yang, Q.; Yang, S.-Y.; Zhang, W.; Zhang, Y.; Yu, X.-Q.*, Lipase-catalyzed highly diastereoselective direct vinylogous Michael addition reaction of alpha,alpha-dicyanoolefins to nitroalkenes. Journal of Molecular Catalysis B-Enzymatic 2014,109, 170-177.

[6]     Zhang, Y.; Wang, N.*;Xie, Z.-B.; Zhou, L.-H.; Yu, X.-Q.*, Ionic liquid as a recyclable and efficient medium for lipase-catalyzed asymmetric cross aldol reaction. Journal of Molecular Catalysis B-Enzymatic 2014,110, 100-110.

[7]     Zhang, W.-W.; Wang, N.*; Zhang, L.; Wu, W.-X.; Hu, C.-L.; Yu, X.-Q.*, Effects of Additives on Lipase Immobilization in Microemulsion-Based Organogels. Applied Biochemistry and Biotechnology 2014,172 (6), 3128-3140.

[8]     Zhang, W.-W.; Wang, N.*; Feng, X.-W.; Zhang, Y.; Yu, X.-Q.*, Biocatalytic Synthesis of Optically Active Hydroxyesters via Lipase-Catalyzed DecarboxylativeAldol Reaction and Kinetic Resolution. Applied Biochemistry and Biotechnology 2014,173 (2), 535-543.

[9]     Xie, Z.-B.; Wang, N.*; Wu, W.-X.; Le, Z.-G.; Yu, X.-Q.*, Trypsin-catalyzed tandem reaction: One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by in situ formed acetaldehyde. Journal of Biotechnology 2014,170, 1-5.

[10] Wu, W.-X.; Wang, N.*; Liu, B.-Y.; Deng, Q.-F.; Yu, X.-Q.*, Lipase-catalyzed synthesis of azido-functionalized aliphatic polyesters towards acid-degradable amphiphilic graft copolymers. Soft Matter 2014,10 (8), 1199-1213.

[11] Zhou, Y.-J.; Hu, C.-L.; Wang, N.*; Zhang, W.-W.; Yu, X.-Q.*, Purification of porcine pancreatic lipase by aqueous two-phase systems of polyethylene glycol and potassium phosphate. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2013,926, 77-82.

[12] Zhou, L.-H.; Wang, N.*; Zhang, W.; Xie, Z.-B.; Yu, X.-Q.*, Catalytical promiscuity of alpha-amylase: Synthesis of 3-substituted 2H-chromene derivatives via biocatalytic domino oxa-Michael/aldol condensations. Journal of Molecular Catalysis B-Enzymatic 2013,91, 37-43.

[13] Xie, Z.-B.; Wang, N.*; Zhou, L.-H.; Wan, F.; He, T.; Le, Z.-G.; Yu, X.-Q.*, Lipase-Catalyzed Stereoselective Cross-Aldol Reaction Promoted by Water. Chemcatchem2013,5 (7), 1935-1940.

[14] Xie, Z.-B.; Wang, N.*; Jiang, G.-F.; Yu, X.-Q.*, Biocatalytic asymmetric aldol reaction in buffer solution. Tetrahedron Letters 2013,54 (8), 945-948.

[15] Wu, W.-X.; Wang, H.-Y.; Wang, N.*; Zhang, W.-W.; Lai, H.; Yu, X.-Q.*, Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen. Polymers 2013,5 (3), 1158-1168.

[16] Wang, N.*; Zhang, W.; Zhou, L.-H.; Deng, Q.-F.; Xie, Z.-B.; Yu, X.-Q.*, One-Pot Lipase-Catalyzed Aldol Reaction Combination of In Situ Formed Acetaldehyde. Applied Biochemistry and Biotechnology 2013,171 (7), 1559-1567.

[17] Zhang, W.-W.; Wang, N.*; Zhou, Y.-J.; He, T.; Yu, X.-Q.*, Enhancement of activity and stability of lipase by microemulsion-based organogels (MBGs) immobilization and application for synthesis of arylethyl acetate. Journal of Molecular Catalysis B-Enzymatic 2012,78, 65-71.

[18] Xie, Z.-B.; Wang, N.*; Wu, M.-Y.; He, T.; Le, Z.-G.; Yu, X.-Q.*, Catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to nitroalkenes by a grinding method. Beilstein Journal of Organic Chemistry 2012,8, 534-538.

[19] Wang, H.-Y.; Zhou, Y.-J.; Wang, Z.; Wang, N.*; Li, K.; Yu, X.-Q.*, Enzyme-Catalyzed Synthesis of a Novel Thermosensitive Polyester with Pendant Ketoprofen. Macromolecular Bioscience 2011,11 (5), 595-599.

[20] Wang, L.; Li, C.; Wang, N.*; Li, K.; Chen, X.; Yu, X.-Q.*, Enzyme-mediated domino synthesis of 2-alkylbenzimidazoles in solvent-free system: A green route to heterocyclic compound. Journal of Molecular Catalysis B-Enzymatic 2010,67 (1-2), 16-20.

[21] Wang, H.-Y.; Zhang, W.-W.; Wang, N.*; Li, C.; Li, K.; Yu, X.-Q.*, Biocatalytic Synthesis and in Vitro Release of Biodegradable Linear Polyesters with Pendant Ketoprofen. Biomacromolecules2010,11 (12), 3290-3293.

[22] Li, C.; Zhou, Y.-J.; Wang, N.*; Feng, X.-W.; Li, K.; Yu, X.-Q.*, Promiscuous protease-catalyzed aldol reactions: A facile biocatalytic protocol for carbon-carbon bond formation in aqueous media. Journal of Biotechnology 2010,150 (4), 539-545.

[23] Wang, H.-Y.; Li, C.; Wang, N.*; Li, K.; Feng, X.-W.; He, T.; Yu, X.-Q.*, Two-step enzymatic selective synthesis of water-soluble ketoprofen-saccharide conjugates in organic media. Bioorganic & Medicinal Chemistry 2009,17 (5), 1905-1910.

[24] Li, K.; He, T.; Li, C.; Feng, X.-W.; Wang, N.*; Yu, X.-Q.*, Lipase-catalysed direct Mannich reaction in water: utilization of biocatalytic promiscuity for C-C bond formation in a "one-pot" synthesis. Green Chemistry 2009,11 (6), 777-779.

[25] Feng, X.-W.; Li, C.; Wang, N.*; Li, K.; Zhang, W.-W.; Wang, Z.; Yu, X.-Q.*, Lipase-catalyseddecarboxylativealdol reaction and decarboxylativeKnoevenagel reaction. Green Chemistry 2009,11 (12), 1933-1936.

[26] Li, C.; Feng, X.-W.; Wang, N.*; Zhou, Y.-J.; Yu, X.-Q.*, Biocatalytic promiscuity: the first lipase-catalysed asymmetric aldol reaction. Green Chemistry 2008,10 (6), 616-618.