Bo Liu

Professor
chembliu@scu.edu.cn

Employment

 

Professor (2007-present)

College of Chemistry

Sichuan University

 

Postdoctoral Research Fellow (2004-2007)

Advisor: Jef K. De Brabander

Department of Biochemistry

University of Texas Southwestern Medical Center, Dallas, Texas

 

Education:

 

Ph.D. in Chemistry (2004)

Advisor: Prof. Weishan Zhou

Shanghai Institute of Organic Chemistry, CAS

 

M.S. in Chemistry (2001)

Advisor: Prof. Xiaoming Feng & Prof. Yaozhong Jiang

Chengdu Institute of Organic Chemistry, CAS

 

B.S. in Chemistry (1998)

College of Chemistry and Chemical Engineering

Southwest Normal University (included in Southwest University at present)

 

Research Interests

1 Total synthesis of complex natural products with important bioactivities

2 Synthesis-oriented methodology

3 Medicine synthesis

Publication list:

1.Heping Deng, Wei Cao, Rong Liu, Yanhui Zhang, and Bo Liu*, Asymmetric Total Synthesis of Hispidanin A, Angew. Chem. Int. Ed., 2017, 56, 5849-5852.

lSelected as Hot paper

lHighlighted by AdvancedScienceNews

2.Changchun Yuan, Biao Du, Heping Deng, Yi Man, Bo Liu*, Total Synthesis of Sarcandrolide J and Shizukaol D: Lindenane Sesquiterpenoid [4+2] Dimers, Angew. Chem. Int. Ed., 2017, 56, 637-640.

lHighlighted by Synfacts (2017, 227)

lSelected as Synfact of the month

lHighlighted by X-MOL

lHighlighted by Chin. J. Org. Chem.2017, 37, 774

3.Liqiang Song, Guili Zhu, Yongjiang Liu, Bo Liu*, Song Qin, Total Synthesis of Atisane-type Diterpenoids: Application of Diels-Alder Cycloadditions of Podocarpane-type Unmasked ortho-Benzoquinones, J. Am. Chem. Soc.2015, 137, 13706-13714.

lHighlighted by Synfacts (2016, 6)

lHighlighted by X-MOL

4.Changchun Yuan, Biao Du, Li Yang, Bo Liu* Bioinspired Total Synthesis of Bolivianine: A Diels-Alder/ Intramolecular Hetero-Diels-Alder Cascade Approach, J. Am. Chem. Soc. 2013, 135, 9291-9294. 

lOne of Most Read Articles in J. Am. Chem. Soc.

lHighlighted by Synfacts (2013, 915)

lSelected as Synfact of the month

lHighlighted by Chin. J. Org. Chem.2013, 33, 2028

lHighlighted by RSC/Chemistry World (2013-06-27)

5.Xuan Huang, Liqiang Song, Jiao Xu, Guili Zhu, Bo Liu* Asymmetric Total Synthesis of Leucosceptroid B, Angew. Chem. Int. Ed.2013, 52, 952-955.

lHighlighted by Synfacts (2013, 246)

lHighlighted by Chin. J. Org. Chem.2013, 33, 654

lYan-Hui Zhang, Rong Liu, Bo Liu*, Total Synthesis of Nannocystin Ax, Chem. Commun., 2017, 53, 5549-5552.

lYan-Hui Zhang, Rong Liu, Bo Liu*, Total Synthesis of Nannocystin Ax, Chem. Commun., 2017, 53, 5549-5552.

6.Yan-Hui Zhang, Rong Liu, Bo Liu*Total Synthesis of Nannocystin Ax, Chem. Commun., 2017, 53, 5549-5552.

7.Yang Yang, Jinpeng Li, Biao Du, Changchun Yuan, Bo Liu*, Song Qin*, An Entry to Vinylcyclopropane through Palladium-catalyzed Intramolecular Cyclopropanation of Alkenes with Unstabilized Allylic tosylhydrazones, Chem. Commun.2015, 51, 6179-6182.

lHighlighted by Synfacts (2015, 744)

8.Biao Du, Changchun Yuan, Tianzi Yu, Li Yang, Yang Yang, Bo Liu*, Song Qin* Asymmetric Total Synthesis of Onoseriolide, Bolivianine and Isobolivianine, Chem. Eur. J.2014, 20, 2613-2622.

9.Guizhou Yue, Li Yang, Changchun Yuan, Xiaoling Jiang, Bo Liu* Total synthesis of chloranthalactone A, Org. Lett.2011, 13, 5406-5408.

lOne of Most Read Articles in Org. Lett.

lHighlighted by Organic Chemistry Highlights (2012-12-31)

lHighlighted in brsmblog.com and chemblogs.net

10.Mingzheng Huang, Liqiang Song, Bo Liu* Construction of the Cyclophane Core of

    the Hirsutellones via a RCM Strategy, Org. Lett.2010, 12, 2504-2507.

11.Chong Huang, Bo Liu* Asymmetric total synthesis ent-heliespirones A & C, Chem. Commun.2010, 46, 5280-5282

12.Guili Zhu, Bo Liu*, Synthesis of derivatives of podocarpane-type diterpenoids through Diels-Alder cycloaddition and photo-decarbonylation from unmasked ortho-benzoquinone, Tetrahedron, 2017, DOI: 10.1016/j.tet.2017.02.032.

13.Guili Zhu, Sachin B. Wadavrao, Bo Liu*, Divergent total synthesis of atisane-type diterpenoids, Chem. Rec., in press, DOI: 10.1002/tcr.201600096.

14.Zhijiang Zhang, Bo Liu*, Total synthesis and confirmation of the revised structures of jiangrines A, C and D, Org. Biomol. Chem., 2017, 15, 207-212.

15.Jinpeng Li, Changchun Yuan, Biao Du, Bo Liu*, An Alternative Total Synthesis of Bolivianine, Chin. Chem. Lett.2017, 28, 113-116.

16.Zhijiang Zhang, Bo Liu*, Total Synthesis of Proposed Structures of Jiangrines C and D, Sci. Chin. Chem.2016,59, 1205-1210.

17.Hongli Yin, Zhe Meng, Bo Liu*, Construction of the Core Structure of Trichotomone, Synthesis, 2016,48, 3951-3956.

18.Heping Deng, Wei Cao, Zhijiang Zhang, Bo Liu*, Asymmetric Synthesis and Absolute Stereochemistry of A Labdane-type Diterpenoid Isolated from the Rhizomes of Isodan yuennanensis, Org. Biomol. Chem.2016, 14, 6225-6230.

19.Li Yang, Liqiang Song, Chong Huang, Mingzheng Huang, Bo Liu*, Exploiting Ortho- Substitution Effect on Formation of Oxygen-containing [10]Paracyclophane through Ring-Closing Metathesis, Org. Chem. Front.2016, 3, 319-323.

20.Rong Liu, Jing Feng, Bo Liu*, Synthetic Progress of Daphnane-type Diterpenoids, Acta Chim. Sinica2016, 74, 24-43.

21.Tianzi Yu, Bo Liu*, Asymmetric Total Synthesis of 3-Furanoeudesmene, A Metabolite from Antarctic Gorgonian and Determination of Its Absolute Configuration, Chin. J. Org. Chem.2015, 35, 2157-2161.

22.Jiao Xu, Bo Liu* Total synthesis of norleucosceptroids F and G, Chin. Chem. Lett. 2015, 26, 1341–1344.

23.Guili Zhu, Rong Liu, Bo Liu*, Total Synthesis of Atisane-type Diterpenoids and Related Diterpenoid Alkaloids, Synthesis2015, 47, 2691-2708. (Invited review)

24.Li Yang, Jing Feng, Jinpeng Li, Bo Liu*, Total synthesis of heliespirone B, Tetrahedron Lett.2015, 56, 4931-4933.

25.Liqiang Song, Chong Huang, Mingzheng Huang, Bo Liu*, Toward the synthesis of hirsutellone B via an intramolecular Diels-Alder /ketene-trapping strategy, Tetrahedron2015, 71, 3602-3607.

26.Jing Feng, Bo Liu*, Formal Carbo [3+3] Annulation and Its Application in Organic Synthesis, Tetrahedron Lett.2015, 56, 1474-1485.

27.Li Yang, Guizhou Yue, Changchun Yuan, Biao Du, Heping Deng, Bo Liu*, Synthetic Studies toward Lindenane-Type Sesquiterpenoid Dimers, Synlett2014, 25, 2471-2474.

28.Hai Tong, Bo Liu*, A Diels-Alder Approach toward the scaffolds of Polycyclic sesquiterpenoids with 2-Pyrone, Synlett2014, 25, 681-686.

29.Biao Du, Changchun Yuan, Langzhong Zhang, Li Yang, Bo Liu* Deprotection of 1,3-Oxathiolanes to Ketones Promoted by Base, Tetrahedron Lett.2013, 54, 2217-2220.

30.Guizhou Yue, Xuan Huang, Bo Liu* Progress in the Total Synthesis of trans-Hydrindane- Containing Terpenoids, Chin. J. Org. Chem. 2013, 33, 1167-1185.

31.Jing Feng, Guili Zhu, Bo Liu*, Xiangdong Zhou* Expedient Synthesis of (R)-Curcuphenol: A Chiral Pool Strategy, Chin, J. Chem.2013, 31, 23-26.

32.Guizhou Yue, Li Yang, Changchun Yuan, Biao Du, Bo Liu* Progress in Total Syntheses of Lindenane-type Sesquiterpenoids and Their Dimers, Chin. J. Org. Chem. 2013, 33, 90-100.

33.Hang Su, Ting Zhou, Bo Liu* Total Synthesis of (±)-Spirobenzofuran, Synlett2013, 615-618.

34.Changchun Yuan, Li Yang, Biao Du, Bo Liu* A Base-promoted deprotection of 1,3-dioxolanes to ketones, Tetrahedron Lett.2012, 53, 6972-6976.

35.Guizhou Yue, Li Yang, Changchun Yuan, Biao Du, Bo Liu* Total Syntheses of Lindenane- type Sesquiterpenoids: (±)-Chloranthalactones A, B, F, (±)-9-Hydroxy Heterogorgiolide and (±)-Shizukanolide E, Tetrahedron, 2012, 68, 9624-9637.

36.Ting Zhou, Guili Zhu, Xuan Huang, Bo Liu* Zeise’s dimmer-catalyzed regioselective hydration of homopropargyl tertiary ether, Tetrahedron Lett.2012, 53, 4955-4958

37.Yongjiang Liu, Chong Huang, Bo Liu* Asymmetric total syntheses of heliannuol E and epi-heliannuol E, Tetrahedron Lett.2011, 52, 5802-5804.

38.Chong Huang, Wenhan Zhang, Bo Liu* Racemic and enantioselective total synthesis of heliespirones A & C, Sci. China. Chem.2011, 54, 43-55.

39.Daxing Yang, Jianfeng Huang, Bo Liu* Platinum-Catalyzed Regioselective Formation of β-Alkoxy Ketones from Internal Alkynes, Eur. J. Org. Chem.2010, 4185-4188.

40.Jianfeng Huang, Xuan Huang, Bo Liu* Gold-catalyzed synthesis of nitrogen-containing heterocycles from ε-N-protected propargylic esters, Org. Biomol. Chem. 2010, 8, 2697-2699.

41.Yunxiu Chen, Jianfeng Huang, Bo Liu* Total syntheses of the proposed structures of cuevaene A, Tetrahedron Lett.2010, 51, 4655-4657.

42.Mingzheng Huang, Chong Huang, Bo Liu* Studies toward the total synthesis of the hirsutellones, Tetrahedron Lett. 2009, 50, 2797-2800.

43.Jef K. De Brabander*, Bo Liu, Mingxing Qian Au(I)- and Pt(II)-Catalyzed Cycloetherification of ω-Hydroxy Propargylic Esters, Org. Lett. 2008, 10, 2533.

44.Xin Jiang, Bo Liu, Sylvain Lebreton, Jef K. De Brabander* Total Synthesis and Structure Revision of the Marine Metabolite Palmerolide A, J. Am. Chem. Soc.2007, 129, 6386. (One of the Most-Accessed Articles in 2007

45.Bo Liu, Jef K. De Brabander* Metal-Catalyzed Regioselective Oxy-Functionalization of Internal Alkynes: An Entry into Ketones, Acetals, and Spiroketals, Org. Lett.2006, 8, 4907.

46.De-Run Li, Dong-Hui Zhang, Cai-Yun Sun, Ji-Wen Zhang, Li Yang, Jian Chen, Bo Liu, Ce Su, Wei-Shan Zhou*, Guo-Qiang Lin* Total Synthesis of Phorboxazole B, Chem. Eur. J.2006, 12, 1185.

47.Bo Liu, Wei-Shan Zhou* Towards the total synthesis of natural peloruside A: stereoselective synthesis of the backbone of the core, Org. Lett.2004, 6, 71.

48.Bo Liu, Wei-Shan Zhou*, Stereoselective synthesis of the C21-C27 fragment of the phorboxazoles, Tetrahedron Lett.2003, 44, 4933.

49.Bo Liu, Wei-Shan Zhou* The first stereoselective synthesis of orostanal, a novel abeo-sterol inducing apoptosis in leukemia cells, Tetrahedron2003, 59, 3379.

50.Zhigang Jiao, Xiaoming Feng * , Bo Liu , Fuxue Chen, Guolin Zhang, Yaozhong Jiang, Enantioselective Strecker reactions between aldimines and trimethylsilyl cyanide promoted by chiral N,N’-dioxides, Eur. J. Org. Chem. 2003 , 3818.

51.Bo Liu, Wei-Shan Zhou* The first stereoselective synthesis of orostanal, a novel abeo-sterol inducing apoptosis in leukemia cells, Tetrahedron Lett.2002, 43, 4187.

52.Bo Liu, Xiaoming Feng*, Fuxue Chen, Guolin Zhang, Xin Cui, Yaozhong Jiang, Enantioselective Strecker reaction promoted by chiral N –oxides, Synlett2001, 1551.

53. US patentJef K. De Brabander, Xin Jiang, Bo LiuPalmerolides: Methods of preparation and derivatives thereof, US patent, US2008249162-A1; WO2008124072-A1; TW200906387-A; US7838691-B2.