Born: September, 1986
Email:email@example.com or firstname.lastname@example.org;
Address: #29, Wangjiang Road, Wuhou District, Chengdu, Sichuan Province, China, 610064
Phones:+86 028-85470816 (O)
Researcher ID: D-3867-2016
Research Gate or LinkedIn: Da-Gang Yu or email@example.com
Postdoc and CSC Ph.D. candidate positions are available! Please, apply!
Education and Working Experience:
Professor, College of Chemistry, Sichuan University
Postdoc with Humboldt Fellowship, Muenster University
Supervisor: Prof. Dr. Frank Glorius
Ph. D., in Organic Chemistry, Peking University, P. R. China.
Supervisor: Prof. Dr. Zhang-Jie Shi
Thesis Title: “Transition Metal-Catalyzed Inert C-O and C-C Bonds Activation”
B. S., in Chemistry, Sichuan University, Chengdu, P. R. China.
Supervisor: Prof. Dr. Xiaoming Feng and Prof. Dr. Li-Hua Yuan
Selected Recent Awards and Scholarships
2017 ACP Lectureship Awards to Japan
2017 Thieme Chemistry Journal Award
2016 Young Talent Award of Sichuan University
2015 “Organic Chemistry Frontiers” Emerging Investigators
2014 Recruitment Program for Young Professionals (The Thousand Young Talents Plan)
2015 Recruitment Program for Young Professionals (The Thousand Young Talents Plan)
2013-2014 Alexander von Humboldt Fellowship
2013 Finalist of the 2013 Reaxys PhD Prize
2012 Dow Sustainability Innovation Student Challenge Award (Grand Prize)
2012 Top Ten Academic Stars of Peking University
2011 SciFinder Recognition in Excellence Program for OMCOS16
2011 “Star of Chemistry” of CCME in Peking University
2010 Special Grade of Chang-Qing Scholarship
2009 First Grade of Chang-Qing Scholarship
Novel Transition Metal-Catalysis (especially Cu- and Fe-catalysis)
Carbon dioxide (CO2) is not only a greenhouse gas but also an inexpensive, readily available and renewable carbon resource. It is very important to utilize such a one-carbon (C1) building block in organic synthesis to construct valuable heterocycles. However, it is very challenging due to its thermodynamic and kinetic stability and inertness. Although significant progress has been achieved,there are lots of limitations in reaction system and substrate scope in this field.
Our group has developed the direct use of carbon dioxide in the lactamization and lactonization of alkenyl and heteroaryl C─H bonds to synthesize important 2-quinolinones and coumarin derivatives in moderate to excellent yields. Importantly, these transition-metal-free and redox-neutral processes are eco-friendly and desirable for the pharmaceutical industry. Moreover, these reactions feature a broad substrate scope, good functional group tolerance, facile scalability and easy product derivatization.
Moreover, we realized a highly regio- and enantioselective copper-catalyzed reductive hydroxymethylation of styrenes and 1,3-dienes with one atmosphere of CO2. Diverse important chiral homobenzylic and homoallylic alcohols were readily prepared from styrenes and 1,3-dienes with high yields and excellent regio-, enantio- and Z/E- selectivities. The utility of this transformation was demonstrated by a broad range of styrenes and 1,3-dienes, facile product modification and the synthesis of bioactive compounds (R)-(?)-curcumene and (S)-(+)-ibuprofen.
Furthermore, we have disclosed the first oxytrifluoromethylation of allylamines with carbon dioxide (CO2) to synthesize important CF3-containing 2-oxazolidones via Cu-catalysis. It is also the first time to utilize CO2, a nontoxic and easily available greenhouse gas, to tune the difunctionalization of alkenes from amino- to oxy-trifluoromethylation. Of note, this multi-component reaction is highly chemoselective, regioselective and diastereoselective under redox-neutral and mild reaction conditions.
More recently, visible light-driven transformation of CO2 has been developed through generation of reactive CO2 radical anion, which is novel and unique in the field of CO2 utilization. The first thiocarboxylation of styrenes and acrylates with CO2 is realized by using visible light as a driving force and catalytic iron salts as promoters. A variety of important β-thioacids are obtained in high yields. This multicomponent reaction proceeds in an atom- and redox-economical way with broad substrate scope under mild reaction conditions. Notably, high regio-, chemo- and diastero-selectivity are observed.
1. Y.-Y. Gui, ? N. Hu, ? X.-W. Chen, L.-L. Liao, T. Ju, J.-H. Ye, Z. Zhang, J. Li, D.-G. Yu*, Highly Regio- and Enantioselective Copper-Catalyzed Reductive Hydroxymethylation of Styrenes and 1,3-Dienes with CO 2. J. Am. Chem. Soc. 2017, DOI: 10.1021/jacs.7b10149. ( ? Equal contribution. Cover)
2. J.-H. Ye, M. Miao, H. Huang,S.-S. Yan, Z.-B. Yin, W.-J. Zhou, D.-G. Yu*, Visible light-driven and Iron-promoted Thiocarboxylation of Styrenes and Acrylates with CO 2. Angew. Chem. Int. Ed. 2017, DOI: 10.1002/anie.201707862. (Online)
3. W.-J. Zhou, G.-M. Cao, G. Shen, X.-Y. Zhu, Y.-Y. Gui, J.-H. Ye, L. Sun, L.-L. Liao,J. Li, D.-G. Yu*, Visible-Light-Driven Pd-Catalyzed Radical Alkylation of C─H Bonds with General Unactivated Alkyl Bromides. Angew. Chem. Int. Ed. 2017, DOI: 10.1002/anie.201704513. (Online)
4. J.-H. Ye,? L. Zhu,? S.-S. Yan, M. Miao,X.-C. Zhang, W.-J. Zhou, J. Li, Y. Lan*, D.-G. Yu*, Radical Trifluoromethylative Dearomatization of Indoles and Furans with CO2. ACS Catal. 2017, 7, 8324. ( ? Equal contribution)
5. Y.-Y. Gui, X.-W. Chen, W.-J. Zhou*, D.-G. Yu*, Arylation of Amides and Ureas C(sp 3)─H Bonds with Aryl Tosylates via in situ Generation from Phenols. Synlett2017, DOI: 10.1055/s-0036-1589126. (Invited paper for the issue of C-O activation)
6. L. Zhu, J.-H. Ye, M. Duan, X. Qi, D.-G. Yu*, R. Bai*, Y. Lan*, On the Mechanism of Copper-Catalyzed Oxytrifluoromethylationof Allylamines with CO 2: A Computational Study. Org. Chem. Front. 2017, DOI: 10.1039/C7QO00838D.
7. Y.-Y. Gui, Z.-X. Wang, W.-J. Zhou*, L.-L. Liao, L. Song, Z.-B. Yin,J. Li, D.-G. Yu*, Arylation of Aniline C(sp 3)─H Bonds with Phenols by an in-situ Activation Strategy. Asian J. Org. Chem.2017, DOI: 10.1002/ajoc.201700450. (Selected as VIP. Highlighted by ChemistryViews. Invited paper for the Special Issue on Early Career Researchers in China)
8. L.-L. Liao, Y.-Y. Gui, X.-B. Zhang, G. Shen, H.-D. Liu, W.-J. Zhou, J. Li, D.-G. Yu*, Phosphorylation of Alkenyl and Aryl C─O Bonds via Photoredox/Nickel Dual Catalysis. Org. Lett. 2017, 19, 3735. (Top 2 most read papers in July, 2017)
9. W.-J. Zhou*, Y.-H. Zhang, C.-G. Mei, H.-D. Liu, D.-G. Yu*, Palladium-Catalyzed Radical-Type Transformations of Alkyl Halides. Chin. J. Org. Chem. 2017，37, 1322. (Invited review)
10. Y.-Y. Gui?, W.-J. Zhou?, J.-H. Ye, D.-G. Yu*, Photochemical Carboxylation of Activated C(sp3)─H Bonds with CO2. ChemSusChem2017, 10, 1337. (? Equal contribution.Highlight)
11. Z. Zhang, T. Ju, J.-H. Ye, D.-G. Yu*, CO 2 = CO + O: Redox-neutral Lactamization and Lactonization of C─H Bonds with CO2. Synlett 2017,Synlett 2017, 28, 741. (Invited Synpacts paper)
12. Z. Zhang ?, T. Ju ?, M. Miao, J.-L. Han, Y.-H. Zhang, X.-Y. Zhu, J.-H. Ye, D.-G. Yu*, Y.-G. Zhi*, Transition-Metal-Free Lactonization of sp 2 C─H Bonds with CO 2. Org. Lett. 2017. 19, 396. ( ? Equal contribution . Top 3 most read papers in January, 2017)
13. Y.-Y. Gui, L.-L. Liao, L. Sun, Z. Zhang, J.-H. Ye, G. Shen, Z.-P. Lu, W.-J. Zhou, D.-G. Yu*, Coupling of C(sp 3)─H Bonds with C(sp 2)─O Electrophiles: Mild, General and Selective. Chem. Comm. 2017, 53, 1192.
14. J.-H. Ye, L. Song, W.-J. Zhou, T. Ju, Z.-B. Yin, S.-S. Yan, Z. Zhang, J. Li, D.-G. Yu*, Selective Oxytrifluoromethylation of Allylamines with CO2. Angew. Chem. Int. Ed.2016, 55, 10022. (Top 4 most readACIEpapers in July, 2016)
15.Z. Zhang, L.-L. Liao, S.-S. Yan, L. Wang, Y.-Q. He, J.-H. Ye, J. Li, Y.-G. Zhi, D.-G. Yu*, Lactamization of sp2C─H Bonds with CO2: Transition-metal-free and Redox-neutral.Angew. Chem. Int. Ed.2016, 55,7068. (the Frontispiece of Communications; Highlighted by Synfacts 2016, 12, 0910 and Chin. J. Org. Chem.)
16. Y.-Y. Gui, L. Sun, Z.-P. Lu, D.-G. Yu*, Photoredox sheds new light on nickel catalysis: from carbon-carbon to carbon-heteroatom bond formation. Org. Chem. Front. 2016, 3, 522. (From themed collection 2015 Emerging Investigators by OCF)
17. X. Wang?, D.-G. Yu?, F. Glorius*, Cp*Rh(III)-Catalyzed Arylation of sp3 C?H Bonds. Angew. Chem. Int. Ed.2015, 54, 10280. (? Equal contribution)
18. D.-G. Yu, T. Gensch, F. de Azambuja, S. Vásquez-Céspedes, F. Glorius*, Co(III)-Catalyzed C–H Activation/Formal SN-type Reactions: Selective and Efficient Cyanation, Halogenation, and Allylation.J. Am. Chem. Soc.2014,136, 17722. (Top 3 most read JACS papers in December, 2014).
19.D.-G. Yu, F. de Azambuja, T. Gensch, C. G. Daniliuc, F. Glorius*, The C–H Activation/1,3-Diyne Strategy: Highly Selective Direct Synthesis of Diverse Bisheterocycles by RhIII-Catalysis. Angew. Chem. Int. Ed.2014, 53, 9650. (Highlighted by Synfacts 2014, 10, 1023)
20.D.-G. Yu, F. de Azambuja, F. Glorius*, Direct Functionalization with Complete and Switchable Positional Control: Free Phenol as A Role Model. Angew. Chem. Int. Ed. 2014, 53, 7710. (Highlight)
21.D.-G. Yu, F. de Azambuja, F. Glorius*, α-MsO/TsO/Cl Ketones as Oxidized Alkyne Equivalents: Redox-Neutral Rhodium(III)-Catalyzed C–H Activation for the Synthesis of N-Heterocycles. Angew. Chem. Int. Ed. 2014, 53, 2754. (Top 6 most accessed ACIE paper in Feb. 2014, Highlighted by Synfacts 2014, 10, 567.)
22. D.-G. Yu, S. Luo, F. Zhao, Z.-J. Shi*, Homogeneous Transition-Metal-Catalzyed C–O Bond Activation. In Homogeneous Catalysis for Unreactive Bond ActivationPages 347–439, 2014 (Wiley book)., Chapter 5, Pages 347–439, 2014 (Wiley book).
23.D.-G. Yu?, M. Suri?, F. Glorius*, RhIII/CuII-Cocatalyzed Synthesis of 1H-Indazoles through C?H Amidation and N?N Bond Formation. J. Am. Chem. Soc. 2013, 135, 8802. ( equal contribution, most read JACS papers in June, 2013)
24.Z.-J. Shi*, D.-G. Yu, Cross-Coupling Reactions. In Comprehensive Inorganic Chemistry II (Second Edition), Volume 6, Pages 47–77 (2013).
25.D.-G. Yu, X. Wang, R.-Y. Zhu, S. Luo, X.-B. Zhang, B.-Q. Wang, L. Wang, Z.-J. Shi*,Direct Arylation/Alkylation/Magnesiation of Benzyl Alcohols in the Presence of Grignard Reagents via Ni, Fe or Co-Catalyzed sp3 C–O Bond Activation. J. Am. Chem. Soc. 2012, 134, 14638. (Highlighted by Synfacts 2012, 8, 1358)
26.D.-G. Yu, Z.-J. Shi*, Mutual Activation: Suzuki–Miyaura Coupling through Direct Cleavage of sp2 C–O Bond of Naphtholate. Angew. Chem. Int. Ed. 2011, 50, 7097. (Highlighted by Synfacts 2011, 10, 1111)
27.D.-G. Yu, B.-J. Li, S. F. Zheng, B.-T. Guan, B.-Q. Wang, Z.-J. Shi*, Direct Application of Phenolic Salts in Nickel-Catalyzed Cross-Coupling with Aryl Grignard Reagents. Angew. Chem. Int. Ed. 2010, 49, 4566. (Hot paper, the frontpieces of Communications, highlighted by ChemistryViews, Synfacts 2010, 9, 1051以及《有机化学》亮点介绍)
28.D.-G. Yu, B.-J. Li, Z.-J. Shi*, Exploration of new C–O electrophiles in cross-coupling reactions. Acc. Chem. Res. 2010, 43, 1486. (Invited account. Top ten most-accessed articles of Acc. Chem. Res. in 2010)
29.C.-L. Sun, H. Li, D.-G. Yu, M. Yu, X. Zhou, X.-Y. Lu, K. Huang, S.-F. Zheng, B.-J. Li, Z.-J. Shi*, An efficient organocatalytic method for constructing biaryls through aromatic C–H activation. Nature Chem. 2010, 2, 1044 (C.-L. Sun, H. Li, and D.-G. Yu performed the experiments and analysed the data and contributed equally to this work, highlighted by Nature Chem., Nature China and Synform)
30.S. Luo?, D.-G. Yu?, R.-Y. Zhu, X. Wang, L. Wang, Z.-J. Shi*, Fe-promoted cross coupling of homobenzylic methyl ethers with Grignard reagents via sp3 C–O bond cleavage. Chem. Comm. 2013. 49, 7794. ( equal contribution)
31.D.-G. Yu, M. Yu, B.-T. Guan, B.-J. Li, Y. Zheng, Z.-H. Wu, Z.-J. Shi*, Carbon–Carbon Formation via Ni-Catalyzed Suzuki-Miyaura Coupling through C–CN Bond Cleavage of Aryl Nitrile. Org. Lett. 2009, 11, 3374. (Highlighted by Synfacts 2009, 11, 1255)
32.Z.-J. Shi *, D.-G. Yu, The “Welding” Technology in Organic Synthesis. Sci. Tec. Rev.2010, 28, 29. (Invited review)
33.D.-G. Yu, B.-J. Li, Z.-J. Shi*, Challenges in C-C Bond Formation through Direct Transformations of sp2 C–H Bonds.Tetrahedron 2012, 68, 5130. (Invited account in special issue for Tetrahedron Young Investigator Award 2012 Advances in Metal-Mediated Organic Synthesis Zhang-Jie Shi. Cover. Top 3 hottest paper in 2012)
34.Z.-C. Cao,D.-G. Yu, R.-Y. Zhu, J.-B. Wei, Z.-J. Shi*, Direct Cross Coupling of Benzyl Alcohols to Construct Diarylmethanes via Palladium Catalysis. Chem. Comm. 2015, 51, 2683.
35.F. Zhao,D.-G. Yu, R.-Y. Zhu, Z.-F. Xi*, Z.-J. Shi*, Cross-Coupling of Aryl/Alkenyl Silyl Ether with Grignard Reagents through Nickel-Catalyzed C–O Bonds Activation. Chem. Lett. 2011, 40, 1001. (Invited research paper in Celebration for the 2010 Nobel Prize in Chemistry)
36.B.-J. Li, D.-G. Yu, C.-L. Sun, Z.-J. Shi*, Activation of “Inert” Alkenyl/Aryl C–O Bond and its Application in Cross-Coupling Reactions. Chem. Eur. J. 2011, 17, 1728. (Review)
37.K. Huang, D.-G. Yu, S.-F. Zheng, Z.-H. Wu, L. Xu, B.-Q. Wang, Z.-J. Shi*, Direct Borylation of Aryl and Vinyl Carbamates via Ni-Catalyzed C–O Activation. Chem. Eur. J. 2010, 17, 786.
38.H. Wang, B. Beiring, D.-G. Yu, K. Collins, F. Glorius, Dendralene Synthesis: Rhodium(III)-Catalyzed Alkenyl C–H Activation and Coupling Reaction with Allenyl Carbinol Carbonate, Angew. Chem. Int. Ed. 2013, 52, 12430.
39.F. Zhao, Y.-F. Zhang, J. Wen, D.-G. Yu, J.-B. Wei, Z.-F. Xi*, Z.-J. Shi*, Programmed Selective sp2 C–O Bond Activation toward Multiarylated Benzenes. Org. Lett. 2013, 15, 3230.
40.K. Huang, G. Li, W.-P. Huang, D.-G. Yu,Z.-J. Shi*, Arylation of α-pivaloxyl Ketones with Arylboronic Reagents via Ni-catalyzed sp3 C–O Activation. Chem. Commun. 2011, 47, 7224.
41.H. Li, C.-L. Sun, M. Yu, D.-G. Yu, B.-J. Li, Z.-J. Shi*, The Catalytic Ability of Various Transition Metals in the Direct Functionalization of Aromatic C–H Bonds. Chem. Eur. J. 2011, 17, 3593.
42.C.-L. Sun, N. Liu, B.-J. Li, D.-G. Yu, Y. Wang, Z.-J. Shi*, Pd-Catalyzed C-H Functionalizations of O-Methyl Oximes with Arylboronic Acids. Org. Lett. 2010, 12, 184.
43.B.-T. Guan, X.-Y. Lu, Y. Zheng, D.-G. Yu, T. Wu, K.-L. Li, B.-J. Li, Z.-J. Shi*, Biaryl Construction through Kumada Coupling with Diaryl Sulfates as One-by-One Electrophiles under Mild Conditions. Org. Lett. 2010,12, 396. (Highlighted by Synfacts 2010, 4, 0455)
44.B.-T. Guan, Y. Wang, B.-J. Li, D.-G. Yu, Z.-J. Shi*, Biaryl Construction via Ni-Catalyzed C–O Activation of Aryl Carboxylates.J. Am. Chem. Soc. 2008, 130, 14468. (Highlighted by Angew. Chem. Int. Ed. 2009, 48, 3569)
1.The 12th National Physical Organic Chemistry Conference, Wuhan, 10/17/2017
2.International Symposium on Organic Chemistry in Western China, Chengdu, 10/08/2017
3.The 15th National Homogenous Catalysis Conference, Hangzhou, 09/27/2017
4.The 15th National Photochemistry Conference, Lanzhou, 08/23/2017
5.The 19th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS19), Jeju, Korea, 6/27/2017
6.Tateshina Conference on Organic Chemistry 2016, Tateshina, 11/10/2016
7.The 19th National Organometalic Chemistry Conference, Hangzhou, 10/30/2016
8.2016 Nanocatalysis and Clean Synthesis Conference, Suzhou, 10/29/2016
9.2016 International Symposium on C-O Activation, Himeji, 10/27/2016
10.The 12th International Symposium on Organic Free Radicals, Shanghai, 9/11/2016
11.The7thWestern Organic Chemistry Conference, Chengdu, 8/5/2016
12.The 30th CCS National Chemistry Conference, Dalian, 7/2/2016
13.The 12th SINO-US Chemistry Professors Conference, Guangzhou, 6/25/2016
14.The 11th SINO-US Chemistry Professors Conference, Soochow, 6/23/2015
15.Institute of Materials, China Academy of Engineering Physics, Jiangyou, 4/24/2015
16.The 7th Sino-German Professor Forum, Muenster, 4/18/2015
17.College of Chemistry, Sichuan University, Chengdu, 26/12/2014
18.2014 Reaxys Inspiring Chemistry Conference, Grindelwald, 9/21/2014
19.2nd International Symposium on C?H Activation, Rennes, 7/2/2014
20.The 7th GCCCD-NRW Annual Conference, Bochum, 5/17/2014
21.The 25th GCCCD Annual Conference, Duisburg, 9/7/2013
22.The 4th CCME-IOC & ICCAS-LMRSS” Alfa Aesar Symposium, Beijing, 2/18/2011
23.Organic Professor and Student Seminar (OPSS), CCME, Peking University, 6/18/2010
24.Organic Professor and Student Seminar (OPSS), CCME, Peking University, 2/24/2009
Lab (since Nov, 2015, about 150 m2, the highest standard and quality in China)
Rotary Evaporator (x8, with cryo cooler, programmable baths and vacuum)
Fume Hood (with vacuum/nitrogen Schlenk line, IKA or Heidolph stirrer/hotplates, vacuum for filtration and air pump for FCC)
Glovebox (with refrigerator)
Solvent Purification System (a safe and convenient way to dispense toluene, DCM, diethylether, THF, 1,4-dioxane, MeCN and DMF)
Cryo Cooler (x3, for reactions under room temperature)
Fridges/Freezers and Ovens
Chemicals and Solvent Cabinets
Instrument Room (with UPLC, UPLC-LTQ, GC, GCMS, vacuum drying oven and canopy hoods)
Lockers for Students
Coffee Room (with computers, HP Laserjet printer, microwave oven, food fridge, water dispenser and hotplate)