Ji Zhang

Professor, Ph.D.

Title: Professor, Ph.D.

Major: Chemical biology, Organic chemistry

Tel: 028-85418580




1993.9-1997.7: Undergraduate in College of Chemistry, SCU

1997.9-2002.6: Ph.D. candidate in College of Chemistry, SCU

2002.7-2007.6: Lecturer, SCU

2003.1-2005.1: Research Assistant, the University of Hong Kong

2007.7-2013.6: Associate Professor, SCU

2013.7- : Professor, SCU


Teaching courses:

Organic Chemistry I (203112030 & 203113030)

Biochemistry (203080030)

Organic Chemistry Experiments


Research interests

Nano-biomaterials: Design, synthesis and establishment of novel non-viral gene and drug delivery systems, structure-activity relationship (SAR) studies

Organic synthesis: Green organic synthetic methodology with high efficiency and selectivity; Microwave-assisted organic reactions


Program for New Century Excellent Talents in University (NCET-11-0354)

First Prize in Natural Science Research Achievements in High School, Ministry of Education, 2010 (ranking of 3rd)

The First Wuliangchun Outstanding Teaching Award for Young Teachers, SCU, 2015

Advanced individual (Excellent teacher), SCU, 2015-16

Top Ten Young Teachers of SCU, 2012-13

Prize for Excellent Teaching Quality toward Undergraduates, SCU, 2011 & 2013

Prize for Excellent Young Teachers, SCU, 2009 & 2011 & 2014

Representative papers (since 2009)

1.Wang, H.-J.; He, X.; Luo, T.-Y.; Zhang, J.*; Liu, Y.-H.; Yu, X.-Q.* “Amphiphilic carbon dots as versatile vector for nucleic acid and drug delivery” Nanoscale. 2017, 9, DOI: 10.1039/C7NR01029J..

2.Zhang, Y.-M; Huang, Z.; Zhang, J.*; Wu, W.-X.; Liu, Y.-H.; Yu, X.-Q.* “Amphiphilic polymers from ring-opening polymerization: a strategy for the enhancement of gene delivery” Biomater. Sci. 2017, 5(4), 718-729.

3.Huang, Z.; Zhang, Y.-M.; Cheng, Q.; Zhang, J.*; Liu, Y.-H.; Wang, B.; Yu, X.-Q.* “Structure-activity relationship studies of symmetrical cationic bolasomes as non-viral gene vectors” J. Mater. Chem. B 2016, 4(33), 5575-5584.

4.Luan, C.-R.; Liu, Y.-H.; Zhang, J.*; Yu, Q.-Y.; Huang, Z.; Wang, B.; Yu, X.-Q.* “Low molecular weight oligomers with aromatic backbone as efficient non-viral gene vectors” ACS Appl. Mater. Interf. 2016, 8(17), 10743-10751.

5.Xun, M.-M.; Xiao, Y.-P.; Zhang, J.*; Liu, Y.-H.; Peng, Q.; Guo, Q.; Wu, W.-X.; Xu, Y.; Yu, X.-Q.* “Low molecular weight PEI-based polycationic gene vectors via Michael addition polymerization with improved serum-tolerance” Polymer2015, 65, 45-54.

6.Guo, Q.; Liu, Y.-H.; Xun, M.-M.; Zhang, J.*; Huang, Z.; Zhou, X.-D.; Yu, X.-Q.* “Diol glycidyl ether-bridged low molecular weight PEI as potential gene delivery vehicles” J. Mater. Chem. B2015, 3(13), 2660-2670.

7.Zhang, Q.-F.; Yu, Q.-Y.; Geng, Y.; Zhang, J.*; Wu, W.-X.; Wang, G.; Gu, Z.; Yu, X.-Q.* “Ring-opening polymerization for hyperbranched polycationic gene delivery vectors with excellent serum tolerance” ACS Appl. Mater. Interfaces 2014, 6(18), 15733-15742.

8.Yi, W.-J.; Yu, X.-C.; Wang, B.; Zhang, J.*; Yu, Q.-Y.; Zhou, X.-D.; Yu, X.-Q.* “TACN-based oilgomers with aromatic backbones for efficient nucleic acid delivery” Chem. Commun. 2014, 50(49), 6454-6457.

9.Yi, W.-J.; Zhang, Q.-F.; Zhang, J.*; Liu, Q.; Ren, L.; Chen, Q.-M.; Guo, L.; Yu, X.-Q.* “Cyclen-based lipidic oligomers as potential gene delivery vehicles” Acta Biomater.2014, 10(3), 1412-1422.

10.Wang, H.-J.; Liu, Y.-H.; Zhang, J.*; Zhang, Y.; Xia, Y.; Yu, X.-Q.* “Cyclen-based cationic lipids with double hydrophobic tails for efficient gene delivery” Biomaterials Sci.2014, 2(10), 1460-1470.

11.Li, C.-Y.; Wang, H.-J.; Cao, J.-M; Zhang, J.*; Yu, X.-Q.* “Bioreducible cross-linked polymers based on G1 peptide dendrimer as potential gene delivery vectors” Eur. J. Med. Chem. 2014, 87, 413-420.

12.Zhang, Q.-F.; Yi, W.-J.; Wang, B.; Zhang, J.*; Ren, L.; Chen, Q.-M.; Guo, L.; Yu, X.-Q.* “Linear polycations by ring-opening polymerization as non-viral gene delivery vectors: structure-activity relationship studies” Biomaterials2013, 34(21), 5391-5401.

13.Xun, M.-M.; Zhang, X.-C.; Zhang, J.*; Jiang, Q.-Q.; Yi, W.-J.; Zhu, W.; Yu, X.-Q.* “Low molecular weight PEI-based biodegradable lipopolymers as gene delivery vectors” Org. Biomol. Chem. 2013, 11(7), 1242-1250.

14.Wang, J.; Wang, S.; Wang, G.; Zhang, J.*; Yu, X.-Q.* “Iron-Mediated Direct Arylation with Arylboronic Acids through an Aryl Radical Transfer Pathway” Chem. Commun.2012, 48(96), 11769-11771.

15.Huang, Q.-D.; Ren, J.; Chen, H.; Ou, W.-J.; Fu, Y.; Zhang, J.*; Zhu, W.; Yu, X.-Q.* “Cyclen based-cationic lipids containing carbamate linkages as efficient gene delivery vector with low toxicity” ChemPlusChem2012, 77(7), 584-591.

16.Feng, J.; Liang, S.; Chen, S.-Y.; Zhang, J.*; Fu, S.-S.; Yu, X.-Q.* “A Metal-Free Oxidative Esterification of Benzyl C-H Bond” Adv. Synth. Catal.2012, 354(7), 1287-1292.

17.Wen, J.; Zhang, R.-Y.; Chen, S.-Y.; Zhang, J.*; Yu, X.-Q.* “Transition Metal-Free Direct Arylation of Arene and N-Heteroarenes with Diaryliodonium Salts” J. Org. Chem.2012, 77(1), 766-771.

18.Wang, J.; Hou, J.-T.; Wen, J.; Zhang, J.*; Yu, X.-Q.* “Iron-catalyzed direct amination of azoles using formamides or amines as nitrogen sources in air” Chem. Commun. 2011, 47(12), 3652-3654.

19.Huang, Q.-D.; Zhong, G.-X.; Zhang, Y.; Ren, J.; Fu, Y.; Zhang, J.*; Zhu, W.; Yu, X.-Q.* “Cyclen-based cationic lipids for highly efficient gene delivery towards tumor cells” PLoS One2011, 6(8), e23134.

20.Huang, Q.-D.; Ou, W.-J.; Chen, H.; Feng, Z.-H.; Wang, J.-Y.; Zhang, J.*; Zhu, W.; Yu, X.-Q.* “Novel cationic lipids possessing protonated cyclen and imidazolium salt for gene delivery” Eur. J. Pharm. Biopharm. 2011, 78(3), 326-335.

21.Li, S.; Wang, Y.; Zhang, J.*; Yang, W.-H.; Dai, Z.-H.; Zhu, W.; Yu, X.-Q.* “Biodegradable cross-linked poly(amino alcohol esters) based on LMW PEI for gene delivery” Mol. Biosyst.2011, 7(3), 1254-1262.

22.Zhang, J.; Meng, X.-G.; Zeng, X.-C.; Yu, X.-Q.* “Metallomicellar Supramolecular Systems and Their Applications in Catalytic Reactions” Coordin. Chem. Rev.2009, 253(17-18), 2166-2177.