Na Wang

Na Wang

Tel028-85418580 O

Emailwnchem@scu.edu.cn

&   EDUCATION AND EXPERIENCE:

2008.7-Present:

Associate Professor, College of Chemistry, Sichuan University, Chengdu, China

2014.2-2016.1:

Post Doc, School of Biotechnology, Royal Institute of Technology (KTH), Stockholm, Sweden.

2006.6-2008.7:

Lecture, College of Chemistry, Sichuan University, Chengdu, China

2001.7-2006.6:

Lecture, College of Science, Guizhou University, Guiyang, China

2001-2006:

Ph. D., Chemical Biology,Department of Chemistry, Zhejiang University, Hangzhou, China

1998.7-2001.6:

A teaching assistant, College of Science, Guizhou University, Guiyang, China

1994-1998:

BS., Analytic Chemistry, Department of Chemistry, Guizhou University, Guiyang, China

 

&   RESEARCH INTERESTS:

1.      Biocatalysis and Biotransformation: Enzyme-catalyzed organic reaction and biocatalytic promiscuityChemo-Enzymatic synthesis of functional polymers and application

2.      Enzyme engineering and protein engineering: Expression, purification , modification and immobilization of enzyme protein.

&   PUBLICATIONS  (Since 2008)

[1]     Na Wang, Xiao-Qi Yu*, Hydrolase-Catalyzed Unconventional Reactions and Applications in Organic Synthesis. Green Chemistry, 2012, Chapter 8, P213-241. Editor: Rafael Luque. Nova Science Publishers, Inc.

[2]     Wu, W.-X.; Qu, L.; Liu, B.-Y.; Zhang, W.-W.; Wang, N.*; Yu, X.-Q.*, Lipase-catalyzed synthesis of acid-degradable poly(beta-thioether ester) and poly(beta-thioether ester-co-lactone) copolymers. Polymer 2015,59, 187-193.

[3]     Liu, B.-Y.; Wu, W.-X.; Wang, N.*; Yu, X.-Q.*, Novel biocompatible fluorescent polymeric micelles based on 1,8-naphthalimide derivatives for cell imaging. Polymer Chemistry 2015,6 (3), 364-368.

[4]     Hu, C.; Wang, N.*; Zhang, W.; Zhang, S.; Meng, Y.; Yu, X., Immobilization of Aspergillusterreus lipase in self-assembled hollow nanospheres for enantioselective hydrolysis of ketoprofen vinyl ester. Journal of Biotechnology 2015,194, 12-18.

[5]     Zhou, L.-H.; Wang, N.*; Chen, G.-N.; Yang, Q.; Yang, S.-Y.; Zhang, W.; Zhang, Y.; Yu, X.-Q.*, Lipase-catalyzed highly diastereoselective direct vinylogous Michael addition reaction of alpha,alpha-dicyanoolefins to nitroalkenes. Journal of Molecular Catalysis B-Enzymatic 2014,109, 170-177.

[6]     Zhang, Y.; Wang, N.*;Xie, Z.-B.; Zhou, L.-H.; Yu, X.-Q.*, Ionic liquid as a recyclable and efficient medium for lipase-catalyzed asymmetric cross aldol reaction. Journal of Molecular Catalysis B-Enzymatic 2014,110, 100-110.

[7]     Zhang, W.-W.; Wang, N.*; Zhang, L.; Wu, W.-X.; Hu, C.-L.; Yu, X.-Q.*, Effects of Additives on Lipase Immobilization in Microemulsion-Based Organogels. Applied Biochemistry and Biotechnology 2014,172 (6), 3128-3140.

[8]     Zhang, W.-W.; Wang, N.*; Feng, X.-W.; Zhang, Y.; Yu, X.-Q.*, Biocatalytic Synthesis of Optically Active Hydroxyesters via Lipase-Catalyzed DecarboxylativeAldol Reaction and Kinetic Resolution. Applied Biochemistry and Biotechnology 2014,173 (2), 535-543.

[9]     Xie, Z.-B.; Wang, N.*; Wu, W.-X.; Le, Z.-G.; Yu, X.-Q.*, Trypsin-catalyzed tandem reaction: One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by in situ formed acetaldehyde. Journal of Biotechnology 2014,170, 1-5.

[10] Wu, W.-X.; Wang, N.*; Liu, B.-Y.; Deng, Q.-F.; Yu, X.-Q.*, Lipase-catalyzed synthesis of azido-functionalized aliphatic polyesters towards acid-degradable amphiphilic graft copolymers. Soft Matter 2014,10 (8), 1199-1213.

[11] Zhou, Y.-J.; Hu, C.-L.; Wang, N.*; Zhang, W.-W.; Yu, X.-Q.*, Purification of porcine pancreatic lipase by aqueous two-phase systems of polyethylene glycol and potassium phosphate. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2013,926, 77-82.

[12] Zhou, L.-H.; Wang, N.*; Zhang, W.; Xie, Z.-B.; Yu, X.-Q.*, Catalytical promiscuity of alpha-amylase: Synthesis of 3-substituted 2H-chromene derivatives via biocatalytic domino oxa-Michael/aldol condensations. Journal of Molecular Catalysis B-Enzymatic 2013,91, 37-43.

[13] Xie, Z.-B.; Wang, N.*; Zhou, L.-H.; Wan, F.; He, T.; Le, Z.-G.; Yu, X.-Q.*, Lipase-Catalyzed Stereoselective Cross-Aldol Reaction Promoted by Water. Chemcatchem2013,5 (7), 1935-1940.

[14] Xie, Z.-B.; Wang, N.*; Jiang, G.-F.; Yu, X.-Q.*, Biocatalytic asymmetric aldol reaction in buffer solution. Tetrahedron Letters 2013,54 (8), 945-948.

[15] Wu, W.-X.; Wang, H.-Y.; Wang, N.*; Zhang, W.-W.; Lai, H.; Yu, X.-Q.*, Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen. Polymers 2013,5 (3), 1158-1168.

[16] Wang, N.*; Zhang, W.; Zhou, L.-H.; Deng, Q.-F.; Xie, Z.-B.; Yu, X.-Q.*, One-Pot Lipase-Catalyzed Aldol Reaction Combination of In Situ Formed Acetaldehyde. Applied Biochemistry and Biotechnology 2013,171 (7), 1559-1567.

[17] Zhang, W.-W.; Wang, N.*; Zhou, Y.-J.; He, T.; Yu, X.-Q.*, Enhancement of activity and stability of lipase by microemulsion-based organogels (MBGs) immobilization and application for synthesis of arylethyl acetate. Journal of Molecular Catalysis B-Enzymatic 2012,78, 65-71.

[18] Xie, Z.-B.; Wang, N.*; Wu, M.-Y.; He, T.; Le, Z.-G.; Yu, X.-Q.*, Catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to nitroalkenes by a grinding method. Beilstein Journal of Organic Chemistry 2012,8, 534-538.

[19] Wang, H.-Y.; Zhou, Y.-J.; Wang, Z.; Wang, N.*; Li, K.; Yu, X.-Q.*, Enzyme-Catalyzed Synthesis of a Novel Thermosensitive Polyester with Pendant Ketoprofen. Macromolecular Bioscience 2011,11 (5), 595-599.

[20] Wang, L.; Li, C.; Wang, N.*; Li, K.; Chen, X.; Yu, X.-Q.*, Enzyme-mediated domino synthesis of 2-alkylbenzimidazoles in solvent-free system: A green route to heterocyclic compound. Journal of Molecular Catalysis B-Enzymatic 2010,67 (1-2), 16-20.

[21] Wang, H.-Y.; Zhang, W.-W.; Wang, N.*; Li, C.; Li, K.; Yu, X.-Q.*, Biocatalytic Synthesis and in Vitro Release of Biodegradable Linear Polyesters with Pendant Ketoprofen. Biomacromolecules2010,11 (12), 3290-3293.

[22] Li, C.; Zhou, Y.-J.; Wang, N.*; Feng, X.-W.; Li, K.; Yu, X.-Q.*, Promiscuous protease-catalyzed aldol reactions: A facile biocatalytic protocol for carbon-carbon bond formation in aqueous media. Journal of Biotechnology 2010,150 (4), 539-545.

[23] Wang, H.-Y.; Li, C.; Wang, N.*; Li, K.; Feng, X.-W.; He, T.; Yu, X.-Q.*, Two-step enzymatic selective synthesis of water-soluble ketoprofen-saccharide conjugates in organic media. Bioorganic & Medicinal Chemistry 2009,17 (5), 1905-1910.

[24] Li, K.; He, T.; Li, C.; Feng, X.-W.; Wang, N.*; Yu, X.-Q.*, Lipase-catalysed direct Mannich reaction in water: utilization of biocatalytic promiscuity for C-C bond formation in a "one-pot" synthesis. Green Chemistry 2009,11 (6), 777-779.

[25] Feng, X.-W.; Li, C.; Wang, N.*; Li, K.; Zhang, W.-W.; Wang, Z.; Yu, X.-Q.*, Lipase-catalyseddecarboxylativealdol reaction and decarboxylativeKnoevenagel reaction. Green Chemistry 2009,11 (12), 1933-1936.

[26] Li, C.; Feng, X.-W.; Wang, N.*; Zhou, Y.-J.; Yu, X.-Q.*, Biocatalytic promiscuity: the first lipase-catalysed asymmetric aldol reaction. Green Chemistry 2008,10 (6), 616-618.