Na Wang

Na Wang

Tel028-85418580 O



Associate Professor, College of Chemistry, Sichuan University, Chengdu, China


Post Doc, School of Biotechnology, Royal Institute of Technology (KTH), Stockholm, Sweden.


Lecture, College of Chemistry, Sichuan University, Chengdu, China


Lecture, College of Science, Guizhou University, Guiyang, China


Ph. D., Chemical Biology,Department of Chemistry, Zhejiang University, Hangzhou, China


A teaching assistant, College of Science, Guizhou University, Guiyang, China


BS., Analytic Chemistry, Department of Chemistry, Guizhou University, Guiyang, China



1.      Biocatalysis and Biotransformation: Enzyme-catalyzed organic reaction and biocatalytic promiscuityChemo-Enzymatic synthesis of functional polymers and application

2.      Enzyme engineering and protein engineering: Expression, purification , modification and immobilization of enzyme protein.


[1]    Zhang, W.; Wang, N.; Liu, Y.-H.; Jiao, S.-Y.; Zhang, W.-W.; Pu, X.-M.; Yu, X.-Q., 1,4-Dihydropyridines: discovery of minimal AIEEgens and their mitochondrial imaging applications. Journal Of Materials Chemistry B 2017, 5 (3), 464-469.

[2]    Zhang, W.; Wang, N.; Yang, Z.-J.; Li, Y.-R.; Yu, Y.; Pu, X.-M.; Yu, X.-Q., Lipase-Initiated Tandem Biginelli Reactions via in situ-Formed Acetaldehydes in One Pot: Discovery of Single-Ring Deep Blue Luminogens. Advanced Synthesis & Catalysis 2017, DOI: 10.1002/adsc.201700599

[3]    Liu, B.-Y.; Wu, W.-X.; Liu, Y.-H.; Jia, C.; Yang, X.-L.; Li, J.; Wang, N.; Yu, X.-Q., Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency. Polymer Chemistry 2017, 10.1039/C7PY01138E.

[4]    Wu, W.-X.; Yang, X.-L.; Liu, B.-Y.; Deng, Q.-F.; Xun, M.-M.; Wang, N.; Yu, X.-Q., Lipase-catalyzed synthesis of oxidation-responsive poly(ethylene glycol)-b-poly(beta-thioether ester) amphiphilic block copolymers. Rsc Advances 2016, 6 (14), 11870-11879.

[5]    Wu, W.-X.; Qu, L.; Liu, B.-Y.; Zhang, W.-W.; Wang, N.; Yu, X.-Q., Lipase-catalyzed synthesis of acid-degradable poly(beta-thioether ester) and poly(beta-thioether ester-co-lactone) copolymers. Polymer 2015, 59, 187-193.

[6]    Liu, B.-Y.; Wu, W.-X.; Wang, N.; Yu, X.-Q., Novel biocompatible fluorescent polymeric micelles based on 1,8-naphthalimide derivatives for cell imaging. Polymer Chemistry 2015, 6 (3), 364-368.

[7]    Hu, C.; Wang, N.; Zhang, W.; Zhang, S.; Meng, Y.; Yu, X., Immobilization of Aspergillus terreus lipase in self-assembled hollow nanospheres for enantioselective hydrolysis of ketoprofen vinyl ester. Journal Of Biotechnology 2015, 194, 12-18.

[8]    Zhou, L.-H.; Wang, N.; Chen, G.-N.; Yang, Q.; Yang, S.-Y.; Zhang, W.; Zhang, Y.; Yu, X.-Q., Lipase-catalyzed highly diastereoselective direct vinylogous Michael addition reaction of alpha,alpha-dicyanoolefins to nitroalkenes. Journal Of Molecular Catalysis B-Enzymatic 2014, 109, 170-177.

[9]    Xie, Z.-B.; Wang, N.; Wu, W.-X.; Le, Z.-G.; Yu, X.-Q., Trypsin-catalyzed tandem reaction: One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by in situ formed acetaldehyde. Journal Of Biotechnology 2014, 170, 1-5.

[10] Wu, W.-X.; Wang, N.; Liu, B.-Y.; Deng, Q.-F.; Yu, X.-Q., Lipase-catalyzed synthesis of azido-functionalized aliphatic polyesters towards acid-degradable amphiphilic graft copolymers. Soft Matter 2014, 10 (8), 1199-1213.

[11] Xie, Z.-B.; Wang, N.; Zhou, L.-H.; Wan, F.; He, T.; Le, Z.-G.; Yu, X.-Q., Lipase-Catalyzed Stereoselective Cross-Aldol Reaction Promoted by Water. Chemcatchem 2013, 5 (7), 1935-1940.

[12] Wang, H.-Y.; Zhang, W.-W.; Wang, N.; Li, C.; Li, K.; Yu, X.-Q., Biocatalytic Synthesis and in Vitro Release of Biodegradable Linear Polyesters with Pendant Ketoprofen. Biomacromolecules 2010, 11 (12), 3290-3293.

[13] Li, K.; He, T.; Li, C.; Feng, X.-W.; Wang, N.; Yu, X.-Q., Lipase-catalysed direct Mannich reaction in water: utilization of biocatalytic promiscuity for C-C bond formation in a "one-pot" synthesis. Green Chemistry 2009, 11 (6), 777-779.

[14] Feng, X.-W.; Li, C.; Wang, N.; Li, K.; Zhang, W.-W.; Wang, Z.; Yu, X.-Q., Lipase-catalysed decarboxylative aldol reaction and decarboxylative Knoevenagel reaction. Green Chemistry 2009, 11 (12), 1933-1936.

[15] Li, C.; Feng, X.-W.; Wang, N.; Zhou, Y.-J.; Yu, X.-Q., Biocatalytic promiscuity: the first lipase-catalysed asymmetric aldol reaction. Green Chemistry 2008, 10 (6), 616-618.