Na Wang

Na Wang

Tel028-85418580 O

Emailwnchem@scu.edu.cn

&   EDUCATION AND EXPERIENCE:

2008.7-Present:

Associate Professor, College of Chemistry, Sichuan University, Chengdu, China

2014.2-2016.1:

Post Doc, School of Biotechnology, Royal Institute of Technology (KTH), Stockholm, Sweden.

2006.6-2008.7:

Lecture, College of Chemistry, Sichuan University, Chengdu, China

2001.7-2006.6:

Lecture, College of Science, Guizhou University, Guiyang, China

2001-2006:

Ph. D., Chemical Biology,Department of Chemistry, Zhejiang University, Hangzhou, China

1998.7-2001.6:

A teaching assistant, College of Science, Guizhou University, Guiyang, China

1994-1998:

BS., Analytic Chemistry, Department of Chemistry, Guizhou University, Guiyang, China

 

&   RESEARCH INTERESTS:

1.      Biocatalysis and Biotransformation: Enzyme-catalyzed organic reaction and biocatalytic promiscuityChemo-Enzymatic synthesis of functional polymers and application

2.      Enzyme engineering and protein engineering: Expression, purification , modification and immobilization of enzyme protein.

&   PUBLICATIONS  

[1]    Zhang, W.; Wang, N.; Liu, Y.-H.; Jiao, S.-Y.; Zhang, W.-W.; Pu, X.-M.; Yu, X.-Q., 1,4-Dihydropyridines: discovery of minimal AIEEgens and their mitochondrial imaging applications. Journal Of Materials Chemistry B 2017, 5 (3), 464-469.

[2]    Zhang, W.; Wang, N.; Yang, Z.-J.; Li, Y.-R.; Yu, Y.; Pu, X.-M.; Yu, X.-Q., Lipase-Initiated Tandem Biginelli Reactions via in situ-Formed Acetaldehydes in One Pot: Discovery of Single-Ring Deep Blue Luminogens. Advanced Synthesis & Catalysis 2017, DOI: 10.1002/adsc.201700599

[3]    Liu, B.-Y.; Wu, W.-X.; Liu, Y.-H.; Jia, C.; Yang, X.-L.; Li, J.; Wang, N.; Yu, X.-Q., Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency. Polymer Chemistry 2017, 10.1039/C7PY01138E.

[4]    Wu, W.-X.; Yang, X.-L.; Liu, B.-Y.; Deng, Q.-F.; Xun, M.-M.; Wang, N.; Yu, X.-Q., Lipase-catalyzed synthesis of oxidation-responsive poly(ethylene glycol)-b-poly(beta-thioether ester) amphiphilic block copolymers. Rsc Advances 2016, 6 (14), 11870-11879.

[5]    Wu, W.-X.; Qu, L.; Liu, B.-Y.; Zhang, W.-W.; Wang, N.; Yu, X.-Q., Lipase-catalyzed synthesis of acid-degradable poly(beta-thioether ester) and poly(beta-thioether ester-co-lactone) copolymers. Polymer 2015, 59, 187-193.

[6]    Liu, B.-Y.; Wu, W.-X.; Wang, N.; Yu, X.-Q., Novel biocompatible fluorescent polymeric micelles based on 1,8-naphthalimide derivatives for cell imaging. Polymer Chemistry 2015, 6 (3), 364-368.

[7]    Hu, C.; Wang, N.; Zhang, W.; Zhang, S.; Meng, Y.; Yu, X., Immobilization of Aspergillus terreus lipase in self-assembled hollow nanospheres for enantioselective hydrolysis of ketoprofen vinyl ester. Journal Of Biotechnology 2015, 194, 12-18.

[8]    Zhou, L.-H.; Wang, N.; Chen, G.-N.; Yang, Q.; Yang, S.-Y.; Zhang, W.; Zhang, Y.; Yu, X.-Q., Lipase-catalyzed highly diastereoselective direct vinylogous Michael addition reaction of alpha,alpha-dicyanoolefins to nitroalkenes. Journal Of Molecular Catalysis B-Enzymatic 2014, 109, 170-177.

[9]    Xie, Z.-B.; Wang, N.; Wu, W.-X.; Le, Z.-G.; Yu, X.-Q., Trypsin-catalyzed tandem reaction: One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by in situ formed acetaldehyde. Journal Of Biotechnology 2014, 170, 1-5.

[10] Wu, W.-X.; Wang, N.; Liu, B.-Y.; Deng, Q.-F.; Yu, X.-Q., Lipase-catalyzed synthesis of azido-functionalized aliphatic polyesters towards acid-degradable amphiphilic graft copolymers. Soft Matter 2014, 10 (8), 1199-1213.

[11] Xie, Z.-B.; Wang, N.; Zhou, L.-H.; Wan, F.; He, T.; Le, Z.-G.; Yu, X.-Q., Lipase-Catalyzed Stereoselective Cross-Aldol Reaction Promoted by Water. Chemcatchem 2013, 5 (7), 1935-1940.

[12] Wang, H.-Y.; Zhang, W.-W.; Wang, N.; Li, C.; Li, K.; Yu, X.-Q., Biocatalytic Synthesis and in Vitro Release of Biodegradable Linear Polyesters with Pendant Ketoprofen. Biomacromolecules 2010, 11 (12), 3290-3293.

[13] Li, K.; He, T.; Li, C.; Feng, X.-W.; Wang, N.; Yu, X.-Q., Lipase-catalysed direct Mannich reaction in water: utilization of biocatalytic promiscuity for C-C bond formation in a "one-pot" synthesis. Green Chemistry 2009, 11 (6), 777-779.

[14] Feng, X.-W.; Li, C.; Wang, N.; Li, K.; Zhang, W.-W.; Wang, Z.; Yu, X.-Q., Lipase-catalysed decarboxylative aldol reaction and decarboxylative Knoevenagel reaction. Green Chemistry 2009, 11 (12), 1933-1936.

[15] Li, C.; Feng, X.-W.; Wang, N.; Zhou, Y.-J.; Yu, X.-Q., Biocatalytic promiscuity: the first lipase-catalysed asymmetric aldol reaction. Green Chemistry 2008, 10 (6), 616-618.